CN104258011A - Traditional Chinese medicine preparation for treating chronic heart failure heart and kidney yang deficiency - Google Patents
Traditional Chinese medicine preparation for treating chronic heart failure heart and kidney yang deficiency Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine preparation for treating chronic heart failure heart and kidney yang deficiency. Traditional Chinese medicine syndrome differentiation and treatment on the chronic heart failure heart and kidney yang deficiency takes the principle of nourishing qi, warming yang, alleviating water retention and resolving stagnation. Therefore, the traditional Chinese medicine preparation is prepared by decocting the following traditional Chinese medicines including polygonum hydropiper L., Chinese chive root, fennel root, herb of gold stargrass, many-nerved bauhinia leaf, rhodiola dumulosa, ventilago leiocarpa benth, velvet bean, goldwool clematis stem, Indian glory-bower, veronicastrum herb and ussuri lepisorus herb by water to prepare a decoction. By clinical experiment, various improvement indexes of a treatment group are obviously superior to those of a control group, and thus the traditional Chinese medicine preparation is worthy of being clinically popularized and applied.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, particularly relate to a kind of Chinese medicine preparation of chronic heart failure syndrome of yang deficiency of heart and kidney.
Background technology
Chronic heart failure is cardiovascular disease common clinically, is the poor clinical syndrome of a kind of prognosis.Modern medicine thinks the contraction that caused by the initial cardiac damage of a variety of causes and the serious low or overload of diastolic function, pump blood is finally caused to reduce, clinical symptoms is based on dyspnea, tired and fluid retention, and with the performance that neuroendocrine system activates, belong to cardiac structure or functional disease.Modern medicine for heart failure treatment from apply diuretic therapy water-sodium retention, treat pump failure to use medicament for expanding vascellum and positive inotropic medicament and improve abnormal hemodynamics, more emphasize now the Drug therapy delaying the reconstruct of ventricle pathologic, recommend prolonged application neurohormonal antagonists as ACEI/ARB, beta-blocker, aldosterone antagonists, to improve patients with heart failure prognosis, reduce patient's admission rate and mortality rate again.
The treatment of chronic heart failure, Western medicine has the advantage of instant effect, but because the contraindication of medicine and toxic and side effects, its clinical practice is subject to a definite limitation.Applicant proves through clinical practice for many years, the advantages such as determined curative effect, side effect be low that utilize treatment by Chinese herbs chronic heart failure to have, and effectively can improve patients symptomatic, improve the life quality of patient, delay advancing of disease.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine preparation of chronic heart failure syndrome of yang deficiency of heart and kidney.Coryza Treated by Syndrome Differentiation chronic heart failure syndrome of yang deficiency of heart and kidney should with QI invigorating warming YANG, diuretic clots absorbing for principle.
The object of the invention is to be achieved through the following technical solutions, the Chinese medicine preparation of this chronic heart failure syndrome of yang deficiency of heart and kidney is made up of the Chinese medicine of following weight portion: Fructus polygoni hydropiperis 6-10 part, Radix et Bulbus Allii tuberosi 10-20 part, Radix Foeniculi 10-20 part, Herba hypoxis aureae 15-25 part, Folium Bauhiniae pernervosae 30-40 part, Radix Rhodiolae Dumulosae 6-10 part, Radix seu Caulis Verntilaginis Leiocarpae 10-20 part, Semen Stizolobii Cochinchinensis 5-8 part, Caulis Clematidis Chrysocomae 10-15 part, Herba Clerodendri Indici 8-12 part, Herba veronicastri villosuli 20-30 part, Herba Lepisori ussuriensis 8-12 part.
Preferably, Fructus polygoni hydropiperis 8 parts, Radix et Bulbus Allii tuberosi 15 parts, Radix Foeniculi 15 parts, Herba hypoxis aureae 20 parts, Folium Bauhiniae pernervosae 35 parts, Radix Rhodiolae Dumulosae 8 parts, Radix seu Caulis Verntilaginis Leiocarpae 15 parts, Semen Stizolobii Cochinchinensis 7 parts, Caulis Clematidis Chrysocomae 13 parts, Herba Clerodendri Indici 10 parts, Herba veronicastri villosuli 25 parts, Herba Lepisori ussuriensis 10 parts.
Above-mentioned Chinese medicine decocting is made decoction by preparation method.
Fang Zhong: Fructus polygoni hydropiperis warming middle-JIAO, diuretic, drastically removing blood stasis and resolving static blood; Radix et Bulbus Allii tuberosi warming middle-JIAO, dissipating blood stasis, circulation of qi promoting; Radix Foeniculi the kidney warming and in, promoting the circulation of QI to relieve pain; The regulating QI of Herba hypoxis aureae the kidney warming; Folium Bauhiniae pernervosae reinforce the kidney gas, refresh oneself; Radix Rhodiolae Dumulosae the kidney invigorating, regulating menstruation and activating blood, tranquilizing by nourishing the heart; Radix seu Caulis Verntilaginis Leiocarpae benefiting vital QI and blood, dispelling, collateral-activating; Semen Stizolobii Cochinchinensis warming middle-JIAO QI invigorating, the kidney invigorating pain relieving; Caulis Clematidis Chrysocomae inducing diuresis to remove edema, dysmenorrhea are invigorated blood circulation; Herba Clerodendri Indici diuretic, subside a swelling, invigorate blood circulation, wind-damp dispelling; Herba veronicastri villosuli promoting the circulation of QI for relieving swelling, dissipating blood stasis detoxify; Herba Lepisori ussuriensis diuretic, invigorate blood circulation, dispel the wind.
Clinical data
1, this research of physical data case is all from my Out-patient Department and inpatient in March ,-2011 in March, 2010, and MethodsThe cases enrolled 60 example, is divided into matched group and treatment group at random altogether, often organizes each 30 examples.Patient age scope 43-85 year, the mean age is 66.6 years old, wherein male 34 example, women 26 example.Two groups at the age, sex, cardiac functional grading, the aspect such as heart failure integration is harmonious good, the equal not statistically significant of comparing difference between two groups.
2, diagnostic criteria is formulated with reference to " 2007 Chinese diagnosis of chronic congestive heart failure treatment guidelines ".1. the increase of left room, left room end systolic volume increase and LVEF≤40%; 2. medical history, symptom and sign that underlying heart disease is many is had; 3. to have or apnea is difficult, weak and fluid retention (edema).
Chronic heart failure syndrome of yang deficiency of heart and kidney differential diagnosis in tcm disease: primary symptom: 1. cardiopalmus; 2. breathe hard, dyspnea with rapid and short breath; 3. uncomfortable in chest or pain; 4. aversion to cold and cold limbs; 5. face or limbs edema or companion hydrothorax, ascites; 6. light red tongue is fat, or matter is dark, white and thin fur or greasy in vain; 7. deep,thready and forceless pulse or knot generation.Double disease: 1. face is pale or dark and gloomy; 2. indigestion and loss of appetite, abdominal distention, oliguria; 3. die Blausucht; 4. tongue with ecchymosis, petechia, thready and hesitant pulse.
All to possess in primary symptom in any four and double disease any two and diagnosablely to decline card for deficiency of heart-YANG and kidney-YANG.
3, Therapeutic Method matched group patient carries out western medicine routine treatment.1. general treatment: have a rest, limit salt, oxygen uptake etc.; 2. diuretic: hydrochlorothiazide 25-50mg or furosemide 20mg, spironolactone 20mg, every day 1-3 time is oral; 3. ACEI: captopril 12.5mg, every day 3 times oral (can not resistance to receptor select Losartan Tablet 50mg po qd); 4. beta-blocker: metoprolol from 6.25mg, 1 oral beginning every day, within one week, post dose doubles, reach Rate control satisfied till; 5. cardiac tonic: digoxin 0.125mg is oral once a day, according to the state of an illness of patient after one week, adjusts its consumption or suspends medicine.
Treatment group uses Chinese medicine preparation of the present invention on the basis of regular western medicine treatment, take Fructus polygoni hydropiperis 8g, Radix et Bulbus Allii tuberosi 15g, Radix Foeniculi 15g, Herba hypoxis aureae 20g, Folium Bauhiniae pernervosae 35g, Radix Rhodiolae Dumulosae 8g, Radix seu Caulis Verntilaginis Leiocarpae 15g, Semen Stizolobii Cochinchinensis 7g, Caulis Clematidis Chrysocomae 13g, Herba Clerodendri Indici 10g, Herba veronicastri villosuli 25g, Herba Lepisori ussuriensis 10g, every agent medicine first uses cold water soak about 30 minutes, water consumption of boiling medicine was advisable there not to be powder 2-3cm, first big fire is boiled, after use slow fire instead and decoct about 20 minutes slowly, decoct secondary, the liquid medicine mixing taken for twice, taking liquid is about 400ml, sooner or later respectively 200ml is taken, within one hour after meal, take.Two groups equal 4 weeks is a course for the treatment of.
Nursing should note the close observation patient rhythm of the heart, heart rate, body temperature, blood pressure, pulse pressure difference, ECG change.Observe patient's peripheral circulation, limb temperature, blood oxygen saturation change.Strictly control amount of infusion by doctor's advice, its speed is generally no more than 30/min, and limit water, sodium takes the photograph people.Accurate recording 24h comes in and goes out the water yield, maintains water, electrolyte balance.Observe curative effect of medication and toxic and side effects.
4, criterion of therapeutical effect TCM syndrome integration curative effect determinate standard: disease efficacy evaluation presses integration total score × 100% more front than method (before treatment the rear total score of total score-treatment)/treatment.
(1) effective: cardinal symptom minor symptom disappears substantially or completely, treatment after disease total mark be 0 or reduce be greater than 70%
(2) effective: after treatment, disease integration reduces >=30%
(3) invalid: after treatment, disease integration reduces less than 30%
(4) increase the weight of: after treatment, disease integration exceedes the front integration for the treatment of
LeeShi heart failure integration curative effect determinate standard:
(1) effective: after treatment, integration reduces >=75%
(2) effective: after treatment, integration reduces at 50%-70%
(3) invalid: after treatment, integration reduces less than 50%
(4) increase the weight of: after treatment, integration exceedes the front integration for the treatment of
NYHA cardiac functional grading curative effect determinate standard (by NYHA stage division).
(1) effective: heart failure basic controlling or cardiac function improve person more than 2 grades
(2) effective: cardiac function improves 1 grade, but less than 2 grades of persons
(3) invalid: cardiac function improves less than 1 grade of person
(4) worsen: cardiac function worsens more than 1 grade or 1 grade
Safety observations: basic vital sign (blood pressure, breathing, heart rate, body temperature), routine blood test, routine urinalysis, stool routine examination, electrolyte, hepatic and renal function and rabat, electrocardiogram etc.
4, therapeutic outcome
Rear two groups of TCM syndrome comparitive study treated by table 1
It is as shown in the table, and treatment group compares with matched group total effective rate that there were significant differences, p < 0.01.
Rear heart failure integral contrast treated by table 2
| ? | Number of cases | Effective (rate) | Effectively (rate) | Invalid (rate) | Increase the weight of (rate) |
| Observation group | 30 | 24(80.0％) | 5(16.7％) | 1(3.3％) | 0(0％) |
| Matched group | 30 | 13(43.3％) | 13(43.3％) | 2(6.7％) | 2(6.7％) |
After carrying out radit analysis respectively, observation group's obvious effective rate 80.0% and matched group 43.3% contrast, and there were significant differences.Two groups of effective percentage, inefficiency, add-on and total effective rate (effective+effective) differences do not have significant difference (the equal > 0.05 of P).
Table 3 liang group cardiac function comparitive study
| ? | Number of cases | Effective (%) | Effectively (%) | Invalid (%) | Worsen (%) | Total effective rate (%) |
| Treatment group | 30 | 9(30.0％) | 19(63.3％) | 2(6.7％) | 0(0％) | 93.3％ |
| Matched group | 30 | 4(13.3％) | 20(66.7％) | 5(16.7％) | 1(3.3％) | 80.0％ |
It is as shown in the table, and treatment group compares with matched group total effective rate has aobvious person's difference, p < 0.05.
In this research treatment group and matched group all cases, patient ECG, blood, urine, stool routine examination, respiratory frequency, Liver and kidney function etc. have no significant change before the treatment afterwards, do not have significant difference between two groups.Matched group has 5 routine patients' appearance fatigue in various degree, and headache is dizzy; There is the symptom such as anorexia or Nausea and vomiting in 4 examples, after adjusting dosage or drug withdrawal, symptom fades away.Not there is obvious adverse reaction in treatment group, Chinese medicine preparation of the present invention is described to blood, urine in conventional range of application, Liver and kidney function etc. all without obvious toxic-side effects, also without untoward reaction such as digestive tract.
Detailed description of the invention
Embodiment one: take Fructus polygoni hydropiperis 8g, Radix et Bulbus Allii tuberosi 15g, Radix Foeniculi 15g, Herba hypoxis aureae 20g, Folium Bauhiniae pernervosae 35g, Radix Rhodiolae Dumulosae 8g, Radix seu Caulis Verntilaginis Leiocarpae 15g, Semen Stizolobii Cochinchinensis 7g, Caulis Clematidis Chrysocomae 13g, Herba Clerodendri Indici 10g, Herba veronicastri villosuli 25g, Herba Lepisori ussuriensis 10g, makes decoction by above-mentioned Chinese medicine decocting.
Embodiment two: take Fructus polygoni hydropiperis 10g, Radix et Bulbus Allii tuberosi 10g, Radix Foeniculi 20g, Herba hypoxis aureae 15g, Folium Bauhiniae pernervosae 40g, Radix Rhodiolae Dumulosae 6g, Radix seu Caulis Verntilaginis Leiocarpae 20g, Semen Stizolobii Cochinchinensis 5g, Caulis Clematidis Chrysocomae 15g, Herba Clerodendri Indici 8g, Herba veronicastri villosuli 20g, Herba Lepisori ussuriensis 8g, makes decoction by above-mentioned Chinese medicine decocting.
Embodiment three: take Fructus polygoni hydropiperis 6g, Radix et Bulbus Allii tuberosi 20g, Radix Foeniculi 10g, Herba hypoxis aureae 25g, Folium Bauhiniae pernervosae 30g, Radix Rhodiolae Dumulosae 10g, Radix seu Caulis Verntilaginis Leiocarpae 10g, Semen Stizolobii Cochinchinensis 8g, Caulis Clematidis Chrysocomae 10g, Herba Clerodendri Indici 12g, Herba veronicastri villosuli 30g, Herba Lepisori ussuriensis 12g, makes decoction by above-mentioned Chinese medicine decocting.
Claims (2)
1. a Chinese medicine preparation for chronic heart failure syndrome of yang deficiency of heart and kidney, is characterized in that this Chinese medicine preparation is made up of the Chinese medicine of following weight portion: Fructus polygoni hydropiperis 6-10 part, Radix et Bulbus Allii tuberosi 10-20 part, Radix Foeniculi 10-20 part, Herba hypoxis aureae 15-25 part, Folium Bauhiniae pernervosae 30-40 part, Radix Rhodiolae Dumulosae 6-10 part, Radix seu Caulis Verntilaginis Leiocarpae 10-20 part, Semen Stizolobii Cochinchinensis 5-8 part, Caulis Clematidis Chrysocomae 10-15 part, Herba Clerodendri Indici 8-12 part, Herba veronicastri villosuli 20-30 part, Herba Lepisori ussuriensis 8-12 part.
2. the Chinese medicine preparation of a kind of chronic heart failure syndrome of yang deficiency of heart and kidney as claimed in claim 1, is characterized in that this Chinese medicine preparation is made up of the Chinese medicine of following weight portion: Fructus polygoni hydropiperis 8 parts, Radix et Bulbus Allii tuberosi 15 parts, Radix Foeniculi 15 parts, Herba hypoxis aureae 20 parts, Folium Bauhiniae pernervosae 35 parts, Radix Rhodiolae Dumulosae 8 parts, Radix seu Caulis Verntilaginis Leiocarpae 15 parts, Semen Stizolobii Cochinchinensis 7 parts, Caulis Clematidis Chrysocomae 13 parts, Herba Clerodendri Indici 10 parts, Herba veronicastri villosuli 25 parts, Herba Lepisori ussuriensis 10 parts.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1393249A (en) * | 2001-07-03 | 2003-01-29 | 万挺春 | Chinese medicine for treating sino-atrial bundle syndrome caused by deficiency of vital function and essence of heart and kidney |
| CN102813728A (en) * | 2012-07-28 | 2012-12-12 | 张茂根 | Traditional Chinese medicine for treating heart-kidney yang deficiency-type chronic heart failure |
| EP2815654A1 (en) * | 2013-06-21 | 2014-12-24 | Essential IP BV | Composition having a beneficial effect on the cardiovascular system, comprising monacolin K, lycopene and vitamin D3 |
-
2014
- 2014-09-19 CN CN201410513439.4A patent/CN104258011A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1393249A (en) * | 2001-07-03 | 2003-01-29 | 万挺春 | Chinese medicine for treating sino-atrial bundle syndrome caused by deficiency of vital function and essence of heart and kidney |
| CN102813728A (en) * | 2012-07-28 | 2012-12-12 | 张茂根 | Traditional Chinese medicine for treating heart-kidney yang deficiency-type chronic heart failure |
| EP2815654A1 (en) * | 2013-06-21 | 2014-12-24 | Essential IP BV | Composition having a beneficial effect on the cardiovascular system, comprising monacolin K, lycopene and vitamin D3 |
Non-Patent Citations (2)
| Title |
|---|
| 夏敏: "慢性心衰的中医药治疗进展", 《国医论坛》 * |
| 蒋梅先: "改善心肾阳气互资是治疗慢性心力衰竭的关键", 《中国中西医结合杂志》 * |
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Application publication date: 20150107 |
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| RJ01 | Rejection of invention patent application after publication |