CN104257682A - Wound surface repairing composition and preparation - Google Patents
Wound surface repairing composition and preparation Download PDFInfo
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- CN104257682A CN104257682A CN201410588382.4A CN201410588382A CN104257682A CN 104257682 A CN104257682 A CN 104257682A CN 201410588382 A CN201410588382 A CN 201410588382A CN 104257682 A CN104257682 A CN 104257682A
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- wound surface
- wound
- preparation
- surface maintenance
- trehalose
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/717—Celluloses
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- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Materials For Medical Uses (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a wound surface repairing composition and a preparation. The wound surface repairing composition is composed of 10-25 percent of trehalose and 75-90 percent of sodium carboxymethylcellulose in percentage by weight. The wound surface repairing composition and the preparation have high moisturizing capacity. A wound surface can be prevented from infection, the tissue fluid exudation of the wound surface is absorbed, and a good environment is provided for the wound surface, so that the wound surface is quickly healed.
Description
Technical field
The present invention relates to a kind of biomedicine technical field, be specifically related to a kind of wound surface maintenance compositions and preparation thereof.
Background technology
Human body skin wound surface disease has now become one of the highest disease of society sickness rate, be no matter postoperative wound surface or traumatic surface also or the wound surface caused by reason such as ulcer, erosion, burn and scald.And the healing of wound surface is a complicated process with repairing.Once wound surface could not correctly process in time, initiation will be made to infect, the lighter slows down wound healing, and severe one causes death.Traditional wound repair method keeps open wound, local debridement and control of medication traumatic infection, promotes wound incrustation.But traditional Wound treatment method also exist healing rate slowly, the drawback such as patient pain, to the physiology of patient with bring great misery psychologically.
Summary of the invention
The object of the invention is to overcome the deficiencies in the prior art, a kind of safe and effective and cheap wound surface maintenance compositions easy to use is provided.
Second object of the present invention is to provide a kind of preparation comprising wound surface maintenance compositions.
Technical scheme of the present invention is summarized as follows:
A kind of wound surface maintenance compositions, by weight percentage by 10% ~ 25% trehalose, 75% ~ 90% sodium carboxymethyl cellulose form.
Preferably: trehalose is 15% ~ 20%, sodium carboxymethyl cellulose is 80%-85%.
The preparation of above-mentioned a kind of wound surface maintenance compositions, by weight percentage by 25 ~ 90% a kind of wound surface maintenance compositions and the acceptable adjuvant of 10% ~ 75% pharmacy make.
The preferred paste of dosage form of preparation or powder.
Wound surface maintenance compositions in the present invention and preparation have good moisture-retaining capacity.Can traumatic infection be prevented, absorb wound tissue liquid and ooze out, simultaneously for wound surface provides good environment to make wound surface quickly-healing.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further illustrated.
Embodiment 1
A kind of wound surface maintenance compositions, is made up of the sodium carboxymethyl cellulose of 10% trehalose and 90% by weight percentage.
Embodiment 2
A kind of wound surface maintenance compositions, is made up of the sodium carboxymethyl cellulose of 13% trehalose and 87% by weight percentage.
Embodiment 3
A kind of wound surface maintenance compositions, is made up of the sodium carboxymethyl cellulose of 15% trehalose and 85% by weight percentage.
Embodiment 4
A kind of wound surface maintenance compositions, is made up of the sodium carboxymethyl cellulose of 18% trehalose and 82% by weight percentage.
Embodiment 5
A kind of wound surface maintenance compositions, is made up of the sodium carboxymethyl cellulose of 20% trehalose and 80% by weight percentage.
Embodiment 6
A kind of wound surface maintenance compositions, is made up of the sodium carboxymethyl cellulose of 23% trehalose and 77% by weight percentage.
Embodiment 7
A kind of wound surface maintenance compositions, is made up of the sodium carboxymethyl cellulose of 25% trehalose and 75% by weight percentage.
Embodiment 8
Comprise a kind of paste of wound surface maintenance compositions, a kind of wound surface maintenance compositions, 25% glycerol, 25% propylene glycol and the 25%PEG400 that are prepared by 25% embodiment 1 by weight percentage make.
Embodiment 9
Comprise a kind of paste of wound surface maintenance compositions, a kind of wound surface maintenance compositions prepared by 30% embodiment 2 by weight percentage, 20% glycerol, 25% propylene glycol, 15%PEG400 and 10%PEG1000 make.
Embodiment 10
Comprise a kind of paste of wound surface maintenance compositions, a kind of wound surface maintenance compositions prepared by 35% embodiment 3 by weight percentage, 15% glycerol, 20% propylene glycol, 15%PEG600 and 15%PEG1000 make.
Embodiment 11
Comprise a kind of powder of wound surface maintenance compositions, a kind of wound surface maintenance compositions prepared by 90% embodiment 4 by weight percentage and 10% starch are made.
Embodiment 12
Comprise a kind of powder of wound surface maintenance compositions, a kind of wound surface maintenance compositions, 5% starch and 15% microcrystalline Cellulose prepared by 80% embodiment 5 are by weight percentage made.
Embodiment 13
Comprise a kind of powder of wound surface maintenance compositions, a kind of wound surface maintenance compositions 60%, starch 10%, the microcrystalline Cellulose 30% prepared by embodiment 7 by weight percentage.
Embodiment 14
The preparation of paste:
By the formula of one of embodiment 8-10, by acceptable for pharmacy adjuvant heating in water bath to 80 DEG C, make its mix homogeneously, then add trehalose and the sodium carboxymethyl cellulose of composition wound surface maintenance compositions, stir and make its suspended dispersed.Be cooled to 40 DEG C, filled to be encapsulated in hermetic container and send into sterile chamber and carry out 60Coradiation sterilizing, after having specified irradiation sterilization according to medicine, i.e. the obtained paste comprising a kind of wound surface maintenance compositions.
Embodiment 15
The preparation of powder:
The trehalose of composition wound surface maintenance compositions, sodium carboxymethyl cellulose are pulverized respectively, cross 200 mesh sieves, by the formula of one of embodiment 11-13, mix homogeneously with the acceptable adjuvant of pharmacy, dress is encapsulated in spray bottle and sends into sterile chamber and carry out 60Coradiation sterilizing, after having specified irradiation sterilization according to medicine, i.e. the obtained powder comprising a kind of wound surface maintenance compositions.Also can directly the trehalose of composition wound surface maintenance compositions, sodium carboxymethyl cellulose be pulverized respectively, cross 200 mesh sieves, mixing sterilizing, uses as powder.
Compositions of the present invention preferably prepares paste, powder, also according to a conventional method, can prepare the gel, liniment, hydrocolloid or the patch that are for external application.
Embodiment 16
Wound healing is tested
Get 100 sd male rats, be divided into 10 groups at random, in back spinal side, cut off hair, clean out with normal saline, after the alcohol disinfecting of 75%, be cut into 2cm × 2cm with scalpel, the edge of a knife of degree of depth 0.1cm, inject the new staphylococcus aureus cultivated in wound again, do not sew up natural exposing 3 days.Test is divided into trehalose group, sodium carboxymethyl cellulose group, embodiment group (wound uses the preparation of embodiment 8-13 respectively), positive controls [wound uses the active dressing (Jiangsu Yangsheng Biological Engineering Co., Ltd.) of skin wound inorganic inducing], blank group (not using any medicine).
Every day, each use sooner or later 1 time, observed wound healing situation.
(1) Wound healing rate=(original wound surface area-do not heal wound surface area)/original wound surface area.Original wound surface and the wound surface that do not heal all are drawn to the method for wound surface shape with transparent graph paper, with imageJ software processes picture, calculate Wound healing rate.
Table 1 Wound healing rate (%)
* with blank group than P < 0.05, * * with blank group than P < 0.01
△ with trehalose group than P < 0.05, △ △ with trehalose group than P < 0.01
(2) wound healing time: form the same day from wound, until wound surface heals completely, calculates wound healing time.
Table 2 wound healing time (my god)
△ with trehalose group than P < 0.05, △ △ with trehalose group than P < 0.01
(3) cut 1-10 group mice edge tissues specimen respectively when medication 7,21d, observe with ordinary optical microscope, the complete and unduplicated high power lens visual field of each section random selecting 5, fibroblast number in counting wound granulation tissue.
Table 3 fibroblast number (my god)
| Experimental group | Before non-medication | 7 days | 21 days |
| Trehalose | 77.19±2.34 | 97.23±1.35 | 127.26±2.36 |
| Sodium carboxymethyl cellulose | 76.29±2.67 | 97.16±1.68 | 122.42±2.46 |
| Embodiment 8 | 77.19±2.96 | 143.68±2.64 △△ | 103.97±1.93 △△ |
| Embodiment 9 | 76.46±3.16 | 142.00±1.38 △△ | 105.31±1.68 △△ |
| Embodiment 10 | 77.31±2.76 | 142.32±1.62 △△ | 104.92±1.35 △△ |
| Embodiment 11 | 76.38±2.71 | 144.35±1.68 △△ | 102.35±1.41 △△ |
| Embodiment 12 | 77.16±2.69 | 142.86±1.32 △△ | 104.13±1.35 △△ |
| Embodiment 13 | 76.31±2.16 | 144.02±1.92 △△ | 103.13±1.26 △△ |
| Positive control | 77.86±2.16 | 124.39±1.69 | 144.39±2.37 |
| Blank | 76.49±2.49 | 81.36±2.06 | 120.39±2.68 |
△ with trehalose group than P < 0.05, △ △ with trehalose group than P < 0.01
Fibroblastic increasing rapidly describes wound surface and is being in quickly-healing period, but after wound healing, fibroblastic quantity also illustrate that the size of wound surface cicatrix simultaneously, and namely wound surface cicatrix is larger, and fibroblast hyper-proliferative is more.Integral experiment, embodiment 8-13 the 7th day time in wound surface quickly-healing so fibroblast is in a large amount of increment state, become fiber number lower when the 21st day, because the 21st day wound completely healing skin form cicatrix, and now fibroblast quantity is lower illustrates that the cicatrix formed is less obvious.On the whole, product of the present invention is not only evident in efficacy for healing wound surface, and is formed with certain inhibitory action to cicatrix.Trehalose, sodium carboxymethyl cellulose, positive control are because wound is also in healing, so fibroblast was in growth state the 7th day, 21 days time.
Claims (4)
1. a wound surface maintenance compositions, it is characterized in that by weight percentage by 10% ~ 25% trehalose, 75% ~ 90% sodium carboxymethyl cellulose form.
2. a kind of wound surface maintenance compositions according to claim 1, it is characterized in that described trehalose is 15% ~ 20%, sodium carboxymethyl cellulose is 80%-85%.
3. comprise the preparation of a kind of wound surface maintenance compositions of claim 1 or 2, it is characterized in that by weight percentage by 25 ~ 90% a kind of wound surface maintenance compositions and the acceptable adjuvant of 10% ~ 75% pharmacy make.
4. preparation according to claim 3, is characterized in that the dosage form of described preparation is paste or powder.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410588382.4A CN104257682B (en) | 2014-10-28 | 2014-10-28 | A kind of wound surface maintenance compositions and preparation |
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|---|---|---|---|
| CN201410588382.4A CN104257682B (en) | 2014-10-28 | 2014-10-28 | A kind of wound surface maintenance compositions and preparation |
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| CN104257682A true CN104257682A (en) | 2015-01-07 |
| CN104257682B CN104257682B (en) | 2016-04-27 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110251423A (en) * | 2019-07-22 | 2019-09-20 | 陕西佰傲再生医学有限公司 | A kind of skin care compositions and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101193645A (en) * | 2005-06-08 | 2008-06-04 | 株式会社塞累克斯 | Liquid for preventing tissue adhesion and method of preventing tissue adhesion |
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- 2014-10-28 CN CN201410588382.4A patent/CN104257682B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101193645A (en) * | 2005-06-08 | 2008-06-04 | 株式会社塞累克斯 | Liquid for preventing tissue adhesion and method of preventing tissue adhesion |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110251423A (en) * | 2019-07-22 | 2019-09-20 | 陕西佰傲再生医学有限公司 | A kind of skin care compositions and preparation method thereof |
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Address after: 300480 No. 453 Hengshan Road, modern industrial zone, economic and Technological Development Zone, Binhai New Area, Tianjin Patentee after: TIANJIN CACHET TECHNOLOGY CO.,LTD. Address before: 300457 third floor, block B9, Tianda science and Technology Park, No. 80, Fourth Street, economic and Technological Development Zone, Binhai New Area, Tianjin Patentee before: TIANJIN CACHET TECHNOLOGY CO.,LTD. |