CN104689230A - Method for preparing traditional Chinese medicine preparation for treatment of vertigo - Google Patents
Method for preparing traditional Chinese medicine preparation for treatment of vertigo Download PDFInfo
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Abstract
The invention relates to a method for preparing a traditional Chinese medicine preparation for the treatment of vertigo. The preparation is prepared from the following raw materials in parts by weight: 35 parts of puerarin, 35 parts of rhizoma atractylodis macrocephalae, 35 parts of caulis spatholobi, 35 parts of radix achyranthis bidentatae, 30 parts of folium nelumbinis, 30 parts of fructus ligustri lucidi, 30 parts of salvia miltiorrhiza, 30 parts of herba agrimoniae, 30 parts of rhizoma acori graminei, 25 parts of gordon euryale seeds, 25 parts of poria cocos, 25 parts of uncaria, 25 parts of folium ginkgo, 25 parts of semen cuscutae, 20 parts of semen strychni, 20 parts of radix ginseng rubra, 20 parts of rubia cordifolia, 20 parts of frankincense, 18 parts of angelica sinensis, 15 parts of polygonum multiflorum, 15 parts of paeonia suffruticosa, 15 parts of cinnamon, 10 parts of cortex magnoliae officinalis, 10 parts of rhizoma zedoariae and 10 parts of semen ziziphi spinosae. The preparation prepared by using the method disclosed by the invention achieves an effect of treating both symptoms and root causes on vertigo, is non-toxic and harmless to the human body, low in cost, and simple in production, and has no side effect; therefore, the preparation has a broad prospect.
Description
Technical field
The invention belongs to Chinese medicine technical field, relate to Chinese medicine formula and applied technical field, be specifically related to a kind of preparation method for the treatment of dizzy Chinese medicine preparation.
Background technology
Dizzy, it is a kind of paraesthesia of subjectivity, two classes can be divided into: one is rotatory vertigo, how caused by the dysfunction of vestibular nervous system and cerebellum, master is felt as with what topple over, feel self to rock or scenery rotation, two is general dizzy, how to be caused by some systemic disease, master is felt as with giddy, feel top-heavy, dizzyly be more common in middle-aged and elderly people, also can send out in adolescence, can recurrent exerbation, hinder normal work and life, severe patient can develop into apoplexy or card of fainting, the depletion syndrome, even threat to life, Meniere in western medicine, vestibular neuronitis, Benign paroxysmal positional vertigo, cervical spondylosis, the diseases such as vertebra one basilar artery insufficiency are equivalent to this disease, this disease can recurrent exerbation, the lighter is as sat journey, the time of outbreak is of short duration, namely the flat sleeping order that closes pacifies a moment, namely severe one feels very dizzy, can not stand, the symptoms such as companion sees nausea and vomiting, is in a cold sweat, hand shaking, and especially easily occur in it fat, the poor person of body and old people, patient feels " fluttering is swung ", does not clearly rotate sense.Patient is to the subjective mistake known from experience of spatial orientation sensation, and patient feels surrounding objects or from rotation, or is oscilaltion, the sensation that rolls.The patient suffering from vertigo has following symptom usually: blood pressure, perspires, pale complexion, diarrhoea; Deafness, tinnitus, ear is vexed; Dark and dim eyesight, diplopia, blurred vision; Neck portion or shoulder arm pain, upper limb numbness, limitation of activity; Headache, disturbance of consciousness, sensorimotor obstacle, language or dysarthria etc., doctor trained in Western medicine generally adopts symptomatic treatment, and is treated respectively for underlying diseases.
Clinical common many uses calmness and tranquilizer, blood vessel dilating agent, anticholinergic agents, antihistamine drug and anesthetis etc.Because said medicine has the side effect such as drowsiness, xerostomia mostly, most of patients is more prone to seek treatment by Chinese herbs safely and effectively.
The traditional Chinese medical science has very long history for dizzy treatment, and have accumulated rich experience in practice, motherland's medical science is thought dizzy and can be caused by wind, expectorant, wet, void, therefore have the saying of " calm do not do dizzy ", " dizziness must be caused by phlegm ", " dizziness must be due to deficiency ", dizzyly many to fall ill because of reasons such as dynamic in patient's excess of YANG hyperactivity of fire or empty positive rising usually, wind sun, stagnation of turbid phlegm in middle-JIAO, deficiency of QI in middle-JIAO, deficiency of kidney-essence, treatment is stopped burning with fresh breeze, blood stasis dispelling of eliminating the phlegm, nourish yin and calm the liver, kidney tonifying, essence replenishing be essential therapeutic arsenals.Successive dynasties doctor nationality is recorded a lot of, as: " Plain Questions the most pure virginity will be discussed greatly " is thought: " all wind trembling and dizziness, all belong to liver "; " the large puzzled opinion of bier " is pointed out: " in item in old pathogen; because meeting the void of its body ... enter brain then vertigo; it is anxious that vertigo then draws order system; order system is anxious then dizzy to turn, " pathogenic factor long term in cervical vertebra, general debility with deficiency of QI in addition, skeleton regression, cause neck blood stasis, passages through which vital energy circulates loses supports, and causes all diseases such as dizzy, stiffness of the nape to occur; " Ling Shu Miraculous Pivot or Divine Axis defends gas " is thought: " deficiency of the upper causing dizziness ", also has " QI of the upper portion of the body being insufficient " in Miraculous Pivot, and " deficiency of marrow-reservoir " etc. cause dizzy because of void.Han dynasty Zhang Zhongjing thinks that phlegm retention is one of reason of dizzy morbidity, had again six climate exopathogens afterwards, damaged by excess of seven emotions causes dizzy, and dificiency in lower-JIAO causes dizzy etc.According to clinical practice, dizzy in close relations with the liver of theory of Chinese medical science.Excessive rising of liver-YANG can directly be sent out dizzy, or because of long-term melancholy angry, stagnated QI transforming into fire, makes liver-yin secretly consume, and wind sun rises dynamic, and pathogen upward attacking orifices in head is sent out as dizzy, or chronic deficiency of kidney-YIN, the liver failing to be nourished, so that deficiecny of liver-YIN, and excessive rising of liver-YANG is sent out as dizzy.But it is very inconvenient that Chinese medicine decoction uses, and has been difficult to extensive patients and accepted, in addition, the dizzy Chinese medicine of existing treatment is very limited, far can not meet clinical application demand.
Summary of the invention
The object of this invention is to provide that a kind for the treatment of both the principal and secondary aspects of a disease, side effect are little, Chinese medicine preparation that safe ready, cheap treatment are dizzy and its preparation method and application.Its objective is to solve treatment vertigo.
The present invention is with reference to the motherland medical science invaluable experience to the pathogenetic understanding of vertigo and treatment, consult existing reasonable formula, determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, according to Chinese Pharmacopoeia and pharmacology compatibility, push away Chen Zhixin gain to some extent, determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs is the core theory of Chinese medicine disease always, how to take into account secondary pathogenesis for main pathogenesis medication simultaneously, taking into account the treatment of general character and individual character, thus at utmost embody intension and the extension of Chinese traditional treatment disease, is a realistic problem of Chinese patent medicine compatibility.Inventor, for dizzy main pathogenesis characteristics, in conjunction with a large amount of formula according to doctor's row practice for many years, by the research to Chinese medicine, and in conjunction with dialectical demonstration, in many ways collects the length of many families, seeks therapeutic regimen.
For realizing the object of the invention, the technical solution used in the present invention is as follows:
Treat a preparation method for dizzy Chinese medicine preparation, described preparation is prepared by following weight proportioning raw material and obtains:
Radix Puerariae 35 parts, the Rhizoma Atractylodis Macrocephalae 35 parts, Caulis Spatholobi 35 parts, Radix Achyranthis Bidentatae 35 parts, 30 parts, Folium Nelumbinis,
Fructus Ligustri Lucidi 30 parts, Radix Salviae Miltiorrhizae 30 parts, Herba Agrimoniae 30 parts, Rhizoma Acori Graminei 30 parts, Semen Euryales 25 parts,
25 parts, Poria, Ramulus Uncariae Cum Uncis 25 parts, Folium Ginkgo 25 parts, Semen Cuscutae 25 parts, Semen Strychni 20 parts,
Radix Ginseng Rubra 20 parts, 20 parts, Radix Rubiae, Olibanum 20 parts, Radix Angelicae Sinensis 18 parts, Radix Polygoni Multiflori 15 parts,
Cortex Moutan 15 parts, Cortex Cinnamomi 15 parts, Cortex Magnoliae Officinalis 10 parts, Rhizoma Curcumae 10 parts, Semen Ziziphi Spinosae 10 parts.
Its preparation method is:
1) raw material is taken according to weight proportion
2) get Radix Puerariae, Radix Achyranthis Bidentatae, Radix Salviae Miltiorrhizae, Herba Agrimoniae, Rhizoma Acori Graminei, Semen Euryales, Poria, Ramulus Uncariae Cum Uncis, Semen Strychni, Radix Ginseng Rubra, Radix Polygoni Multiflori, Rhizoma Curcumae add 3 times of weight 90% alcohol dipping 24 hours, reflux, extract, twice, each 1 hour, merge extractive liquid, was condensed into the clear paste that density is 1.2 g/ml;
3) get residual components water boiling and extraction 2 times, first time extracts the water adding 3 times of weight, and extraction time is 0.5 hour; Second time extracts the water adding 2 times of weight, and extraction time is 0.5 hour; Filter, merging filtrate, is concentrated into the clear paste that density is 1.2 g/ml;
4) by step 2), the clear paste prepared of step 3) mixes and get final product.
Medicine of the present invention can adopt the conventional method in existing pharmaceutical field to produce, and can add various pharmaceutically acceptable carrier when needs.Described carrier comprises the excipient, filler, binding agent, wetting agent, disintegrating agent, absorption enhancer, surfactant, absorption carrier, lubricant etc. of pharmaceutical field routine.
Preferably, make capsule according to a conventional method, every 0.1g, through being up to the standards as finished product.
Usage and dosage, one time 1,3 times on the one.
Chinese medicine composition of the present invention is under Traditional Chinese medical theory and clinical experience instruct, selected medicament composing prescription, each drug component is through dialectical compatibility, complement each other using, there is synergism, play strengthening the spleen stomach function regulating altogether, effect of eliminating phlegm of having one's ideas straightened out, warming the meridian and promoting blood circulation, promoting blood circulation to remove blood stasis, thus the treatment of vertigo is reached to the object for the treatment of both the principal and secondary aspects of a disease.
The component of the present composition all adopts natural raw material of Chinese medicine, and its preparation is easy, medicine source is wide, cost is low.It follows the prescriptions principle of the traditional Chinese medical science, and various component drug adopts decocting and takes after mixing it with water and takes.Through clinical practice checking, it is evident in efficacy, reliable effect, mild in medicine property and, there is not toxic and side effects.
Detailed description of the invention
Embodiment 1
Treat a preparation method for dizzy Chinese medicine preparation, described preparation is prepared by following weight proportioning raw material and obtains:
Radix Puerariae 35 parts, the Rhizoma Atractylodis Macrocephalae 35 parts, Caulis Spatholobi 35 parts, Radix Achyranthis Bidentatae 35 parts, 30 parts, Folium Nelumbinis,
Fructus Ligustri Lucidi 30 parts, Radix Salviae Miltiorrhizae 30 parts, Herba Agrimoniae 30 parts, Rhizoma Acori Graminei 30 parts, Semen Euryales 25 parts,
25 parts, Poria, Ramulus Uncariae Cum Uncis 25 parts, Folium Ginkgo 25 parts, Semen Cuscutae 25 parts, Semen Strychni 20 parts,
Radix Ginseng Rubra 20 parts, 20 parts, Radix Rubiae, Olibanum 20 parts, Radix Angelicae Sinensis 18 parts, Radix Polygoni Multiflori 15 parts,
Cortex Moutan 15 parts, Cortex Cinnamomi 15 parts, Cortex Magnoliae Officinalis 10 parts, Rhizoma Curcumae 10 parts, Semen Ziziphi Spinosae 10 parts.
Its preparation method is:
1) raw material is taken according to weight proportion
2) get Radix Puerariae, Radix Achyranthis Bidentatae, Radix Salviae Miltiorrhizae, Herba Agrimoniae, Rhizoma Acori Graminei, Semen Euryales, Poria, Ramulus Uncariae Cum Uncis, Semen Strychni, Radix Ginseng Rubra, Radix Polygoni Multiflori, Rhizoma Curcumae add 3 times of weight 90% alcohol dipping 24 hours, reflux, extract, twice, each 1 hour, merge extractive liquid, was condensed into the clear paste that density is 1.2 g/ml;
3) get residual components water boiling and extraction 2 times, first time extracts the water adding 3 times of weight, and extraction time is 0.5 hour; Second time extracts the water adding 2 times of weight, and extraction time is 0.5 hour; Filter, merging filtrate, is concentrated into the clear paste that density is 1.2 g/ml;
4) by step 2), step 3) prepare clear paste mixing, be pressed into soft capsule with encapsulating machine, every 0.1g, through being up to the standards as finished product.
Usage and dosage, one time 1,3 times on the one.
Embodiment 2
One, toxicity test
This experiment adopts healthy SD rat, medicine prepared by oral administration embodiment 1, successive administration 30 days, during observing rat administration and after drug withdrawal, within 1 week, growth of animal state, movable diet, hematology, blood biochemical analysis, organs and tissues structure and routine urinalysis etc. all have no significant effect, and show that clinical drug safety is reliable.
Two, invention formulation has obvious inhibitory action to rat rotatory nystagmus, the tolerance time of vestibule irriate can be extended, alleviate vestibule autonomic nervous dysfunction, blood vessel dilating can be played, improve microcirculation, increase blood flow, alleviate dizzy and tinnitus, deaf effect;
Embodiment 3
Clinical data
The routine clinical observation of sudden patients with vertigo 63 of 1 selection diagnosis and treatment since 2012.Patient all meets sudden Diagnosis of Vertigo standard.Patient is divided into treatment group and matched group two groups at random, treatment group 32 example, matched group 31 example.The course of disease, the degrees of symptoms for the treatment of group and matched group two groups of cases are basically identical, without significant difference, have comparability.
Treatment group give embodiment 1 prepare preparation, 3 times on the 1st, 1 time 1;
Matched group gives diphenidol tablet, 3 times on the 1st, 1 50mg;
All patients stops using the other medicines relevant to treating primary disease and other Therapeutic Method at treatments period.
Efficacy assessment standard:
Clinical efficacy
Cure: treatment is dizzy afterwards waits transference cure.
Effective: after treatment, the symptom such as dizzy obviously alleviates, micro-have murky, or have a dizzy spell slight but without self and scenery rotation, shake dynamic, can orthobiosis and work.
Effective: dizzy or dizzyly to alleviate after treatment, only with slight self or scenery rotation, shake dynamic, though can adhere to
Work, but live and work is affected.
Invalid: the symptoms such as giddy is heavy and dizzy are without improvement or increase the weight of.
Result is as shown in table 1:
Table 1: efficacy result
| Group | Example time | Cure | Effective | Effectively | Invalid | Total effective rate |
| Treatment group | 32 | 20 | 7 | 4 | 1 | 96.8％ |
| Matched group | 31 | 11 | 6 | 6 | 8 | 74.1％ |
Therefore the embodiment of the present invention 1 group is all significantly higher than matched group medicine in total effective rate and cure rate etc.
Embodiment 4
Exemplary embodiments
Cao, man, 47 years old, patient started with dizziness without clear and definite inducement before 1 year, dizzy is cardinal symptom, and increase the weight of gradually, once cervical spondylosis was diagnosed as, Meniere disease, Multiple Hospitalization is treated, symptom still occurs repeatedly, before first quarter moon, appearance is suddenly realized instantaneously, feel dizzy after waking up, feel sick, dark and dim eyesight, continue to alleviate, and it is vexed with breast, dysphoria with smothery sensation, nausea and vomiting, upper limb numbness, have a medical check-up: blood pressure l40/90mmHg, rule is neat, hear sounds is low, thick, yellow and greasy fur, stringy and rolling pulse, tcm diagnosis: dizzy disease, give embodiment 1 prepare Chinese medicine preparation after three days symptom alleviate to some extent, continue to take medicine 1 week, dizziness subtracts greatly, above-mentioned symptom disappears substantially, continue to strengthen treatment 1 week, all diseases are all removed, and recovery from illness, follows up a case by regular visits to and do not recur.
Liu, female, 59 years old.Patient because of dizzy, dizzy 2 weeks, increase the weight of half a day and see a doctor.Quarrel from the cause and people, gloomyly not understand, namely feel dizzy next day, headache, binocular is swollen, and appetite declines, susceptible to lose temper due to restlessness, sleeps night peaceful, distending pain under two rib, xerostomia, bitter taste, constipation with dry stool, haves a medical check-up: blood pressure blood pressure l30/85mmHg, flushed face.Be diagnosed as dizzy.Giving Chinese medicine preparation prepared by embodiment 1,5th is a course for the treatment of.Dizzyly after taking medicine 3 days to alleviate, dizzy basic elimination in 5 days, after the following the service conditioning course for the treatment of, dizzy disappearance, follows up a case by regular visits to and does not recur.
It is with low cost that the application is used for the treatment of dizzy preparation, evident in efficacy, has broad application prospects.
Claims (2)
1. treat a preparation method for dizzy Chinese medicine preparation, it is characterized in that, described preparation method comprises the steps:
Following raw material for standby is taken according to weight proportion, wherein,
Radix Puerariae 35 parts, the Rhizoma Atractylodis Macrocephalae 35 parts, Caulis Spatholobi 35 parts, Radix Achyranthis Bidentatae 35 parts, 30 parts, Folium Nelumbinis,
Fructus Ligustri Lucidi 30 parts, Radix Salviae Miltiorrhizae 30 parts, Herba Agrimoniae 30 parts, Rhizoma Acori Graminei 30 parts, Semen Euryales 25 parts,
25 parts, Poria, Ramulus Uncariae Cum Uncis 25 parts, Folium Ginkgo 25 parts, Semen Cuscutae 25 parts, Semen Strychni 20 parts,
Radix Ginseng Rubra 20 parts, 20 parts, Radix Rubiae, Olibanum 20 parts, Radix Angelicae Sinensis 18 parts, Radix Polygoni Multiflori 15 parts,
Cortex Moutan 15 parts, Cortex Cinnamomi 15 parts, Cortex Magnoliae Officinalis 10 parts, Rhizoma Curcumae 10 parts, Semen Ziziphi Spinosae 10 parts;
2) get Radix Puerariae, Radix Achyranthis Bidentatae, Radix Salviae Miltiorrhizae, Herba Agrimoniae, Rhizoma Acori Graminei, Semen Euryales, Poria, Ramulus Uncariae Cum Uncis, Semen Strychni, Radix Ginseng Rubra, Radix Polygoni Multiflori, Rhizoma Curcumae, mixing, adds 3 times of weight 90% alcohol dipping 24 hours, reflux, extract, twice, each 1 hour, merge extractive liquid, was condensed into the clear paste that density is 1.2 g/ml;
3) get surplus stock, by water boiling and extraction 2 times, first time extracts the water adding 3 times of weight, and extraction time is 0.5 hour; Second time extracts the water adding 2 times of weight, and extraction time is 0.5 hour; Filter, merging filtrate, is concentrated into the clear paste that density is 1.2 g/ml;
4) by step 2) and the clear paste prepared of step 3) mix and get final product.
2. method described in claim 1 is used for dizzy purposes.
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Cited By (1)
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| CN105770591A (en) * | 2016-03-18 | 2016-07-20 | 杭州富阳飞博科技有限公司 | Pharmaceutical preparation for treating dizziness and preparation method thereof |
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| CN1440801A (en) * | 2003-03-31 | 2003-09-10 | 江西汇仁药业有限公司 | Dizziness treating Chinese medicine |
| CN1626159A (en) * | 2003-12-12 | 2005-06-15 | 董亮 | Method for preparing pills of quenching dizziness |
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| CN105770591A (en) * | 2016-03-18 | 2016-07-20 | 杭州富阳飞博科技有限公司 | Pharmaceutical preparation for treating dizziness and preparation method thereof |
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Application publication date: 20150610 |