CN104258268A - Preparation method of antidinic preparation for electrical aerial work - Google Patents

Abstract

The invention relates to a preparation method of an antidinic preparation for electrical aerial work. The antidinic preparation is prepared from the following raw materials in parts by weight: 35 parts of immature bitter orange, 30 parts of radix curcumae, 25 parts of radix puerariae, 25 parts of caulis bambusae in taeniam, 25 parts of rhizoma arisaematis, 20 parts of gardeniae, 20 parts of uncaria, 20 parts of dendrobe, 20 parts of glossy privet fruit, 20 parts of poria cocos, 18 parts of cortex albiziae, 18 parts of selfheal, 15 parts of white hyacinth bean, 15 parts of myrrh, 15 parts of root of common peony, 10 parts of curcuma zedoary, 10 parts of dandelion, 10 parts of rhizoma alismatis, 8 parts of fingered citron, 8 parts of rhizoma sparganii, 5 parts of plantain herb, 5 parts of polygala tenuifolia, 5 parts of root of Chinese pulsatilla, 5 parts of liquorice and 3 parts of wolfberry. The preparation disclosed by the invention treats both symptoms and root causes of vertigo; and the preparation is non-toxic and harmless to human bodies, free from side effect, low in cost, simple to prepare and broad in prospect.

Description

A kind of preparation method preventing dizzy preparation for electric power work high above the ground

 

Technical field

The invention belongs to medical art, relate to a kind of for dizzy preparation, more specifically, it relates to a kind of preparation method preventing dizzy preparation for electric power work high above the ground.

Background technology

The features such as it is many that power construction has open work, and work high above the ground is many, and labor intensity is large, high-altitude electric operating, away from the tens of rice in ground, transfers to other use, works as acrobat, only has palm wide with stopping over, and gingerly, camps step by step forever.As the power worker being responsible for work high above the ground specially, generally, have every month within 20 days, all obtain creepage tower or electric pole, if and run into duration tighter project, except sleep of having a meal, all the other all times all will treat on tower, and seven or eight hours every days, foot did not land.Some work high above the ground persons stand in eminence and look down, and will produce a kind of probably all psychology, worry to throw and can lose one's life, thus more worry more panic, cold sweat directly emits, and two lower limbs are aching and limp trembles; And after the others's work high above the ground a period of time, just there will be pale complexion, astasia, the symptom such as very dizzy, this is all dizzy symptom in fact,

Dizzy, be a kind of common symptom clinically.This disease can recurrent exerbation, and the lighter is as sat journey, and the time of outbreak is of short duration, and namely the flat sleeping order that closes pacifies a moment; Namely severe one feels very dizzy, can not stand, the symptoms such as companion sees nausea and vomiting, is in a cold sweat, hand shaking, especially easily occurs in it fat, the poor person of body and old people.Patient is to the subjective mistake known from experience of spatial orientation sensation, and patient feels surrounding objects or from rotation, or is oscilaltion, the sensation that rolls.Dizzy is the 3rd of outpatient service common sympton, and most people all experiences this disease in life.The patient suffering from vertigo has following symptom usually: blood pressure, perspires, pale complexion, diarrhoea; Deafness, tinnitus, ear is vexed; Dark and dim eyesight, diplopia, blurred vision; Neck portion or shoulder arm pain, upper limb numbness, limitation of activity; Headache, disturbance of consciousness, sensorimotor obstacle, language or dysarthria etc., doctor trained in Western medicine generally adopts symptomatic treatment, and is treated respectively for underlying diseases.Clinical common many uses calmness and tranquilizer, blood vessel dilating agent, anticholinergic agents, antihistamine drug and anesthetis etc.Because said medicine has the side effect such as drowsiness, xerostomia mostly, most of patients is more prone to seek treatment by Chinese herbs safely and effectively.

The traditional Chinese medical science has very long history for dizzy treatment, and have accumulated rich experience in practice, and successive dynasties doctor nationality is recorded a lot of, as: " Plain Questions the most pure virginity will be discussed greatly " is thought: " all wind trembling and dizziness, all belong to liver "; " the large puzzled opinion of bier " is pointed out: " in item in old pathogen; because meeting the void of its body ... enter brain then vertigo; it is anxious that vertigo then draws order system; order system is anxious then dizzy to turn, " pathogenic factor long term in cervical vertebra, general debility with deficiency of QI in addition, skeleton regression, cause neck blood stasis, passages through which vital energy circulates loses supports, and causes all diseases such as dizzy, stiffness of the nape to occur; " Ling Shu Miraculous Pivot or Divine Axis defends gas " is thought: " deficiency of the upper causing dizziness ", also has " QI of the upper portion of the body being insufficient " in Miraculous Pivot, and " deficiency of marrow-reservoir " etc. cause dizzy because of void.Han dynasty Zhang Zhongjing thinks that phlegm retention is one of reason of dizzy morbidity, had again six climate exopathogens afterwards, damaged by excess of seven emotions causes dizzy, and dificiency in lower-JIAO causes dizzy etc.According to clinical practice, dizzy in close relations with the liver of theory of Chinese medical science.Excessive rising of liver-YANG can directly be sent out dizzy, or because of long-term melancholy angry, stagnated QI transforming into fire, makes liver-yin secretly consume, and wind sun rises dynamic, and pathogen upward attacking orifices in head is sent out as dizzy, or chronic deficiency of kidney-YIN, the liver failing to be nourished, so that deficiecny of liver-YIN, and excessive rising of liver-YANG is sent out as dizzy.

Western medicine is theoretical: dizzy needs, from raising cerebral cortex regulatory function, regulate and control autonomic excitement and inhibit feature, promote neural relative equilibrium and reach the dizzy angle treatment of control; From tcm theory: mainly enter Liver Channel, fire, suppressing the hyperactive liver to relieve the wind syndrome are let out in liver heat removing.But it is very inconvenient that Chinese medicine decoction uses, and has been difficult to extensive patients and accepted, in addition, the dizzy Chinese medicine of existing treatment is very limited, formerly can not meet clinical application demand.

 

Summary of the invention

The object of this invention is to provide that a kind for the treatment of both the principal and secondary aspects of a disease, side effect are little, safe ready, the cheap preparation method preventing dizzy preparation.Its objective is to solve treatment vertigo, especially, preparation prepared by the present invention is applicable to dizzy electric power work high above the ground occurred frequently, and it may be used for treatment work high above the ground vertigo, also can dizzy effectively in prevention work, the risk factor of reduction work high above the ground.

The present invention is with reference to the motherland medical science invaluable experience to the pathogenetic understanding of vertigo and treatment, consult existing reasonable formula, determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, according to Chinese Pharmacopoeia and pharmacology compatibility, push away Chen Zhixin gain to some extent, determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs is the core theory of Chinese medicine disease always, how to take into account secondary pathogenesis for main pathogenesis medication simultaneously, taking into account the treatment of general character and individual character, thus at utmost embody intension and the extension of Chinese traditional treatment disease, is a realistic problem of Chinese patent medicine compatibility.Inventor is for dizzy main pathogenesis characteristics, in conjunction with a large amount of formula according to doctor's row practice for many years, by the research to Chinese medicine, and in conjunction with dialectical demonstration, in many ways the length of many families is collected, seek therapeutic regimen, from motherland's medical treasure-house, filter out reduce phlegm, relieve dizziness, high fever, infantile convulsions, epilepsy, etc., only dizzy, for stagnation of turbid phlegm in middle-JIAO, what clear YANG failing to ascend caused has a dizzy spell, bulge of the ear tinnitus, uncomfortable in chest, feel sick natural Chinese medicine, by theory of Chinese medical science prescription, skim the cream off milk, it is rapid-action, effect is strong, short treating period, safety are high, without obvious toxic-side effects.All medicines share, and bring out the best in each other.

For realizing the object of the invention, the technical solution used in the present invention is as follows:

Prevent a preparation method for dizzy preparation for electric power work high above the ground, described preparation is prepared by following weight proportioning raw material and obtains,

Fructus Aurantii Immaturus 35 parts, Radix Curcumae 30 parts, Radix Puerariae 25 parts, Caulis Bambusae In Taenia 25 parts, Rhizoma Arisaematis 25 parts,

Fructus Gardeniae 20 parts, Ramulus Uncariae Cum Uncis 20 parts, Herba Dendrobii 20 parts, Fructus Ligustri Lucidi 20 parts, 20 parts, Poria,

Cortex Albiziae 18 parts, Spica Prunellae 18 parts, Semen Lablab Album 15 parts, Myrrha 15 parts, Radix Paeoniae Rubra 15 parts,

Rhizoma Curcumae 10 parts, Herba Taraxaci 10 parts, Rhizoma Alismatis 10 parts, Fructus Citri Sarcodactylis 8 parts, Rhizoma Sparganii 8 parts,

Herba Plantaginis 5 parts, Radix Polygalae 5 parts, the Radix Pulsatillae 5 parts, 5 parts, Radix Glycyrrhizae, Fructus Lycii 3 parts.

Its preparation method is:

1) take raw material according to weight proportion, get Rhizoma Arisaematis, Herba Dendrobii, Radix Glycyrrhizae are ground into fine powder respectively, cross 100 mesh sieves, and complex A is prepared in mixing;

2) get Fructus Aurantii Immaturus, Radix Curcumae, Radix Puerariae, Caulis Bambusae In Taenia, Poria, Cortex Albiziae, Spica Prunellae, Semen Lablab Album, Myrrha, Radix Polygalae mix homogeneously, the water intense fire adding 3 times of weight boils, then slow fire boiling 30 minutes, collecting by filtration filtrate and filtering residue; In filtering residue, add 1 times of weight water, intense fire boils, then slow fire boiling 30 minutes, collecting by filtration filtrate; Merge above-mentioned twice filtrate, after cooling, be condensed into the extractum that density is 1.33g/ml; After 80 DEG C of oven dry, be ground into powder, be complex B;

3) residual components and Fructus Gardeniae, Ramulus Uncariae Cum Uncis, Fructus Ligustri Lucidi, Radix Paeoniae Rubra, Rhizoma Curcumae, Herba Taraxaci, Rhizoma Alismatis is got, Fructus Citri Sarcodactylis, Rhizoma Sparganii, Herba Plantaginis, the Radix Pulsatillae, Fructus Lycii 70% alcohol heating reflux 2 hours, filter, filtrate recycling ethanol, then concentrated acquisition condensed cream, Concentrating Process Control temperature is 60 DEG C, and controlling condensed cream density is 1.33g/ml, and crushed after being dried obtains complex C;

Homogeneous phase mixing complex A, complex B and complex C prepare the compound medicament composition of the application.

Medicine of the present invention can adopt the conventional method in existing pharmaceutical field to produce, and can add various pharmaceutically acceptable carrier when needs.Described carrier comprises the excipient, filler, binding agent, wetting agent, disintegrating agent, absorption enhancer, surfactant, absorption carrier, lubricant etc. of pharmaceutical field routine.

Preferably, make capsule according to a conventional method, every 0.1g, through being up to the standards as finished product.

Usage and dosage, one time 1,3 times on the one.

During for pre-anti-dazzle, within first two hours, take 1-2 sheet in work high above the ground.

Technical solutions according to the invention are on the clinical experience basis that Chinese traditional treatment is dizzy, in conjunction with modern pharmacy achievement develop with the compound preparation of Integrated TCM.Chinese medicine and Western medicine are combined effectively, there is dispelling wind and removing obstruction in the collateral very by force, flat dizzy dizzy effect of dispelling, symptom can be improved rapidly, stop disease, to dizzy effect having healing, overcome the shortcomings such as the slow and toxicity of prior art Chinese medicine onset is large, reach the object for the treatment of both the principal and secondary aspects of a disease.

The component of medicine of the present invention all adopts natural raw material of Chinese medicine, and its preparation is easy, and medicine source is extensive, with low cost, it adopts different extracting method to obtain its effective ingredient to greatest extent, follows the prescriptions principle of the traditional Chinese medical science, all medicines share, and bring out the best in each other, and invention formulation dose is little, effective ingredient is easy to release, and absorb fast, bioavailability is high, drug effect is given full play to, and through clinical practice checking, it is reliably evident in efficacy, mild in medicine property and, there is not toxic and side effects, have a extensive future.

 

Detailed description of the invention

Embodiment 1

Prevent a preparation method for dizzy preparation for electric power work high above the ground, described preparation is prepared by following weight proportioning raw material and obtains,

Fructus Aurantii Immaturus 35 parts, Radix Curcumae 30 parts, Radix Puerariae 25 parts, Caulis Bambusae In Taenia 25 parts, Rhizoma Arisaematis 25 parts,

Fructus Gardeniae 20 parts, Ramulus Uncariae Cum Uncis 20 parts, Herba Dendrobii 20 parts, Fructus Ligustri Lucidi 20 parts, 20 parts, Poria,

Cortex Albiziae 18 parts, Spica Prunellae 18 parts, Semen Lablab Album 15 parts, Myrrha 15 parts, Radix Paeoniae Rubra 15 parts,

Rhizoma Curcumae 10 parts, Herba Taraxaci 10 parts, Rhizoma Alismatis 10 parts, Fructus Citri Sarcodactylis 8 parts, Rhizoma Sparganii 8 parts,

Herba Plantaginis 5 parts, Radix Polygalae 5 parts, the Radix Pulsatillae 5 parts, 5 parts, Radix Glycyrrhizae, Fructus Lycii 3 parts.

Its preparation method is:

1) take raw material according to weight proportion, get Rhizoma Arisaematis, Herba Dendrobii, Radix Glycyrrhizae are ground into fine powder respectively, cross 100 mesh sieves, and complex A is prepared in mixing;

2) get Fructus Aurantii Immaturus, Radix Curcumae, Radix Puerariae, Caulis Bambusae In Taenia, Poria, Cortex Albiziae, Spica Prunellae, Semen Lablab Album, Myrrha, Radix Polygalae mix homogeneously, the water intense fire adding 3 times of weight boils, then slow fire boiling 30 minutes, collecting by filtration filtrate and filtering residue; In filtering residue, add 1 times of weight water, intense fire boils, then slow fire boiling 30 minutes, collecting by filtration filtrate; Merge above-mentioned twice filtrate, after cooling, be condensed into the extractum that density is 1.33g/ml; After 80 DEG C of oven dry, be ground into powder, be complex B;

3) residual components and Fructus Gardeniae, Ramulus Uncariae Cum Uncis, Fructus Ligustri Lucidi, Radix Paeoniae Rubra, Rhizoma Curcumae, Herba Taraxaci, Rhizoma Alismatis is got, Fructus Citri Sarcodactylis, Rhizoma Sparganii, Herba Plantaginis, the Radix Pulsatillae, Fructus Lycii 70% alcohol heating reflux 2 hours, filter, filtrate recycling ethanol, then concentrated acquisition condensed cream, Concentrating Process Control temperature is 60 DEG C, and controlling condensed cream density is 1.33g/ml, and crushed after being dried obtains complex C;

Homogeneous phase mixing complex A, complex B and complex C prepare the compound medicament composition of the application, make capsule according to a conventional method, every 0.1g, through being up to the standards as finished product.

Usage and dosage, one time 1,3 times on the one.

 

Embodiment 2

One, toxicity test

This experiment adopts healthy SD rat, medicine prepared by oral administration embodiment 1, successive administration 30 days, during observing rat administration and after drug withdrawal, within 1 week, growth of animal state, movable diet, hematology, blood biochemical analysis, organs and tissues structure and routine urinalysis etc. all have no significant effect, and show that clinical drug safety is reliable.

Two, invention formulation rotates rear property nystagmus to rat obvious inhibitory action, the tolerance time of vestibule irriate can be extended, alleviate vestibule autonomic nervous dysfunction, blood vessel dilating can be played, improve microcirculation, increase blood flow, alleviate dizzy and tinnitus, deaf effect;

Embodiment 3

Clinical data

1. choose outpatient's totally 73 examples with complete case.Be divided into treatment group, matched group two groups at random, wherein treatment group 37 people, matched group 36 people.Above data, between group, age of patient, the course of disease and dizzy degree are basically identical, and no significant difference (P>0.05), has comparability.

Treatment group give embodiment 1 prepare preparation, 3 times on the 1st, 1 time 1;

Matched group 3 times on the 1st, takes 5 YIXUANNING JIAONANG for 1 time; All patients stops using the medicine relevant to treating primary disease and other Therapeutic Method at treatments period.

Diagnostic criteria

1. tcm diagnosis

(1) typical vertigo symptoms is had: self have and rotate or rolling innervation, or what comes into a driver's thing has sense of rotation; Or conscious dizziness, dusk

Heavy or dizzy swollen discomfort.(2) history of repeated attack can be had.

2. Chinese medical discrimination

Stagnation of turbid phlegm in middle-JIAO is demonstrate,proved

Dizzy and see heaviness of the head as being covered, or sharply dizzy, self or scenery rotate, and body uncomfortable in chest is stranded, lack of appetite drowsirness, nausea and vomiting, Hiccough and deaf, white and greasy fur, the sliding or stringy and rolling pulse of soft pulse.

3. dizzy weight grade scale

(1) slight: consciously to have a dizzy spell, without self or scenery sense of rotation or shake dynamic; Or the murky and not shadow of simple head

It is movable to ring.

(2) moderate: conscious dizziness also has self to rotate or shakes dynamic, but does not affect life; Or simple dizzy and affect activity,

But can work be adhered to.

(3) severe: conscious dizziness also has self and scenery sense of rotation, and head body dare not rotate; Or dizzy merely, upset,

Be difficult to competent at a job.

Efficacy assessment standard:

1, clinical efficacy

Recovery from illness: treatment is dizzy afterwards waits transference cure.

Effective: after treatment, the symptom such as dizzy obviously alleviates, micro-have murky, or it is slight but without self and scape to have a dizzy spell

The rotation of thing, innervation of shaking, can orthobiosis and work.Or clinical symptoms comparatively treats front reduction by 2 grades.

Effective: dizzy or dizzyly to alleviate after treatment, only with slight self or scenery rotation, shake dynamic, though can adhere to

Work, but live and work is affected.Or clinical symptoms comparatively treats front reduction by 1 grade.

Invalid: the symptoms such as giddy is heavy and dizzy are without improvement or increase the weight of.

Result is as shown in table 1:

Table 1: efficacy result

Group	Example time	Recovery from illness	Effective	Effectively	Invalid	Total effective rate
							Treatment group	37	26	8	1	2	94.6％
Matched group	36	12	6	10	8	77.7％

Therefore the embodiment of the present invention 1 group is all significantly higher than matched group medicine in total effective rate and cure rate etc.

 

Embodiment 4

Exemplary embodiments

1 thanks certain, man, 41 years old.Dizzy after getting up twice morning on every Mondays, general about 10 minutes, eyes are closed can be quite a lot of, posture can only be kept in bed time dizzy, clearheaded, be diagnosed as dizzy, every morning one gets up and takes Betahistine, after taking a few box, still have dizzy sensation of getting up morning, give preparation prepared by embodiment 1, after the course for the treatment of of taking medicine, vertigo symptoms disappears, continue to strengthen the treatment recovery from illness course for the treatment of, follow up a case by regular visits to half a year without recurrence.

2 Lin works, high-altitude electric operating person, because project needs, often all obtain creepage tower or electric pole, within one day sometimes, have seven or eight hours feet not land, once felt dizzy in work position, fall down staircase, fortunately safeguard procedures put in place, just do not cause danger, after this preparation prepared by embodiment 1 is all taken in each work high above the ground, then without the appearance of vertigo symptoms.

The application is for preventing dizzy preparation with low cost, evident in efficacy, has broad application prospects.

Claims (2)

1. prevent a preparation method for dizzy preparation for electric power work high above the ground, it is characterized in that, the preparation method of described preparation is:

1) raw material for standby is taken according to weight portion; Wherein,

Fructus Aurantii Immaturus 35 parts, Radix Curcumae 30 parts, Radix Puerariae 25 parts, Caulis Bambusae In Taenia 25 parts, Rhizoma Arisaematis 25 parts,

Fructus Gardeniae 20 parts, Ramulus Uncariae Cum Uncis 20 parts, Herba Dendrobii 20 parts, Fructus Ligustri Lucidi 20 parts, 20 parts, Poria,

Cortex Albiziae 18 parts, Spica Prunellae 18 parts, Semen Lablab Album 15 parts, Myrrha 15 parts, Radix Paeoniae Rubra 15 parts,

Rhizoma Curcumae 10 parts, Herba Taraxaci 10 parts, Rhizoma Alismatis 10 parts, Fructus Citri Sarcodactylis 8 parts, Rhizoma Sparganii 8 parts,

Herba Plantaginis 5 parts, Radix Polygalae 5 parts, the Radix Pulsatillae 5 parts, 5 parts, Radix Glycyrrhizae, Fructus Lycii 3 parts;

2) get Rhizoma Arisaematis, Herba Dendrobii, Radix Glycyrrhizae, be ground into fine powder respectively, crosses 100 mesh sieves, and mixing is prepared into complex A;

3) get Fructus Aurantii Immaturus, Radix Curcumae, Radix Puerariae, Caulis Bambusae In Taenia, Poria, Cortex Albiziae, Spica Prunellae, Semen Lablab Album, Myrrha, Radix Polygalae, mix homogeneously, the water intense fire adding 3 times of weight boils, then slow fire boiling 30 minutes, collecting by filtration filtrate and filtering residue; In filtering residue, add 1 times of weight water, intense fire boils, then slow fire boiling 30 minutes, collecting by filtration filtrate; Merge above-mentioned twice filtrate, after cooling, be condensed into the extractum that density is 1.33g/ml; After 80 DEG C of oven dry, be ground into powder, be complex B;

4) Fructus Gardeniae, Ramulus Uncariae Cum Uncis, Fructus Ligustri Lucidi, Radix Paeoniae Rubra, Rhizoma Curcumae, Herba Taraxaci, Rhizoma Alismatis is got, Fructus Citri Sarcodactylis, Rhizoma Sparganii, Herba Plantaginis, the Radix Pulsatillae, Fructus Lycii, with 70% alcohol heating reflux 2 hours, filter, filtrate recycling ethanol, then concentrated acquisition condensed cream, crushed after being dried obtains complex C;

5) Homogeneous phase mixing complex A, complex B and complex C, to obtain final product.

2. according to claim 1 the preparation prepared of method for the dizzy therapeutic use of high-altitude electric operating.