CN104225675A - 一种具有一氧化氮(no)催化活性的材料的制备方法 - Google Patents
一种具有一氧化氮(no)催化活性的材料的制备方法 Download PDFInfo
- Publication number
- CN104225675A CN104225675A CN201410394884.3A CN201410394884A CN104225675A CN 104225675 A CN104225675 A CN 104225675A CN 201410394884 A CN201410394884 A CN 201410394884A CN 104225675 A CN104225675 A CN 104225675A
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- Prior art keywords
- nitric oxide
- concentration
- catalytic activity
- preparation
- copper
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- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 title claims abstract description 778
- 239000000463 material Substances 0.000 title claims abstract description 127
- 230000003197 catalytic effect Effects 0.000 title claims abstract description 101
- 238000002360 preparation method Methods 0.000 title claims abstract description 97
- 239000007853 buffer solution Substances 0.000 claims abstract description 61
- JPVYNHNXODAKFH-UHFFFAOYSA-N Cu2+ Chemical compound [Cu+2] JPVYNHNXODAKFH-UHFFFAOYSA-N 0.000 claims abstract description 18
- 150000001875 compounds Chemical class 0.000 claims abstract description 18
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 claims abstract description 18
- 229910052711 selenium Inorganic materials 0.000 claims abstract description 17
- 239000011669 selenium Substances 0.000 claims abstract description 17
- 229910001431 copper ion Inorganic materials 0.000 claims abstract description 16
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 claims abstract description 15
- -1 flavonoid compound Chemical class 0.000 claims abstract description 15
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims abstract description 14
- 229930003949 flavanone Natural products 0.000 claims abstract description 10
- 235000011981 flavanones Nutrition 0.000 claims abstract description 10
- 229930003935 flavonoid Natural products 0.000 claims abstract description 10
- 235000017173 flavonoids Nutrition 0.000 claims abstract description 10
- 229960003180 glutathione Drugs 0.000 claims abstract description 10
- ZONYXWQDUYMKFB-UHFFFAOYSA-N SJ000286395 Natural products O1C2=CC=CC=C2C(=O)CC1C1=CC=CC=C1 ZONYXWQDUYMKFB-UHFFFAOYSA-N 0.000 claims abstract description 8
- 230000000844 anti-bacterial effect Effects 0.000 claims abstract description 6
- 150000001879 copper Chemical class 0.000 claims abstract description 5
- 238000005316 response function Methods 0.000 claims abstract description 5
- 108010024636 Glutathione Proteins 0.000 claims abstract description 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract description 3
- 235000013824 polyphenols Nutrition 0.000 claims abstract description 3
- 239000000243 solution Substances 0.000 claims description 106
- 239000011149 active material Substances 0.000 claims description 96
- 238000006243 chemical reaction Methods 0.000 claims description 86
- 238000004140 cleaning Methods 0.000 claims description 82
- 238000000502 dialysis Methods 0.000 claims description 82
- 238000004108 freeze drying Methods 0.000 claims description 82
- QNGIKJLVQNCRRC-UHFFFAOYSA-N Selenocystamine Chemical compound NCC[Se][Se]CCN QNGIKJLVQNCRRC-UHFFFAOYSA-N 0.000 claims description 44
- OOTFVKOQINZBBF-UHFFFAOYSA-N cystamine Chemical compound CCSSCCN OOTFVKOQINZBBF-UHFFFAOYSA-N 0.000 claims description 43
- 229940099500 cystamine Drugs 0.000 claims description 43
- ORTQZVOHEJQUHG-UHFFFAOYSA-L copper(II) chloride Chemical group Cl[Cu]Cl ORTQZVOHEJQUHG-UHFFFAOYSA-L 0.000 claims description 42
- ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical compound [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 claims description 42
- XMOCLSLCDHWDHP-IUODEOHRSA-N epi-Gallocatechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@H]2O)=CC(O)=C(O)C(O)=C1 XMOCLSLCDHWDHP-IUODEOHRSA-N 0.000 claims description 40
- LNTHITQWFMADLM-UHFFFAOYSA-N gallic acid Chemical compound OC(=O)C1=CC(O)=C(O)C(O)=C1 LNTHITQWFMADLM-UHFFFAOYSA-N 0.000 claims description 40
- WQGWDDDVZFFDIG-UHFFFAOYSA-N pyrogallol Chemical compound OC1=CC=CC(O)=C1O WQGWDDDVZFFDIG-UHFFFAOYSA-N 0.000 claims description 40
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- PFTAWBLQPZVEMU-UKRRQHHQSA-N (-)-epicatechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-UKRRQHHQSA-N 0.000 claims description 20
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- YCIMNLLNPGFGHC-UHFFFAOYSA-N catechol Chemical compound OC1=CC=CC=C1O YCIMNLLNPGFGHC-UHFFFAOYSA-N 0.000 claims description 20
- LPTRNLNOHUVQMS-UHFFFAOYSA-N epicatechin Natural products Cc1cc(O)cc2OC(C(O)Cc12)c1ccc(O)c(O)c1 LPTRNLNOHUVQMS-UHFFFAOYSA-N 0.000 claims description 20
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- SFLSHLFXELFNJZ-QMMMGPOBSA-N (-)-norepinephrine Chemical compound NC[C@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-QMMMGPOBSA-N 0.000 claims description 10
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- MHUWZNTUIIFHAS-CLFAGFIQSA-N dioleoyl phosphatidic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(COP(O)(O)=O)OC(=O)CCCCCCC\C=C/CCCCCCCC MHUWZNTUIIFHAS-CLFAGFIQSA-N 0.000 claims description 10
- 229960002748 norepinephrine Drugs 0.000 claims description 10
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- 150000002215 flavonoids Chemical group 0.000 claims description 9
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- 239000010949 copper Substances 0.000 claims description 8
- RTIXKCRFFJGDFG-UHFFFAOYSA-N chrysin Chemical compound C=1C(O)=CC(O)=C(C(C=2)=O)C=1OC=2C1=CC=CC=C1 RTIXKCRFFJGDFG-UHFFFAOYSA-N 0.000 claims description 6
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- HMUJXQRRKBLVOO-AWEZNQCLSA-N 4'-methoxy-5,7-dihydroxyflavanone Chemical compound C1=CC(OC)=CC=C1[C@H]1OC2=CC(O)=CC(O)=C2C(=O)C1 HMUJXQRRKBLVOO-AWEZNQCLSA-N 0.000 claims description 4
- DANYIYRPLHHOCZ-UHFFFAOYSA-N 5,7-dihydroxy-4'-methoxyflavone Chemical compound C1=CC(OC)=CC=C1C1=CC(=O)C2=C(O)C=C(O)C=C2O1 DANYIYRPLHHOCZ-UHFFFAOYSA-N 0.000 claims description 4
- 229910021589 Copper(I) bromide Inorganic materials 0.000 claims description 4
- LEVWYRKDKASIDU-IMJSIDKUSA-N L-cystine Chemical compound [O-]C(=O)[C@@H]([NH3+])CSSC[C@H]([NH3+])C([O-])=O LEVWYRKDKASIDU-IMJSIDKUSA-N 0.000 claims description 4
- 241001597008 Nomeidae Species 0.000 claims description 4
- REFJWTPEDVJJIY-UHFFFAOYSA-N Quercetin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC=C(O)C(O)=C1 REFJWTPEDVJJIY-UHFFFAOYSA-N 0.000 claims description 4
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- OXBLHERUFWYNTN-UHFFFAOYSA-M copper(I) chloride Chemical compound [Cu]Cl OXBLHERUFWYNTN-UHFFFAOYSA-M 0.000 claims description 4
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- BPMFZUMJYQTVII-UHFFFAOYSA-N guanidinoacetic acid Chemical compound NC(=N)NCC(O)=O BPMFZUMJYQTVII-UHFFFAOYSA-N 0.000 claims description 4
- SQFSKOYWJBQGKQ-UHFFFAOYSA-N kaempferide Chemical compound C1=CC(OC)=CC=C1C1=C(O)C(=O)C2=C(O)C=C(O)C=C2O1 SQFSKOYWJBQGKQ-UHFFFAOYSA-N 0.000 claims description 4
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WO2016023494A1 (zh) * | 2014-08-12 | 2016-02-18 | 成都西南交大科技园管理有限责任公司 | 一种构建一氧化氮催化型粘附涂层的方法 |
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CN106581742B (zh) * | 2016-11-22 | 2019-06-21 | 成都迈德克科技有限公司 | 一种在钛合金表面构建no催化型纳米涂层的方法 |
CN107010706A (zh) * | 2017-05-16 | 2017-08-04 | 昌邑市银江生物科技有限公司 | 一种利用花生壳提取物分离水中铜盐的方法 |
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CN112915267B (zh) * | 2020-02-19 | 2022-05-31 | 西南交通大学 | 具有催化释放一氧化氮功能的涂层及其制备方法、抗凝血材料及其制备方法与应用 |
CN111773440A (zh) * | 2020-05-22 | 2020-10-16 | 南京大学 | 一种基于类酶催化反应的抗凝血材料 |
CN113144290A (zh) * | 2020-09-09 | 2021-07-23 | 苏州大学附属第一医院 | 一种促成骨和免疫调节的骨科材料表面涂层及其制备方法 |
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