CN1042196C - Disease-preventing medicine for silkworm and its production process - Google Patents
Disease-preventing medicine for silkworm and its production process Download PDFInfo
- Publication number
- CN1042196C CN1042196C CN93111354A CN93111354A CN1042196C CN 1042196 C CN1042196 C CN 1042196C CN 93111354 A CN93111354 A CN 93111354A CN 93111354 A CN93111354 A CN 93111354A CN 1042196 C CN1042196 C CN 1042196C
- Authority
- CN
- China
- Prior art keywords
- silkworm
- disease
- erythromycin
- triazine
- ethanol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 241000255789 Bombyx mori Species 0.000 title claims abstract description 30
- 239000003814 drug Substances 0.000 title claims abstract description 22
- 201000010099 disease Diseases 0.000 title claims abstract description 14
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims abstract description 14
- 238000004519 manufacturing process Methods 0.000 title claims description 6
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 claims abstract description 26
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 16
- 229960003276 erythromycin Drugs 0.000 claims abstract description 13
- 229940079593 drug Drugs 0.000 claims abstract description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 9
- 238000003756 stirring Methods 0.000 claims abstract description 6
- 239000012153 distilled water Substances 0.000 claims abstract description 5
- PHOZLFWBYCPFME-UHFFFAOYSA-N 2-ethoxy-1,3,5-triazine Chemical compound CCOC1=NC=NC=N1 PHOZLFWBYCPFME-UHFFFAOYSA-N 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 5
- JIHQDMXYYFUGFV-UHFFFAOYSA-N 1,3,5-triazine Chemical compound C1=NC=NC=N1 JIHQDMXYYFUGFV-UHFFFAOYSA-N 0.000 claims description 2
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 6
- 238000002360 preparation method Methods 0.000 abstract description 4
- 208000035143 Bacterial infection Diseases 0.000 abstract description 3
- 208000022362 bacterial infectious disease Diseases 0.000 abstract description 3
- REORCBRCNBPMHQ-UHFFFAOYSA-N 1-[3,5-bis(2-hydroxybutyl)-1,3,5-triazinan-1-yl]butan-2-ol Chemical compound CCC(O)CN1CN(CC(O)CC)CN(CC(O)CC)C1 REORCBRCNBPMHQ-UHFFFAOYSA-N 0.000 abstract 2
- 208000031888 Mycoses Diseases 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 239000007921 spray Substances 0.000 abstract 1
- 239000007788 liquid Substances 0.000 description 6
- 230000002265 prevention Effects 0.000 description 6
- 230000000694 effects Effects 0.000 description 4
- 235000013305 food Nutrition 0.000 description 4
- 241000255791 Bombyx Species 0.000 description 3
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 3
- ZKQDCIXGCQPQNV-UHFFFAOYSA-N Calcium hypochlorite Chemical compound [Ca+2].Cl[O-].Cl[O-] ZKQDCIXGCQPQNV-UHFFFAOYSA-N 0.000 description 2
- -1 No. 1 Substances 0.000 description 2
- 239000007844 bleaching agent Substances 0.000 description 2
- 239000000428 dust Substances 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 238000009366 sericulture Methods 0.000 description 2
- 238000005507 spraying Methods 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- ODINCKMPIJJUCX-UHFFFAOYSA-N Calcium oxide Chemical compound [Ca]=O ODINCKMPIJJUCX-UHFFFAOYSA-N 0.000 description 1
- 206010017533 Fungal infection Diseases 0.000 description 1
- 235000008708 Morus alba Nutrition 0.000 description 1
- 240000000249 Morus alba Species 0.000 description 1
- 241000382353 Pupa Species 0.000 description 1
- 206010040047 Sepsis Diseases 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000000843 anti-fungal effect Effects 0.000 description 1
- 229940121375 antifungal agent Drugs 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- WIIZWVCIJKGZOK-RKDXNWHRSA-N chloramphenicol Chemical compound ClC(Cl)C(=O)N[C@H](CO)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1 WIIZWVCIJKGZOK-RKDXNWHRSA-N 0.000 description 1
- 229940097572 chloromycetin Drugs 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 239000000645 desinfectant Substances 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 208000024386 fungal infectious disease Diseases 0.000 description 1
- 239000002075 main ingredient Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 244000144977 poultry Species 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 230000000384 rearing effect Effects 0.000 description 1
- 208000013223 septicemia Diseases 0.000 description 1
- 238000003892 spreading Methods 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000010902 straw Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention provides a disease-preventing drug for silkworm and a preparation method thereof, the drug comprises hexahydro-1, 3, 5-tri (ethyl-hydroxyethyl) s-triazine, erythromycin, 95% ethanol and distilled water, and the proportion is 300-700: 1-10: 200: 500-100. The preparation method of the medicine comprises dissolving erythromycin with 95% ethanol, adding hexahydro-1, 3, 5-tri (ethyl-hydroxyethyl) s-triazine, stirring, and adding water. Can be used as silkworm spray or feeding, has good surface disinfection and in vivo antibacterial effects, and can treat two diseases of silkworm bacterial disease and fungal disease.
Description
The present invention relates to a kind of silkworm and use anti-disease medicines, particularly about a kind of be used to breed silkworms add the food and the medicine and the manufacture method of disinfection of silkworm body diseases prevention.
At present, be used for the sterilization of breeding silkworms, silkworm body and seat disinfectant particularly, the powder such as No. 1, bleaching powder mascardine-proof dust, anti-dissipation that mainly contain diseases prevention, Main Ingredients and Appearance is that formaldehyde or bleaching powder are formed, as carrier, spreading is difficult to be uniformly dispersed this class medicine powder on silkworm body, silkworm rearing bed with hargil or Calx etc., and its dust sucks human body and influences the sericulture personnel health.Be again, at present control Bombyxmori Linnaeus bacterial disease adopts antibiotic such as chloromycetin to freshen food more, prevention effect is single, for overcoming above-mentioned shortcoming, the object of the present invention is to provide and a kind ofly can be used for the silkworm body and seat spraying disinfection, again can per os add the silkworm of food and the certain therapeutic effect of tool and use anti-disease medicines, can doublely simultaneously control Bombyxmori Linnaeus mycosis and bacterial disease two class diseases.
A kind of silkworm of the present invention is adopted six hydrogen-1,3 with anti-disease medicines and manufacture method, 5-three (2-ethoxy), s-triazine (C
9H
21N
3O
3) make antifungal, the tool excellent surface is sterilized, the interior bacteriostasis of body; With medical erythromycin is antibacterial agent, with after the erythromycin dissolving, adds six hydrogen-1,3 with 95% ethanol, mix in 5-three (2-ethoxy) s-triazine, again adding distil water silkworm of the present invention use anti-disease medicines.Its proportioning: six hydrogen-1,3,5-three (2-ethoxy) s-triazine: erythromycin: ethanol: distilled water is 300-700: 1-10: 200: 500-100.Through the test chamber plot experiment, 50 times of liquid of medicine of the present invention are 95-100% to the prevention effect of muscardine, are 96-100% to the bacteremic septicemia preventive effect, and a silkworm egg surplus the rural area sericulture demonstration test 100,000 all obtains better effect of increasing production.Silkworm of the present invention is nontoxic to silkworm and person poultry safety with anti-disease medicines, both medicinal liquid can be sprayed on and raise silkworm on the Folium Mori, also can be sprayed directly on to the silkworm body, and better protection effect is all arranged, and can produce very great society benefit and economic benefit.Stored at ambient temperature 2 years through storage stability test, its drug effect does not reduce.
The present invention is described further with embodiment:
Embodiment 1: with preparation 1000ml medicine is example: six hydrogen-1,3,5-three (2-ethoxy) s-triazine 400g, erythromycin 2.5g dissolve erythromycin with 200ml95% ethanol earlier, erythromycin after will dissolving again adds 400g six hydrogen-1,3, in 5-three (2-ethoxy) s-triazine, stir 60 minutes to mix homogeneously, add the 400ml distilled water again to 1000ml, be medicine of the present invention, every 10ml medicine adds 500ml water during use, can use after stirring evenly.
Embodiment 2: with preparation 1000ml medicine is example, six hydrogen-1,3,5-three (2-ethoxy) s-triazine 600g, erythromycin 5g, with 200ml95% ethanol earlier evenly with the erythromycin dissolving, erythromycin after will dissolving is again poured 600g six hydrogen-1,3 into, in 5-three (2-ethoxy) s-triazine, stir 60 minutes to mix homogeneously, add the 200ml distilled water again and get final product to 1000ml, every 10ml medicine adds 600ml water during use, stirs evenly the back and uses.
Using method:
When 1, morbidity is light: freshen food once since the first feeding and the glutonous stage in two silkworms in age per ages, the next day of five ages once.The medicinal liquid for preparing is sprayed on 5 kilograms of Folium Mori by every 500ml raises silkworm, with a low volume device or hand sprayer medicinal liquid is sprayed on Folium Mori and the silkworm body immediately after also can giving Mulberry.Be Bombyx Batryticatus and Bombyx Batryticatus in prevention a small bundle of straw, etc. for silkworms to spin cocoons on, available this medicine carries out the matured silkworm spraying disinfection.
2, morbidity is when heavier: from two age first feeding add medicine once every day.
3, pupal cell sterilization: be prevention Bombyx Batryticatus and deteriorated blood pupa, above-mentioned medicinal liquid be sprayed on pupal cell after cutting cocoon, or pupal cell put into above-mentioned medicinal liquid soaked for 30 seconds.
Claims (2)
1, a kind of silkworm is used anti-disease medicines, it is characterized in that: by six hydrogen-1,3,5-three (2-ethoxy) s-triazine, erythromycin, 95% ethanol and distilled water are formed, and its proportioning is 300-700: 1-10: 200: 500-100.
2, the silkworm of claim 1 is used the manufacture method of anti-disease medicines, it is characterized in that: after with 95% ethanol erythromycin being dissolved, add six hydrogen-1,3 again, in 5-three (second-ethoxy) s-triazine, Hou Jiashui stirs.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN93111354A CN1042196C (en) | 1993-07-14 | 1993-07-14 | Disease-preventing medicine for silkworm and its production process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN93111354A CN1042196C (en) | 1993-07-14 | 1993-07-14 | Disease-preventing medicine for silkworm and its production process |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1097305A CN1097305A (en) | 1995-01-18 |
| CN1042196C true CN1042196C (en) | 1999-02-24 |
Family
ID=4989143
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN93111354A Expired - Fee Related CN1042196C (en) | 1993-07-14 | 1993-07-14 | Disease-preventing medicine for silkworm and its production process |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1042196C (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103565829B (en) * | 2013-11-27 | 2015-09-23 | 王羽骋 | A kind of method improving silkworm cocoon yield stability |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3981998A (en) * | 1974-03-08 | 1976-09-21 | Waldstein David A | Bactericidal and fungicidal 1,3,5 trialkanol triazines |
| US4061750A (en) * | 1976-09-13 | 1977-12-06 | Kewannee Industries | Antimicrobial composition |
| US4071628A (en) * | 1977-01-21 | 1978-01-31 | Kewanee Industries | Synergistic antimicrobial mixtures |
-
1993
- 1993-07-14 CN CN93111354A patent/CN1042196C/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3981998A (en) * | 1974-03-08 | 1976-09-21 | Waldstein David A | Bactericidal and fungicidal 1,3,5 trialkanol triazines |
| US4061750A (en) * | 1976-09-13 | 1977-12-06 | Kewannee Industries | Antimicrobial composition |
| US4071628A (en) * | 1977-01-21 | 1978-01-31 | Kewanee Industries | Synergistic antimicrobial mixtures |
Non-Patent Citations (4)
| Title |
|---|
| CHEMICAL ABSTRACTS VOL.100,81229Q 1984.1.1 DUMITRU AURICA等 * |
| CHEMICAL ABSTRACTS VOL.110,110116Q 1989.1.1 BRAZDA GEORG等 * |
| CHEMICAL ABSTRACTS VOL.110,1101989.1.1 1989.1.1 BRAZDA GEORG等 * |
| CHEMICAL ABSTRACTS VOL.110,1101989.1.1 1989.1.1 BRAZDA GEORG等;CHEMICAL ABSTRACTS VOL.100,81229Q 1984.1.1 DUMITRU AURICA等;CHEMICAL ABSTRACTS VOL.110,110116Q 1989.1.1 BRAZDA GEORG等 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1097305A (en) | 1995-01-18 |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C19 | Lapse of patent right due to non-payment of the annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |