CN104208090B - A kind of preventing and treating Bovine Ephemeral Fever compositions - Google Patents
A kind of preventing and treating Bovine Ephemeral Fever compositions Download PDFInfo
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- CN104208090B CN104208090B CN201410476366.6A CN201410476366A CN104208090B CN 104208090 B CN104208090 B CN 104208090B CN 201410476366 A CN201410476366 A CN 201410476366A CN 104208090 B CN104208090 B CN 104208090B
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- ephemeral fever
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Abstract
The present invention relates to field of veterinary, particularly provide a kind of preventing and treating Bovine Ephemeral Fever compositions, said composition by carbasalate calcium, astragalus polysaccharides, be coated enrofloxacin, polygynax, be coated Vc and form.It is up to 97% with the average cure rate of the prescription medicine oral medication Bovine Ephemeral Fever case of the present invention, there is the advantages such as stable in properties, good palatability, long shelf-life.This prescription medicine and oral medication method have easy to use, without treating stress, need not the advantage such as professional veterinary technical staff, saving manpower, every medical expense suffering from cattle is made to significantly reduce, only the 1/3 of traditional therapy, and be conducive to suffering from the recovery of cattle production performance.Preventing and treating for Bovine Ephemeral Fever provides strong material and technical guarantee, and new thinking has been started in the preventing and treating for this disease simultaneously.
Description
Technical field
The present invention relates to field of veterinary, particularly provide a kind of preventing and treating Bovine Ephemeral Fever compositions.
Background technology
Bovine Ephemeral Fever, also known as Ephemeral fever or temporarily hot, is the acute febrile infectious disease caused by bovine epizootic fever virus.This disease
Mainly encroaching on cattle, wherein milch cow, cattle and Babalus bubalis L. are the most susceptible, and adult dairy cattle is in a bad way than young milch cow, give milk in early days and in
The milch cow of phase is even more serious than the cattle of dry milk phase.Primary disease is periodic epidemic, and general interval occurs the most fairly large in 3～4 years
Popular, occur the most year after year, occur more with summer, mosquito active phase in autumn, many rainy seasons that especially weather is sultry or round the clock
The weather that the temperature difference is bigger easily causes popular.This disease is popular extensively, and spread speed is fast, and sickness rate is high, big on production performance impact, leads
Cause part sick cattle paralysis and eliminated or dead because of secondary other diseases, cause serious economic loss can to morbidity cattle farm.
Cardinal symptom is sudden onset, high heat, shed tears, watery nasal discharge, rapid breathing, sialorrhea with foam, hind leg walking is dumb even
Not rising, the sick cattle of major part can recover normal, how in optimum process through the heating of 3-4 days sleepingly.In uncomplicated situation
Lower case fatality rate is generally not more than 2%～3%.But some feeding and management is improper or the morbidity cattle farm mortality rate treated in time
Higher.Such as the Bovine Ephemeral Fever of Shandong outburst autumn in 2013, the death rate in many cattle farms is more than 10%, and milk yield reduces
More than 60%, cause great economic loss to cattle farm.
The base therapy principle of this disease be antipyretic-antalgic, preventing and treating secondary infection, heart tonifying, fluid infusion, correction acid base imbalance,
Relieving asthma, oxygenating etc..Traditional Therapeutic Method is mainly by venous transfusion or intramuscular injection.Process by traditional therapy, cattle
Field needs the veterinary technician of specialty and a large amount of paraprofessional personnel.It addition, what ill cattle needed most is quiet rest, forbidding stress
Stimulate, and traditional Therapeutic Method, because for the treatment of cattle is carried out arrest, Baoding, injection can cause the fear of cattle, struggle, ouch,
Shying group thus cause serious stress, serious harm disease cattle and the health of whole cows are often made the state of an illness add further by this
Weight；And existing additive method and medicine to this disease all without good therapeutic effect, therefore need badly exploitation a kind of brand-new for
The medicine of this disease treatment.
Summary of the invention
Based on above-mentioned reason, the present inventor provides a kind of preventing and treating Bovine Ephemeral Fever compositions, said composition by
Carbasalate calcium, astragalus polysaccharides, be coated enrofloxacin, polygynax, be coated Vc composition.It is administered orally with the prescription medicine of the present invention
The treatment average cure rate of Bovine Ephemeral Fever case is up to 97%, and this prescription medicine has stable in properties, good palatability, long shelf-life etc.
Advantage.This prescription medicine can directly be drunk water or spice is taken, and has easy to use, without treating stress, need not specialty beast
The advantages such as doctor technical staff, saving manpower, can make every medical expense suffering from cattle significantly reduce, only the 1/ of traditional therapy
3, and be conducive to suffering from the recovery of cattle production performance.Preventing and treating for Bovine Ephemeral Fever provides strong material and technical guarantee, simultaneously
New thinking has been started in preventing and treating for this disease.
The concrete technical scheme of the present invention is:
The key component of preventing and treating Bovine Ephemeral Fever compositions is calculated as by weight:
Above-mentioned all ingredients belong to the conventional products in veterinary drug market, directly can buy on veterinary drug market.
Described carbasalate calcium soluble powder, have antipyretic, analgesia, antiinflammatory triple effect unification effect, be that European Union is unique
Approval is for the oral antipyretic analgesic of poultry；This medicine drinking-water or spice good absorbing, instant effect, without any untoward reaction.
Described astragalus polysaccharides is that the dry root of leguminous plant Radix Astagali or Radix Astragali is extracted, concentrate, purification and
The water solublity heteropolysaccharide become, can have the effects such as antiviral, anti-stress, antioxidation as immunopotentiating agent or regulator simultaneously；
The described enrofloxacin that is coated is animal specific fluoroquinolones, has that has a broad antifungal spectrum, bactericidal activity be strong, body
In widely distributed, the feature such as have no side effect, and has good in terms of prevention and treatment animal bacteria epidemic disease and mycoplasma infection
Good effect.But due to the bitterness of enrofloxacin self, clinical practice is extremely restricted.Of the present invention it is coated En Nuo
Sha Xing (production of Zhengzhou Fu Yuan pharmaceutcal corporation, Ltd) uses lipid microcapsule body dispersion technology, and enrofloxacin is completely enclosed in lipoid
In matter bimolecular, bitterness disappears and will not be destroyed drug effect by gastric environment and not destroy cud microecological environment, treats that medicine enters machine
After body, carrier decomposes under the effect of intestinal fat enzyme, thus discharges medicine, plays curative effect；
Described polygynax is aminoglycoside antibiotics, to intestinal such as escherichia coli, Salmonella, Proteus
Bacteriaceae antibacterial has good antibacterial action, oral after major part is the most varied discharges with feces, oral can prevent and treat Bovine Ephemeral Fever and continue
The gastroenteritis sent out；
The described Vc that is coated, also known as ascorbic acid, is a kind of extremely strong reducing agent, free-radical antagonists.There is promotion tissue
Injury repairing, reduces blood vessel and oozes out, prevent hemorrhage；Enhancing human body immunity power and anti-stress ability；Participate in various kinds of cell metabolism
Journey.So, vitamin C has the highest using value in terms of antiviral and preventing viral infectious disease.But Vc is making moist, is meeting
Instability under heat, acid, alkali or illumination, is particularly present Cu2+、Fe3+Under the conditions of plasma or ascorbic acid oxidase etc. oxidizable point
Solve.The Vc of being coated of the present invention (Anhui Tiger Biotechnology Co., Ltd.'s production) is by common vitamin C warp
Cross Crushing of Ultrafine, micro-bonding, add microcapsule, micro-technology such as be coated carries out microcapsule, micro-is coated process.Be coated Vc can high temperature resistant, wet,
Heat, mineral, acid, alkali, extruding etc., it is simple to and other medicines collocation, pass through cattle stomach and absorb at small intestinal epimere.
Carbasalate calcium soluble powder belongs to the medicine and have anti-stress effect of inducing sweat of quick acting；Astragalus polysaccharides is wide spectrum
Anti virus herb extract；Enrofloxacin cures mainly the antibacterial secondary infection of respiratory tract, and neomycin cures mainly gastral antibacterial and continues
Sending out and infect, two kinds of antibacterials have identical antibacterial action；Vc in scavenging activated oxygen, removing toxic substances and protective tissue from damage etc.
Aspect plays pivotal role.Above-mentioned 5 kinds of ingredients are in antipyretic, anti-stress, antiviral, bacteriological protection secondary infection, enhancing body
The aspects such as resistance act in accordance with the division of their functions and duties, and effect is complementary, collaborative disease-resistant, is used in mixed way without any untoward reaction.This prescription and treatment side
Method has fully demonstrated the contemporary disease treatment theory for the treatment of both the principal and secondary aspects of a disease, the combination of Chinese and Western medicine, emphasis animal welfare.
Component is optimized and repetition test by inventor, is finally obtained a kind of preventing and treating Bovine Ephemeral Fever compositions, its
Key component is calculated as by weight:
In the case of above-mentioned consumption, the therapeutic effect for Bovine Ephemeral Fever is optimal, and substantially has no side effect；
Time specifically used, can by aforementioned pharmaceutical compositions according to the consumption that a weight portion is 75mg/kg Niu Tichong by group
Compound directly stir after spice or add Direct-fed in drinking-water to.
The pharmaceutical composition of the present invention is than traditional treatment Bovine Ephemeral Fever medicine, and cure rate is higher, can reach 97% with
On, and there is not toxic and side effects, do not result in impact especially for giving milk of milch cow, in addition, due to whole combination yet
The medicine of thing is the veterinary drug raw material that China allows to use, and with low cost, whole treatment cost is only the three of traditional therapy
/ mono-less than, can be in China's popularization and application widely.
In sum, the average cure rate of the prescription medicine oral medication Niu Liuhang case of the present invention is used to be up to 97%,
There is the advantages such as stable in properties, good palatability, long shelf-life, and Integrated TCM, there is antipyretic-antalgic, antiviral, bacteriological protection
Drug effect, this prescription medicine and the oral medication methods such as secondary infection, enhancing body resistance have easy to use can directly drink water
Or spice is taken, nothing treats stress, need not professional veterinary technical staff, save the advantages such as manpower, makes every to suffer from cattle
Medical expense significantly reduces, only the 1/3 of traditional therapy, and is conducive to suffering from the recovery of cattle production performance；For Bovine Ephemeral Fever
Preventing and treating provide strong material and technical guarantee, new thinking has been started in the preventing and treating for this disease simultaneously.
Detailed description of the invention
Below by specific embodiment, the present invention is further illustrated.
Embodiment 1:
Preventing and treating Bovine Ephemeral Fever compositions, its key component is calculated as by weight:
Embodiment 2:
Preventing and treating Bovine Ephemeral Fever compositions, its key component is calculated as by weight:
Embodiment 3:
Preventing and treating Bovine Ephemeral Fever compositions, its key component is calculated as by weight:
Embodiment 4:
Preventing and treating Bovine Ephemeral Fever compositions, its key component is calculated as by weight:
Experimental example 5
Choosing three large-scale milch cow farms that Bovine Ephemeral Fever occurs and carry out contrast test, the most ill milch cow is equally divided into two
Group, one group uses traditional therapy treatment, one group of compositions using the present invention directly to drink water or spice oral medication, its
In:
Traditional therapy is:
(1) antipyretic-antalgic: intramuscular injection 30% dipyrone 30 milliliters, 1～2 times/day.
(2) for the secondary infection of prevention pulmonary, intramuscular injection penicillin 5,600,000 IU, streptomycin 3,000,000 microgram add glucose
1500 milliliters of medium-sized vein injections of saline, 2 times/day.
(3) analgesia, heart tonifying, fluid infusion, removing toxic substances.Walk lamely and paralysis cattle can intravenous injection sodium salicylate 200 milliliters, to alleviate pain
Pain and relief of symptoms；The person of having a weak heart can 40 milliliters, 50 milliliters vitamin Cs of intravenous injection caffeine and sodium benzoate and low molecular dextran
1000 milliliters.
(4) sleepingly do not rise, head and neck lateral bending person can intravenous injection 10% glucose 1500 milliliters, 5% calcium bromide 200 milliliters and
VITAMIN B15 0 milliliter；Rear quarters is stiff or hindlimb paralysis person's intramuscular injection Rhizoma Corydalis Decumbentis 40 milliliters, 2 times/day.
The compositions Therapeutic Method of the present invention is: according to suffering from Niu Tichong calculating consumption: compositions soluble powder 75mg/kg body
Weight, directly drinking-water or spice are administered orally, and 2 times/day, are used in conjunction 3～5；
Final therapeutic effect see table
Table 1 raising dairy cattle field A (breeding milk cow 160)
| Therapeutic Method | Sick cattle number (head) | Cure rate | Average cure time | Treatment cost/head |
| Oral medication | 32 | 97% (31/32) | 3.5 my god | 35.7 yuan |
| Traditional treatment | 32 | 97% (31/32) | 3.7 my god | 111.0 it is first |
Table 2 raising dairy cattle field B (breeding milk cow 210)
| Therapeutic Method | Sick cattle number (head) | Cure rate | Average cure time | Treatment cost/head |
| Oral medication | 35 | 97% (34/35) | 4 days | 40.3 yuan |
| Traditional treatment | 35 | 94% (33/35) | 3.6 | 108.4 it is first |
Table 3 raising dairy cattle field C (breeding milk cow 150)
| Therapeutic Method | Sick cattle number (head) | Cure rate | Average cure time | Treatment cost/head |
| Oral medication | 27 | 100% (27/27) | 4 days | 40.5 yuan |
| Traditional treatment | 27 | 96% (26/27) | 3.8 my god | 114.8 it is first |
The therapeutic effect of relatively 3 test cattle farms is it can be seen that the average cure rate of oral medication group of 3 cattle farms is above
97%, the average cure rate of traditional treatment group is then less than 97%, it is seen that the therapeutic effect of the present composition is controlled higher than tradition
Treatment method；
The average cure time of 3 cattle farms 3.8 days, wherein oral medication group 3.9 days, traditional treatment group 3.7 days, without substantially
Difference；
Average every sick cattle of 3 cattle farms control average 75 yuan for the treatment of cost, wherein oral medication group averagely every 38.8 yuan,
Traditional treatment group 111.1 yuan, the average expenses for medicine of traditional treatment group is 2.9 times of oral medication group, it is seen that the treatment of the present invention becomes
This detail is less than traditional therapy.It addition, oral medication group recovers the milk yield of cattle also apparently higher than traditional treatment group.
Claims (2)
1. a preventing and treating Bovine Ephemeral Fever compositions, it is characterised in that: its component is calculated as by weight:
Compositions the most according to claim 1, it is characterised in that: its component is calculated as by weight:
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| CN201410476366.6A CN104208090B (en) | 2014-09-18 | 2014-09-18 | A kind of preventing and treating Bovine Ephemeral Fever compositions |
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| CN201410476366.6A CN104208090B (en) | 2014-09-18 | 2014-09-18 | A kind of preventing and treating Bovine Ephemeral Fever compositions |
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| CN104208090B true CN104208090B (en) | 2016-08-17 |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101829285A (en) * | 2010-03-30 | 2010-09-15 | 张小栋 | Medicament formula of traditional Chinese medicine for treating bovine ephemeral fever and application method thereof |
| CN102784219A (en) * | 2012-08-01 | 2012-11-21 | 青岛绿曼生物工程有限公司 | Compound pure Chinese medicine composition for treating bovine ephemeral fever and preparation method of same |
| CN103054984A (en) * | 2011-10-21 | 2013-04-24 | 董根荣 | Chinese veterinary medicinal granules for preventing bovine epizootic fever and preparation method of granules |
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2014
- 2014-09-18 CN CN201410476366.6A patent/CN104208090B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101829285A (en) * | 2010-03-30 | 2010-09-15 | 张小栋 | Medicament formula of traditional Chinese medicine for treating bovine ephemeral fever and application method thereof |
| CN103054984A (en) * | 2011-10-21 | 2013-04-24 | 董根荣 | Chinese veterinary medicinal granules for preventing bovine epizootic fever and preparation method of granules |
| CN102784219A (en) * | 2012-08-01 | 2012-11-21 | 青岛绿曼生物工程有限公司 | Compound pure Chinese medicine composition for treating bovine ephemeral fever and preparation method of same |
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