CN104257930A - 治疗鸡常见细菌病的中草药组合物 - Google Patents
治疗鸡常见细菌病的中草药组合物 Download PDFInfo
- Publication number
- CN104257930A CN104257930A CN201410566526.6A CN201410566526A CN104257930A CN 104257930 A CN104257930 A CN 104257930A CN 201410566526 A CN201410566526 A CN 201410566526A CN 104257930 A CN104257930 A CN 104257930A
- Authority
- CN
- China
- Prior art keywords
- parts
- chicken
- herba
- chinese herbal
- herbal medicine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241000287828 Gallus gallus Species 0.000 title claims abstract description 40
- 241000411851 herbal medicine Species 0.000 title abstract description 10
- 239000000203 mixture Substances 0.000 title abstract description 5
- 208000035143 Bacterial infection Diseases 0.000 title abstract description 4
- 239000000843 powder Substances 0.000 claims abstract description 6
- 239000002994 raw material Substances 0.000 claims abstract description 6
- 239000002131 composite material Substances 0.000 claims description 29
- 201000010099 disease Diseases 0.000 claims description 19
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 19
- 241000894006 Bacteria Species 0.000 claims description 14
- 240000000783 Origanum majorana Species 0.000 claims description 9
- 235000006297 Origanum majorana Nutrition 0.000 claims description 9
- UAJTZZNRJCKXJN-UHFFFAOYSA-M sodium;2-dodecoxy-2-oxoethanesulfonate Chemical compound [Na+].CCCCCCCCCCCCOC(=O)CS([O-])(=O)=O UAJTZZNRJCKXJN-UHFFFAOYSA-M 0.000 claims description 9
- 230000000694 effects Effects 0.000 abstract description 22
- 206010039438 Salmonella Infections Diseases 0.000 abstract description 5
- 206010039447 salmonellosis Diseases 0.000 abstract description 5
- 240000007673 Origanum vulgare Species 0.000 abstract description 3
- 235000013628 Lantana involucrata Nutrition 0.000 abstract description 2
- 235000006677 Monarda citriodora ssp. austromontana Nutrition 0.000 abstract description 2
- 235000013330 chicken meat Nutrition 0.000 abstract 2
- 244000135727 Abrus pulchellus subsp cantoniensis Species 0.000 abstract 1
- 235000017112 Abrus pulchellus subsp cantoniensis Nutrition 0.000 abstract 1
- 244000146462 Centella asiatica Species 0.000 abstract 1
- 235000004032 Centella asiatica Nutrition 0.000 abstract 1
- 208000014085 Chronic respiratory disease Diseases 0.000 abstract 1
- 208000005577 Gastroenteritis Diseases 0.000 abstract 1
- 244000303040 Glycyrrhiza glabra Species 0.000 abstract 1
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 abstract 1
- 235000017443 Hedysarum boreale Nutrition 0.000 abstract 1
- 235000007858 Hedysarum occidentale Nutrition 0.000 abstract 1
- 235000013717 Houttuynia Nutrition 0.000 abstract 1
- 240000000691 Houttuynia cordata Species 0.000 abstract 1
- 241000438687 Juncus roemerianus Species 0.000 abstract 1
- 208000012873 acute gastroenteritis Diseases 0.000 abstract 1
- 239000001947 glycyrrhiza glabra rhizome/root Substances 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 description 18
- 238000012360 testing method Methods 0.000 description 13
- 229940079593 drug Drugs 0.000 description 12
- 229960004821 amikacin Drugs 0.000 description 8
- LKCWBDHBTVXHDL-RMDFUYIESA-N amikacin Chemical compound O([C@@H]1[C@@H](N)C[C@H]([C@@H]([C@H]1O)O[C@@H]1[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O1)O)NC(=O)[C@@H](O)CCN)[C@H]1O[C@H](CN)[C@@H](O)[C@H](O)[C@H]1O LKCWBDHBTVXHDL-RMDFUYIESA-N 0.000 description 8
- MYSWGUAQZAJSOK-UHFFFAOYSA-N ciprofloxacin Chemical compound C12=CC(N3CCNCC3)=C(F)C=C2C(=O)C(C(=O)O)=CN1C1CC1 MYSWGUAQZAJSOK-UHFFFAOYSA-N 0.000 description 8
- 239000003440 toxic substance Substances 0.000 description 8
- 244000025254 Cannabis sativa Species 0.000 description 7
- 231100000614 poison Toxicity 0.000 description 7
- 239000008280 blood Substances 0.000 description 6
- 210000004369 blood Anatomy 0.000 description 6
- 235000009508 confectionery Nutrition 0.000 description 6
- 208000015181 infectious disease Diseases 0.000 description 6
- 210000000952 spleen Anatomy 0.000 description 6
- 208000024891 symptom Diseases 0.000 description 6
- 206010008631 Cholera Diseases 0.000 description 5
- 208000018569 Respiratory Tract disease Diseases 0.000 description 5
- 230000001684 chronic effect Effects 0.000 description 5
- 210000002784 stomach Anatomy 0.000 description 5
- 230000001225 therapeutic effect Effects 0.000 description 5
- 241000588724 Escherichia coli Species 0.000 description 4
- 241000205840 Escherichia coli O8 Species 0.000 description 4
- CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 description 4
- 229930182566 Gentamicin Natural products 0.000 description 4
- 206010023126 Jaundice Diseases 0.000 description 4
- 206010030113 Oedema Diseases 0.000 description 4
- REFJWTPEDVJJIY-UHFFFAOYSA-N Quercetin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC=C(O)C(O)=C1 REFJWTPEDVJJIY-UHFFFAOYSA-N 0.000 description 4
- 230000003385 bacteriostatic effect Effects 0.000 description 4
- 229960003405 ciprofloxacin Drugs 0.000 description 4
- 208000001848 dysentery Diseases 0.000 description 4
- 239000000796 flavoring agent Substances 0.000 description 4
- 235000019634 flavors Nutrition 0.000 description 4
- LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 description 4
- 229960004949 glycyrrhizic acid Drugs 0.000 description 4
- UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 description 4
- 235000019410 glycyrrhizin Nutrition 0.000 description 4
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 description 4
- 230000036039 immunity Effects 0.000 description 4
- IYRMWMYZSQPJKC-UHFFFAOYSA-N kaempferol Chemical compound C1=CC(O)=CC=C1C1=C(O)C(=O)C2=C(O)C=C(O)C=C2O1 IYRMWMYZSQPJKC-UHFFFAOYSA-N 0.000 description 4
- MWDZOUNAPSSOEL-UHFFFAOYSA-N kaempferol Natural products OC1=C(C(=O)c2cc(O)cc(O)c2O1)c3ccc(O)cc3 MWDZOUNAPSSOEL-UHFFFAOYSA-N 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 210000004185 liver Anatomy 0.000 description 4
- 210000004072 lung Anatomy 0.000 description 4
- 206010012735 Diarrhoea Diseases 0.000 description 3
- 206010061218 Inflammation Diseases 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 208000004880 Polyuria Diseases 0.000 description 3
- 230000000844 anti-bacterial effect Effects 0.000 description 3
- 230000035619 diuresis Effects 0.000 description 3
- 235000013601 eggs Nutrition 0.000 description 3
- 235000013305 food Nutrition 0.000 description 3
- 229930182470 glycoside Natural products 0.000 description 3
- 150000002338 glycosides Chemical class 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 230000001717 pathogenic effect Effects 0.000 description 3
- 230000001737 promoting effect Effects 0.000 description 3
- 230000035945 sensitivity Effects 0.000 description 3
- 235000013599 spices Nutrition 0.000 description 3
- 239000000341 volatile oil Substances 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 206010007247 Carbuncle Diseases 0.000 description 2
- 239000004378 Glycyrrhizin Substances 0.000 description 2
- 206010018612 Gonorrhoea Diseases 0.000 description 2
- 206010019345 Heat stroke Diseases 0.000 description 2
- 241000594394 Hedyotis Species 0.000 description 2
- VTAJIXDZFCRWBR-UHFFFAOYSA-N Licoricesaponin B2 Natural products C1C(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2)C(O)=O)C)(C)CC2)(C)C2C(C)(C)CC1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O VTAJIXDZFCRWBR-UHFFFAOYSA-N 0.000 description 2
- WRACWYWAPQQRKC-UHFFFAOYSA-N Madasiatic acid Chemical compound C1C(O)C(O)C(C)(C)C2C(O)CC3(C)C4(C)CCC5(C(O)=O)CCC(C)C(C)C5C4=CCC3C21C WRACWYWAPQQRKC-UHFFFAOYSA-N 0.000 description 2
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 2
- ZVOLCUVKHLEPEV-UHFFFAOYSA-N Quercetagetin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=C(O)C(O)=C(O)C=C2O1 ZVOLCUVKHLEPEV-UHFFFAOYSA-N 0.000 description 2
- HWTZYBCRDDUBJY-UHFFFAOYSA-N Rhynchosin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=CC(O)=C(O)C=C2O1 HWTZYBCRDDUBJY-UHFFFAOYSA-N 0.000 description 2
- VQQVWGVXDIPORV-UHFFFAOYSA-N Tryptanthrine Chemical compound C1=CC=C2C(=O)N3C4=CC=CC=C4C(=O)C3=NC2=C1 VQQVWGVXDIPORV-UHFFFAOYSA-N 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 229940088710 antibiotic agent Drugs 0.000 description 2
- 230000036528 appetite Effects 0.000 description 2
- 235000019789 appetite Nutrition 0.000 description 2
- QCYLIQBVLZBPNK-UHFFFAOYSA-N asiaticoside A Natural products O1C(C(=O)C(C)C)=CC(C)C(C2(C(OC(C)=O)CC34C5)C)C1CC2(C)C3CCC(C1(C)C)C45CCC1OC1OCC(O)C(O)C1O QCYLIQBVLZBPNK-UHFFFAOYSA-N 0.000 description 2
- UAHWPYUMFXYFJY-UHFFFAOYSA-N beta-myrcene Chemical compound CC(C)=CCCC(=C)C=C UAHWPYUMFXYFJY-UHFFFAOYSA-N 0.000 description 2
- NJKOMDUNNDKEAI-UHFFFAOYSA-N beta-sitosterol Natural products CCC(CCC(C)C1CCC2(C)C3CC=C4CC(O)CCC4C3CCC12C)C(C)C NJKOMDUNNDKEAI-UHFFFAOYSA-N 0.000 description 2
- 230000003115 biocidal effect Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- LQGUBLBATBMXHT-UHFFFAOYSA-N chrysophanol Chemical compound C1=CC=C2C(=O)C3=CC(C)=CC(O)=C3C(=O)C2=C1O LQGUBLBATBMXHT-UHFFFAOYSA-N 0.000 description 2
- KZJWDPNRJALLNS-FBZNIEFRSA-N clionasterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CC[C@H](CC)C(C)C)[C@@]1(C)CC2 KZJWDPNRJALLNS-FBZNIEFRSA-N 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 230000002708 enhancing effect Effects 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 150000004676 glycans Chemical class 0.000 description 2
- 239000001685 glycyrrhizic acid Substances 0.000 description 2
- 208000001786 gonorrhea Diseases 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 210000002216 heart Anatomy 0.000 description 2
- 208000006454 hepatitis Diseases 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 229960000367 inositol Drugs 0.000 description 2
- CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 description 2
- 238000007689 inspection Methods 0.000 description 2
- 210000002429 large intestine Anatomy 0.000 description 2
- -1 lauro lene Chemical compound 0.000 description 2
- XMGQYMWWDOXHJM-UHFFFAOYSA-N limonene Chemical compound CC(=C)C1CCC(C)=CC1 XMGQYMWWDOXHJM-UHFFFAOYSA-N 0.000 description 2
- CDOSHBSSFJOMGT-UHFFFAOYSA-N linalool Chemical compound CC(C)=CCCC(C)(O)C=C CDOSHBSSFJOMGT-UHFFFAOYSA-N 0.000 description 2
- 235000013372 meat Nutrition 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 229920001282 polysaccharide Polymers 0.000 description 2
- 239000005017 polysaccharide Substances 0.000 description 2
- 244000144977 poultry Species 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 238000003672 processing method Methods 0.000 description 2
- 235000005875 quercetin Nutrition 0.000 description 2
- 229960001285 quercetin Drugs 0.000 description 2
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 2
- 229930182490 saponin Natural products 0.000 description 2
- 150000007949 saponins Chemical class 0.000 description 2
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 2
- KZJWDPNRJALLNS-VJSFXXLFSA-N sitosterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CC[C@@H](CC)C(C)C)[C@@]1(C)CC2 KZJWDPNRJALLNS-VJSFXXLFSA-N 0.000 description 2
- NLQLSVXGSXCXFE-UHFFFAOYSA-N sitosterol Natural products CC=C(/CCC(C)C1CC2C3=CCC4C(C)C(O)CCC4(C)C3CCC2(C)C1)C(C)C NLQLSVXGSXCXFE-UHFFFAOYSA-N 0.000 description 2
- 235000014347 soups Nutrition 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 description 2
- 231100000167 toxic agent Toxicity 0.000 description 2
- 150000008130 triterpenoid saponins Chemical group 0.000 description 2
- KYWIYKKSMDLRDC-UHFFFAOYSA-N undecan-2-one Chemical compound CCCCCCCCCC(C)=O KYWIYKKSMDLRDC-UHFFFAOYSA-N 0.000 description 2
- 210000003932 urinary bladder Anatomy 0.000 description 2
- KZJWDPNRJALLNS-VPUBHVLGSA-N (-)-beta-Sitosterol Natural products O[C@@H]1CC=2[C@@](C)([C@@H]3[C@H]([C@H]4[C@@](C)([C@H]([C@H](CC[C@@H](C(C)C)CC)C)CC4)CC3)CC=2)CC1 KZJWDPNRJALLNS-VPUBHVLGSA-N 0.000 description 1
- GRWFGVWFFZKLTI-IUCAKERBSA-N (-)-α-pinene Chemical compound CC1=CC[C@@H]2C(C)(C)[C@H]1C2 GRWFGVWFFZKLTI-IUCAKERBSA-N 0.000 description 1
- CSVWWLUMXNHWSU-UHFFFAOYSA-N (22E)-(24xi)-24-ethyl-5alpha-cholest-22-en-3beta-ol Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(C)C=CC(CC)C(C)C)C1(C)CC2 CSVWWLUMXNHWSU-UHFFFAOYSA-N 0.000 description 1
- 239000001490 (3R)-3,7-dimethylocta-1,6-dien-3-ol Substances 0.000 description 1
- WCGUUGGRBIKTOS-GPOJBZKASA-N (3beta)-3-hydroxyurs-12-en-28-oic acid Chemical compound C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CC[C@@H](C)[C@H](C)[C@H]5C4=CC[C@@H]3[C@]21C WCGUUGGRBIKTOS-GPOJBZKASA-N 0.000 description 1
- XBZYWSMVVKYHQN-MYPRUECHSA-N (4as,6as,6br,8ar,9r,10s,12ar,12br,14bs)-10-hydroxy-2,2,6a,6b,9,12a-hexamethyl-9-[(sulfooxy)methyl]-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-4a-carboxylic acid Chemical compound C1C[C@H](O)[C@@](C)(COS(O)(=O)=O)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CCC(C)(C)C[C@H]5C4=CC[C@@H]3[C@]21C XBZYWSMVVKYHQN-MYPRUECHSA-N 0.000 description 1
- CDOSHBSSFJOMGT-JTQLQIEISA-N (R)-linalool Natural products CC(C)=CCC[C@@](C)(O)C=C CDOSHBSSFJOMGT-JTQLQIEISA-N 0.000 description 1
- KLEXDBGYSOIREE-UHFFFAOYSA-N 24xi-n-propylcholesterol Natural products C1C=C2CC(O)CCC2(C)C2C1C1CCC(C(C)CCC(CCC)C(C)C)C1(C)CC2 KLEXDBGYSOIREE-UHFFFAOYSA-N 0.000 description 1
- AHWQTWBZNABQTO-UHFFFAOYSA-N 3,5-dihydroxy-2-(hydroxymethyl)-6-(1h-indol-3-yloxy)oxan-4-one Chemical compound OC1C(=O)C(O)C(CO)OC1OC1=CNC2=CC=CC=C12 AHWQTWBZNABQTO-UHFFFAOYSA-N 0.000 description 1
- JZFQZINWXSEVSO-URUUWQEUSA-N 3-[(2z)-2-sulfooxyimino-2-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]sulfanylethyl]indole-1-sulfonic acid Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1S\C(=N/OS(O)(=O)=O)CC1=CN(S(O)(=O)=O)C2=CC=CC=C12 JZFQZINWXSEVSO-URUUWQEUSA-N 0.000 description 1
- XLYLQUQHYUOPIW-UHFFFAOYSA-N 3-oxo-Tetradecanal Chemical compound CCCCCCCCCCCC(=O)CC=O XLYLQUQHYUOPIW-UHFFFAOYSA-N 0.000 description 1
- 206010000087 Abdominal pain upper Diseases 0.000 description 1
- 206010063409 Acarodermatitis Diseases 0.000 description 1
- HIGQPQRQIQDZMP-FLIBITNWSA-N Acetic acid geraniol ester Natural products CC(C)=CCC\C(C)=C/COC(C)=O HIGQPQRQIQDZMP-FLIBITNWSA-N 0.000 description 1
- 206010061623 Adverse drug reaction Diseases 0.000 description 1
- 208000006400 Arbovirus Encephalitis Diseases 0.000 description 1
- 208000004429 Bacillary Dysentery Diseases 0.000 description 1
- 241000193830 Bacillus <bacterium> Species 0.000 description 1
- 239000004857 Balsam Substances 0.000 description 1
- 206010007882 Cellulitis Diseases 0.000 description 1
- 206010008909 Chronic Hepatitis Diseases 0.000 description 1
- LPZCCMIISIBREI-MTFRKTCUSA-N Citrostadienol Natural products CC=C(CC[C@@H](C)[C@H]1CC[C@H]2C3=CC[C@H]4[C@H](C)[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C)C(C)C LPZCCMIISIBREI-MTFRKTCUSA-N 0.000 description 1
- GQEVCHQXWPWARL-UHFFFAOYSA-N Couroupitine A Natural products N1=CC=CC2=CC(=O)N3C4=CC=CC=C4C(=O)C3=C21 GQEVCHQXWPWARL-UHFFFAOYSA-N 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 description 1
- QBDCOUHKEVYWLO-UHFFFAOYSA-N Decanoylacetaldehyde Natural products CCCCCCCCCC(=O)CC=O QBDCOUHKEVYWLO-UHFFFAOYSA-N 0.000 description 1
- ARVGMISWLZPBCH-UHFFFAOYSA-N Dehydro-beta-sitosterol Natural products C1C(O)CCC2(C)C(CCC3(C(C(C)CCC(CC)C(C)C)CCC33)C)C3=CC=C21 ARVGMISWLZPBCH-UHFFFAOYSA-N 0.000 description 1
- UBSCDKPKWHYZNX-UHFFFAOYSA-N Demethoxycapillarisin Natural products C1=CC(O)=CC=C1OC1=CC(=O)C2=C(O)C=C(O)C=C2O1 UBSCDKPKWHYZNX-UHFFFAOYSA-N 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 208000030453 Drug-Related Side Effects and Adverse reaction Diseases 0.000 description 1
- 208000000059 Dyspnea Diseases 0.000 description 1
- 206010013975 Dyspnoeas Diseases 0.000 description 1
- 206010052369 Encephalitis lethargica Diseases 0.000 description 1
- 208000004232 Enteritis Diseases 0.000 description 1
- 241000059485 Escherichia coli O78 Species 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- QWVMSYBGKWZIIE-RDFNRINOSA-N Flavochrome Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C1OC2(C)CCCC(C)(C)C2=C1)C=CC=C(/C)C=CC3C(=CCCC3(C)C)C QWVMSYBGKWZIIE-RDFNRINOSA-N 0.000 description 1
- 241000628997 Flos Species 0.000 description 1
- 206010017915 Gastroenteritis shigella Diseases 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- MPDGHEJMBKOTSU-UHFFFAOYSA-N Glycyrrhetinsaeure Natural products C12C(=O)C=C3C4CC(C)(C(O)=O)CCC4(C)CCC3(C)C1(C)CCC1C2(C)CCC(O)C1(C)C MPDGHEJMBKOTSU-UHFFFAOYSA-N 0.000 description 1
- 240000002045 Guettarda speciosa Species 0.000 description 1
- 235000001287 Guettarda speciosa Nutrition 0.000 description 1
- 241000217776 Holocentridae Species 0.000 description 1
- OVSQVDMCBVZWGM-SJWGPRHPSA-N Hyperin Natural products O[C@H]1[C@H](O)[C@@H](O)[C@@H](CO)O[C@H]1OC1=C(C=2C=C(O)C(O)=CC=2)OC2=CC(O)=CC(O)=C2C1=O OVSQVDMCBVZWGM-SJWGPRHPSA-N 0.000 description 1
- FVQOMEDMFUMIMO-UHFFFAOYSA-N Hyperosid Natural products OC1C(O)C(O)C(CO)OC1OC1C(=O)C2=C(O)C=C(O)C=C2OC1C1=CC=C(O)C(O)=C1 FVQOMEDMFUMIMO-UHFFFAOYSA-N 0.000 description 1
- 235000000177 Indigofera tinctoria Nutrition 0.000 description 1
- KGXOHVOUKNLUNP-ZJQBRPOHSA-N Isatan B Natural products O=C(Oc1c2c([nH]c1)cccc2)[C@@H]1[C@H](O)[C@H](O)[C@@](O)(CO)O1 KGXOHVOUKNLUNP-ZJQBRPOHSA-N 0.000 description 1
- 241000334154 Isatis tinctoria Species 0.000 description 1
- PNNNRSAQSRJVSB-UHFFFAOYSA-N L-rhamnose Natural products CC(O)C(O)C(O)C(O)C=O PNNNRSAQSRJVSB-UHFFFAOYSA-N 0.000 description 1
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 1
- 229930194248 Licoflavone Natural products 0.000 description 1
- MEHHCBRCXIDGKZ-UHFFFAOYSA-N Licoflavone C Natural products CC(C)=CCC1=C(O)C=C(O)C(C(C=2)=O)=C1OC=2C1=CC=C(O)C=C1 MEHHCBRCXIDGKZ-UHFFFAOYSA-N 0.000 description 1
- UPYKUZBSLRQECL-UKMVMLAPSA-N Lycopene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1C(=C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=C)CCCC2(C)C UPYKUZBSLRQECL-UKMVMLAPSA-N 0.000 description 1
- WYQVAPGDARQUBT-FGWHUCSPSA-N Madecassol Chemical compound O([C@@H]1[C@@H](CO)O[C@H]([C@@H]([C@H]1O)O)OC[C@H]1O[C@H]([C@@H]([C@@H](O)[C@@H]1O)O)OC(=O)[C@]12CC[C@H]([C@@H]([C@H]1C=1[C@@]([C@@]3(CC[C@H]4[C@](C)(CO)[C@@H](O)[C@H](O)C[C@]4(C)[C@H]3CC=1)C)(C)CC2)C)C)[C@@H]1O[C@@H](C)[C@H](O)[C@@H](O)[C@H]1O WYQVAPGDARQUBT-FGWHUCSPSA-N 0.000 description 1
- BNMGUJRJUUDLHW-HCZMHFOYSA-N Madecassoside Chemical compound O([C@@H]1[C@@H](CO)O[C@H]([C@@H]([C@H]1O)O)OC[C@H]1O[C@H]([C@@H]([C@@H](O)[C@@H]1O)O)OC(=O)[C@]12CC[C@H]([C@@H]([C@H]1C=1[C@@]([C@@]3(C[C@@H](O)[C@H]4[C@](C)(CO)[C@@H](O)[C@H](O)C[C@]4(C)[C@H]3CC=1)C)(C)CC2)C)C)[C@@H]1O[C@@H](C)[C@H](O)[C@@H](O)[C@H]1O BNMGUJRJUUDLHW-HCZMHFOYSA-N 0.000 description 1
- BNMGUJRJUUDLHW-HLUHVYOBSA-N Madecassoside Natural products C[C@@H]1CC[C@@]2(CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)C[C@@H](O)[C@H](O)[C@@](C)(CO)[C@@H]5[C@H](O)C[C@@]34C)[C@@H]2[C@H]1C)C(=O)O[C@@H]6O[C@H](CO[C@@H]7O[C@H](CO)[C@@H](O[C@@H]8O[C@H](C)[C@H](O)[C@@H](O)[C@H]8O)[C@H](O)[C@H]7O)[C@@H](O)[C@H](O)[C@H]6O BNMGUJRJUUDLHW-HLUHVYOBSA-N 0.000 description 1
- 201000005505 Measles Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- CZCIKBSVHDNIDH-NSHDSACASA-N N(alpha)-methyl-L-tryptophan Chemical compound C1=CC=C2C(C[C@H]([NH2+]C)C([O-])=O)=CNC2=C1 CZCIKBSVHDNIDH-NSHDSACASA-N 0.000 description 1
- CZCIKBSVHDNIDH-UHFFFAOYSA-N Nalpha-methyl-DL-tryptophan Natural products C1=CC=C2C(CC(NC)C(O)=O)=CNC2=C1 CZCIKBSVHDNIDH-UHFFFAOYSA-N 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 206010030302 Oliguria Diseases 0.000 description 1
- 235000010677 Origanum vulgare Nutrition 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 206010034038 Parotitis Diseases 0.000 description 1
- 241000382362 Persicaria tinctoria Species 0.000 description 1
- 206010035664 Pneumonia Diseases 0.000 description 1
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 1
- 241000588769 Proteus <enterobacteria> Species 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 241000607132 Salmonella enterica subsp. enterica serovar Gallinarum Species 0.000 description 1
- 241000531795 Salmonella enterica subsp. enterica serovar Paratyphi A Species 0.000 description 1
- 241000293871 Salmonella enterica subsp. enterica serovar Typhi Species 0.000 description 1
- 241000447727 Scabies Species 0.000 description 1
- 206010040047 Sepsis Diseases 0.000 description 1
- 241000607760 Shigella sonnei Species 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- UQZIYBXSHAGNOE-USOSMYMVSA-N Stachyose Natural products O(C[C@H]1[C@@H](O)[C@H](O)[C@H](O)[C@@H](O[C@@]2(CO)[C@H](O)[C@@H](O)[C@@H](CO)O2)O1)[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@H](CO[C@@H]2[C@@H](O)[C@@H](O)[C@@H](O)[C@H](CO)O2)O1 UQZIYBXSHAGNOE-USOSMYMVSA-N 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- JZFQZINWXSEVSO-UHFFFAOYSA-N Sulfoglucobrassicin Natural products OC1C(O)C(O)C(CO)OC1SC(=NOS(O)(=O)=O)CC1=CN(S(O)(=O)=O)C2=CC=CC=C12 JZFQZINWXSEVSO-UHFFFAOYSA-N 0.000 description 1
- 239000005844 Thymol Substances 0.000 description 1
- 208000002474 Tinea Diseases 0.000 description 1
- 241000130764 Tinea Species 0.000 description 1
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- KGEKLUUHTZCSIP-HOSYDEDBSA-N [(1s,4s,6r)-1,7,7-trimethyl-6-bicyclo[2.2.1]heptanyl] acetate Chemical compound C1C[C@]2(C)[C@H](OC(=O)C)C[C@H]1C2(C)C KGEKLUUHTZCSIP-HOSYDEDBSA-N 0.000 description 1
- PKKMITFKYRCCOL-JMZFCNQTSA-N [(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] (1z)-2-(1-methoxyindol-3-yl)-n-sulfooxyethanimidothioate Chemical compound C12=CC=CC=C2N(OC)C=C1C\C(=N\OS(O)(=O)=O)S[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O PKKMITFKYRCCOL-JMZFCNQTSA-N 0.000 description 1
- DNDNWOWHUWNBCK-PIAXYHQTSA-N [(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] (1z)-2-(1h-indol-3-yl)-n-sulfooxyethanimidothioate Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1S\C(=N/OS(O)(=O)=O)CC1=CNC2=CC=CC=C12 DNDNWOWHUWNBCK-PIAXYHQTSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 231100000354 acute hepatitis Toxicity 0.000 description 1
- 150000001336 alkenes Chemical class 0.000 description 1
- VYBREYKSZAROCT-UHFFFAOYSA-N alpha-myrcene Natural products CC(=C)CCCC(=C)C=C VYBREYKSZAROCT-UHFFFAOYSA-N 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 150000004056 anthraquinones Chemical class 0.000 description 1
- 230000000767 anti-ulcer Effects 0.000 description 1
- 239000000729 antidote Substances 0.000 description 1
- WYQVAPGDARQUBT-XCWYDTOWSA-N asiaticoside Natural products O=C(O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@H]2[C@H](O)[C@H](O)[C@H](O[C@H]3[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O3)[C@@H](CO)O2)O1)[C@@]12[C@@H]([C@@H](C)[C@H](C)CC1)C=1[C@](C)([C@@]3(C)[C@@H]([C@@]4(C)[C@H]([C@@](CO)(C)[C@@H](O)[C@H](O)C4)CC3)CC=1)CC2 WYQVAPGDARQUBT-XCWYDTOWSA-N 0.000 description 1
- 229940022757 asiaticoside Drugs 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- MJVXAPPOFPTTCA-UHFFFAOYSA-N beta-Sistosterol Natural products CCC(CCC(C)C1CCC2C3CC=C4C(C)C(O)CCC4(C)C3CCC12C)C(C)C MJVXAPPOFPTTCA-UHFFFAOYSA-N 0.000 description 1
- LGJMUZUPVCAVPU-UHFFFAOYSA-N beta-Sitostanol Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(C)CCC(CC)C(C)C)C1(C)CC2 LGJMUZUPVCAVPU-UHFFFAOYSA-N 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 210000001217 buttock Anatomy 0.000 description 1
- 235000005473 carotenes Nutrition 0.000 description 1
- 150000001746 carotenes Chemical class 0.000 description 1
- HHTWOMMSBMNRKP-UHFFFAOYSA-N carvacrol Natural products CC(=C)C1=CC=C(C)C(O)=C1 HHTWOMMSBMNRKP-UHFFFAOYSA-N 0.000 description 1
- RECUKUPTGUEGMW-UHFFFAOYSA-N carvacrol Chemical compound CC(C)C1=CC=C(C)C(O)=C1 RECUKUPTGUEGMW-UHFFFAOYSA-N 0.000 description 1
- 235000007746 carvacrol Nutrition 0.000 description 1
- 229930002875 chlorophyll Natural products 0.000 description 1
- 235000019804 chlorophyll Nutrition 0.000 description 1
- ATNHDLDRLWWWCB-AENOIHSZSA-M chlorophyll a Chemical compound C1([C@@H](C(=O)OC)C(=O)C2=C3C)=C2N2C3=CC(C(CC)=C3C)=[N+]4C3=CC3=C(C=C)C(C)=C5N3[Mg-2]42[N+]2=C1[C@@H](CCC(=O)OC\C=C(/C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)[C@H](C)C2=C5 ATNHDLDRLWWWCB-AENOIHSZSA-M 0.000 description 1
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 description 1
- 229960001231 choline Drugs 0.000 description 1
- NZPQWZZXRKZCDU-UHFFFAOYSA-N chrysophanol Natural products Cc1cc(O)c2C(=O)c3c(O)cccc3Oc2c1 NZPQWZZXRKZCDU-UHFFFAOYSA-N 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 239000002934 diuretic Substances 0.000 description 1
- 230000001882 diuretic effect Effects 0.000 description 1
- HFJRKMMYBMWEAD-UHFFFAOYSA-N dodecanal Chemical compound CCCCCCCCCCCC=O HFJRKMMYBMWEAD-UHFFFAOYSA-N 0.000 description 1
- 206010013990 dysuria Diseases 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 229960003720 enoxolone Drugs 0.000 description 1
- 239000010685 fatty oil Substances 0.000 description 1
- 210000003608 fece Anatomy 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- QWVMSYBGKWZIIE-FZKBJVJCSA-N flavochrome Chemical compound O1C2(C)CCCC(C)(C)C2=CC1C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1C(C)=CCCC1(C)C QWVMSYBGKWZIIE-FZKBJVJCSA-N 0.000 description 1
- 229930003935 flavonoid Natural products 0.000 description 1
- 229930182486 flavonoid glycoside Natural products 0.000 description 1
- 150000002215 flavonoids Chemical class 0.000 description 1
- 235000017173 flavonoids Nutrition 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- HIGQPQRQIQDZMP-DHZHZOJOSA-N geranyl acetate Chemical compound CC(C)=CCC\C(C)=C\COC(C)=O HIGQPQRQIQDZMP-DHZHZOJOSA-N 0.000 description 1
- 210000004907 gland Anatomy 0.000 description 1
- JRJLFQURIXLQJD-YCLXMMFGSA-N glucobrassicin Natural products OC[C@@H]1O[C@H](SC(=NOS(=O)(=O)O)[C@H](O)[C@H](O)Cc2c[nH]c3ccccc23)[C@@H](O)[C@H](O)[C@H]1O JRJLFQURIXLQJD-YCLXMMFGSA-N 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 208000014617 hemorrhoid Diseases 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 230000000774 hypoallergenic effect Effects 0.000 description 1
- 230000007365 immunoregulation Effects 0.000 description 1
- 229940097275 indigo Drugs 0.000 description 1
- COHYTHOBJLSHDF-UHFFFAOYSA-N indigo powder Natural products N1C2=CC=CC=C2C(=O)C1=C1C(=O)C2=CC=CC=C2N1 COHYTHOBJLSHDF-UHFFFAOYSA-N 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 206010022000 influenza Diseases 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- WYXXLXHHWYNKJF-UHFFFAOYSA-N isocarvacrol Natural products CC(C)C1=CC=C(O)C(C)=C1 WYXXLXHHWYNKJF-UHFFFAOYSA-N 0.000 description 1
- 235000008718 isoliquiritigenin Nutrition 0.000 description 1
- JBQATDIMBVLPRB-UHFFFAOYSA-N isoliquiritigenin Natural products OC1=CC(O)=CC=C1C1OC2=CC(O)=CC=C2C(=O)C1 JBQATDIMBVLPRB-UHFFFAOYSA-N 0.000 description 1
- DXDRHHKMWQZJHT-FPYGCLRLSA-N isoliquiritigenin Chemical compound C1=CC(O)=CC=C1\C=C\C(=O)C1=CC=C(O)C=C1O DXDRHHKMWQZJHT-FPYGCLRLSA-N 0.000 description 1
- 235000008777 kaempferol Nutrition 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 229940089454 lauryl aldehyde Drugs 0.000 description 1
- 239000010985 leather Substances 0.000 description 1
- 229940087305 limonene Drugs 0.000 description 1
- 235000001510 limonene Nutrition 0.000 description 1
- 229930007744 linalool Natural products 0.000 description 1
- 201000003453 lung abscess Diseases 0.000 description 1
- IQPNAANSBPBGFQ-UHFFFAOYSA-N luteolin Chemical compound C=1C(O)=CC(O)=C(C(C=2)=O)C=1OC=2C1=CC=C(O)C(O)=C1 IQPNAANSBPBGFQ-UHFFFAOYSA-N 0.000 description 1
- LRDGATPGVJTWLJ-UHFFFAOYSA-N luteolin Natural products OC1=CC(O)=CC(C=2OC3=CC(O)=CC(O)=C3C(=O)C=2)=C1 LRDGATPGVJTWLJ-UHFFFAOYSA-N 0.000 description 1
- 235000009498 luteolin Nutrition 0.000 description 1
- PEFNSGRTCBGNAN-QNDFHXLGSA-N luteolin 7-O-beta-D-glucoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC(O)=C2C(=O)C=C(C=3C=C(O)C(O)=CC=3)OC2=C1 PEFNSGRTCBGNAN-QNDFHXLGSA-N 0.000 description 1
- 210000002751 lymph Anatomy 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- PRAUVHZJPXOEIF-AOLYGAPISA-N madecassic acid Chemical compound C1[C@@H](O)[C@H](O)[C@@](C)(CO)[C@@H]2[C@H](O)C[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CC[C@@H](C)[C@H](C)[C@H]5C4=CC[C@@H]3[C@]21C PRAUVHZJPXOEIF-AOLYGAPISA-N 0.000 description 1
- PRAUVHZJPXOEIF-UHFFFAOYSA-N madecassica acid Natural products C1C(O)C(O)C(C)(CO)C2C(O)CC3(C)C4(C)CCC5(C(O)=O)CCC(C)C(C)C5C4=CCC3C21C PRAUVHZJPXOEIF-UHFFFAOYSA-N 0.000 description 1
- 229940090813 madecassoside Drugs 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 201000004792 malaria Diseases 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 208000004396 mastitis Diseases 0.000 description 1
- 239000002398 materia medica Substances 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 description 1
- UXOUKMQIEVGVLY-UHFFFAOYSA-N morin Natural products OC1=CC(O)=CC(C2=C(C(=O)C3=C(O)C=C(O)C=C3O2)O)=C1 UXOUKMQIEVGVLY-UHFFFAOYSA-N 0.000 description 1
- OYYJOBIUXKENQW-USACIQFYSA-N neoglucobrassicin Natural products COn1cc(CC(=NS(=O)(=O)O)SC[C@H]2O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]2O)c3ccccc13 OYYJOBIUXKENQW-USACIQFYSA-N 0.000 description 1
- 201000008383 nephritis Diseases 0.000 description 1
- PEFNSGRTCBGNAN-UHFFFAOYSA-N nephrocizin Natural products OC1C(O)C(O)C(CO)OC1OC1=CC(O)=C2C(=O)C=C(C=3C=C(O)C(O)=CC=3)OC2=C1 PEFNSGRTCBGNAN-UHFFFAOYSA-N 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 229920001542 oligosaccharide Polymers 0.000 description 1
- 150000002482 oligosaccharides Chemical class 0.000 description 1
- 230000000242 pagocytic effect Effects 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- FFWOKTFYGVYKIR-UHFFFAOYSA-N physcion Chemical compound C1=C(C)C=C2C(=O)C3=CC(OC)=CC(O)=C3C(=O)C2=C1O FFWOKTFYGVYKIR-UHFFFAOYSA-N 0.000 description 1
- OISYIJRGMYJBRH-UHFFFAOYSA-N physcione Natural products COc1cc(O)c2C(=O)c3ccc(O)cc3C(=O)c2c1 OISYIJRGMYJBRH-UHFFFAOYSA-N 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 229940072033 potash Drugs 0.000 description 1
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Substances [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 1
- 235000015320 potassium carbonate Nutrition 0.000 description 1
- 239000001103 potassium chloride Substances 0.000 description 1
- 235000011164 potassium chloride Nutrition 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- OVSQVDMCBVZWGM-DTGCRPNFSA-N quercetin 3-O-beta-D-galactopyranoside Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1OC1=C(C=2C=C(O)C(O)=CC=2)OC2=CC(O)=CC(O)=C2C1=O OVSQVDMCBVZWGM-DTGCRPNFSA-N 0.000 description 1
- BBFYUPYFXSSMNV-UHFFFAOYSA-N quercetin-7-o-galactoside Natural products OC1C(O)C(O)C(CO)OC1OC1=CC(O)=C2C(=O)C(O)=C(C=3C=C(O)C(O)=CC=3)OC2=C1 BBFYUPYFXSSMNV-UHFFFAOYSA-N 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- IKGXIBQEEMLURG-BKUODXTLSA-N rutin Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@@H]1OC[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 IKGXIBQEEMLURG-BKUODXTLSA-N 0.000 description 1
- 229960004555 rutoside Drugs 0.000 description 1
- 239000004576 sand Substances 0.000 description 1
- 208000005687 scabies Diseases 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 208000013223 septicemia Diseases 0.000 description 1
- 201000005113 shigellosis Diseases 0.000 description 1
- 229950005143 sitosterol Drugs 0.000 description 1
- 235000015500 sitosterol Nutrition 0.000 description 1
- 206010040872 skin infection Diseases 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- UQZIYBXSHAGNOE-XNSRJBNMSA-N stachyose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO[C@@H]3[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O3)O)O2)O)O1 UQZIYBXSHAGNOE-XNSRJBNMSA-N 0.000 description 1
- WNIFXKPDILJURQ-UHFFFAOYSA-N stearyl glycyrrhizinate Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C)CCC(C(=O)OCCCCCCCCCCCCCCCCCC)(C)CC5C4=CC(=O)C3C21C WNIFXKPDILJURQ-UHFFFAOYSA-N 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 235000018553 tannin Nutrition 0.000 description 1
- 229920001864 tannin Polymers 0.000 description 1
- 239000001648 tannin Substances 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 229960000790 thymol Drugs 0.000 description 1
- 206010044008 tonsillitis Diseases 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 230000008736 traumatic injury Effects 0.000 description 1
- 229940096998 ursolic acid Drugs 0.000 description 1
- PLSAJKYPRJGMHO-UHFFFAOYSA-N ursolic acid Natural products CC1CCC2(CCC3(C)C(C=CC4C5(C)CCC(O)C(C)(C)C5CCC34C)C2C1C)C(=O)O PLSAJKYPRJGMHO-UHFFFAOYSA-N 0.000 description 1
- 201000002498 viral encephalitis Diseases 0.000 description 1
- NCYCYZXNIZJOKI-UHFFFAOYSA-N vitamin A aldehyde Natural products O=CC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C NCYCYZXNIZJOKI-UHFFFAOYSA-N 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/78—Saururaceae (Lizard's-tail family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/19—Acanthaceae (Acanthus family)
- A61K36/195—Strobilanthes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
- A61K36/315—Isatis, e.g. Dyer's woad
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/85—Verbenaceae (Verbena family)
- A61K36/855—Clerodendrum, e.g. glorybower
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
本发明涉及一种治疗鸡常见细菌病的中草药组合物,它是由下述重量份的原料制成的粉剂:鱼腥草4-6份,大青叶4-6份,牛至草3-4份,灯芯草3-4份,鸡骨草2-4份,积雪草1-2份,甘草1-2份。本发明用以治疗鸡常见细菌病如大肠杆菌病、慢性呼吸道病、霍乱、沙门氏菌病,具有治愈率高、效果好、安全、无毒副作用、使用方便的特点。
Description
技术领域
本发明涉及一种治疗鸡常见细菌病的中草药组合物。
背景技术
鸡常见细菌病主要包括:大肠杆菌病、慢性呼吸道病、霍乱、沙门氏菌病等,治疗过程常采用抗生素类药物,都有效果,但临床上,要交叉用药,避免产生抗药性,另外,抗生素类西药,虽然具有一定的疗效,但缺点是抗药性和副作用较严重,而且在鸡肉和鸡蛋里会有化学药物残留,给人类健康带来潜在威胁;中草药具有天然、无毒副作用、无化学药物残留、不易产生抗药性等特点,用于养鸡业的防病、治病,具有广泛的应用前景。但目前市售的用于治疗鸡的大肠杆菌病、慢性呼吸道病、霍乱、沙门氏菌病的中草药,使用效果差,治愈率低,疗程长且成本高。
发明内容
本发明的目的在于针对上述问题,提供一种治疗鸡常见细菌病的中草药组合物。
本发明的技术方案是:一种治疗鸡常见细菌病的中草药组合物,它是由下述重量份的原料制成的粉剂:鱼腥草4-6份,大青叶4-6份,牛至草3-4份,灯芯草3-4份,鸡骨草2-4份,积雪草1-2份,甘草1-2份。
制成本治疗鸡常见细菌病的中草药组合物的优选原料重量份是:鱼腥草6份,大青叶6份,牛至草4份,灯芯草3份,鸡骨草3份,积雪草2份,甘草1份。
本发明组方中各组份药理功效是:
鱼腥草功效:鱼腥草别名岑草、紫背鱼腥草。性微寒、味苦。归肺、肝、膀胱、大肠经。含挥发油,内含抗菌有效成分癸酰乙醛,月桂醛,a-蒎烯和芳樟醇,甲基正壬基甲酮,樟烯,月桂烯,柠檬烯,乙酸龙脑酯,丁香烯,阿福甙,金丝桃甙,芸香甙。有清热解毒,利尿消肿之功效。主治肺炎,肺脓疡,热痢,疟疾,水肿,淋病,白带,痈肿,痔疮,脱肛,湿疹,秃疮,疥癣。
大青叶功效:大青叶别名蓝叶、蓝菜、蓝腚叶。性味苦、咸、大寒。归心、肝、胃经。含黄酮类.蓼蓝全草含黄色素及鞣质,根含蒽醌类.菘蓝叶含色氨酸、靛红烷B、葡萄糖芸苔素、新葡萄糖芸苔素、葡萄糖芸苔素-1-磺酸盐、靛蓝、腺甙、色胺酮。尚含β-谷甾醇、γ-谷甾醇、棕榈酸、蔗糖等。有清热凉血、解心、胃热毒之功效。主治流感,热病发斑,咽喉炎,扁桃腺炎,腮腺炎,流脑,肠炎,菌痢,外敷疮肿毒。
牛至草功效:牛至草别名江宁府茵陈、小叶薄荷、满坡香、土香薷、白花茵陈、香草、五香草、山薄荷、暑草、小甜草、止痢草等。味辛、微苦、性凉,具解表、理气、清暑、利湿之功效。全草含水苏糖和挥发油,油中主要含百里香酚,香荆芥酚,乙酸牛儿醇酯及聚伞花素等,叶还含熊果酸。对金黄色葡萄球菌、伤寒杆菌、变形杆菌抗菌作用最强,对大肠杆菌、宋内痢疾杆菌和副伤寒杆菌也有较好的抗菌作用,能促进健康人和急性肾炎患者的淋巴转化作用,并具有免疫调节作用。用于感冒发热、中暑、胸膈胀满腹痛吐泻痢疾、黄疸、水肿、带下、小儿疽积、麻疹、皮肤瘙痒、疮疡肿痛、跌打损伤等。
灯芯草功效:灯芯草别名秧草、水灯心、野席草、龙须草、灯草、水葱。性味微寒,甘、淡。归心、肺、小肠、膀胱经。茎髓含纤维、脂肪油、蛋白质等,茎含多糖类,用甲醇在灯心草中提得木犀草素、木犀草素-7-葡糖甙、氯化钾等。具利水通淋、清心降火之功效。用于淋病、水肿、小便不利、尿少涩痛、湿热黄疸。
鸡骨草功效:鸡骨草别名红母鸡草、石门坎、黄食草、细叶龙鳞草、大黄草。性味甘、苦,凉,无毒,归心、肺、肝、胃、肾经。全草粗皂甙水解产物含多种三萜类皂甙元,还含相思子皂甙,胆碱和相思子碱,根中含大黄酚和大黄素甲醚。具清热解毒,舒肝止痛之功效。用于黄疸,胁肋不舒,胃脘胀痛;急、慢性肝炎,乳腺炎。
积雪草功效:积雪草别名崩大碗、马蹄草等,味甘淡辛、寒。入心、肺、脾、胃、大肠五经。含多种α-香树脂醇型的三萜成分,其中有积雪草甙、参枯尼甙、异参枯尼甙,羟基积雪草甙,玻热模甙、破热米甙和破热米酸等,以及马达积雪草酸。此外,尚含内消旋肌醇、积雪草糖、蜡、胡萝卜烃类、叶绿素,以及山柰酚、槲皮素和葡萄糖、鼠李糖的黄酮甙。全草主要含三萜酸和三萜皂甙。另含山柰素和槲皮素及其甙、积雪草碱、内消旋肌醇、积雪草低聚糖、谷甾醇、维生素C、胡萝卜素、绿色挥发油及树脂状物质。具有清热利湿,解毒消肿之功效。用于湿热黄疸,中暑腹泻,砂淋血淋,痈肿疮毒,跌扑损伤。
甘草功效:甘草别名美草、密甘、密草、国老、甜草、皮草。性平,味甘。归十二经。甘草主要含甘草酸、甘草甜素、24-羟基甘草次酸、甘草黄酮、甘草素、异甘草素、甘草多糖等成份,具有抗溃疡、促进胰腺分泌、保肝、降脂、调节巨噬细胞的吞噬功能等作用。甘草酸是天然解毒剂,可用于机体抗衰老、增强免疫力、维持水盐代谢平衡等。甘草有补脾益气、清热解毒、调和诸药之功效。用于脾胃虚弱,缓解药物毒性、烈性。
本发明组方依据:鸡的大肠杆菌病、慢性呼吸道病、霍乱、沙门氏菌病已成为制约养鸡业发展的主要疾病,鸡发病后,呈现败血症死亡,或呼吸困难,腹泻,排黄白色和绿色粪便等症状,成年鸡出现这些症状的同时产蛋下降。故治疗上,宜以抗菌消炎、清热燥湿、凉血解毒、止痢为治则。方中鱼腥草、大青叶清热解毒,凉血止血;牛至草、灯芯草、健脾益气,燥湿利水,增强食欲;鸡骨草、积雪草抗菌消炎,另外增进食欲,加速消化;牛至草增强机体免疫功能,健脾和胃;甘草甘温益气、和中健脾,通行十二经络,调和诸药。方中诸药相和,共奏抗菌消炎、清热燥湿、凉血解毒、止痢、养阴生津的功效,适用于鸡的大肠杆菌病、慢性呼吸道病、霍乱、沙门氏菌病等细菌病。为方便在治疗中的应用,制成粉剂。
本发明治疗鸡常见细菌病的中草药组合物,是在进行了大量实际应用的基础上,依据传统医学古方,结合现代流行病学、病原学理论筛选而成,对鸡大肠杆菌病、慢性呼吸道病、霍乱和鸡沙门菌病等具有很好的治疗效果。
具体实施方式
结合实施例对本发明作进一步说明。
实施例:
1、分别称取原料(饮片):鱼腥草240 g;大青叶240 g;牛至草160 g;灯芯草120 g;鸡骨草120 g;积雪草80 g;甘草40 g。
2、将上述原料分别粉碎成粗粉,混合,搅匀,分装,即制得本治疗鸡常见细菌病的中草药组合物。
利用本治疗鸡常见细菌病的中草药组合物进行的一些试验情况如下:
1、本治疗鸡常见细菌病的中草药组合物对鸡大肠杆菌药敏试验
选取临床患鸡大肠杆菌病病例,经分离、鉴定出病原菌大肠杆菌O8。称取一定量的本发明中草药组合物制成液体,每mL含生药1g,灭菌,分装,4 ℃保存备用。将临床分离的大肠杆菌O8先接种于平板,于37 ℃培养18 h后,挑选典型菌落接种于5 mL肉汤中,于37℃培养18 h后,0.5麦氏单位标准比浊管比浊,用肉汤将菌液稀释至106 CFU/mL,备用。
药物敏感性试验:采用平皿打孔法,在孔内加入1g/mL本发明中草药液体,以加满而不溢出孔外为宜。选取公认的对大肠杆菌效果较好的三种抗生素如环丙沙星(1 μg/mL)、丁胺卡那霉素(1 μg/mL)、庆大霉素(1 μg/mL)的药敏试验作对照,置于37 ℃恒温培养箱中培养24 h,测量抑菌圈直径,每种药物的药敏试验重复三次。判定标准:按照《中药药理学》和《美国临床实验室标准化研究所2005年版有关药敏试验标准化》的标准,即抑菌直径≥20 mm为极敏,20 mm>抑菌直径≥15 mm为高敏;15 mm>抑菌直径≥10 mm为中敏,10 mm以下为低敏。
本治疗鸡常见细菌病的中草药组合物敏感性试验结果见表1。
表1 本中草药组合物对大肠杆菌的药敏试验结果 mm
药物 | 大肠杆菌O78 |
环丙沙星 | 20.0±1.0 |
丁胺卡那霉素 | 19.8±0.5 |
庆大霉素 | 19.5±0.9 |
本中草药组合物 | 22.2±1.0 |
表1显示,对大肠杆菌O8,本中草药组合物为极敏,抑菌直径达22.2 mm,环丙沙星、丁胺卡那霉素和庆大霉素为高敏。药物敏感试验表明,本中草药组合物对大肠杆菌O8的抑制作用最敏感,环丙沙星次之,丁胺卡那霉素、庆大霉素稍次。结果表明,本中草药组合物在治疗鸡大肠杆菌病实践中应作为首选。
2、人工感染鸡大肠杆菌病的疗效试验
人工感染鸡大肠杆菌病的疗效试验:180只50日龄伊莎褐蛋鸡随机分为6组,每组30只,分组及处理方法见表1。除健康对照组注射灭菌生理盐水1 mL,其余各组每只雏鸡均注射大肠杆菌液(6×106个/mL)1 mL。攻毒36 h后试验鸡(健康对照组除外)出现大肠杆菌病典型症状,开始按表1剂量给药,连用5 d,观察给药后的临床变化,每天记录各组鸡的临床症状和死亡数。
表1 试验动物分组及处理方法 (单位:只)
组 别 | 数量 | 处 理 |
本发明中草药组合物高剂量组 | 30 | 感染,每只鸡0.4g本发明中草药拌料 |
本发明中草药组合物中剂量组 | 30 | 感染,每只鸡0.2g本发明中草药拌料 |
本发明中草药组合物低剂量组 | 30 | 感染,每只鸡0.1g本发明中草药拌料 |
丁胺卡那霉素治疗组 | 30 | 感染,1g药物加水1.5kg |
感染对照组 | 30 | 感染,不给药 |
健康对照组 | 30 | 不感染,不给药 |
表2 鸡大肠杆菌病人工感染试验的治疗结果 (单位:只、%)
组 别 | 死亡数 | 死亡率 | 有效率 | 治愈率 |
本中草药组合物高剂量组 | 2 | 6.7 | 93.3 | 91.0 |
本中草药组合物中剂量组 | 3 | 10.0 | 90.0 | 90.0. |
本中草药组合物低剂量组 | 5 | 16.7 | 83.3 | 78.0 |
丁胺卡那霉素治疗组 | 5 | 16.7 | 77.5 | 72.0 |
感染对照组 | 25 | 83.3 | ||
健康对照组 | 0 | 0 |
由表2可知,本中草药组合物高、中、低剂量组与感染对照组相比较,治愈率均差异极显著(P<0.01);本中草药组合物高、中剂量组与丁胺卡那霉素比较,治愈率呈显著差异(P<0.05);低剂量组的治愈率与丁胺卡那霉素相比较差异不显著(P>0.05)。
3、自然感染鸡大肠杆菌病的疗效试验
自然发病成年蛋鸡分别由河北省昌黎县、滦县、乐亭县、卢龙县、抚宁县各养殖户提供,根根据临床症状、剖检变化、动物接种试验和实验室检查结果,最后确诊为鸡大肠杆菌病。以各自感染鸡群为试验组,发病鸡群按1g/只成年蛋鸡的剂量将本中草药组合物混于饲料中饲喂,每日2次,投药5~7d为一个疗程。停药后继续观察3~5d,以临床症状消失,饮水、采食和精神状态恢复正常者判为治愈,再结合病理剖检抽测结果确定防治效果,统计治愈率。治疗结果见表3。
表3 本中草药组合物对自然感染大肠杆菌病病鸡的治疗效果(单位:只、%)
鸡场 | 周龄 | 发病时间 | 治疗数 | 死淘数 | 痊愈数 | 治愈率 | 用药天数 |
昌黎 | 20 | 2014.06.05 | 500 | 10 | 490 | 98.0 | 6 |
滦县 | 25 | 2014.07.15 | 1500 | 45 | 1455 | 97.0 | 7 |
乐亭 | 24 | 2014.05.05 | 1700 | 68 | 1632 | 96.0 | 6 |
卢龙 | 26 | 2014.08.08 | 2000 | 60 | 1940 | 97.0 | 5 |
抚宁 | 30 | 2014.02.24 | 2500 | 125 | 2375 | 95.0 | 6 |
平均治愈率 | 8200 | 308 | 7892 | 96.24 |
通过对8200只自然感染大肠杆菌发病成年产蛋鸡的治疗,本中草药组合物对成年产蛋鸡的大肠杆菌病有显著的治疗效果,平均治愈率为96.24%,一般经5~7d症状消失,恢复正常采食,产蛋率回升,经2~4周恢复到接近正常产蛋水平。
Claims (2)
1.一种治疗鸡常见细菌病的中草药组合物,其特征在于它是由下述重量份的原料制成的粉剂:鱼腥草4-6份,大青叶4-6份,牛至草3-4份,灯芯草3-4份,鸡骨草2-4份,积雪草1-2份,甘草1-2份。
2.根据权利要求1所述的治疗鸡常见细菌病的中草药组合物,其特征在于它是由下述重量份的原料制成的粉剂:鱼腥草6份,大青叶6份,牛至草4份,灯芯草3份,鸡骨草3份,积雪草2份,甘草1份。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201410566526.6A CN104257930B (zh) | 2014-10-23 | 2014-10-23 | 治疗鸡常见细菌病的中草药组合物 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201410566526.6A CN104257930B (zh) | 2014-10-23 | 2014-10-23 | 治疗鸡常见细菌病的中草药组合物 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN104257930A true CN104257930A (zh) | 2015-01-07 |
CN104257930B CN104257930B (zh) | 2018-02-13 |
Family
ID=52149587
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201410566526.6A Expired - Fee Related CN104257930B (zh) | 2014-10-23 | 2014-10-23 | 治疗鸡常见细菌病的中草药组合物 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN104257930B (zh) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109169725A (zh) * | 2018-08-21 | 2019-01-11 | 江苏大学 | 一种复合抗菌剂的制备方法及应用 |
CN111358850A (zh) * | 2020-04-26 | 2020-07-03 | 河南牧翔动物药业有限公司 | 一种用于防治鸡大肠杆菌病的中药组合物及其制备方法 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1380098A (zh) * | 2002-05-20 | 2002-11-20 | 张勇飞 | 一种抗感染复合制剂及其制备方法 |
CN102885884A (zh) * | 2012-10-31 | 2013-01-23 | 河南亚卫动物药业有限公司 | 一种治疗家禽细菌性疾病的颗粒剂及其制备方法 |
CN103372075A (zh) * | 2012-04-11 | 2013-10-30 | 广东省农业科学院畜牧研究所 | 一种抗鸡大肠杆菌病的中药超微粉组合物及其制备方法 |
CN103430904A (zh) * | 2013-09-17 | 2013-12-11 | 张国增 | 一种提高鸡免疫力的饲养方法 |
-
2014
- 2014-10-23 CN CN201410566526.6A patent/CN104257930B/zh not_active Expired - Fee Related
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1380098A (zh) * | 2002-05-20 | 2002-11-20 | 张勇飞 | 一种抗感染复合制剂及其制备方法 |
CN103372075A (zh) * | 2012-04-11 | 2013-10-30 | 广东省农业科学院畜牧研究所 | 一种抗鸡大肠杆菌病的中药超微粉组合物及其制备方法 |
CN102885884A (zh) * | 2012-10-31 | 2013-01-23 | 河南亚卫动物药业有限公司 | 一种治疗家禽细菌性疾病的颗粒剂及其制备方法 |
CN103430904A (zh) * | 2013-09-17 | 2013-12-11 | 张国增 | 一种提高鸡免疫力的饲养方法 |
Non-Patent Citations (2)
Title |
---|
张宏福主编: "《饲料营养研究进展2010》", 30 September 2010 * |
王新华等主编: "《禽病检验与防治》", 31 August 2013 * |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109169725A (zh) * | 2018-08-21 | 2019-01-11 | 江苏大学 | 一种复合抗菌剂的制备方法及应用 |
CN109169725B (zh) * | 2018-08-21 | 2020-11-20 | 江苏大学 | 一种复合抗菌剂的制备方法及应用 |
CN111358850A (zh) * | 2020-04-26 | 2020-07-03 | 河南牧翔动物药业有限公司 | 一种用于防治鸡大肠杆菌病的中药组合物及其制备方法 |
CN111358850B (zh) * | 2020-04-26 | 2022-04-19 | 河南牧翔动物药业有限公司 | 一种用于防治鸡大肠杆菌病的中药组合物及其制备方法 |
Also Published As
Publication number | Publication date |
---|---|
CN104257930B (zh) | 2018-02-13 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN102526510B (zh) | 一种用于预防和治疗鸭病毒性肝炎的中药组合物 | |
CN104489279A (zh) | 治疗奶牛乳房炎的中草药饲料添加剂 | |
CN104055913A (zh) | 治疗崩漏的中药制剂 | |
CN104257930A (zh) | 治疗鸡常见细菌病的中草药组合物 | |
CN104825960A (zh) | 一种治疗肺结核的中药及其制备方法 | |
TW202330006A (zh) | 氣虛及/或血虛相關症狀之預防、改善或緩和用之組合物 | |
CN104547902A (zh) | 中药制剂用于制备治疗慢性肠炎、阑尾炎药物中的用途 | |
CN111588801B (zh) | 一种预防畜禽疫病的中药分散颗粒剂及其制备方法 | |
CN104189234A (zh) | 治疗崩漏的中药制剂 | |
CN104547351B (zh) | 治疗鸡传染性鼻炎的中草药口服液 | |
CN103432245B (zh) | 治疗仔猪白痢的中草药口服液 | |
CN105456957A (zh) | 一种治疗狐臭的中药组合物 | |
CN104922648A (zh) | 一种治疗鸡腹泻的中药组合物及其制备方法 | |
CN105327147A (zh) | 用于治疗猪气喘病的药物组合物及其制备方法 | |
CN105106591A (zh) | 用于治疗牛肺水肿的药物及其制备方法 | |
CN104771585A (zh) | 一种治疗急性肾炎的中药组合物及制备方法 | |
CN104873730A (zh) | 一种治疗肝气郁结型急性乳腺炎的中药及制备方法 | |
CN104996800A (zh) | 一种含有中药添加剂的蛋鸡饲料及其制备方法 | |
CN104225261A (zh) | 一种治疗坐骨神经痛的中药组合物及制备方法和应用 | |
CN108992559A (zh) | 用于防治风热感冒及病毒性流感的兽用中药组合物及其制备方法 | |
CN103536857B (zh) | 一种治疗痿症的中药 | |
CN104352598A (zh) | 防治鸡腹泻的中草药组合物 | |
CN103623192B (zh) | 用于治疗猪蓝耳病的药物及其制备方法 | |
CN104208168B (zh) | 一种用于治疗家禽呼吸道感染的复方中药组合物及其制备方法 | |
CN103432276B (zh) | 治疗仔猪急性副伤寒的中草药口服液 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
GR01 | Patent grant | ||
GR01 | Patent grant | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20180213 |