CN104257820A - Agastache rugosus and eupatorium cold tablets - Google Patents

Abstract

The invention relates to agastache rugosus and eupatorium cold tablets as a Chinese patent medicine for treating cold. The agastache rugosus and eupatorium cold tablets are used for treating wind-heat type common cold and wind-cold type common cold and have a quick effect in treating colds with symptoms including cold insides and heat outsides, cold and heat insides, anorexia, abdominal distension and upsetting and colds in type similar to dyspepsia. The agastache rugosus and eupatorium cold tablets are prepared by the following steps: crushing eight traditional Chinese medicines in ultrafine powders, and uniformly stirring in percentage by mass: 40 percent of agastache rugosus and eupatorium, 15 percent of rhizoma atractylodis, 10 percent of rhizoma menispermi, 10 percent of radix bupleuri, 10 percent of magnolia obavata, 5 percent of patchouli, 5 percent of perilla oil and 5 percent of tangerine peel; and carrying out film coating by using a premixed agent to prepare tablets, wherein each tablet is 0.5g.

Description

Leaves of pulse plants pendant common cold tablet

Technical field

The present invention relates to a kind of medicine for the treatment of flu, more specifically a kind of Chinese patent medicine tablet.

Background technology

Flu is a kind of commonly encountered diseases, frequently-occurring disease.The present invention treats anemopyretic cold and anemofrigid cold, especially to cold in the interior and heat in the exterior, and the cold folder heat of folder, anorexia, abdominal distention, the symptom such as vexed, the flu of similar dyspepsia type. the rare this kind of double Chinese patent medicine controlling anemopyretic cold and anemofrigid cold of existing market, in order to make up this technical deficiency, have developed leaves of pulse plants pendant common cold tablet.

Summary of the invention

The leaves of pulse plants pendant common cold tablet principal agent antipyretic clearing away summer-heat of Herba Eupatorii, dispelling dampness to invigorate the stomach.Rhizoma Atractylodis damp eliminating.Rhizoma Menispermi heat-clearing and toxic substances removing, reducing swelling and alleviating pain.Radix Bupleuri antipyretic and anti-inflammatory.Cortex Magnoliae Officinalis circulation of qi promoting removing food stagnancy.Patchouli oil dispelling summer-heat from superficies of the body, removing dampness to restore normal function of the stomach.Perilla oil expectorant, lung moistening.Pericarpium Citri Reticulatae regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.

The aerial parts that Herba Eupatorii (Eupatorium fortunei Turcz.) is feverfew Herba Eupatorii (Herba Chlorophyti).Herb is containing volatile oil 1.5%-2.0%.Volatile oil of Herba Eupatorii popularity cold virus has inhibitory action.Herba Eupatorii 100% water decoction, with tube dilution method, has inhibitory action to diphtheria corynebacterium, staphylococcus aureus, sarcina, Bacillus proteus, Bacillus typhi etc.Its volatile oil infected by influenza has inhibitory action.There is the effect of antipyretic clearing away summer-heat, dispelling dampness to invigorate the stomach, preventing or arresting vomiting. clinical practice:1, for dampness taste, distension and fullness in the abdomen, hygropyrexia from the beginning of, and the sweet disease such as greasy in mouth.Herba Eupatorii fragrant odour, be good at removing dampness and be amusing, effect is similar to Herba Pogostemonis, treatment dampness taste disease, and two medicines often mutual reinforcement between are use.2, for heat-damp in summer disease.Herba Eupatorii can be waken up summer-heat removing dampness, for interiorly to accumulate, fear of cold, heating, feeling of fullness in the head, the disease such as uncomfortable in chest, anorexia.3., Herba Eupatorii fragrant odour, pungently can disperse, perfume (or spice) can go dirty, therefore it has effect of removing dampness expelling summer-heat.Can be used for treatment diseases caused by exogenous pathogenic factor heat-damp in summer or hygropyrexia from the beginning of, Symptoms is lossless heating, abdominal distention uncomfortable in chest.Spleen channel damp and hot (in mouth sweet greasy, sialism, implication are rancid) person is also suitable for.Herba Eupatorii is the monarch drug of leaves of pulse plants pendant common cold tablet.

Rhizoma Atractylodis: Compositae herbaceos perennial: Atractylodes lancea (Thunb.) DC. (Atractylodes lancea (Thunb)) DC.) and the dry rhizome of Atractylis chinensis (Atrcatylodes chinensis (DC) koidz .).Be wild.Main component: containing volatile oil, wherein mainly contains atractylol (C15H26O), atractylone (C15H20O).Again containing a large amount of first kind and fourth kind vitamin.Effect and effect: 1, stomach invigorating.2, diuresis, diaphoresis, diuresis is not obvious, but can sodium be increased, potassium is discharged from urine.3, calm, effective ingredient is volatile oil.4, blood sugar lowering.5, strong effect, may be relevant with its contained vitamin.For the important drugs of damp eliminating, no matter all Ke application of endogenous dampness, exogenous damp.The experience of forefathers is said: " control exogenous damp the most effective with Rhizoma Atractylodis.Rhizoma Atractylodis are ministerial drugs.

Rhizoma Menispermi: another name Caulis menispermi, Latin literary fame Menispermum dauricum DC. is the rhizome of menispermaceous plants Caulis menispermi.There is the function of heat-clearing and toxic substances removing, reducing swelling and alleviating pain.Cure mainly the disease such as laryngopharynx swelling and pain, cough due to lung-heat.Containing alkaloid (matrine, oxymatrine), separately containing total polysaccharides.Pharmacology action: 1, antitumor action: contained by Radix Sophorae Tonkinensis, multiple alkaloid has inhibitory action to S180 sarcoma, sarcoma S37, mouse cervical cancer U14, yoshida sarcoma, ascitic type liver cancer, the oxygen cell of oxymatrine to tumor has selective killing effect in addition.2, on the impact of cardiovascular system: Radix Sophorae Tonkinensis total alkali has hypotensive effect, this effect may be relevant with its vasodilative effect.Radix Sophorae Tonkinensis total alkali can also significantly increase guinea pig isolated heart coronary flow.3, on the impact of immunologic function: Sophora Tankinensis lumbar injection obviously can suppress the phagocytic function of Turnover of Mouse Peritoneal Macrophages.4, on the impact of central nervous system: Radix Sophorae Tonkinensis can suppress spontaneous activity in mice, the excitation of antagonism amfetamine, strengthens pentobarbital sodium, thiopentone and chloral hydrate to the inhibitory action of maincenter.5, antiulcer action.

Radix Bupleuri: main containing compositions such as saikoside class, flavonoids.[pharmacological action] (one) antipyretic and anti-inflammatory.(2) calmness, analgesia, epilepsy: the thick saponin of Radix Bupleuri, sapogenin A have obvious sedation, and can extend the length of one's sleep of mice.And have obvious analgesic activity to mouse experiment pain.(3) hepatic cholagogic: bupleurum preparation has significant antagonism to zoopery hepatic injury, hepatocellular degeneration, necrosis can be alleviated, the hepatic glycogen of accumulation in hepatocyte and the large portion of rna content is made to recover or close to normal, serum transaminase vigor significantly be declined; And the fibroplasia of liver injury can be suppressed, promote that fiber absorbs, reduce the generation of liver cirrhosis.Wherein best with the effect of sweet bavin mixture.Radix Bupleuri can make total bile output of Canis familiaris L. and bile salt component increase.Its effective ingredient is flavone.(4) to the adjustment of gastrointestinal: the thick saponin of Radix Bupleuri has the effect significantly suppressing gastric secretion, makes pepsin activity lower, ulcer coefficient reduces.(5) blood pressure lowering and anticoagulant, the thick saponin of Radix Bupleuri can make rat blood pressure decline, decreased heart rate.During intravenous injection, its effect is stronger.(6) immunologic function is strengthened: Radix Bupleuri extract and Bupleurum chinense polysaccharide have immunostimulant effect.After Radix Bupleuri obviously can promote mice secondary immunity, sheep red blood cell (SRBC) antibody is formed.Bupleurum chinense polysaccharide has remarkable potentiation to the mouse lymphocyte hypertrophy that Con A and PHA causes, and prompting Radix Bupleuri all has potentiation to T, bone-marrow-derived lymphocyte.Radix Bupleuri can strengthen the phagocytosis of Kupffer cell; The phagocytosis of mononuclear phagocyte can be strengthened.(7) to blood fat, sugar, protein metabolism; Saikoside and sapogenin have the effect reducing serum cholesterol and triglyceride.α mono-chondrillasterol has the effect reducing cholesterolemia.Saikoside obviously can increase the synthesis of rats'liver internal protein.Bupleurum falcatum obviously can raise the blood glucose of rat, and glycogen commercial weight also can rise significantly.Radix Bupleuri promotes the synthesis of hepatic glycogen and protein, is the another aspect effect that Chinese medicine protects the liver.

Cortex Magnoliae Officinalis, Cortex Magnoliae Officinalis Magnolia officinalis Rehd. et Wils. virtue dry dried bark, root bark and branch skin.Sweetening treatment is wet Chinese medicine, has circulation of qi promoting removing food stagnancy, dampness except effect that is full, lowering the adverse QI to relieve asthma; Cure mainly stagnation of QI due to dyspepsia; Abdominal distention constipation; Retention of dampness in middle-JIAO, gastral cavity painful abdominal mass is vomited and diarrhoea; Expectorant stops up QI rising in reverse order; Fullness in the chest is breathed with cough.

Patchouli oil (patchouli oil) is Labiatae thorn stamen grass platymiscium (pogostemon cablin Banth.; P. patchouli pelletiver Var. snavis Hook; P. heyneanus Benth.), be a kind of conventional Chinese herbal medicine, patchouli oil is main medicinal ingredient, and in chemical composition, patchouli oil is mainly containing patchoulene, patchouli alcohol and Pogostone.Oil of Herba Pogostemonis ^[3]main containing methyl chavicol (to allyl benzene methyl ether CAS140-67-0), can about 80% be reached.Both contrasts chemical composition, patchouli oil is not containing methyl chavicol, and oil of Herba Pogostemonis is not containing patchouli alcohol and ketone.Patchouli oil and oil of Herba Pogostemonis, pharmacologically also different, both have antimicrobial antiphlogistic effect, it is generally acknowledged that patchouli oil is than oil of Herba Pogostemonis better effects if.There are some researches show that the metabolite (1-hydroxymethyl p-allylphenol etc.) of methyl chavicol has carcinogenecity, therefore oil of Herba Pogostemonis is there are no applying in medicine, mainly based on the consideration of safety.Dispelling summer-heat from superficies of the body; Removing dampness to restore normal function of the stomach.Main summertime flu; Cold and heat are had a headache; Breast gastral cavity painful abdominal mass is vexed; Vomiting is had loose bowels.

Perilla oil take Folium Perillae as the edible oil that raw material extracts, and is the medicine food dual purpose plant of the first batch of approval of country, has the effects such as expectorant, lung moistening, pain relieving, removing toxic substances.Perilla oil reaches 56.14-64.82% containing а-linolenic acid, а-linolenic acid is the fatty acid of needed by human, it is converted into vital activity factor D HA and the EPA(plant NAOHUANGJIN of metabolism necessity in human body), not containing cholesterol, to human body, there is more significant health care and medical efficacy.Effect: effect for reducing blood fat, improves memory, anti-senescence function, antitumaous effect.Other effects 1, blood fat-reducing blood pressure-decreasing, 2, hepatoprotective, 3, nourishing the brain and improving intelligence, vision protection.Rhizoma Menispermi, Radix Bupleuri, Cortex Magnoliae Officinalis, patchouli oil, the perilla oil five tastes are adjuvant drugs of leaves of pulse plants pendant common cold tablet.

Pericarpium Citri Reticulatae [English name] PERICARPIUM CITRI RETICULATAE is the dry mature skin of rutaceae orange and variety thereof.Peel is with Chen Zheliang, therefore named.Regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.For fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm.Main Function is row QI of the spleen and stomach.The main transmitting and distributing the fluids of taste, therefore QI of the spleen and stomach is capable, can dry, spleen invigorating, reduce phlegm.Modern pharmacological research proves: volatile oil contained by Pericarpium Citri Reticulatae has the effect of fragrant stomach invigorating and the wind dispelling therapeutic method to keep the adverse QI flowing downwards; Sputum can be made easily to bring up.This cures mainly consistent with its function.Pericarpium Citri Reticulatae is for making.

Above eight taste Chinese medicine superfine grindings, evenly mix and stir by following mass percent: the leaves of pulse plants wears 40%, Rhizoma Atractylodis 15%, Rhizoma Menispermi 10%, Radix Bupleuri 10%, Cortex Magnoliae Officinalis 10%, Herba Pogostemonis 5%, perilla oil 5%, Pericarpium Citri Reticulatae 5%, then use pre-mixing agent film coating, the authentication code of pharmaceutic adjuvant: [F20100031], make tablet, every sheet 0.5 gram.

Detailed description of the invention

The technical program is through clinical trial tens example, and general patient 1-2 days can have positive effect or rehabilitation.Effective percentage more than 85%.Case one: permitted certain, man, 17 years old, drench with rain and catch cold, private prosecution is felt cold, and stream nose asks water two days, and 37.8 degree Celsius of body temperature, tongue is thick in vain, floating and rapid pulse.Oral leaves of pulse plants pendant common cold tablet, each 3, every day three times, warm water is swallowed after meal.Follow up a case by regular visits to after two days, recovery from illness.

Case two: Zhang, female 29 years old, pharyngalgia, poor appetite, has no temperature, yellow and greasy fur, deep pulse speed.Oral leaves of pulse plants pendant common cold tablet, each 3, every day three times, warm water is swallowed after meal.Follow up a case by regular visits to after two days, appetite has been opened, and pharynx is not bitterly.Expectoration yellow sputum, then take one day, private prosecution rehabilitation.

  

Claims (1)

1. treat a Chinese medicinal tablet for anemopyretic cold and anemofrigid cold, it is characterized in that its mass percent and medical material are made: the leaves of pulse plants wears 40%, Rhizoma Atractylodis 15%, Rhizoma Menispermi 10%, Radix Bupleuri 10%, Cortex Magnoliae Officinalis 10%, Herba Pogostemonis 5%, perilla oil 5%, Pericarpium Citri Reticulatae 5%.