CN104208227B - Treat Chinese medicine composition of adenomyosis and preparation method and application - Google Patents
Treat Chinese medicine composition of adenomyosis and preparation method and application Download PDFInfo
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Abstract
The invention discloses the Chinese medicine composition for the treatment of adenomyosis, it is made up of by weight following components：8~12 parts of Semen Cuscutae, 8~12 parts of dried human placenta, 8~12 parts of Radix Angelicae Sinensis, 4~8 parts of Ligusticum wallichii, 8~12 parts of corydalis tuber, 4~8 parts of rascal, 8~12 parts of Chinese herbaceous peony, 13~17 parts of Ramulus euonymi.The invention also discloses the preparation method and application of above-mentioned Chinese medicine composition.Find that Chinese medicine composition of the invention has clear and definite clinical therapeutic efficacy to Patients with Adenomyosis by clinical observation and research, including effectively reduction of patient progressive dysmenorrhoea can aggravate, reduce excessive menstruation, reduce uterine volume and reduce tcm syndrome total mark.The Chinese medicine composition that the present invention is provided can long-term use, and side reaction is few, can be developed further into the new Chinese medicine for the treatment of adenomyosis.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, and in particular to a kind of Chinese medicine composition for treating adenomyosis and its preparation
Method and application.
Background technology
Adenomyosis (adenomyosis, AM) refers to that endometrial gland and interstitial are present in mesometrium, adjoint
The compensatory hypertrophy and hypertrophy of surrounding muscle layer cell, is a kind of estrogen-dependent diseases.The disease is apt to occur in 30~50 years old
Women of Childbearing Age, overall incidence is 5%-70%, and increase, lifestyle change and ring recently as Cesarean operation
Border factor etc. influences, and its incidence of disease is in rejuvenation and ascendant trend.So far, the cause of disease and pathogenesis of AM are not yet clear and definite,
A kind of frequently-occurring disease, difficult disease are turned into.The disease is mainly shown as MBV showed increased, the exacerbation of dysmenorrhoea progressive, corpus uteri
The increase of product uniformity and the clinical symptoms such as infertile, have had a strong impact on numerous women physically and mentally healthy.The dysmenorrhoea of Patients with Adenomyosis
Rate is up to 80%, it has also become the topmost clinical main suit of AM patient, and excessive menstruation is again the most common merging symptom of dysmenorrhoea.
AM western medical treatments method mainly divides drug therapy and operative treatment, and drug therapy is mainly suppression estrogen secretion,
Create the purpose that an environment for low estrogen suppresses disease development to reach.Though hormone therapy can relief of symptoms, direct shadow
Patient's endocrine function is rung, bone metabolism can be also influenceed, liver function, unsuitable Long-term taking medicine, high recurrence rate after drug withdrawal is damaged.Uterine cavity
Graceful moon pleasure (levonorgestrel-releasing intrauterine system) is placed as this disease of western medical treatment more effective measures, its principle in recent years
It is to suppress expression of the ERs in endometrium by discharging Levonorgestrel in uterine cavity local slow, so that in antagonism
Film hyperplasia, significantly reduces MBV, alleviates dysmenorrhoea.But still suffer from a series of adverse reactions gently after placing graceful moon pleasure, including
Drop bleeding, amenorrhoea, decylization, ring displacement, tenderness of breasts and ovarian cyst etc., limit it in clinical extensive utilization.Operation
Therapeutic modality is divided into radical surgery and conservative operation dealing, to youth, has the feasible conservative surgeries in treating of fertility patient requests i.e.
AM lesion resection arts, but conservative surgeries in treating there are problems that thoroughly removing focus and recurrence after operation rate.To without life
Educate requirement, and lesion extensively, severe symptoms, expectant treatment nonresponder, complete hysterectomy is most common method, is also unique energy
Effect a radical cure the sick means.However, a series of complication can be produced after uterectomy, including surrounding organ damage, Massive Bleeding, art
The perimenopausal symptom (hectic fever, irritability, anxiety, depression etc.) that postoperative infection and ovarian function reduction cause.With the progress of society
And the raising that people are required quality of life, find new more effective and Reservations uterus treatment method very necessary.Many institutes
It is known, Chinese medicine pain of alleviation, regulating menstruation and assisting pregnancy, improve the quality of living, the aspect such as Small side effects, late result stabilization it is equal
There is its unique advantage.Therefore the reliable Chinese medicine of curative effect is found, is occurred not for avoiding taking merely the western medicine disease
Good reaction tool is of great significance.
The content of the invention
The technical problem to be solved in the present invention is to provide a kind of Chinese medicine composition for treating adenomyosis.
The invention solves the problems that another technical problem be to provide a kind of Chinese medicine composition for treating adenomyosis
Preparation method.
The technical problem also to be solved of the invention is to provide a kind of Chinese medicine composition for treating adenomyosis in system
Application in standby treatment adenomyosis medicine.
For the Chinese medicine composition for treating adenomyosis, the technical solution adopted by the present invention is, by following components by weight
Amount number composition：
8~12 parts of dried human placenta, 8~12 parts of Semen Cuscutae, 8~12 parts of Radix Angelicae Sinensis, 4~8 parts of Ligusticum wallichii, 8~12 parts of corydalis tuber, rascal
4~8 parts, 8~12 parts of Chinese herbaceous peony, 13~17 parts of Ramulus euonymi.
Preferably, above-mentioned Chinese medicine composition is made up of by weight following component：
10 parts of dried human placenta, 10 parts of Semen Cuscutae, 10 parts of Radix Angelicae Sinensis, 6 parts of Ligusticum wallichii, 10 parts of corydalis tuber, 6 parts of rascal, 10 parts of Chinese herbaceous peony, ghost
15 parts of fletching.
For the preparation method for treating the Chinese medicine composition of adenomyosis, the technical solution adopted by the present invention is, the system
Preparation Method comprises the following steps：
(1) 30 are soaked after mixing the Semen Cuscutae of formula ratio, Radix Angelicae Sinensis, Ligusticum wallichii, corydalis tuber, rascal, Chinese herbaceous peony, Ramulus euonymi
~50 minutes, obtain including the mixture A of medicinal material and soaking water；
(2) dried human placenta of formula ratio is soaked 30~50 minutes, big fire is boiled, and to boiling, small fire decocts 30~60 again
Minute, room temperature is cooled to, obtain including the mixture B of the dried human placenta dregs of a decoction and liquid；
(3) the mixture A and mixture B that will be obtained are mixed, stir evenly rear big fire it is boiled to boiling again small fire decoct 30~
60 minutes, it is collected by filtration and obtains the first pan-fried Aqueous extracts；Then add water again, stir evenly rear big fire boiled to boiling small fire decoction 20 again
~40 minutes, it is collected by filtration and obtains the second pan-fried Aqueous extracts；Merge first and decoct Aqueous extracts and the second pan-fried Aqueous extracts, subtract through 60 DEG C of vacuum
Pressure concentration obtains final product Chinese medicine composition extract.
Preferably, in step (1), amount of water by 4~8 times of immersion medicinal material gross weight.
Preferably, in step (2), amount of water is 2~6 times of dried human placenta weight.
Preferably, in step (3), amount of water to the water surface exceeds 1~3cm of dregs of a decoction surface again.
Chinese medicine composition the answering in treatment adenomyosis medicine is prepared for the treatment of adenomyosis of the present invention
With.
AM is a kind of modern diseases in gynaecology, and motherland's medical science has no the record of this name of disease to adenomyosis.It is main according to its
Sings and symptoms is showed, and can belong to the traditional Chinese medical science " dysmenorrhoea ", " Disorder lumps in the abdomen ", " irregular menstruation ", the disease category such as " infertile ".According to the modern times
The research of the traditional Chinese medical science, the etiology and pathogenesis of adenomyosis can be summarized as follows substantially：External cause is generally chill or damp and hot heresy and qi and blood phase
Knot, it is adenomyosis to cause QI-blood circulation to be obstructed and send out；Internal cause is generally disorder of emotion, the stagnation of the circulation of vital energy, or internal organs disorder of qi and blood, so as to lead
" perverse trend is come and gone, and day is accumulated the moon and is gathered, eventually to gradually Yi Cheng Disorder " is caused, therefore on the interpretation of the cause, onset and process of an illness：" stopping in hemostasis " is the key of this disease.However, individually
Emphasize to stop in hemostasis have certain limitation for this sick interpretation of the cause, onset and process of an illness key, this course of disease is in general long, often involves
In kidney, kidney qi virtual loss, punching times is impaired, and uterus store blood dysfunction can cause part menses not follow Chang Dao and drive in the wrong direction；While kidney qi
Weakness, vigour virtual loss promotes powerless, and it is not smooth to often result in QI-blood circulation, and punching is appointed impaired, and blood circulating out of vessels accumulation is stasis of blood Xing Cheng Disorder
Lump in the abdomen；Blood operation is not smooth, and general rule bitterly, does not show as " dysmenorrhoea ", forms the card of simulataneous insufficiency and excessive.And perimenopausal women due to
Through, it is pregnant, produce, breast, wasting QI-blood, in addition menses gradually exhaust, kidney hides Kidney-Yin and Yuanyang of residing, yin deficiency affecting yang, or the deficiency of yang affecting yin, Kidney-Yin true
YANG deficiency, it is impossible to moisten foster, warm internal organs, punching appoints void to decline and menoxenia occur.The determination of etiologic factors based on differentiation, kidney deficiency in both YIN and YANG be this disease again
One pathogenesis.《Fu Qingzhu works on obstetrics and gynecology》Speech：" through this in kidney ", " going out all kidneys through water ", but the kidney being the origin of congenital constitution, main reproduction, is day
The source in the last of the ten Heavenly stems, the residence of extreme misery hides Kidney-Yin, Yuanyang of residing.Theory of traditional Chinese medical science thinks that kidney qi is contained, and menarche, abundant CHONG meridian with unobstructed REN meridian, uterus qi and blood is expired
Overflow, then menses are under.If kidney qi deficiency fortune blood is powerless, or kidney essense is lost few, loses, or kidney-yin deficiency foster in moistening, and abnormal heat is burnt essence and blood, or kidney
The deficiency of yang, blood mistake is warm and sluggish, can cause blood stasis, therefore control with invigorating kidney, promoting blood circulation stagnation resolvation.
In sum, it is this sick main pathogenesis to stop in hemostasis, and to cause a disease originally, kidney deficiency is the pathology of perimenopausal women
Feature.Kidney deficiency blood stasis, vessels of the uterus blocks, not general rule pain event menalgia, and QI-blood circulation is obstructed, therefore menstruation discharge is not smooth, discharges
It is not smooth again blood stasis to be caused to aggravate, make stasis more very, such cause and effect is concerned with, and forms vicious circle.Chinese traditional treatment adenomyosis, controls
Treating should be according to the principle of reatment of " determination of etiologic factors based on differentiation is examined because opinion is controlled ", using tonifying the kidney and support yang, dispersing stagnated hepatoqi, Xiao Disorder dissipating binds promoting blood circulation and removing blood stasis
Method.
The present invention chooses raw material, Chinese medicine group of the present invention according to the etiology and pathogenesis and traditional Chinese medical theory of adenomyosis
The effect of compound has tonifying kidney and benefiting sperm, nourishing blood and invigorating qi, regulating qi-flowing for relieving pain, Xiao Disorder dissipating binds promoting blood circulation and removing blood stasis, from dried human placenta, Semen Cuscutae,
Radix Angelicae Sinensis, Ligusticum wallichii, corydalis tuber, rascal, Chinese herbaceous peony, Ramulus euonymi part obtain the Chinese traditional medicine composition with treatment adenomyosis effect for raw material
Thing.
The foundation of raw material is selected by of the invention：Dried human placenta, Semen Cuscutae tonifying kidney and benefiting sperm, nourishing blood and invigorating qi are altogether monarch drug in a prescription, Radix Angelicae Sinensis,
The analgesic of Ligusticum wallichii promoting blood circulation for regulating menstruation is all ministerial drug；Assistant is with corydalis tuber, rascal dispersing stagnated hepatoqi, promoting blood circulation analgesic therapy, the radix paeoniae rubrathe, Ramulus euonymi promoting blood circulationization
Stasis of blood, Xiao Disorder dissipating binds are altogether to make medicine.All medicines share, is treated both principal and secondary aspect of disease, and tonifying kidney and benefiting sperm, nourishing blood and invigorating qi, regulating qi-flowing for relieving pain, promoting blood circulationization are played altogether
The effect of stasis of blood, Xiao Disorder dissipating binds.
Rested on a scientific basis according to above traditional Chinese medical theory and choose raw material and scientific matching raw material, can mutually assisted between each component
Adjust, mutually promote, play a part of Synergistic, with good tonifying kidney and benefiting sperm, nourishing blood and invigorating qi, regulating qi-flowing for relieving pain, it is promoting blood circulation and removing blood stasis,
The effect of Xiao Disorder dissipating binds, dysmenorrhoea can be relieved, MBV be reduced, reduce uterine volume and is reduced tcm syndrome total mark.
The beneficial effects of the invention are as follows：
By clinical observation with research find, Chinese medicine composition of the invention to Patients with Adenomyosis have clearly face
Bed therapeutic effect, including effectively reduction of patient dysmenorrhoea progressive can aggravate, reduce excessive menstruation, reduce uterine volume and reduction
Tcm syndrome total mark.
Specific embodiment
Embodiment 1：
A kind of Chinese medicine composition for treating adenomyosis, is made up of by weight following components：10 parts of dried human placenta, Tu
10 parts of silk, Radix Angelicae Sinensis 10g, 6 parts of Ligusticum wallichii, 10 parts of corydalis tuber, 6 parts of rascal, 10 parts of Chinese herbaceous peony, 15 parts of Ramulus euonymi.
Preparation method：Added after the Semen Cuscutae of formula ratio, Radix Angelicae Sinensis, Ligusticum wallichii, corydalis tuber, rascal, Chinese herbaceous peony, Ramulus euonymi are mixed
6 times of water of weight soak 40 minutes, obtain including the mixture A including medicinal material and soaking water；Simultaneously individually to the purple of formula ratio
River car adds the water of 4 times of medicinal material gross weight to soak 40 minutes, and big fire is boiled, and to boiling, small fire is decocted 45 minutes again, is cooled to room
Temperature, obtains including the mixture B including the dried human placenta dregs of a decoction and liquid.The mixture A and mixture B that will be obtained are mixed, and are stirred evenly
Big fire is boiled afterwards decocts 45 minutes to small fire of seething with excitement again, collects to obtain the first pan-fried Aqueous extracts through screen filtration.Add water to again and exceed
Dregs of a decoction surface 2cm, small fire is decocted 30 minutes again to stir evenly the boiled extremely boiling of rear big fire, collects to obtain the second pan-fried water extraction through screen filtration
Liquid.Merge first and decoct Aqueous extracts and the second pan-fried Aqueous extracts, Chinese medicine composition extract is obtained final product through 60 DEG C of vacuum-concentrcteds.
Embodiment 2：
A kind of Chinese medicine composition for treating adenomyosis, including following parts by weight component：8 parts, Tu of dried human placenta
8 parts of son, Radix Angelicae Sinensis 8g, 4 parts of Ligusticum wallichii, 8 parts of corydalis tuber, 4 parts of rascal, 8 parts of Chinese herbaceous peony, 13 parts of Ramulus euonymi.
Preparation method：Added after the Semen Cuscutae of formula ratio, Radix Angelicae Sinensis, Ligusticum wallichii, corydalis tuber, rascal, Chinese herbaceous peony, Ramulus euonymi are mixed
4 times of water of weight soak 30 minutes, obtain including the mixture A including medicinal material and soaking water；Simultaneously individually to the purple of formula ratio
River car adds 2 times of water of weight to soak 30 minutes, and big fire is boiled, and to boiling, small fire is decocted 30 minutes again, is cooled to room temperature, is obtained
Mixture B to including including the dried human placenta dregs of a decoction and liquid.The mixture A and mixture B that will be obtained are mixed, and stir evenly rear big fire
Boiled to boiling, small fire is decocted 30 minutes again, and the first pan-fried Aqueous extracts are collected to obtain through screen filtration.Add water to again beyond dregs of a decoction table
Face 1cm, small fire is decocted 20 minutes again to stir evenly the boiled extremely boiling of rear big fire, collects to obtain the second pan-fried Aqueous extracts through screen filtration.Merge
First decocts Aqueous extracts and second decocts Aqueous extracts, and Chinese medicine composition extract is obtained final product through 60 DEG C of vacuum-concentrcteds.
Embodiment 3：
A kind of Chinese medicine composition for treating adenomyosis, including following parts by weight component：12 parts, Tu of dried human placenta
12 parts of son, Radix Angelicae Sinensis 12g, 8 parts of Ligusticum wallichii, 12 parts of corydalis tuber, 8 parts of rascal, 12 parts of Chinese herbaceous peony, 17 parts of Ramulus euonymi.
Preparation method：Added after the Semen Cuscutae of formula ratio, Radix Angelicae Sinensis, Ligusticum wallichii, corydalis tuber, rascal, Chinese herbaceous peony, Ramulus euonymi are mixed
8 times of water of weight soak 50 minutes, obtain including the mixture A including medicinal material and soaking water；Simultaneously individually to the purple of formula ratio
River car adds 6 times of water of weight to soak 50 minutes, and big fire is boiled, and to boiling, small fire is decocted 60 minutes again, is cooled to room temperature, is obtained
Mixture B to including including the dried human placenta dregs of a decoction and liquid.The mixture A and mixture B that will be obtained are mixed, and stir evenly rear big fire
Boiled to boiling, small fire is decocted 60 minutes again, and the first pan-fried Aqueous extracts are collected to obtain through screen filtration.Add water to again beyond dregs of a decoction table
Face 3cm, small fire is decocted 40 minutes again to stir evenly the boiled extremely boiling of rear big fire, collects to obtain the second pan-fried Aqueous extracts through screen filtration.Merge
First decocts Aqueous extracts and second decocts Aqueous extracts, and Chinese medicine composition extract is obtained final product through 60 DEG C of vacuum-concentrcteds.
The effect that above-mentioned 3 embodiments are used for clinical treatment adenomyosis is as follows：
1. the object of observation
1.1 diagnostic criteria
AM Western medicine diagnostic criterias：
Consensus of experts meeting can be discussed by the endometriosis diagnosis and treatment specification that professor Lang Jinghe takes the lead with reference in September, 2007
Diagnosis on adenomyosis in " the Clinics and Practices specification of endometriosis " that proposes.
AM Standards of Chinese Medical Syndrome Differentiation：
1. main symptom：Dysmenorrhea, and being aggravated in progressive, hyper-menorrhea or menostaxis, dark menses, blockage of menstruation or
Accompany clot.2. secondary card；Waist sacrum is ached or soreness and weakness of waist and knees, anus pendant pain, intercourse pain, dizziness and tinnitus, spiritlessness and weakness, hot sweating,
Profuse leukorrhea, complexion is dark dim.3. tongue vein：Tongue nature purple is dim, tongue body ecchymosis, petechia, deep thready pulse or puckery.Main symptom must in above-mentioned standard
Standby, secondary card possesses 2 or more than 2, with reference to tongue vein, can be used as clinical diagnosis.
1.2 include, exclusion standard
Inclusive criteria：
1. doctor trained in Western medicine adenomyosis diagnostic criteria and Standards of Chinese Medical Syndrome Differentiation person are met；2. age 30~50 years old；3. six months
Other drugs clinical test person is not participated in inside；4. Informed Consent Form person is signed.Research object need meet simultaneously 1.~4. can
Include this research.
Exclusion standard：
1. the age is below 30 years old or more than 50 years old person；2. endometriosis, various benign or evil are associated with
Property tumour, cardiovascular and cerebrovascular, liver, kidney and hemopoietic system, endocrine system disease (such as hyperthyroidism, diabetes) serious disease person；3. can not
The precise expression state of an illness person of oneself；4. this medicine allergy etc. is affected the treatment or security judgement person；5. other were participated in 6 months
The patient of clinical drug trial.Research object meet 1.~5. any point can exclude this research.
1.3 reject standard
Meet above inclusion criteria, but do not receive the patient for the treatment of because of a variety of causes.
1.4 come off standard
It has been be selected in that, but do not completed the patient for the treatment of fore-and-aft observing according to the rules because of a variety of causes.
1.5 dysmenorrhoea symptom integral standards
Issued with reference to the Ministry of Public Health《New Chinese medicine guideline of clinical investigations》In (version in 1993)《New Chinese medicine treats basin
The guideline of clinical investigations of thorax Endometriosis》Draft, it is specific as follows：
1.6 MBV standards of grading
Issued with reference to the Ministry of Public Health《New Chinese medicine guideline of clinical investigations》In (version in 1993)《New Chinese medicine treats basin
The guideline of clinical investigations of thorax Endometriosis》Draft, it is specific as follows：
1. MBV<80mL remembers 0 point；2. 80~100mL of MBV remembers 1 point；3. 100~150mL of MBV remembers 2 points；④
MBV>150mL remembers 3 points.
1.7 uterine volumes calculate standard
Row Visual quality measurement uterus three-dimensional radial line before and after treatment, by irregular spheroid volume computing formula (4/3 π abc)
Calculate the volume (abc represents uterus three radius values of tangent plane in Three Dimensional Interface respectively) in uterus
1.8 Syndrome in TCM marquis's total mark standards
Issued with reference to the Ministry of Public Health《New Chinese medicine guideline of clinical investigations》In (version in 1993)《New Chinese medicine treats basin
The guideline of clinical investigations of thorax Endometriosis》Draft, be shown in Table 1
The tcm symptom of table 1 and sign (syndrome) ranking criterion
2. experiment packet
The Patients with Adenomyosis in Jiangsu Province's hospitals of traditional Chinese and western medicine's OPD of Obs ＆ Gyn and ward is chosen with reference to above standard,
Selection altogether meets the patient 114 of inclusive criteria, and it is (real that 114 patients are divided into 48,1 group of Chinese medicine (embodiment 1), 2 groups of Chinese medicine
Apply example 2) 28,38,3 groups of Chinese medicine (embodiment 3) and control group (Man Yuele) 20.Age of each group patient, body mass index and
The state of an illness (including the scoring of dysmenorrhoea symptom score, MBV, uterine volume size, tcm syndrome total mark) is relatively without aobvious before treatment
Write sex differernce (P>0.05), experimental result has comparativity.
3. treatment method
1. 2 groups of Chinese medicine：1 group of Chinese medicine：Treated using Chinese medicine composition Aqueous extracts described in above-described embodiment 1, Chinese medicine of the present invention
Composition extract, one portion per day is divided to morning and afternoon two to be taken inferior to 1 hour after meal, and menstrual period withdraw, and 48 are treated altogether.
2. 2 groups of Chinese medicine：Treated using Chinese medicine composition Aqueous extracts described in above-described embodiment 2, traditional Chinese medicine composition water of the present invention
Extract, one portion per day is divided to morning and afternoon two to be taken inferior to 1 hour after meal, and menstrual period withdraw, and 28 are treated altogether.
3. 3 groups of Chinese medicine：Treated using Chinese medicine composition Aqueous extracts described in above-described embodiment 3, traditional Chinese medicine composition water of the present invention
Extract, one portion per day is divided to morning and afternoon two to be taken inferior to 1 hour after meal, and menstrual period withdraw, and 38 are treated altogether.
4. control group：Patient placed graceful moon pleasure (production of Bayer Bitterfeld GmbH Schering Corp) in the 3rd~7 of the menstrual cycle the day,
Placed in strict accordance with operating guidance under Transvaginal Ultrasound in Monitoring by special messenger, 20 are treated altogether.
4. treatment course
With 3 months for 1 treatment course, this Study of Traditional Chinese Medicine group treats 1 course for the treatment of to each group.
5. observation index
Each group carries out therapeutic evaluation afterwards before the treatment respectively, and observation index includes dysmenorrhoea symptom integral, menstruation before and after treatment
Amount scoring, uterine volume size, tcm syndrome total mark, Drug side reaction.
6. statistical method
Data carry out statistical procedures using SPSS17.0 statistical softwares, and measurement data is checked using t, all measurement datas
Represented using average ± standard deviation, enumeration data uses card side (χ2) inspection.P is two-sided test, P<0.05 is notable to have
Sex differernce, P<0.01 is have pole significant difference.
7. experimental result
1. the herbal mixture of embodiment 1, the herbal mixture of embodiment 2 and the herbal mixture of embodiment 3 can significantly alleviate uterus
Gland patients with myopathy dysmenorrhoea symptom, and embodiment 1, example 2, the herbal mixture effect of example 3 are better than control group.
As shown in table 2, compared with before the treatment of this group, dysmenorrhoea symptom product after 1 group of Chinese medicine, 2 groups of Chinese medicine, 3 groups of treatments of Chinese medicine
Dividing significantly reduces (P<0.01, P<0.01, P<0.01)；In addition, dysmenorrhoea scoring after 1 group of Chinese medicine, 2 groups of Chinese medicine, 3 groups of treatments of Chinese medicine
It is substantially less than (P after control group treatment<0.01, P<0.05、P<0.05).
2. the herbal mixture of embodiment 1, the herbal mixture of embodiment 2 and the herbal mixture of embodiment 3 can substantially reduce uterus
Gland patients with myopathy excessive menstruation, and embodiment 1, the herbal mixture effect of example 2 are better than control group.
As shown in table 2, compared with before the treatment of this group, MBV scoring after 1 group of Chinese medicine, 2 groups of Chinese medicine, 3 groups of treatments of Chinese medicine
Significantly reduce (P<0.01, P<0.01、P<0.01)；In addition, MBV scoring is significantly low after 1 group of Chinese medicine, 2 groups of treatments of Chinese medicine
In (P after control group treatment<0.01, P<0.05).
3. the herbal mixture of embodiment 1, the herbal mixture of embodiment 2 and the herbal mixture of embodiment 3 can be reduced significantly uterus
Gland patients with myopathy uterine volume size, and embodiment 1, the herbal mixture effect of example 2 are better than control group.
As shown in table 2, compared with before the treatment of this group, MBV scoring after 1 group of Chinese medicine, 2 groups of Chinese medicine, 3 groups of treatments of Chinese medicine
Significantly reduce (P<0.01, P<0.01、P<0.05)；In addition, uterine volume is significantly less than right after 1 group of Chinese medicine, 2 groups of treatments of Chinese medicine
According to (P after group treatment<0.01, P<0.05).
4. the herbal mixture of embodiment 1, the herbal mixture of embodiment 2, the herbal mixture of embodiment 3 can significantly reduce uterine gland
Patients with myopathy tcm syndrome total mark, and embodiment 1, the herbal mixture effect of example 3 are better than control group.
As shown in table 2, compared with before the treatment of this group, tcm syndrome is total after 1 group of Chinese medicine, the 3 groups of treatments of 2 groups of Chinese medicine and Chinese medicine
Integration significantly reduces (P<0.01, P<0.05,P<0.01)；In addition, tcm syndrome total mark after 1 group of Chinese medicine, 3 groups of treatments of Chinese medicine
It is substantially less than (P after control group treatment<0.01, P<0.05).
Rear items parameters for observation on effect compares each seminar of table 2 before the treatment
Note：Compare with before treatment after 1 group of Chinese medicine, 2 groups of Chinese medicine, 3 groups of treatments of Chinese medicine,*P<0.05,**P<0.01；1 group of Chinese medicine,
Compare with after control group treatment after 2 groups of Chinese medicine, 3 groups of treatments of Chinese medicine,#P<0.05,##P<0.01。
5. Drug side reaction is notable after the herbal mixture of embodiment 1, the herbal mixture of embodiment 2, the treatment of the herbal mixture of embodiment 3
Less than control group
After two groups of treatments, blood, urine, stool routine, liver function, renal function etc. are showed no obvious abnormalities.Additionally, as seen from Table 3,
Through χ2There is medicine pair instead compared with control group treating in inspection, 1 group of Chinese medicine, 2 groups of Chinese medicine, 3 groups of Chinese medicine after the l course for the treatment of terminates
Answering number and percentage aspect has pole significant difference, significantly lower than control after 1 group of Chinese medicine, the 3 groups of treatments of 2 groups of Chinese medicine and Chinese medicine
Group (P<0.01, P<0.01, P<0.01), prompting inventive formulation has good security.It is above-mentioned visible, during the present invention is provided
Medicine compound can long-term use, Drug side reaction is few, can be developed further into the new Chinese medicine for the treatment of adenomyosis.
After the treatment of each seminar of table 3 there is number and percentage comparisons in Drug side reaction
From the above mentioned, the Chinese medicine composition of embodiment 1,2,3 clinically has to Patients with Adenomyosis and clearly faces
Bed therapeutic effect and Drug side reaction is few.
Invention described above implementation method, is not intended to limit the scope of the present invention..It is any in the present invention
Spirit and principle within modification, equivalent and the improvement made etc., should be included in claim protection model of the invention
Within enclosing.
Claims (7)
1. a kind of Chinese medicine composition for treating the dysmenorrhoea that adenomyosis causes, it is characterised in that by following components by weight
Array into：8~12 parts of dried human placenta, 8~12 parts of Semen Cuscutae, 8~12 parts of Radix Angelicae Sinensis, 4~8 parts of Ligusticum wallichii, 8~12 parts of corydalis tuber, rascal
4~8 parts, 8~12 parts of Chinese herbaceous peony, 13~17 parts of Ramulus euonymi.
2. a kind of Chinese medicine composition for treating the dysmenorrhoea that adenomyosis causes as claimed in claim 1, it is characterised in that by
Following components is constituted by weight：10 parts of dried human placenta, 10 parts of Semen Cuscutae, 10 parts of Radix Angelicae Sinensis, 6 parts of Ligusticum wallichii, 10 parts of corydalis tuber, green grass or young crops
6 parts of skin, 10 parts of Chinese herbaceous peony, 15 parts of Ramulus euonymi.
3. a kind of preparation method of the Chinese medicine composition for treating the dysmenorrhoea that adenomyosis causes as claimed in claim 1, its
It is characterised by comprising the following steps：
(1) 30~50 are soaked after mixing the Semen Cuscutae of formula ratio, Radix Angelicae Sinensis, Ligusticum wallichii, corydalis tuber, rascal, Chinese herbaceous peony, Ramulus euonymi
Minute, obtain including the mixture A of medicinal material and soaking water；
(2) dried human placenta of formula ratio is soaked 30~50 minutes, big fire is boiled, and to boiling, small fire decocts 30~60 points again
Clock, is cooled to room temperature, obtains including the mixture B of the dried human placenta dregs of a decoction and liquid；
(3) mixture A and mixture B are mixed, stirs evenly rear big fire boiled to the small fire decoction 30~60 minutes, filtering of seething with excitement again
Collection obtains first and decocts Aqueous extracts；Then added water again to the dregs of a decoction, stir evenly rear big fire boiled to boiling small fire decoction 20~40 again
Minute, it is collected by filtration and obtains the second pan-fried Aqueous extracts；Merge first and decoct Aqueous extracts and the second pan-fried Aqueous extracts, through 60 DEG C of vacuum decompressions
Concentration obtains final product Chinese medicine composition extract.
4. a kind of preparation method of the Chinese medicine composition for treating the dysmenorrhoea that adenomyosis causes as claimed in claim 3, its
Be characterised by, in step (1), amount of water by 4~8 times of immersion medicinal material weight.
5. a kind of preparation method of the Chinese medicine composition for treating the dysmenorrhoea that adenomyosis causes as claimed in claim 3, its
It is characterised by, in step (2), amount of water is 2~6 times of dried human placenta weight.
6. a kind of preparation method of the Chinese medicine composition for treating the dysmenorrhoea that adenomyosis causes as claimed in claim 3, its
It is characterised by, in step (3), amount of water to the water surface exceeds 1~3cm of dregs of a decoction surface again.
7. a kind of Chinese medicine composition for treating the dysmenorrhoea that adenomyosis causes as claimed in claim 1 is preparing treatment uterus
Gland myopathy causes the application in dysmenorrhoea medicine.
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