CN104237322A - Dual-input capacitance coupling non-contact conductivity detector - Google Patents
Dual-input capacitance coupling non-contact conductivity detector Download PDFInfo
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- CN104237322A CN104237322A CN201410515285.2A CN201410515285A CN104237322A CN 104237322 A CN104237322 A CN 104237322A CN 201410515285 A CN201410515285 A CN 201410515285A CN 104237322 A CN104237322 A CN 104237322A
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Abstract
The invention discloses a dual-input capacitance coupling non-contact conductivity detector. The dual-input capacitance coupling non-contact conductivity detector comprises an input electrode (1), an input electrode (2), an output electrode (3), a detecting pipe (4), a signal generator (5) and a data acquisition device (6), wherein the input electrode (1) and the input electrode (2) are respectively connected to the signal generator (5); the output electrode (3) is connected to the data acquisition device (6); the input electrode (1), the input electrode (2) and the output electrode (3) are respectively connected to the detecting pipe (4). The dual-input capacitance coupling non-contact conductivity detector further comprises a multi-input multi-output capacity coupling non-contact conductivity detector (7). The dual-input capacitance coupling non-contact conductivity detector disclosed by the invention has the characteristics of being high in sensitivity, and convenient to disassemble and assemble. The invention provides a convenient operable detecting means for branches of learning, such as biology, medicine and chemistry. The dual-input capacitance coupling non-contact conductivity detector can be used as detectors of analyzing instruments of microstream control chips, liquid phase chromatograms, ion chromatograms, capillary electrophoresis, and the like.
Description
Technical field
The present invention relates to analysis and detecting instrument, particularly a kind of dual input capacitive coupling non-contact electric conductivity detector being mainly used in the analytical instrument such as micro-fluidic chip, liquid chromatography, chromatography of ions and Capillary Electrophoresis.
Background technology
In recent years, for adapting to the development trend of analytical instrument microminiaturization, all kinds of electric conductivity detector arises at the historic moment, and highly sensitive detection method is the important content of analytical chemistry research always, and the sensitivity therefore improving detecting device has become electric conductivity detector development and realized the key issue of application.The principle of Conductivity detection carries out measuring according to the conductivity difference of different material.Therefore, electric conductivity detector is a kind of general detecting device in principle.But in fact, due to detection sensitivity, the detected object mainly ionic compound of electric conductivity detector, the material that especially molar conductivity such as inorganic ions is larger.At present, the advantages such as the analysis efficiency that the application of electric conductivity detector in Capillary Electrophoresis embodies, make scientific research personnel more and more pay close attention to the advantage of Conductivity detection.
Conductivity detection divides from detection method and is divided into again contact and contactless two kinds of situations.The electric conductivity detector of contact is by holing on the tube wall of kapillary, electrode insertion further detects, because Capillary Electrophoresis needs high-voltage power supply to flow to drive solution, therefore the mode of this boring can cause a lot of problem, and electrode insertion also easy contaminated electrode, foul solution.So the cleaning of electrode and replacing are equally also the one side reasons of contact limiting type electric conductivity detector application.
Through development in recent years, electric conductivity detector develops into present C by initial CD
4d.The people such as Zemann proposed capacitive coupling non-contact electric conductivity detector (C in 1998
4d).The people such as Hauser, again in 2002, use the high-voltage AC signal of 450 Vpp to improve C greatly
4the sensitivity of D.The people such as Wang used the glass-film of 10-15 μm to achieve contactless measurement in 2002.The people such as Laugere devise again differential amplifier circuit and four electrode C
4d is used for detecting.
Capacitively coupled contactless conductivity detector development in recent years is rapid, because its electrode structure is fairly simple, and completely solves the problem such as the pollution of electrode, the interference of separation high pressure, therefore becomes a study hotspot of current Electrochemical Detection.C
4d makes real the becoming of electric conductivity detecting method move towards business-like electrochemical detection method.
Summary of the invention
Technical matters to be solved by this invention is to provide one and has highly sensitive dual input capacitive coupling non-contact electric conductivity detector, can be applied to the Micro-Column Separation systems such as micro-fluidic chip, liquid chromatography, chromatography of ions and Capillary Electrophoresis.
The technical solution adopted for the present invention to solve the technical problems is: dual input capacitive coupling non-contact electric conductivity detector of the present invention, comprises signal input part, detection cell, signals collecting end.It is characterized in that: two input ports of described signal input part are linked into two input electrodes of detection cell respectively, and two described input signal phase angle differences are adjusted to 170 °, and the output electrode of detection cell is linked into signals collecting end.
As a preferred embodiment of the present invention, for improving the sensitivity of detection cell, to reach best Detection results, three angles of described threeway glass tube are respectively 120 °, 120 °, 120 ° of these three kinds of angles, two described input signal phase angle differences are adjusted to 170 °-180 °, can go out on the constant basis of peak-to-peak signal to effectively reduce detection baseline like this, thus improve detection sensitivity.
The invention has the beneficial effects as follows, tool is highly sensitive, disassembly and assembly feature easily, effectively reduce the equiva lent impedance of output electrode, thus improve the ratio of solution resistance in whole device; On the basis keeping peak heights constant, baseline can be reduced significantly, thus improves detection sensitivity further again simultaneously.Input and output electrode all adopt Copper Foil, and disassembly and assembly conveniently can be operated.This dual input capacitive coupling non-contact electric conductivity detector improves sensitivity effectively, for the subjects such as biology, medical science and chemistry provide one to facilitate exercisable detection means.Coupling can be carried out with analytic systems such as micro-fluidic chip, liquid chromatography, chromatography of ions and Capillary Electrophoresis.
Accompanying drawing explanation
Fig. 1 is the apparatus structure schematic diagram of dual input capacitive coupling non-contact electric conductivity detector of the present invention and multiple-input and multiple-output capacitive coupling non-contact electric conductivity detector.
Fig. 2 is the equivalent circuit diagram of dual input capacitive coupling non-contact electric conductivity detector of the present invention.
Fig. 3 is that dual input capacitive coupling non-contact electric conductivity detector of the present invention is to the response curve of each log concentration of KCl.
Fig. 4 is the apparatus structure schematic diagram of dual input type threeway capacitive coupling non-contact electric conductivity detector of the present invention.
Fig. 5 is that dual input type threeway capacitive coupling non-contact electric conductivity detector of the present invention is to the response curve of each log concentration of KCl.
Specific embodiments
Below in conjunction with drawings and Examples, the present invention is further described.
With reference to Fig. 1, dual input capacitive coupling non-contact electric conductivity detector of the present invention, by signal generator, detection cell, data acquisition system (DAS) is formed.Described dual input capacitive coupling non-contact electric conductivity detector comprises input electrode 1, input electrode 2, output electrode 3, detector tube 4, signal generator 5, N2000 chromatographic work station 6.What device detector tube adopted is the glass tube of internal diameter 3.5 mm, external diameter 5 mm.Three electrodes are closely wrapped on glass tube with Copper Foil, and glass tube length is 20 cm, clamps Copper Foil with crocodile clip, receives signal input output end.Glass tube one end is closed, and one end open, from openend sample introduction.The outer field paint of electrode enameled wire burning-off, is closely wrapped in around glass tube.Three electrodes also closely can be wrapped in around glass tube obtained with the enameled wire of burning-off cover warnish.On this basis, multiple-input and multiple-output capacitive coupling non-contact electric conductivity detector is also constructed.
With reference to Fig. 2, dual input capacitive coupling non-contact electric conductivity detector of the present invention, as the preferred structure of one, has illustrated the electrical block diagram of dual input capacitive coupling non-contact electric conductivity detector in Fig. 2.Input electrode electric capacity is comprised, solution resistance, solution electric capacity, output electrode electric capacity, collection terminal resistance in figure.Two input signal phase angle differences are adjusted to 170 °, there is end and be transmitted to two input capacitances first respectively in two signals, and then be transmitted to output capacitance through solution, two high_frequency sine wave signals are interfered at output capacitance place, signal after interference by the resistance of measuring junction, finally by data acquisition system.There is shown the equivalent electrical circuit of whole detection cell, be mainly made up of electric capacity and resistance.
With reference to Fig. 3, as the embodiment of dual input capacitive coupling non-contact electric conductivity detector of the present invention, there is shown the response curve of the Klorvess Liquid log concentration of capacitive coupling non-contact electric conductivity detector and dual input capacitive coupling non-contact electric conductivity detector.We configure the Klorvess Liquid of variable concentrations respectively, take the mode of flow injection, record the response change value under each concentration respectively.The non-contact electric conductivity detector of dual input capacitive coupling as we can see from the figure has obvious advantage than capacitive coupling non-contact electric conductivity detector at concentration-response curve, and the Monitoring lower-cut of dual input capacitive coupling non-contact electric conductivity detector also decreases.In general, the sensitivity of capacitive coupling non-contact electric conductivity detector has had obvious raising.
With reference to Fig. 4, dual input type threeway capacitive coupling non-contact electric conductivity detector of the present invention, by signal generator, detection cell, data acquisition system (DAS) is formed.Described dual input capacitive coupling non-contact electric conductivity detector detection cell comprises input electrode 1, input electrode 2, output electrode 3, three-way pipe detector tube 4.What device threeway detector tube adopted is the threeway glass tube of internal diameter 1.5 mm, external diameter 3 mm.Three electrodes are closely wrapped on glass tube with Copper Foil, clamps Copper Foil, receive signal input output end with crocodile clip.Three angles of this threeway glass tube have following three kinds of situations: 120 °, 120 °, 120 °; 180 °, 90 °, 90 °; 135 °, 135 °, 90 °.Often kind of glass tube has two kinds of connected modes, and be respectively: one end sample introduction, two ends go out sample simultaneously; One end sample introduction, one end is blocked, and one brings out sample.Based on the comparison of performance, we select three angles to be 120 °, 120 °, 120 °, one end sample introduction, and one end is blocked, and a threeway glass tube bringing out sample, two input signal phase angle differences are adjusted to 170 °-180 °.
With reference to Fig. 5, as the embodiment of dual input type threeway capacitive coupling non-contact electric conductivity detector of the present invention, there is shown capacitive coupling non-contact electric conductivity detector and dual input threeway capacitive coupling non-contact electric conductivity detector to the response curve of Klorvess Liquid log concentration.We prepare the Klorvess Liquid of variable concentrations respectively, take the mode of flow injection, record the response change value under each concentration respectively.The threeway of dual input type as we can see from the figure capacitive coupling non-contact electric conductivity detector has had more significantly advantage than capacitive coupling non-contact electric conductivity detector at concentration-response curve, and slope has had larger lifting.The sensitivity of dual input type threeway capacitive coupling non-contact electric conductivity detector has had obvious raising.
Claims (9)
1. dual input capacitive coupling non-contact electric conductivity detector, comprise input electrode (1), input electrode (2), output electrode (3), detector tube (4), signal generator (5), data acquisition unit (6), and multiple-input and multiple-output capacitive coupling non-contact electric conductivity detector (7).
2. dual input capacitive coupling non-contact electric conductivity detector as claimed in claim 1, it is characterized in that: described input electrode (1), input electrode (2), output electrode (3) are connected respectively to detector tube (4), and detector tube (4) material can be glass tube, polymer pipe etc.
3. dual input type threeway capacitive coupling non-contact electric conductivity detector as claimed in claim 1, it is characterized in that: described input electrode (15) is connected to the port one of detector tube (19), input electrode (16) is connected to the port two of threeway detector tube (19), and output electrode (17) is connected to the port three of threeway detector tube (19).
4. dual input capacitive coupling non-contact electric conductivity detector as claimed in claim 3, is characterized in that: rubber plug (18) blocks the port two of threeway detector tube (19).
5. dual input type threeway capacitive coupling non-contact electric conductivity detector as claimed in claim 3, is characterized in that: three ends of threeway detector tube (19) become 120 ° respectively, 120 °, 120 ° of three kinds of angles and other not decile angles.
6. the dual input capacitive coupling non-contact electric conductivity detector as described in claim 1,3, is characterized in that: the material of input electrode and output electrode is conductive foil or tinsel.
7. the dual input capacitive coupling non-contact electric conductivity detector as described in claim 1,3, is characterized in that: the access signal of dual input and multi input electrode is AC signal.
8. dual input type threeway capacitive coupling non-contact electric conductivity detector as claimed in claim 3, is characterized in that: inject air, liquid or colloid etc. in the port two of threeway detector tube (19).
9. the dual input capacitive coupling non-contact electric conductivity detector as described in claim 1-7, is characterized in that: signal output part carries out signal amplification and collection by AC amplifier, lock-in amplifier etc.
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| CN201410515285.2A CN104237322A (en) | 2014-09-30 | 2014-09-30 | Dual-input capacitance coupling non-contact conductivity detector |
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| CN201410515285.2A CN104237322A (en) | 2014-09-30 | 2014-09-30 | Dual-input capacitance coupling non-contact conductivity detector |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019202092A1 (en) * | 2018-04-18 | 2019-10-24 | Universiteit Twente | System and method for measuring conductivity |
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| WO2000075650A1 (en) * | 1999-06-04 | 2000-12-14 | Ce Resources Pte Ltd. | Potential gradient detector for electrophoresis |
| US20050109621A1 (en) * | 2003-11-26 | 2005-05-26 | Peter C. Hauser | Method and apparatus for performing high-voltage contactless conductivity (HV-CCD) electrophoresis |
| CN1804607A (en) * | 2005-01-13 | 2006-07-19 | 清华大学 | Chip type capacitance coupling contactless conductivity detector |
| WO2010016807A1 (en) * | 2008-08-07 | 2010-02-11 | Agency For Science, Technology And Research | Contactless conductivity detector |
| CN102641759A (en) * | 2012-05-02 | 2012-08-22 | 大连理工大学 | Method for manufacturing contactless conductivity detection microchip of integrated thickness controllable insulation layer |
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2014
- 2014-09-30 CN CN201410515285.2A patent/CN104237322A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000075650A1 (en) * | 1999-06-04 | 2000-12-14 | Ce Resources Pte Ltd. | Potential gradient detector for electrophoresis |
| US20050109621A1 (en) * | 2003-11-26 | 2005-05-26 | Peter C. Hauser | Method and apparatus for performing high-voltage contactless conductivity (HV-CCD) electrophoresis |
| CN1804607A (en) * | 2005-01-13 | 2006-07-19 | 清华大学 | Chip type capacitance coupling contactless conductivity detector |
| WO2010016807A1 (en) * | 2008-08-07 | 2010-02-11 | Agency For Science, Technology And Research | Contactless conductivity detector |
| CN102641759A (en) * | 2012-05-02 | 2012-08-22 | 大连理工大学 | Method for manufacturing contactless conductivity detection microchip of integrated thickness controllable insulation layer |
Non-Patent Citations (3)
| Title |
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| ANDREAS J. ZEMANN: "Capacitively coupled contactless conductivity detection in capillary electrophoresis", 《ELECTROPHORESIS 》, no. 24, 31 December 2003 (2003-12-31), pages 2125 - 2137 * |
| HAO ZHENG ET AL.: "Double Input Capacitively Coupled Contactless Conductivity Detector with Phase Shift", 《ANALYTICAL CHEMISTRY》, vol. 86, no. 20, 24 September 2014 (2014-09-24) * |
| 谭峰等: "毛细管电泳电容耦合非接触电导检测-双端进样同时测定无机阴离子和阳离子", 《分析化学（ FENXI HUAXUE） 研究报告》, vol. 33, no. 3, 31 March 2005 (2005-03-31), pages 313 - 316 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019202092A1 (en) * | 2018-04-18 | 2019-10-24 | Universiteit Twente | System and method for measuring conductivity |
| US11719659B2 (en) | 2018-04-18 | 2023-08-08 | Universiteit Twente | System and method for measuring conductivity |
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Application publication date: 20141224 |