CN104228259B - Method for preparing push-tear type child protective medicinal composite membrane - Google Patents
Method for preparing push-tear type child protective medicinal composite membrane Download PDFInfo
- Publication number
- CN104228259B CN104228259B CN201410442567.4A CN201410442567A CN104228259B CN 104228259 B CN104228259 B CN 104228259B CN 201410442567 A CN201410442567 A CN 201410442567A CN 104228259 B CN104228259 B CN 104228259B
- Authority
- CN
- China
- Prior art keywords
- composite membrane
- paper
- glue
- semi
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Landscapes
- Wrappers (AREA)
- Laminated Bodies (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Abstract
The invention relates to a method for preparing a push-tear type child protective medicinal composite membrane. The method is characterized by comprising the following steps: (1) printing information on paper, compounding the paper with a polyester film or a polypropylene film through a first glue layer, and curing, thereby preparing semi-finished polyester or polypropylene film paper; (2) coating a heat-seal adhesive on any side of an aluminum foil, thereby preparing a semi-finished aluminum foil gluing product; and (3) compounding the semi-finished polyester or polypropylene film paper prepared in the step (1) with the semi-finished aluminum foil gluing product prepared in the step (2) through a second glue layer, and curing, thereby obtaining a finished product. The invention develops a push-tear type child protective PTP aiming at preventing children from wrongly eating partial medicines with high danger level in the conventional market, and the push-tear type child protective PTP is high in safety, is suitable for the conventional aluminum-aluminum and aluminum-plastic blister packaging and also can serve as flexible double-aluminum package of liquid, tablets and capsules.
Description
Technical field
The present invention relates to a kind of medical bubble-cap packaging composite film, particularly relate to one and push-poke formula child-resistant medicine open
By the preparation method of packaging composite film, it is suitable for aluminum current aluminum, aluminium-plastic bubble plate packing, can also use as soft pair of aluminum simultaneously
Packing liquid, tablet, capsule etc..
Background technology
Medicine blister package on existing market covers aluminium foil, and major part is all layer based on pure aluminum foil, at aluminum
Protective layer it is attached with, then in protective layer printing, then at printing ink layer surface last layer light oil guard ink outside paper tinsel.
But it is all harmful for major part medicine to the child of child particularly 0 to 12 one full year of life, the most effectively prevents
Age bracket child eats drink by mistake and brings irremediable loss here, is a great problem of current medicine bottle blister package.On market
There is corresponding product to carry out child-resistant with regulation for plastic bottle packing and contacted this type of hazardous drugs, but blister package youngster
Virgin protection there is presently no corresponding product and regulation in implementation of China and application, how to relate to a kind of suitably packaging structure,
Reach to increase child difficulty by child mode, it is possible to by thickness, the selection of variety of raw material is suitable for not
With the requirement of shelter of age bracket child, become the technical issues that need to address of the present invention.
Summary of the invention
It is an object of the invention to overcome above-mentioned deficiency, it is provided that a kind of can increase the difficulty of child blister package, peace
The preparation method pushing-poke formula child-resistant pharmaceutical pack composite membrane open of good perfection.
The object of the present invention is achieved like this: a kind of system pushing-poke formula child-resistant pharmaceutical pack composite membrane open
Preparation Method, it includes paper, the first compound adhesive water layer, mylar or polypropylene film, the second compound adhesive set gradually
Water layer, aluminium foil and heat-sealing glue.
Its manufacturing process:
First at word or patterns such as printed on paper product information, Business Names, multi-function peripheral is then passed through
It is combined with mylar or polypropylene film, ripening certain time, makes paper polyester or polypropylene film semi-finished product；
In the arbitrary face coated heat sealing of coating machine aluminium foil, make aluminium foil gluing semi-finished product, this type of heat-seal adhesive can same PE,
PET, PP, PVC, Aclar, Formpack etc. seal；
Finally, then by multi-function peripheral composite paper polyester or polypropylene film semi-finished product become with aluminium foil gluing half
Product, ripening certain time, complete finished product.
Wherein, paper recited above can select suitable grammes per square metre and the paper of supplier according to outward appearance and thickness etc., gram
Weight is from the paper of 25 grams to 100 grams, such as SAPPI 40G art paper, red crowned crane 50G art paper etc..
The composite glue that the first compound adhesive water layer between paper and mylar uses can use water-based glue, without molten
Agent, or solvent glue, can be divided into casein glue according to composition, acrylic acid glue, polyurethane glue, such as DOW 168 glue,
756/766 glue etc. is hoped by state.
Mylar and polypropylene film, as third layer, can arbitrarily select two kinds of materials, and these two kinds of materials are at base material
The difference that upper existence is certain, but similar in the effect of final utilization, play bonding paper as pushing paper composite bed open
Supporting layer.
Second compound adhesive water layer is the glue layer between mylar or polypropylene film and aluminium foil, and this type of glue to be expired
The function that foot is easily pushed open, belongs to two-component polyurethane adhesive water, and raw material, including the low hydroxyl-value polyester resin of high molecular, inorganic particulate
Grain additive, forms containing isocyanate curing agent.Wherein the polyester of the low hydroxyl value of high molecular has the L206, Han Hua of Degussa
ES410, inorganic particle can select porosity at 1.0-2.0ml/g, and oil absorption is at 100-300g/100g, and particle diameter is at 2-8
Gasil series HP880 of micron inorganic silicon dioxide granule, such as U.S. PQ, HP340M, wherein the first two plants the weight of material
Ratio controls at the low hydroxyl-value polyester resin of high molecular: between inorganic particle additive=100:1 to 100:10, the selection of firming agent,
Need to make the appropriate adjustments according to the kind selected.Control OH/NCO ratio between 0.9-1.3.
Aluminium foil raw material can select different-thickness, and the aluminium foil of aluminium foil state, alloy shape according to the follow-up difficulty poked
State is mainly based on 1145 alloys that 1 series and 8 series, such as Shanghai are prosperous, H state, the aluminium foil of 20 microns, Lu Feng 8011 alloy, O
State, the aluminium foil of 30 microns.
The heat-seal adhesive of innermost layer, main component has vinyl chloride-vinyl acetate resin, acrylic resin, polyester resin, inorganic particle, food stage
Wax is formulated, can meet and seal with different substrate materials.
The feature of primary coat of the present invention is as follows:
(1) difference and typical medicine packaging PTP blister package, the child-resistant PTP of the present invention needs to take two kinds
Opening ways could take out the medicine in blister package, and according to order, first pushes paper and mylar or poly-third open
Olefin(e) acid thin film, then pokes aluminium foil layer, which increases child and takes out the difficulty of medicine.If taked by force in this mode
Any of which all can not open this type of packaging
(2) in the case of the opening ways poked, aluminum foil thickness can be increased or change aluminium foil state to improve child
Protection level, can realize different age group child dividing by the bursting strength data of aluminium foil.
(3) comparing more common PTP aluminium foil, this type of packages printing is elegance to be improved.
For market upper part, the bubble-cap PTP of child's hazardous drugs is packed, increase child by two kinds of opening ways
Opening the difficulty of blister package, two kinds of opening ways are to push paper and mylar or polyacrylic film open, then respectively
Break aluminium foil layer with private seal and reach to take out the purpose of medicine.
Accompanying drawing explanation
Fig. 1 is the preparation method section structure signal that the present invention pushed-poked formula child-resistant pharmaceutical pack composite membrane open
Figure.
Wherein: paper the 1, first compound adhesive water layer 2, mylar or polypropylene film the 3, second compound adhesive water layer 4,
Aluminium foil 5, heat-sealing glue 6.
Detailed description of the invention
See Fig. 1, a kind of preparation side pushing-poke formula child-resistant pharmaceutical pack composite membrane open that the present invention relates to
Method, it is mainly by paper the 1, first compound adhesive water layer 2, mylar or polypropylene film the 3, second compound adhesive water layer 4, aluminum
Paper tinsel 5 and heat-sealing glue 6 form, and described paper the 1, first compound adhesive water layer 2, mylar or polypropylene film 3, second are multiple
Rubber alloy water layer 4, aluminium foil 5 and heat-sealing glue 6 ecto-entad set gradually.Concrete production method is:
Embodiment 1:
(1) SAPPI 40G halftone paper printing corona, by the first composite glue on multi-function peripheral, this glue is adopted
Hoping 756 glue with state, oven temperature is between 60-90 DEG C, and speed is between 80-150m/min, and compound richness dimension is combined level
PET12, rolling enters curing chamber as semi-finished product A.
(2) the prosperous aluminium foil in Shanghai 1145, H state, AL20 micron is in coating machine gluing, and glue is by a watt gram ternary chlorine vinegar copolymer, moral
Admittedly match L411, PP wax according to 1:1:0.05 ratio add, solvent ethyl ester, oven temperature more than 180 degree, this semi-finished product conduct
B。
(3) the second composite glue on the polyester side of semi-finished product A, this glue by Degussa L206, Bayer L75, PQ's
HP200 meteorology silicon dioxide forms according to proportioning 10:2:2, solvent ethyl ester, and compound side finished product B, rolling is entered curing chamber, gone out ripe
Change final finished behind room.
Embodiment 2:
(1) SAPPI 50G halftone paper printing corona, by the first composite glue Henkel 2702 on multi-function peripheral
Polyurethane glue, oven temperature is between 60-90 DEG C, and speed is between 80-150m/min, and compound national practice of forms of behavior BOPP18, rolling is entered
Curing chamber is as semi-finished product A.
(2) the prosperous aluminium foil in Shanghai 1145, O state, AL30 micron is in coating machine gluing, and glue is by a watt gram ternary chlorine vinegar copolymer, Supreme Being
This graceful acrylic resin 842, PP wax according to 2:1:0.05 ratio add, solvent ethyl ester, oven temperature more than 180 degree, this
Semi-finished product are as B.
(3) the second composite glue on the polyester side of semi-finished product A, ES100, the Bayer N3390 of this glue Korea S SK, PQ's
HP200 meteorology silicon dioxide forms according to proportioning 8:2:2, solvent ethyl ester, and compound side finished product B, rolling is entered curing chamber, gone out ripening
Final finished behind room.
Embodiment 3:
(1) red crowned crane 30G halftone paper printing corona, uses Henkel by the first compound adhesive water layer on multi-function peripheral
2702 polyurethane glues, oven temperature is between 60-90 DEG C, and speed, between 80-150m/min, is combined national practice of forms of behavior BOPP18, receives
Involve in curing chamber as semi-finished product A.
(2) the rich aluminium foil in Shandong 8011, O state, AL30 micron in coating machine gluing, glue by Han Hua ternary chlorine vinegar copolymer, on
Hai Weikai L1600A polyester, PP wax adds according to 5:1:0.05 ratio, solvent ethyl ester, and oven temperature is more than 180 degree, and this is half years old
Finished product is as B.
(3) the second composite glue on the polyester side of semi-finished product A, this glue uses the ES100 of Korea S SK, Bayer N3390, PQ
HP200 meteorology silicon dioxide form according to proportioning 8:2:2, solvent ethyl ester, compound side finished product B, rolling is entered curing chamber, is gone out ripe
Change final finished behind room.
The function pushing-poke formula child-resistant open can be met by above example, the following is and compare more current medicine
The test result that packaging commonly pokes formula packaging (PTP) is as follows:
| Test event | Heat seal strength N/15MM (155℃/1sec/2Bar) | Overall bursting strength N/MM2 | Aluminium foil bursting strength N/MM2 | Push intensity N/15MM(the second compound adhesive open The peel strength of water layer) |
| Common PTP | 12 | 250 | 230 | / |
| Embodiment 1 | 11.5 | 800 | 230 | 2.0 |
| Embodiment 2 | 13 | 930 | 350 | 2.4 |
| Embodiment 3 | 10.8 | 1020 | 389 | 2.8 |
Claims (7)
1. the preparation method pushing-poke formula child-resistant pharmaceutical pack composite membrane open, it is characterised in that described method bag
Include following steps:
(1) printed on paper information, is then combined it by the first glue layer with mylar or polypropylene film, ripe
Change, make paper polyester or polypropylene film semi-finished product；
(2) in the arbitrary face coated heat sealing of aluminium foil, aluminium foil gluing semi-finished product are made；
(3) paper polyester step (1) prepared or the polyester of polypropylene film semi-finished product or polypropylene face and step (2)
The aluminium foil surface of the aluminium foil gluing semi-finished product prepared is combined by the second glue layer, and ripening obtains finished product；
The glue raw material of described second glue layer includes polyester resin, inorganic particle additive and contains isocyanate curing agent；
Described inorganic particle selects porosity in 1.0-2.0ml/g, oil absorption at 100-300g/100g, and particle diameter is in 2-8 micron nothing
Machine silica dioxide granule；
Polyester resin: between inorganic particle additive mass ratio=100:1 to 100:10, the consumption of described firming agent controls OH/
NCO ratio is between 0.9-1.3.
The preparation method pushing-poke formula child-resistant pharmaceutical pack composite membrane open the most according to claim 1, its feature
Being, described polyester resin is the low hydroxyl-value polyester resin of high molecular.
The preparation method pushing-poke formula child-resistant pharmaceutical pack composite membrane open the most according to claim 2, its feature
Being, described high molecular low hydroxyl value polyester is the ES410 of L206 or Han Hua of Degussa.
The preparation method pushing-poke formula child-resistant pharmaceutical pack composite membrane open the most according to claim 1, its feature
Being, described paper grammes per square metre is 25 grams ~ 100 grams.
The preparation method pushing-poke formula child-resistant pharmaceutical pack composite membrane open the most according to claim 1, its feature
Being, the glue that described first glue layer uses is water-based glue.
The preparation method pushing-poke formula child-resistant pharmaceutical pack composite membrane open the most according to claim 1, its feature
It is, described aluminum foil thickness 20 microns ~ 30 microns.
The preparation method pushing-poke formula child-resistant pharmaceutical pack composite membrane open the most according to claim 1, its feature
Be, described heat-sealing glue mainly by vinyl chloride-vinyl acetate resin, acrylic resin, polyester resin, inorganic particle, food grade wax preparation and
Become.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410442567.4A CN104228259B (en) | 2014-09-02 | 2014-09-02 | Method for preparing push-tear type child protective medicinal composite membrane |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410442567.4A CN104228259B (en) | 2014-09-02 | 2014-09-02 | Method for preparing push-tear type child protective medicinal composite membrane |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104228259A CN104228259A (en) | 2014-12-24 |
| CN104228259B true CN104228259B (en) | 2017-01-11 |
Family
ID=52217563
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410442567.4A Active CN104228259B (en) | 2014-09-02 | 2014-09-02 | Method for preparing push-tear type child protective medicinal composite membrane |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104228259B (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104275873A (en) * | 2014-10-31 | 2015-01-14 | 四川汇利实业有限公司 | Paper-aluminum bubble cap bottom plate composite film for child protection |
| CN105437695B (en) * | 2015-12-29 | 2018-05-22 | 浙江省食品药品检验研究院 | A kind of medical bubble-cap is packed for epiphragma and preparation method thereof |
| CN106905895A (en) * | 2017-01-25 | 2017-06-30 | 江阴宝柏包装有限公司 | A kind of preparation method of side stripping type bubble-cap aluminium foil epiphragma, epiphragma and package body |
| CN111055560A (en) * | 2019-12-04 | 2020-04-24 | 江阴宝柏包装有限公司 | Dry powder inhalant packaging film |
| CN115534459A (en) * | 2022-10-12 | 2022-12-30 | 浙江周庆盖业有限公司 | Medicinal composite membrane and preparation method thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3803850A1 (en) * | 1987-04-27 | 1988-11-10 | Leipzig Verpackung | Composite material |
| EP2112090A1 (en) * | 2008-04-22 | 2009-10-28 | Alcan Technology & Management Ltd. | Cover film for blister packaging |
| CN102153984B (en) * | 2011-01-26 | 2013-06-26 | 山西省应用化学研究所 | Method for preparing single-component high-heat-resistance aqueous polyurethane adhesive |
-
2014
- 2014-09-02 CN CN201410442567.4A patent/CN104228259B/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN104228259A (en) | 2014-12-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104228259B (en) | Method for preparing push-tear type child protective medicinal composite membrane | |
| CN110126376A (en) | Multilayer film | |
| JP6511713B2 (en) | Laminate for packaging material | |
| CN201761759U (en) | Novel cold forming easy-peeling film | |
| JP2015066802A (en) | Non-adsorbent sealant film and laminate for packaging material composed of the same | |
| TWI648202B (en) | container | |
| CN204160839U (en) | Formula child-resistant medical bubble-cap packaging composite film is pushed-poked to one open | |
| JP6511712B2 (en) | Laminate for packaging material | |
| CN208947975U (en) | A kind of bubble chamber film preventing bubbles burst and packaging bag | |
| CN203567280U (en) | Suppository composite membrane | |
| CN207496168U (en) | PE release films | |
| CN202986212U (en) | Environment-friendly modified polyester polyvinyl chloride and low-density polyethylene solid medicinal compound hard piece | |
| CN202480503U (en) | Composite sheet for environment-friendly composite glue modified polrvinyl chloride-polyvinylidene chloride drug | |
| CN201912439U (en) | Blister package | |
| CN105751626A (en) | Low-temperature hot-seal spraying covering membrane | |
| JP2006082857A (en) | Synthetic resin-made container | |
| CN202399606U (en) | Composite film for packaging medicine | |
| CN212073254U (en) | Environment-friendly child protection blister packaging film | |
| JP6735527B2 (en) | Non-adsorptive sealant film and laminate for packaging material comprising the same | |
| CN206048958U (en) | A kind of medicine composite packaging stiff sheet | |
| CN206446209U (en) | The Key works Drug packing aluminium foil of safety and environmental protection | |
| CN103112221A (en) | High-barrier composite packing paper | |
| CN106188586B (en) | A kind of preparation process of high-strength thin-film | |
| CN206124358U (en) | Zero medicinal packing PTP aluminium foil of pinhole degree | |
| CN104228212A (en) | Low-temperature-heat-sealed easily-stripped high-barrier medicinal cap film material |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |