CN104208745A - Odor removing agent used for health products and preparation method thereof - Google Patents

Abstract

The invention provides an odor removing agent used for health products and a preparation method thereof, the odor removing agent is a solid odor removing product prepared from an odor removing factor, an adsorption agent, a bactericide, an excipient, a disintegrant and deionized water according to a certain proportion, and the preparation method is as follows: the odor removing factor, the adsorption agent, the bactericide, and the disintegrant are proportionally mixed evenly, then an excipient solution is added and mixed evenly to form a mixture soft material, and then the mixture soft material is dried and granulated to obtain the odor removing agent used for the health products. Aiming at root materials producing odor, an odor removing component, a bactericide component, an adsorption component and other effective components are respectively combined, and through the reasonable collocation of the effective components and preparation formulation, the effects of control of microbial growth and effective odor removing can be achieved.

Description

A kind of taste agent and preparation method thereof of dispelling for hygienic articles

Technical field

The invention belongs to disposable use hygiene article sector, relate in particular to a kind of taste agent and preparation method thereof of dispelling for hygienic articles.

Background technology

Hygienic articles directly contacts human body, adds the taste agent of dispelling and can play the effect that not only maintains body surface health but also dispelling abnormal flavor in hygienic articles.In prior art, the taste agent of dispelling for hygienic articles is limited to fragrant atmosphere material, physical absorbent, plant extract etc. more, although have taste masking effect, because its action principle generally belongs to, abnormal smells from the patient is covered or physical absorption more, and therefore dispel taste effect and persistent period all have much room for improvement.In addition, the taste agent of dispelling in prior art is extensively applied with liquid dosage form, conventionally adopts the mode of directly spraying, and its effect persistence is poor, is that converted products or direct use are all inconvenient, thereby affects its scale application.

Summary of the invention

The object of this invention is to provide a kind of simple, effect taste agent of dispelling significantly of preparing, be particularly useful for disposable sanitary product.

For realizing above technical goal, the present invention by the following technical solutions: a kind of taste agent of dispelling for hygienic articles, is comprised of the raw material that comprises following mass percent:

The described taste factor of dispelling is aminoacid, can be selected from glycine, alanine, glutamic acid, cystine.Above-mentioned aminoacid has significant antioxidation, the taste of dispelling, preservative efficacy.In addition, aminoacid is as body metabolism product, usings that it meets human physilogical characteristic as the taste agent of dispelling, and do not have potential safety hazard.

Described adsorbent is selected from activated carbon, kieselguhr, cyclodextrin, wheat-germ meal etc., with low cost and be easy to buy.

Described antibacterial is selected from benzalkonium chloride, benzalkonium bromide, chlorhexidine acetate, chlorhexidine gluconate, polyhexamethylene guanidine, potassium sorbate.Above-mentioned antibacterial is respectively cationic Surface Active Germicide and organic acid antiseptic, all belongs to spectrum antibacterial, acts on long-actingly, has been widely used in medicine and cosmetic field simultaneously.

Described excipient is selected from carbomer, CMC, polyvinyl alcohol, polyvinylpyrrolidone, gelatin etc.

Described disintegrating agent is selected from medical starch, carboxymethyl starch sodium, crospolyvinylpyrrolidone, lactose etc.

The present invention also provides the taste agent preparation method of dispelling for hygienic articles, comprises the following steps:

1) prepare excipient solution: according to formula proportion, take above-mentioned excipient, be dissolved in deionized water and form excipient solution, stand-by.

2) prepare solid material mixture: according to formula proportion, take respectively the above-mentioned taste factor, adsorbent, antibacterial, the disintegrating agent of dispelling, join and in container, mix and stir, stand-by.

3) prepare mixture soft material: by step 1) excipient solution prepared joins step 2) in the solid material mixture prepared, be thoroughly mixed to form mixture soft material.

4) prepare soft material wet granular: with 40 order-60 eye mesh screens by step 4) soft material prepared sieves, gets the part that particle diameter is less and be soft material wet granular.

5) prepare the dry granule of soft material: utilize physical method by step 4) the soft material wet grain drying prepared is to water content 8%-12%, obtains the dry granule of soft material.

6) by step 5) the dry granule of soft material prepared carries out granulate, obtains the taste agent of dispelling for hygienic articles.

Step 5 in above-mentioned preparation method) described physical method is to be dried 20 minutes-60 minutes under 90 ℃ of-110 ℃ of conditions.

The advantage of technique scheme is: the material root for producing abnormal flavour, combine respectively the effect materials such as taste composition, antimicrobial component and adsorbent of dispelling, and realized and more in wide region, tackled multiple abnormal flavour composition.The reasonably combined taste better effects if of dispelling, the persistence of product of making by functional component and dosage form is stronger.

The specific embodiment

Embodiment 1

The taste agent of dispelling that the preparation 1kg of take is used for hygienic articles is as example.

Take carbomer 10g and be dissolved in 350g deionized water, make carbomer solution.

Take alanine 55g, glutamic acid 27g, cystine 12g, kieselguhr 100g, chlorhexidine acetate 5g, potassium sorbate 5g, medical starch 686g by above raw material mix homogeneously.

Above-mentioned carbomer solution is evenly showered in above-mentioned raw materials intermixture, and mix homogeneously makes pine, the soft material that soft, sticky, humidity is suitable.

Above-mentioned soft material is made to soft material wet granular by 40 order-60 eye mesh screens.

By above-mentioned soft material wet granular freeze-day with constant temperature 30 minutes under 100 ℃ of conditions, obtain water content and be 10% the dry granule of soft material.

The dry granule of above-mentioned soft material is carried out to granulate, obtain the taste agent of dispelling for hygienic articles.

Following experiment is carried out in the taste agent of dispelling for hygienic articles to embodiment 1 preparation.

Microbe colony detects: the microorganism detection method that the GB15979-2002 Appendix B of take is recorded is standard, on sanitary towel top layer, following effective site is added the 0.5g taste agent of dispelling, getting the 10g of sanitary towel shreds, be dipped in 200mL normal saline and mix, after natural subsidence, get supernatant 1mL and carry out flat board cultivation, after 48 hours, detect clump count, testing result is in Table 1.

Table 1: microbe colony testing result

Test number	1#	2#	3#	4#	5#
						48h	Without bacterium colony	Without bacterium colony	Without bacterium colony	Without bacterium colony	Without bacterium colony

Above result shows, the taste agent of originally dispelling has very strong inhibitory action to microorganism.

Olfactory sensation confirmatory experiment: get 1#, two clean sanitary towels of 2#, launch to be put on desktop; Tear 1# sanitary towel, take the 0.5g taste agent of dispelling and evenly spill the middle effective site between dust-free paper and Time of Fluff Slurry; Simultaneously in Xiang Liangpian sanitary towel, pour 5mL sources of odor material into, sanitary towel's former state is wrapped, places 3 minutes, by the olfactory sensation evaluation taste effect of dispelling, evaluation result is in Table 2.

Table 2: olfactory sensation confirmatory experiment result

Above result shows, this taste agent of dispelling is rapid-action, and abnormal flavour is dispelled significantly.

Embodiment 2

The taste agent of dispelling that the preparation 1kg of take is used for hygienic articles is as example.

Take PVP 30g, be dissolved in 350g deionized water, make PVP solution.

Take glycine 42g, alanine 34g, cystine 24g, kieselguhr 100g, chlorhexidine gluconate 8g, potassium sorbate 5g, medical starch 657g by above raw material mix homogeneously.

Above-mentioned carbomer solution is evenly showered in above-mentioned raw materials intermixture, and mix homogeneously makes pine, the soft material that soft, sticky, humidity is suitable

Above-mentioned soft material is made to soft material wet granular by 40 order-60 eye mesh screens.

By above-mentioned soft material wet granular freeze-day with constant temperature 20-40 minute under 100 ℃ of conditions, obtain water content and be 10% the dry granule of soft material

The dry granule of above-mentioned soft material is carried out to granulate, obtain the taste agent of dispelling for hygienic articles.

Following experiment is carried out in the taste agent of dispelling for hygienic articles to embodiment 2 preparations.

Bacteriostasis rate experiment: the taste agent of dispelling is with 30g/m ²addition add in dust-free paper, the dust-free paper that clip 2cm * 3cm contains the taste agent of dispelling carries out bacteriostasis rate detection as sample.Detection method is recorded bacteriostasis property test method with reference to GB15979-2002 appendix C, and three groups of parallel testings, the results are shown in Table 3.

Table 3: the taste agent bacteriostasis rate experimental result of dispelling

Test item numbering	Candida albicans	Gold-coloured staphylococci	Escherichia coli
				1#	98.30%	99.01%	99.24%
2#	97.97%	99.22%	99.35%
				3#	98.02%	99.15%	99.21%
On average	98.09%	99.12%	99.26%

Antimicrobial stability experiment: the stability test method of recording with reference to CG15975-2002 Appendix D, get embodiment 1 sample and make the taste chip of dispelling, after placing three months, 37 ℃ of baking ovens carry out bacteriostasis rate detection, and experimental result is in Table 4:

Table 4: antimicrobial stability experimental result

Test item numbering	Candida albicans	Gold-coloured staphylococci	Escherichia coli
				1#	98.02%	98.69%	99.14%
2#	98.12%	99.02%	99.05%
				3#	97.69%	98.95%	98.87%
On average	97.94%	98.88%	99.02%

Above experimental result meets completely in the People's Republic of China's disposable use hygienic article sanitary standard candida albicans, gold-coloured staphylococci and colibacillary killing rate is more than or equal to 50% regulation, bacteriostasis property is excellent, has good antimicrobial stability simultaneously.

Above embodiments of the invention are had been described in detail, but described content is only preferred embodiment of the present invention, not in order to limit the present invention.All any modifications of making in application range of the present invention, be equal to and replace and improvement etc., within all should being included in protection scope of the present invention.

Claims (8)

1. for the taste agent of dispelling of hygienic articles, it is characterized in that: by the raw material that comprises following mass percent, formed:

2. the taste agent of dispelling for hygienic articles according to claim 1, is characterized in that: described in the taste factor of dispelling be selected from any one or more in glycine, alanine, glutamic acid, cystine.

3. the taste agent of dispelling for hygienic articles according to claim 1, is characterized in that: described adsorbent is selected from any one or more in activated carbon, kieselguhr, cyclodextrin, wheat-germ meal.

4. the taste agent of dispelling for hygienic articles according to claim 1, is characterized in that: described antibacterial is selected from any one or more in benzalkonium chloride, benzalkonium bromide, chlorhexidine acetate, chlorhexidine gluconate, polyhexamethylene guanidine, potassium sorbate.

5. the taste agent of dispelling for hygienic articles according to claim 1, is characterized in that: described excipient is selected from any one or more in carbomer, CMC, polyvinyl alcohol, polyvinylpyrrolidone, gelatin.

6. the taste agent of dispelling for hygienic articles according to claim 1, is characterized in that: described disintegrating agent is selected from any one or more in medical starch, carboxymethyl starch sodium, crospolyvinylpyrrolidone, lactose.

7. a preparation method for the taste agent of dispelling for hygienic articles described in claim 1-6 any one, is characterized in that comprising the steps:

1) prepare excipient solution: according to formula proportion, take excipient claimed in claim 1, be dissolved in deionized water and form excipient solution, stand-by.

2) prepare solid material mixture: according to formula proportion, take respectively the taste factor, adsorbent, antibacterial, the disintegrating agent of dispelling claimed in claim 1, join and in container, mix and stir, stand-by.

3) prepare mixture soft material: by step 1) excipient solution prepared joins step 2) in the solid material mixture prepared, be thoroughly mixed to form mixture soft material.

4) prepare soft material wet granular: with 40 order-60 eye mesh screens by step 4) soft material prepared sieves, gets the part that particle diameter is less and be soft material wet granular.

5) prepare the dry granule of soft material: utilize physical method by step 4) the soft material wet grain drying prepared is to water content 8%-12%, obtains the dry granule of soft material.

6) by step 5) the dry granule of soft material prepared carries out granulate, obtains the taste agent of dispelling for hygienic articles.

8. according to claim 7 for the taste agent preparation method of dispelling of hygienic articles, it is characterized in that: step 5) described physical method is under 90 ℃ of-110 ℃ of conditions dry 20 minutes-60 minutes.