CN105437695B - A kind of medical bubble-cap is packed for epiphragma and preparation method thereof - Google Patents
A kind of medical bubble-cap is packed for epiphragma and preparation method thereof Download PDFInfo
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- CN105437695B CN105437695B CN201511007383.6A CN201511007383A CN105437695B CN 105437695 B CN105437695 B CN 105437695B CN 201511007383 A CN201511007383 A CN 201511007383A CN 105437695 B CN105437695 B CN 105437695B
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- epiphragma
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B27/00—Layered products comprising a layer of synthetic resin
- B32B27/06—Layered products comprising a layer of synthetic resin as the main or only constituent of a layer, which is next to another layer of the same or of a different material
- B32B27/10—Layered products comprising a layer of synthetic resin as the main or only constituent of a layer, which is next to another layer of the same or of a different material of paper or cardboard
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B15/00—Layered products comprising a layer of metal
- B32B15/04—Layered products comprising a layer of metal comprising metal as the main or only constituent of a layer, which is next to another layer of the same or of a different material
- B32B15/08—Layered products comprising a layer of metal comprising metal as the main or only constituent of a layer, which is next to another layer of the same or of a different material of synthetic resin
- B32B15/09—Layered products comprising a layer of metal comprising metal as the main or only constituent of a layer, which is next to another layer of the same or of a different material of synthetic resin comprising polyesters
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B15/00—Layered products comprising a layer of metal
- B32B15/20—Layered products comprising a layer of metal comprising aluminium or copper
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B27/00—Layered products comprising a layer of synthetic resin
- B32B27/36—Layered products comprising a layer of synthetic resin comprising polyesters
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B37/00—Methods or apparatus for laminating, e.g. by curing or by ultrasonic bonding
- B32B37/06—Methods or apparatus for laminating, e.g. by curing or by ultrasonic bonding characterised by the heating method
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B37/00—Methods or apparatus for laminating, e.g. by curing or by ultrasonic bonding
- B32B37/10—Methods or apparatus for laminating, e.g. by curing or by ultrasonic bonding characterised by the pressing technique, e.g. using action of vacuum or fluid pressure
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B37/00—Methods or apparatus for laminating, e.g. by curing or by ultrasonic bonding
- B32B37/12—Methods or apparatus for laminating, e.g. by curing or by ultrasonic bonding characterised by using adhesives
- B32B37/1284—Application of adhesive
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B38/00—Ancillary operations in connection with laminating processes
- B32B38/14—Printing or colouring
- B32B38/145—Printing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B38/00—Ancillary operations in connection with laminating processes
- B32B38/16—Drying; Softening; Cleaning
- B32B38/164—Drying
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B43/00—Operations specially adapted for layered products and not otherwise provided for, e.g. repairing; Apparatus therefor
- B32B43/003—Cutting
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B7/00—Layered products characterised by the relation between layers; Layered products characterised by the relative orientation of features between layers, or by the relative values of a measurable parameter between layers, i.e. products comprising layers having different physical, chemical or physicochemical properties; Layered products characterised by the interconnection of layers
- B32B7/04—Interconnection of layers
- B32B7/10—Interconnection of layers at least one layer having inter-reactive properties
Abstract
The invention discloses a kind of medical bubble-caps to be packed for epiphragma, it is combined by paper, laminated polyester film, aluminium foil, the outer surface of paper is provided with ink layer and light oil reservoir, first adhesive phase is set between paper and laminated polyester film, second adhesive layer is set between laminated polyester film and aluminium foil, and the another side of aluminium foil sets hot sealing layer.The preparation method of epiphragma comprises the following steps：1）Printing；2）It is compound for the first time；3）It cures for the first time；4）Gluing；5）Second compound；6）Second of curing；7）Cutting；8）Packaging.The present invention is compound by the way that paper, polyester film and aluminium foil are carried out, so as to increase epiphragma intensity, prevent children from staving epiphragma, security is improved, the setting of aluminium foil further stops vapor and oxygen, preparation method of the present invention is simple and practicable, epiphragma prepared by the preparation method, pull-off force index is up to 55.3 106.9N/15mm, and adhesive layer heat sealing strength is up to 13.5 16.2 N/15mm.
Description
Technical field
The invention belongs to pack technical field of membrane, and in particular to a kind of medical bubble-cap is packed for epiphragma and preparation method thereof.
Background technology
Drug is closely bound up as the health and life of a kind of special commodity and people, how fully to keep medicine
The performance of product, packaging play conclusive effect.The quality standard of drug, the manufacturing from packaging material, sale keeping,
Pharmaceutical factory packaging drug, transport storage have certain index to provide until breaking a seal using the overall process of drug.With economy and skill
The development of art, medical industry are grown rapidly, and more and more pharmaceutical producing enterprises have passed through GMP certifications, and the strength of enterprise constantly adds
By force, Key works Drug packing industry also shows that vitality in recent years.Its main function of drug is protection and improves human health, so as to certainly
The main function for having determined Key works Drug packing is the security, validity and stability for ensureing drug for a long time under various conditions.
In recent years, because of technological progress, the mankind are to the concern of health and the enhancing of environmental consciousness, and Key works Drug packing is towards safer, more comprehensively
Develop with free of contamination direction.World's Key works Drug packing forward direction diversification, packaging material variation, emphatically safely, comply with environmental protection
Trend development.In the use of material, pharmaceutical packaging tends to use multi-layer compound film to enhance intensity.
At present, blister package just becomes branch more active in China's packing articles.China's entry into the WTO, more states
Border pharmacy corporation enters China, though exacerbating the competition of Chinese pharmaceutical industry, improves the technical standard of entire industry.No matter
Western medicine, Chinese medicine Key works Drug packing is weeded out the old and bring forth the new in packaging just as packing business benefit is best, the highest product of technology content.
In recent years, with the foundation and development of polymer science, new material, new process continue to bring out, various drug packing material quilts
It widely uses.
Traditional blister package abbreviation PTP (Press through packaging).In order to which medicament is taken from encapsulation
Go out, apply a force to medicinal aluminum foil, medicament is made to be taken out through aluminium foil layer.But since this packaging mode of getting it filled is simple
（Drug is can be taken off by simply squeezing）, drug is easy to be obtained by children, be poisoned so as to eat drug by mistake.Every year because adopting
The children caused by such drug or chemicals packed, which wrongly take accident and are up to 14-16 ten thousand, to rise, wherein about 20,000 needs
Hospital treatment, and be more unfortunately about to have 30-50 therefore death every year.Chidren Poisoning has become children's accident
The third-largest killer.
Easily damaged for this kind of individual layer aluminium foil, built-in drug is easily taken by children, is poisoned so as to eat drug by mistake
The phenomenon that, the present invention designs a kind of medical bubble-cap for being not easy to be staved by children and is packed for epiphragma and preparation method thereof, so as to improve
Its security used reduces the incidence that children eat accident by mistake.
The content of the invention
For problems of the prior art, present invention aims at provide a kind of medical bubble-cap be packed for epiphragma and
Its preparation method.
The present invention is realized by the following technical programs：
A kind of medical bubble-cap is packed for epiphragma, it is characterised in that by paper of the dosage for 40-105 grams/m, thickness
Spend the laminated polyester film for 12-50 μm, the aluminium foil that thickness is 20-60 μm is combined, the outer surface of the paper is disposed with
Ink layer and light oil reservoir are provided with first adhesive phase, the laminated polyester film and aluminium foil between the paper and laminated polyester film
Between be provided with the second adhesive layer, the another side of the aluminium foil is provided with hot sealing layer.
A kind of medical bubble-cap is packed for epiphragma, it is characterised in that the thickness of the laminated polyester film is 25-45 μm.
A kind of medical bubble-cap is packed for epiphragma, it is characterised in that the thickness of the aluminium foil is 35-55 μm.
A kind of medical bubble-cap is packed for epiphragma, it is characterised in that the dosage of the paper is 50-80 grams/m.
A kind of medical bubble-cap is packed for epiphragma, it is characterised in that and the hot sealing layer is formed by VC glue even applications,
The dosage of VC glue is 3.5-4.5 grams/m.
A kind of medical bubble-cap is packed for the preparation method of epiphragma, it is characterised in that comprises the following steps：
1）Printing：Paper is sent in intaglio press and is printed, printing layer, Ran Hou are formed on the outer surface of paper
Gloss oil is coated in printing layer, a light oil reservoir is formed after drying, no more than 150m/ points, printing post-baking temperature is print speed printing speed
50-80℃；
2）It is compound for the first time：It is continuous with the speed for being no more than 150m/ points by the one side application of adhesive of laminated polyester film
Processing is dried and obtains second adhesive phase by 60-69 DEG C, 70-74 DEG C, 85-90 DEG C of three sections of baking ovens successively, then in heat
Under conditions of drum temperature is 55-65 DEG C, laminated polyester film and aluminium foil hot pressing are combined with each other；
3）It cures for the first time：The laminated polyester film being combined with each other and aluminium foil are placed in curing chamber carry out it is ripe for the first time
Change；
4）Gluing：It will be carried out by the outer surface that composite membrane after curing is positioned in glue spreader to aluminium foil for the first time
Glue, gluing speed carry out drying process no more than 100m/ points, and the composite membrane after gluing continuously passes through 60-69 DEG C, 70- successively
74 DEG C, 85-90 DEG C of three sections of baking ovens be dried processing formed composite membrane hot sealing layer；
5）Second compound：The one side of laminated polyester film is coated into glue, is applied with the speed for being no more than 300m/ points
It covers, forms first adhesive phase, be coated with the laminated polyester film of glue and carried out with the paper after printing compound, formation is compound
Film；
6）Second of curing：Composite membrane is placed in curing chamber and carries out second of curing, epiphragma is made；
7）Cutting：It is operated in strict accordance with cutting requirement；
8）Packaging：It is packed using modeling bag and corrugated case, transportation and packing hit-gain trust disk.
A kind of medical bubble-cap described in 6 is packed for the preparation method of epiphragma, it is characterised in that step 2）Middle adhesive uses
Polyurethane solvent type adhesive.
A kind of medical bubble-cap is packed for the preparation method of epiphragma, it is characterised in that step 3）Middle first time curing temperature
It spends for 48--53 DEG C, curing time 50-60h.
A kind of medical bubble-cap is packed for the preparation method of epiphragma, it is characterised in that step 4）On middle aluminium foil outer surface
Glue is solvent-borne type VC glue, and spread is 3.5-4.5 grams/m；Step 5）Middle glue be non-solvent adhesive, spread
For 2.5-3.5 grams/square.
A kind of medical bubble-cap is packed for the preparation method of epiphragma, it is characterised in that step 6）In second cure temperature
It spends for 35-40 DEG C, the curing time is not less than 48h.
The present invention is compound by the way that paper, polyester film and aluminium foil are carried out, and so as to be effectively increased lid film strength, prevents children
Epiphragma is staved, improves the security used, the setting of aluminium foil can also further stop vapor and oxygen, preparation side of the invention
Method is simple and practicable, the epiphragma prepared by the preparation method, and pull-off force index reaches 55.3-106.9N/15mm, adhesive layer heat
It closes intensity and reaches 13.5-16.2 N/15mm.
Description of the drawings
Fig. 1 is schematic structural view of the invention；
Fig. 2 is preparation method technological process portion of the present invention.
Specific embodiment
By specific examples below, the invention will be further described.
Embodiment 1
A kind of medical bubble-cap is packed for epiphragma, by paper 1 that dosage is 40 grams/m, the polyester film that thickness is 12 μm
Layer 2, the aluminium foil 3 that thickness is 20 μm are combined, and the outer surface of paper 1 is disposed with ink layer 4 and light oil reservoir 5, paper 1 and polyester
First adhesive phase 6 is provided between film layer 2, the second adhesive layer 7, aluminium foil 3 are provided between laminated polyester film 2 and aluminium foil 3
Another side be provided with hot sealing layer 8, hot sealing layer 8 is formed by VC glue even applications, and the dosage of VC glue is 3.5 grams/m.
The preparation method of medicinal blister package epiphragma, comprises the following steps in the present embodiment：
1）Printing：Paper is sent in intaglio press and is printed, printing layer, Ran Hou are formed on the outer surface of paper
Gloss oil is coated in printing layer, a light oil reservoir is formed after drying, no more than 150m/ points, printing post-baking temperature is print speed printing speed
50℃；2）It is compound for the first time：The one side of laminated polyester film is coated into polyurethane solvent type adhesive, to be no more than 150m/ points
Speed continuously successively by 60 DEG C, 70 DEG C, 85 DEG C of three sections of baking ovens processing is dried and obtains second adhesive phase, then in heat
Under conditions of drum temperature is 55 DEG C, laminated polyester film and aluminium foil hot pressing are combined with each other；3）It cures for the first time：One will be compounded in
Laminated polyester film and the aluminium foil risen, which is placed in curing chamber, carries out first time curing, first time curing temperature is 48 DEG C, curing when
Between be 50h；
4）Gluing：By by composite membrane after curing for the first time be positioned in glue spreader to aluminium foil outer surface carry out it is upper molten
Dosage form VC glue, spread are 3.5 grams/m, and gluing speed carries out drying process no more than 100m/ points, answering after gluing
Close the hot sealing layer that processing formation composite membrane is continuously dried in film by 60 DEG C, 70 DEG C, 85 DEG C of three sections of baking ovens successively；5）Second
It is compound：The one side of laminated polyester film is coated into non-solvent adhesive, spread is 2.5 grams/m, to be no more than
300m/ points of speed is coated, and forms first adhesive phase, is coated with the laminated polyester film of glue and after printing
Paper carries out compound, formation composite membrane；6）Second of curing：Composite membrane is placed in curing chamber and carries out second of curing, is made
Epiphragma, second of curing temperature are 35 DEG C, curing time 50h；7）Cutting：It is operated in strict accordance with cutting requirement；8）Bag
Dress：It is packed using modeling bag and corrugated case, transportation and packing hit-gain trust disk.
Embodiment 2
A kind of medical bubble-cap is packed for epiphragma, by paper 1 that dosage is 105 grams/m, the polyester film that thickness is 50 μm
Layer 2, the aluminium foil 3 that thickness is 60 μm are combined, and the outer surface of paper 1 is disposed with ink layer 4 and light oil reservoir 5, paper 1 and polyester
First adhesive phase 6 is provided between film layer 2, the second adhesive layer 7, aluminium foil 3 are provided between laminated polyester film 2 and aluminium foil 3
Another side be provided with hot sealing layer 8, hot sealing layer 8 is formed by VC glue even applications, and the dosage of VC glue is 4.5 grams/m.
The preparation method of medicinal blister package epiphragma, comprises the following steps in the present embodiment：
1）Printing：Paper is sent in intaglio press and is printed, printing layer, Ran Hou are formed on the outer surface of paper
Gloss oil is coated in printing layer, a light oil reservoir is formed after drying, no more than 150m/ points, printing post-baking temperature is print speed printing speed
80℃；2）It is compound for the first time：The one side of laminated polyester film is coated into polyurethane solvent type adhesive, to be no more than 150m/ points
Speed continuously successively by 69 DEG C, 74 DEG C, 90 DEG C of three sections of baking ovens processing is dried and obtains second adhesive phase, then in heat
Under conditions of drum temperature is 65 DEG C, laminated polyester film and aluminium foil hot pressing are combined with each other；3）It cures for the first time：One will be compounded in
Laminated polyester film and the aluminium foil risen, which is placed in curing chamber, carries out first time curing, first time curing temperature is 53 DEG C, curing when
Between be 60h；
4）Gluing：By by composite membrane after curing for the first time be positioned in glue spreader to aluminium foil outer surface carry out it is upper molten
Dosage form VC glue, spread are 4.5 grams/m, and gluing speed carries out drying process no more than 100m/ points, answering after gluing
Close the hot sealing layer that processing formation composite membrane is continuously dried in film by 69 DEG C, 74 DEG C, 90 DEG C of three sections of baking ovens successively；5）Second
It is compound：The one side of laminated polyester film is coated into non-solvent adhesive, spread is 3.5 grams/m, to be no more than
300m/ points of speed is coated, and forms first adhesive phase, is coated with the laminated polyester film of glue and after printing
Paper carries out compound, formation composite membrane；6）Second of curing：Composite membrane is placed in curing chamber and carries out second of curing, is made
Epiphragma, second of curing temperature are 40 DEG C, curing time 110h；7）Cutting：It is operated in strict accordance with cutting requirement；8）Bag
Dress：It is packed using modeling bag and corrugated case, transportation and packing hit-gain trust disk.
Embodiment 3
A kind of medical bubble-cap is packed for epiphragma, by paper 1 that dosage is 50 grams/m, the polyester film that thickness is 25 μm
Layer 2, the aluminium foil 3 that thickness is 35 μm are combined, and the outer surface of paper 1 is disposed with ink layer 4 and light oil reservoir 5, paper 1 and polyester
First adhesive phase 6 is provided between film layer 2, the second adhesive layer 7, aluminium foil 3 are provided between laminated polyester film 2 and aluminium foil 3
Another side be provided with hot sealing layer 8, hot sealing layer 8 is formed by VC glue even applications, and the dosage of VC glue is 3.7 grams/m.
The preparation method of medicinal blister package epiphragma, comprises the following steps in the present embodiment：
1）Printing：Paper is sent in intaglio press and is printed, printing layer, Ran Hou are formed on the outer surface of paper
Gloss oil is coated in printing layer, a light oil reservoir is formed after drying, no more than 150m/ points, printing post-baking temperature is print speed printing speed
60℃；2）It is compound for the first time：The one side of laminated polyester film is coated into polyurethane solvent type adhesive, to be no more than 150m/ points
Speed continuously successively by 62 DEG C, 71 DEG C, 87 DEG C of three sections of baking ovens processing is dried and obtains second adhesive phase, then in heat
Under conditions of drum temperature is 57 DEG C, laminated polyester film and aluminium foil hot pressing are combined with each other；3）It cures for the first time：One will be compounded in
Laminated polyester film and the aluminium foil risen, which is placed in curing chamber, carries out first time curing, first time curing temperature is 50 DEG C, curing when
Between be 52h；
4）Gluing：By by composite membrane after curing for the first time be positioned in glue spreader to aluminium foil outer surface carry out it is upper molten
Dosage form VC glue, spread are 3.7 grams/m, and gluing speed carries out drying process no more than 100m/ points, answering after gluing
Close the hot sealing layer that processing formation composite membrane is continuously dried in film by 62 DEG C, 71 DEG C, 87 DEG C of three sections of baking ovens successively；5）Second
It is compound：The one side of laminated polyester film is coated into non-solvent adhesive, spread is 2.8 grams/m, to be no more than
300m/ points of speed is coated, and forms first adhesive phase, is coated with the laminated polyester film of glue and after printing
Paper carries out compound, formation composite membrane；6）Second of curing：Composite membrane is placed in curing chamber and carries out second of curing, is made
Epiphragma, second of curing temperature are 39 DEG C, curing time 70h；7）Cutting：It is operated in strict accordance with cutting requirement；8）Bag
Dress：It is packed using modeling bag and corrugated case, transportation and packing hit-gain trust disk.
Embodiment 4
A kind of medical bubble-cap is packed for epiphragma, by paper 1 that dosage is 80 grams/m, the polyester film that thickness is 45 μm
Layer 2, the aluminium foil 3 that thickness is 55 μm are combined, and the outer surface of paper 1 is disposed with ink layer 4 and light oil reservoir 5, paper 1 and polyester
First adhesive phase 6 is provided between film layer 2, the second adhesive layer 7, aluminium foil 3 are provided between laminated polyester film 2 and aluminium foil 3
Another side be provided with hot sealing layer 8, hot sealing layer 8 is formed by VC glue even applications, and the dosage of VC glue is 4.0 grams/m.
The preparation method of medicinal blister package epiphragma, comprises the following steps in the present embodiment：
1）Printing：Paper is sent in intaglio press and is printed, printing layer, Ran Hou are formed on the outer surface of paper
Gloss oil is coated in printing layer, a light oil reservoir is formed after drying, no more than 150m/ points, printing post-baking temperature is print speed printing speed
70℃；2）It is compound for the first time：The one side of laminated polyester film is coated into polyurethane solvent type adhesive, to be no more than 150m/ points
Speed continuously successively by 65 DEG C, 72 DEG C, 86 DEG C of three sections of baking ovens processing is dried and obtains second adhesive phase, then in heat
Under conditions of drum temperature is 60 DEG C, laminated polyester film and aluminium foil hot pressing are combined with each other；3）It cures for the first time：One will be compounded in
Laminated polyester film and the aluminium foil risen, which is placed in curing chamber, carries out first time curing, first time curing temperature is 49 DEG C, curing when
Between be 55h；
4）Gluing：By by composite membrane after curing for the first time be positioned in glue spreader to aluminium foil outer surface carry out it is upper molten
Dosage form VC glue, spread are 4.0 grams/m, and gluing speed carries out drying process no more than 100m/ points, answering after gluing
Close the hot sealing layer that processing formation composite membrane is continuously dried in film by 65 DEG C, 72 DEG C, 86 DEG C of three sections of baking ovens successively；5）Second
It is compound：The one side of laminated polyester film is coated into non-solvent adhesive, spread is 3.0 grams/m, to be no more than
300m/ points of speed is coated, and forms first adhesive phase, is coated with the laminated polyester film of glue and after printing
Paper carries out compound, formation composite membrane；6）Second of curing：Composite membrane is placed in curing chamber and carries out second of curing, is made
Epiphragma, second of curing temperature are 36 DEG C, curing time 80h；7）Cutting：It is operated in strict accordance with cutting requirement；8）Bag
Dress：It is packed using modeling bag and corrugated case, transportation and packing hit-gain trust disk.
Embodiment 5
A kind of medical bubble-cap is packed for epiphragma, by paper 1 that dosage is 70 grams/m, the polyester film that thickness is 35 μm
Layer 2, the aluminium foil 3 that thickness is 45 μm are combined, and the outer surface of paper 1 is disposed with ink layer 4 and light oil reservoir 5, paper 1 and polyester
First adhesive phase 6 is provided between film layer 2, the second adhesive layer 7, aluminium foil 3 are provided between laminated polyester film 2 and aluminium foil 3
Another side be provided with hot sealing layer 8, hot sealing layer 8 is formed by VC glue even applications, and the dosage of VC glue is 43 grams/m.
The preparation method of medicinal blister package epiphragma, comprises the following steps in the present embodiment：
1）Printing：Paper is sent in intaglio press and is printed, printing layer, Ran Hou are formed on the outer surface of paper
Gloss oil is coated in printing layer, a light oil reservoir is formed after drying, no more than 150m/ points, printing post-baking temperature is print speed printing speed
75℃；2）It is compound for the first time：The one side of laminated polyester film is coated into polyurethane solvent type adhesive, to be no more than 150m/ points
Speed continuously successively by 67 DEG C, 73 DEG C, 89 DEG C of three sections of baking ovens processing is dried and obtains second adhesive phase, then in heat
Under conditions of drum temperature is 63 DEG C, laminated polyester film and aluminium foil hot pressing are combined with each other；3）It cures for the first time：One will be compounded in
Laminated polyester film and the aluminium foil risen, which is placed in curing chamber, carries out first time curing, first time curing temperature is 52 DEG C, curing when
Between be 58h；
4）Gluing：By by composite membrane after curing for the first time be positioned in glue spreader to aluminium foil outer surface carry out it is upper molten
Dosage form VC glue, spread are 4.4 grams/m, and gluing speed carries out drying process no more than 100m/ points, answering after gluing
Close the hot sealing layer that processing formation composite membrane is continuously dried in film by 67 DEG C, 73 DEG C, 89 DEG C of three sections of baking ovens successively；5）Second
It is compound：The one side of laminated polyester film is coated into non-solvent adhesive, spread is 3.3 grams/m, to be no more than
300m/ points of speed is coated, and forms first adhesive phase, is coated with the laminated polyester film of glue and after printing
Paper carries out compound, formation composite membrane；6）Second of curing：Composite membrane is placed in curing chamber and carries out second of curing, is made
Epiphragma, second of curing temperature are 38 DEG C, curing time 90h；7）Cutting：It is operated in strict accordance with cutting requirement；8）Bag
Dress：It is packed using modeling bag and corrugated case, transportation and packing hit-gain trust disk.
Test case
Pull-off force：Polyester/aluminium blister package is a kind of cover closing material applied to drug blister package with composite membrane.This product
It is not traditional Key works Drug packing aluminium foil（PTP aluminium foils）, it is not to take out drug by simply racking PTP aluminium foils.But pass through
It opens cover closing material and takes out drug.Pull-off force is the tensile strength for investigating cover closing material, so unsuitable too small, the mistake of the value of pull-off force
It is small that cover closing material can be caused to rupture and opened difficult.It is tested by 30 groups of pull-off forces and easily takes off experiment, broken force value and be less than
Easily there is exposure phenomenon in 40N/15mm, epiphragma, open difficult.So method is with reference to GB/T 1040.3-2006 standards.It will break
Power index must not be set to less than 40N/15mm.
It takes respectively and prepares composite membrane according to the method for embodiment 1-5, each embodiment extracts six samples, totally 30 samples
It is tested, test result is as follows, according to being ranked sequentially to embodiment 5 of embodiment 1：30 groups of pull-off force test data (N/
15mm)：55.3, 56.9, 58.3, 66.6, 65.6, 68.0, 76.1, 76.6, 75.3, 76.8,
77.2, 75.7, 74.3, 74.6, 75.8, 76.4, 74.5, 74.0, 77.8, 77.1, 79.6,
80.4, 81.5, 80.6, 90.4, 91.3, 105.8, 106.9, 104.9, 106.9.It can from test structure
To find out, the composite membrane of preparation method preparation of the present invention breaks force value between 55.3-106.9N/15mm, realizes epiphragma not
Easily rupturable purpose.
Adhesive layer heat sealing strength is tested：Investigate this product and the intensity after polyvinyl chloride hard sheet heat seal.Test method uses
Heat sealing strength measuring method（YBB00122003）The method of middle film carries out respectively.To the selection of Heat seal conditions in verification process, examine
Consider the fastness of heat seal and the appearance of sample after heat seal does not substantially deform, allow also for outer layer as thicker paper
Layer, it is slower to temperature conduction, Heat seal conditions are set to：165 DEG C ± 5 DEG C of temperature, pressure 0.2MPa, time 1s.
This product paper/polyester/aluminium blister package is a kind of cover closing material applied to drug blister package with epiphragma.It is not to pass
The Key works Drug packing aluminium foil of system（PTP aluminium foils）, it is not to take out drug by simply racking PTP aluminium foils.But by opening envelope
Cover material takes out drug.So heat sealing strength should not be too large, cross conference and cause to open difficulty.By 30 groups of heat sealing strengths and easily
Experiment is taken off, heat sealing strength is higher than 20.0N/15mm, and unlatching is had any problem.So limit value on heat sealing strength is set to 20.0N/
15mm, it is contemplated that the leakproofness of Key works Drug packing, lower limiting value refer to Key works Drug packing aluminium foil YBB00152002 standard 7.0N/15mm,
So heat sealing strength is set to 7.0-20.0 N/15mm.
It takes respectively and prepares composite membrane according to the method for embodiment 1-5, each embodiment extracts six samples, totally 30 samples
It is tested, test result is as follows, according to being ranked sequentially to embodiment 5 of embodiment 1：30 groups of heat sealing strength test data
(N/15mm)：13.5, 14.4, 13.5, 15.9, 15.3, 14.8, 14.3, 15.6, 14.2, 14.8,
15.8,14.9,14.5,15.2,15.3,14.1,14.2,15.1,14.8,14.2,15.7,
14.3, 14.6, 15.8, 16.2, 14.2, 14.7, 15.8, 15.2, 15.5.It can from test result
Go out, composite membrane prepared by preparation method of the present invention, heat sealing strength value realizes that composite membrane is easy between 13.5-16.2 N/15mm
The purpose taken off.
Claims (4)
1. a kind of medical bubble-cap is packed for epiphragma, it is characterised in that by the paper that dosage is 40-105 grams/m（1）, thickness be
25-45 μm of laminated polyester film（2）, thickness be 35-55 μm of aluminium foil（3）It is combined, the paper（1）Outer surface set successively
It is equipped with ink layer（4）And light oil reservoir（5）, the paper（1）With laminated polyester film（2）Between be provided with first adhesive phase（6）, institute
State laminated polyester film（2）With aluminium foil（3）Between be provided with the second adhesive layer（7）, the aluminium foil（3）Another side be provided with heat-sealing
Layer（8）；The epiphragma breaks force value as 55.3-106.9N/15mm, and heat sealing strength value is 13.5-16.2 N/15mm；
The medical bubble-cap is packed for the preparation method of epiphragma, comprises the following steps：
1）Printing：Paper is sent in intaglio press and is printed, printing layer is formed on the outer surface of paper, is then being printed
Gloss oil is coated on brush layer, a light oil reservoir is formed after drying, for print speed printing speed no more than 150m/ points, printing post-baking temperature is 50-
80℃；
2）It is compound for the first time：By the one side application of adhesive of laminated polyester film, to be no more than 150m/ points of speed continuously successively
Processing is dried and obtains second adhesive phase by 60-69 DEG C, 70-74 DEG C, 85-90 DEG C of three sections of baking ovens, then in hot drum temperature
It spends that under conditions of 55-65 DEG C, laminated polyester film and aluminium foil hot pressing are combined with each other；
3）It cures for the first time：The laminated polyester film being combined with each other and aluminium foil are placed on progress first time curing in curing chamber；
First time curing temperature is 48--53 DEG C, curing time 50-60h；
4）Gluing：It will be glued by the outer surface that composite membrane after curing is positioned in glue spreader to aluminium foil for the first time, on
Glue speed carries out drying process no more than 100m/ point, the composite membrane after gluing continuously successively by 60-69 DEG C, 70-74 DEG C,
The hot sealing layer that processing forms composite membrane is dried in 85-90 DEG C of three sections of baking ovens；The gluing of aluminium foil outer surface is solvent-borne type VC glue, on
Glue amount is 3.5-4.5 grams/m；
5）Second compound：The one side of laminated polyester film is coated into glue, is coated with the speed for being no more than 300m/ points,
First adhesive phase is formed, the laminated polyester film of glue is coated with and the paper after printing carries out compound, formation composite membrane；
Glue is non-solvent adhesive, and spread is 2.5-3.5 grams/square；
6）Second of curing：Composite membrane is placed in curing chamber and carries out second of curing, epiphragma is made；Second of curing temperature
For 35-40 DEG C, the curing time is not less than 48h；
7）Cutting：It is operated in strict accordance with cutting requirement；
8）Packaging：It is packed using modeling bag and corrugated case, transportation and packing hit-gain trust disk.
2. a kind of medical bubble-cap as described in claim 1 is packed for epiphragma, it is characterised in that the paper（1）Dosage be 50-
80 grams/m.
3. a kind of medical bubble-cap as described in claim 1 is packed for epiphragma, it is characterised in that the hot sealing layer（8）It is equal by VC glue
Even to spray, the dosage of VC glue is 3.5-4.5 grams/m.
4. a kind of medical bubble-cap as described in claim 1 is packed for epiphragma, it is characterised in that step 2）Middle adhesive is using poly-
Urethane solvent type adhesive.
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