CN104206406B - A kind of nano-emulsion insecticide and preparation method thereof - Google Patents
A kind of nano-emulsion insecticide and preparation method thereof Download PDFInfo
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- CN104206406B CN104206406B CN201410476783.0A CN201410476783A CN104206406B CN 104206406 B CN104206406 B CN 104206406B CN 201410476783 A CN201410476783 A CN 201410476783A CN 104206406 B CN104206406 B CN 104206406B
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Abstract
The invention discloses a kind of nano-emulsion insecticide, is it mainly made by the raw material of following weight ratio: cyhalothrin 1 part, pleocidin 0.1-0.5 part, matrine 0.2-0.8 part, nano titanium oxide 10-20 part, soybean oil 200-300 part, egg yolk lecithin 50-70 part, n-butanol 10-16 part, Tween 80? 0.1-0.5 part.Present invention also offers described nano-emulsion method for producing insecticide.Relative to prior art, the nano-emulsion insecticide of gained of the present invention, cost is low, and technique is simple, and very low dose just can reach stronger insecticidal effect, and the lasting period is long, low to ecosystem destruction.
Description
Technical field
The present invention relates to a kind of nano-emulsion insecticide containing plurality of active ingredients and preparation method thereof, belong to pesticide field.
Background technology
Insecticide is mainly used in the medicine preventing and treating pest and urban health insect. use that history is long-range, consumption is large, wide in variety.At twentieth century, developing rapidly of agricultural, insecticide makes farm output rise higher.But nearly all insecticide all seriously can change the ecosystem, major part is harmful, and other meeting is concentrated in food chain.We must average out in agricultural development and environment and health.Therefore, find existing excellent insecticidal effect, again research is further worth to the insecticide that the destruction of the ecosystem is minimum.
At present, existing insecticide not only insecticidal effect is not strong, and lasting medicine power is poor, but also there is the problem of the heavy damage ecosystem.
Summary of the invention
Goal of the invention: in order to overcome the deficiencies in the prior art, the invention provides a kind of nano-emulsion insecticide and preparation method thereof.
Technical scheme: for achieving the above object, the invention provides a kind of nano-emulsion insecticide, and it is mainly made by the raw material of following weight ratio:
Cyhalothrin 1 part, pleocidin 0.1-0.5 part, matrine 0.2-0.8 part, nano titanium oxide 10-20 part, soybean oil 200-300 part, egg yolk lecithin 50-70 part, n-butanol 10-16 part, Tween 80 0.1-0.5 part.
As preferably, described nano-emulsion insecticide is mainly made by the raw material of following weight ratio:
Cyhalothrin 1 part, pleocidin 0.2-0.4 part, matrine 0.4-0.6 part, nano titanium oxide 14-16 part, soybean oil 240-260 part, egg yolk lecithin 55-65 part, n-butanol 12-14 part, Tween 80 0.2-0.4 part.
Preferred as another kind, the average grain diameter of described composite nano-emulsion is 60-80nm.
Present invention also offers described nano-emulsion method for producing insecticide, it is mainly made by following steps:
(1) cyhalothrin, pleocidin, egg yolk lecithin and Tween 80, joins in soybean oil, and mixing, obtains oil-phase solution;
(2) under agitation, above-mentioned oil-phase solution is added to the water, obtains oil-water mixture;
(3) n-butanol, matrine and nano titanium oxide are added to the water dissolving, are slowly added dropwise in above-mentioned oil-water mixture, controlling oil mixing with water liquid temp is 30-40 DEG C;
(4), after dropping terminates, by ultrasonic for solution to transparent, to obtain final product.
As preferably, the ultrasonic power of described step (4) is 200-400W, and ultrasonic time is 5-15min
Beneficial effect: relative to prior art, the nano-emulsion insecticide of gained of the present invention, cost is low, and technique is simple, and very low dose just can reach stronger insecticidal effect, and the lasting period is long, low to ecosystem destruction.
Embodiment
Below in conjunction with embodiment, the present invention is further described.
Embodiment 1:
Prescription:
Cyhalothrin 1g, pleocidin 0.1g, matrine 0.2g, nano titanium oxide 10g, soybean oil 200g, egg yolk lecithin 50g, n-butanol 10g, Tween 80 0.1g.
Preparation method:
(1) cyhalothrin, pleocidin, egg yolk lecithin and Tween 80, joins in soybean oil, and mixing, obtains oil-phase solution;
(2) under agitation, above-mentioned oil-phase solution is added to the water, obtains oil-water mixture;
(3) n-butanol, matrine and nano titanium oxide are added to the water dissolving, are slowly added dropwise in above-mentioned oil-water mixture, controlling oil mixing with water liquid temp is 30 DEG C;
(4), after dropping terminates, the ultrasonic 5min of 200W, solution is transparent, to obtain final product.
The average grain diameter of gained nano-emulsion insecticide is 60nm.
Embodiment 2:
Prescription:
Cyhalothrin 1g, pleocidin 0.5g, matrine 0.8g, nano titanium oxide 20g, soybean oil 300g, egg yolk lecithin 70g, n-butanol 16g, Tween 80 0.5g.
Preparation method:
(1) cyhalothrin, pleocidin, egg yolk lecithin and Tween 80, joins in soybean oil, and mixing, obtains oil-phase solution;
(2) under agitation, above-mentioned oil-phase solution is added to the water, obtains oil-water mixture;
(3) n-butanol, matrine and nano titanium oxide are added to the water dissolving, are slowly added dropwise in above-mentioned oil-water mixture, controlling oil mixing with water liquid temp is 40 DEG C;
(4), after dropping terminates, the ultrasonic 15min of 400W, solution is transparent, to obtain final product.
The average grain diameter of gained nano-emulsion insecticide is 80nm.
Embodiment 3:
Prescription:
Cyhalothrin 1g, pleocidin 0.3g, matrine 0.5g, nano titanium oxide 15g, soybean oil 250g, egg yolk lecithin 60g, n-butanol 13g, Tween 80 0.3g.
Preparation method:
(1) cyhalothrin, pleocidin, egg yolk lecithin and Tween 80, joins in soybean oil, and mixing, obtains oil-phase solution;
(2) under agitation, above-mentioned oil-phase solution is added to the water, obtains oil-water mixture;
(3) n-butanol, matrine and nano titanium oxide are added to the water dissolving, are slowly added dropwise in above-mentioned oil-water mixture, controlling oil mixing with water liquid temp is 35 DEG C;
(4), after dropping terminates, the ultrasonic 10min of 300W, solution is transparent, to obtain final product.
The average grain diameter of gained nano-emulsion insecticide is 70nm.
Embodiment 4:
Prescription:
Cyhalothrin 1g, pleocidin 0.2g, matrine 0.4g, nano titanium oxide 14g, soybean oil 240g, egg yolk lecithin 55g, n-butanol 12g, Tween 80 0.2g.
Preparation method:
(1) cyhalothrin, pleocidin, egg yolk lecithin and Tween 80, joins in soybean oil, and mixing, obtains oil-phase solution;
(2) under agitation, above-mentioned oil-phase solution is added to the water, obtains oil-water mixture;
(3) n-butanol, matrine and nano titanium oxide are added to the water dissolving, are slowly added dropwise in above-mentioned oil-water mixture, controlling oil mixing with water liquid temp is 32 DEG C;
(4), after dropping terminates, the ultrasonic 8min of 250W, solution is transparent, to obtain final product.
The average grain diameter of gained nano-emulsion insecticide is 65nm.
Embodiment 5:
Prescription:
Cyhalothrin 1g, pleocidin 0.4g, matrine 0.6g, nano titanium oxide 16g, soybean oil 260g, egg yolk lecithin 65g, n-butanol 14g, Tween 80 0.4g.
Preparation method:
(1) cyhalothrin, pleocidin, egg yolk lecithin and Tween 80, joins in soybean oil, and mixing, obtains oil-phase solution;
(2) under agitation, above-mentioned oil-phase solution is added to the water, obtains oil-water mixture;
(3) n-butanol, matrine and nano titanium oxide are added to the water dissolving, are slowly added dropwise in above-mentioned oil-water mixture, controlling oil mixing with water liquid temp is 38 DEG C;
(4), after dropping terminates, the ultrasonic 10min of 350W, solution is transparent, to obtain final product.
The average grain diameter of gained nano-emulsion insecticide is 75nm.
The effect experiment of experimental example gained insecticide of the present invention to diamondback moth larvae the results are shown in Table 1
Test is the diamond-back moth raised in indoor continuous generation for examination worm source, and test method adopts blade infusion process;
Contrast 1 group and adopt the embodiment of the present invention 3 prescription and preparation method, the ultrasonic disperse step in removal step (3), the non-nano breast insecticide of gained;
Contrast 2 groups and adopt the embodiment of the present invention 3 prescription, change method, obtained average grain diameter is less than the nanoemulsion of 60nm;
Contrast 3 groups and adopt the embodiment of the present invention 3 prescription, change method, obtained average grain diameter is greater than the nanoemulsion of 80nm;
Drug dose is the recommended dose of pleocidin field control;
Median lethal concentration (LC
50): represent and make the lethal required drug concentration of the tested animal of half (insect) in an experiment, with mg/m
3represent.Its value is less, and show that the toxicity of medicine is larger, effect is stronger;
Lethality after medicine: refer to after drug administration after certain hour, death toll accounts for the percentage of total test number.
Table 1 gained insecticide of the present invention is to the effect experiment result of diamondback moth larvae
Note: compared with contrast 1 group, * P<0.05; With contrast 2 groups or contrast compared with in the of 3 groups, #P<0.05.
As seen from the above table, the non-nano of contrast 1 group of comparing breast insecticide, contrast 2 groups, contrast the nano-emulsion insecticide of 3 groups and the embodiment of the present invention 3,4,5 groups, median lethal concentration significantly reduces, and after medicine, after 3 days lethality and medicine, 7 days lethality also significantly improve.
But, contrast 2 groups of comparing is less than 60nm and contrasts the emulsion that 3 groups are greater than 80nm, the emulsion of the 60-80nm of gained of the present invention, and median lethal concentration significantly reduces, after medicine, after 3 days lethality and medicine, 7 days lethality also significantly improve, and show the insecticidal effect that nano-emulsion insecticide of the present invention is more excellent.
Claims (4)
1. a nano-emulsion insecticide, is characterized in that, it is mainly made by the raw material of following weight ratio:
Cyhalothrin 1 part, pleocidin 0.1-0.5 part, matrine 0.2-0.8 part, nano titanium oxide 10-20 part,
Soybean oil 200-300 part, egg yolk lecithin 50-70 part, n-butanol 10-16 part, Tween 80 0.1-0.5 part;
The average grain diameter of described nano-emulsion insecticide is 60-80nm.
2. nano-emulsion insecticide according to claim 1, is characterized in that, it is mainly made by the raw material of following weight ratio:
Cyhalothrin 1 part, pleocidin 0.2-0.4 part, matrine 0.4-0.6 part, nano titanium oxide 14-16 part,
Soybean oil 240-260 part, egg yolk lecithin 55-65 part, n-butanol 12-14 part, Tween 80 0.2-0.4 part.
3. the nano-emulsion method for producing insecticide described in any one of claim 1-2, is characterized in that, it is mainly made by following steps:
(1) cyhalothrin, pleocidin, egg yolk lecithin and Tween 80, joins in soybean oil, and mixing, obtains oil-phase solution;
(2) under agitation, above-mentioned oil-phase solution is added to the water, obtains oil-water mixture;
(3) n-butanol, matrine and nano titanium oxide are added to the water dissolving, are slowly added dropwise in above-mentioned oil-water mixture, controlling oil mixing with water liquid temp is 30-40 DEG C;
(4), after dropping terminates, by ultrasonic for solution to transparent, to obtain final product.
4. nano-emulsion method for producing insecticide according to claim 3, is characterized in that, the ultrasonic power of described step (4) is 200-400W, and ultrasonic time is 5-15min.
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| CN104206406B true CN104206406B (en) | 2016-02-10 |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101548679A (en) * | 2009-05-12 | 2009-10-07 | 沈阳药科大学 | Matrine type alkaloid microemulsion and preparation method thereof |
| CN101755820A (en) * | 2009-10-22 | 2010-06-30 | 深圳诺普信农化股份有限公司 | Pesticide suspension concentrate containing pleocidin and preparation method thereof |
| CN102669124A (en) * | 2012-05-22 | 2012-09-19 | 江苏省绿盾植保农药实验有限公司 | Biological source compound insecticide and application thereof |
| CN103563966A (en) * | 2013-11-14 | 2014-02-12 | 河南牧翔动物药业有限公司 | Lambda-cyhalothrin nanoemulsion and preparation method thereof |
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- 2014-09-17 CN CN201410476783.0A patent/CN104206406B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101548679A (en) * | 2009-05-12 | 2009-10-07 | 沈阳药科大学 | Matrine type alkaloid microemulsion and preparation method thereof |
| CN101755820A (en) * | 2009-10-22 | 2010-06-30 | 深圳诺普信农化股份有限公司 | Pesticide suspension concentrate containing pleocidin and preparation method thereof |
| CN102669124A (en) * | 2012-05-22 | 2012-09-19 | 江苏省绿盾植保农药实验有限公司 | Biological source compound insecticide and application thereof |
| CN103563966A (en) * | 2013-11-14 | 2014-02-12 | 河南牧翔动物药业有限公司 | Lambda-cyhalothrin nanoemulsion and preparation method thereof |
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