CN103461336B - A kind of pleocidin and griseofulvin composite microcapsule insecticide - Google Patents
A kind of pleocidin and griseofulvin composite microcapsule insecticide Download PDFInfo
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- CN103461336B CN103461336B CN201310445290.6A CN201310445290A CN103461336B CN 103461336 B CN103461336 B CN 103461336B CN 201310445290 A CN201310445290 A CN 201310445290A CN 103461336 B CN103461336 B CN 103461336B
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- pleocidin
- griseofulvin
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- composite microcapsule
- insecticide
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- IIUZTXTZRGLYTI-UHFFFAOYSA-N Dihydrogriseofulvin Natural products COC1CC(=O)CC(C)C11C(=O)C(C(OC)=CC(OC)=C2Cl)=C2O1 IIUZTXTZRGLYTI-UHFFFAOYSA-N 0.000 title claims abstract description 43
- UXWOXTQWVMFRSE-UHFFFAOYSA-N Griseoviridin Natural products O=C1OC(C)CC=C(C(NCC=CC=CC(O)CC(O)C2)=O)SCC1NC(=O)C1=COC2=N1 UXWOXTQWVMFRSE-UHFFFAOYSA-N 0.000 title claims abstract description 43
- DDUHZTYCFQRHIY-UHFFFAOYSA-N Negwer: 6874 Natural products COC1=CC(=O)CC(C)C11C(=O)C(C(OC)=CC(OC)=C2Cl)=C2O1 DDUHZTYCFQRHIY-UHFFFAOYSA-N 0.000 title claims abstract description 43
- 229960002867 griseofulvin Drugs 0.000 title claims abstract description 43
- DDUHZTYCFQRHIY-RBHXEPJQSA-N griseofulvin Chemical compound COC1=CC(=O)C[C@@H](C)[C@@]11C(=O)C(C(OC)=CC(OC)=C2Cl)=C2O1 DDUHZTYCFQRHIY-RBHXEPJQSA-N 0.000 title claims abstract description 43
- 239000002917 insecticide Substances 0.000 title claims abstract description 26
- 239000002131 composite material Substances 0.000 title claims abstract description 23
- 239000003094 microcapsule Substances 0.000 title claims abstract description 23
- 239000012876 carrier material Substances 0.000 claims abstract description 8
- 239000003431 cross linking reagent Substances 0.000 claims abstract description 8
- 239000008394 flocculating agent Substances 0.000 claims abstract description 8
- 239000004014 plasticizer Substances 0.000 claims abstract description 8
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 claims description 12
- DKGAVHZHDRPRBM-UHFFFAOYSA-N Tert-Butanol Chemical compound CC(C)(C)O DKGAVHZHDRPRBM-UHFFFAOYSA-N 0.000 claims description 12
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 11
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 9
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical group CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 claims description 9
- 108010010803 Gelatin Proteins 0.000 claims description 8
- 239000008273 gelatin Substances 0.000 claims description 8
- 229920000159 gelatin Polymers 0.000 claims description 8
- 235000019322 gelatine Nutrition 0.000 claims description 8
- 235000011852 gelatine desserts Nutrition 0.000 claims description 8
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical group O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims description 6
- 229910052938 sodium sulfate Inorganic materials 0.000 claims description 6
- 235000011152 sodium sulphate Nutrition 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 4
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 4
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 4
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 3
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 3
- 239000003814 drug Substances 0.000 abstract description 16
- 229940079593 drug Drugs 0.000 abstract description 9
- 230000002045 lasting effect Effects 0.000 abstract description 8
- 241000238631 Hexapoda Species 0.000 abstract description 7
- 239000008186 active pharmaceutical agent Substances 0.000 abstract description 7
- 229940088679 drug related substance Drugs 0.000 abstract description 7
- 231100000331 toxic Toxicity 0.000 abstract description 3
- 230000002588 toxic effect Effects 0.000 abstract description 3
- 241000254173 Coleoptera Species 0.000 abstract description 2
- 241001124144 Dermaptera Species 0.000 abstract description 2
- 241000255925 Diptera Species 0.000 abstract description 2
- 241000257303 Hymenoptera Species 0.000 abstract description 2
- 241000256602 Isoptera Species 0.000 abstract description 2
- 241000255777 Lepidoptera Species 0.000 abstract description 2
- 241000238814 Orthoptera Species 0.000 abstract description 2
- 241000258242 Siphonaptera Species 0.000 abstract description 2
- 241001414989 Thysanoptera Species 0.000 abstract description 2
- 230000009471 action Effects 0.000 abstract description 2
- 238000003756 stirring Methods 0.000 description 18
- 239000000725 suspension Substances 0.000 description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 12
- WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 description 10
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 9
- 230000000694 effects Effects 0.000 description 9
- 241000607479 Yersinia pestis Species 0.000 description 8
- 231100000225 lethality Toxicity 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 5
- 230000001105 regulatory effect Effects 0.000 description 5
- 241000196324 Embryophyta Species 0.000 description 4
- 239000003242 anti bacterial agent Substances 0.000 description 4
- 229940088710 antibiotic agent Drugs 0.000 description 4
- 230000000853 biopesticidal effect Effects 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- 241001465754 Metazoa Species 0.000 description 3
- 241000500437 Plutella xylostella Species 0.000 description 3
- 239000002202 Polyethylene glycol Substances 0.000 description 3
- 230000003115 biocidal effect Effects 0.000 description 3
- 230000015556 catabolic process Effects 0.000 description 3
- 238000006731 degradation reaction Methods 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 235000011187 glycerol Nutrition 0.000 description 3
- 229920001223 polyethylene glycol Polymers 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 235000010413 sodium alginate Nutrition 0.000 description 3
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 2
- 231100000111 LD50 Toxicity 0.000 description 2
- 238000012271 agricultural production Methods 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000000575 pesticide Substances 0.000 description 2
- 238000012827 research and development Methods 0.000 description 2
- 239000000661 sodium alginate Substances 0.000 description 2
- 229940005550 sodium alginate Drugs 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 244000025254 Cannabis sativa Species 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 241000244206 Nematoda Species 0.000 description 1
- 108700019146 Transgenes Proteins 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 239000003905 agrochemical Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000000035 biogenic effect Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000001647 drug administration Methods 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 230000000749 insecticidal effect Effects 0.000 description 1
- 231100000518 lethal Toxicity 0.000 description 1
- 230000001665 lethal effect Effects 0.000 description 1
- 238000004811 liquid chromatography Methods 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000003071 parasitic effect Effects 0.000 description 1
- 230000008635 plant growth Effects 0.000 description 1
- 239000005648 plant growth regulator Substances 0.000 description 1
- 231100000572 poisoning Toxicity 0.000 description 1
- 230000000607 poisoning effect Effects 0.000 description 1
- 244000144977 poultry Species 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 229930000044 secondary metabolite Natural products 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 238000009333 weeding Methods 0.000 description 1
Abstract
The invention discloses a kind of pleocidin and griseofulvin composite microcapsule insecticide, it is primarily of made by following component: 10 parts of pleocidin, 5-15 part griseofulvin, 100-200 part carrier material, 1-2 part flocculating agent, 0.5-1 part crosslinking agent, 1-2 part plasticizer.The present invention is relative to prior art, and the pleocidin of gained and griseofulvin composite microcapsule insecticide, have drug substance stable, strong drug action, the feature that the lasting period is permanent.The insect that can effectively kill comprises Lepidoptera, diptera and Thysanoptera, also has certain toxic action to the insect of coleoptera, orthoptera, Hymenoptera, Isoptera, Siphonaptera, Dermaptera and some particular types psocopteran simultaneously.
Description
Technical field
The present invention relates to a kind of biopesticide, be specifically related to a kind of pleocidin and griseofulvin composite microcapsule insecticide, be applied to agriculture field.
Background technology
The biological living of the pests such as biopesticide refers to for anti-to be cured the disease, worm, grass and metabolite thereof and transgene product, and can be made into the biogenic preparation of commodity, comprise the genetically modified plants etc. of bacterium, virus, fungi, nematode, plant, Natural Enemies of Insects, farm antibiotics, plant growth regulator and Resistant crop smothering.Biopesticide is applied to agricultural production and has semicentennial history, but develops always comparatively slow for various reasons.In recent years, people more and more note the sustainable development of agricultural production and the coordination of human and environment, particularly due to the toxic and side effect of chemical pesticide and the difficult of screening novel pesticide, enterprise and researcher is made to start notice to turn to research and development and the use of biopesticide.
Antibiotic is the secondary metabolite that microorganism produces, and for preventing and treating plant pest and weeds, is developed recently field the most rapidly.Farm antibiotics researchs and develops on the basis of the medical antibiotic development forties in 20th century, since the seventies, some have the farm antibiotics of control insect, mite, animal parasitic protozoon and worm, weeding and adjustment animal and plant growth function, continuous research and development out, expand the application of farm antibiotics.Some antibiotic medicines are insoluble drug, are difficult to absorb when entering in pest body, and it is short to kill the duration, and this just needs the principle applying Modern Pharmaceutics to design new formulation.
Summary of the invention
Goal of the invention: in order to overcome the deficiencies in the prior art, the invention provides a kind of pleocidin and griseofulvin composite microcapsule insecticide.
Technical scheme: for achieving the above object, a kind of pleocidin provided by the invention and griseofulvin composite microcapsule insecticide, it is primarily of made by following component: 10 parts of pleocidin, 5-15 part griseofulvin, 100-200 part carrier material, 1-2 part flocculating agent, 0.5-1 part crosslinking agent, 1-2 part plasticizer.
Preferably, described a kind of pleocidin and griseofulvin composite microcapsule insecticide, it is primarily of made by following component: 10 parts of pleocidin, 8-12 part griseofulvin, 140-160 part carrier material, 1.4-1.8 part flocculating agent, 0.6-0.8 part crosslinking agent, 1.2-1.6 part plasticizer.
Preferably, described carrier material is selected from one or more in gelatin, sodium alginate, shitosan and sodium carboxymethylcellulose.
Preferably, described flocculating agent is selected from one or more in ethanol, isopropyl alcohol, the tert-butyl alcohol and sodium sulphate.
Preferably, described crosslinking agent is formaldehyde.
Preferably, described plasticizer is selected from one or more in sorbierite, polyethylene glycol, propane diols and glycerine.
Above-mentioned a kind of pleocidin and griseofulvin composite microcapsule insecticide, it is made by following preparation method:
(1) carrier material is dissolved in the water, makes carrier solution;
(2) pleocidin and griseofulvin are mixed, join in above-mentioned carrier solution, stir and make suspension;
(3) flocculating agent is dissolved in the water, joins in above-mentioned suspension, stir;
(4) finally add plasticizer and crosslinking agent, stir, obtain product.
Preferably, in described step (2), the PH of suspension is 8-9.
Preferably, the mixing time in described step (3) is 0.5-1 hour, and whipping temp is 20-30 DEG C.
Beneficial effect: the present invention is relative to prior art, and the pleocidin of gained and griseofulvin composite microcapsule insecticide, to person poultry harmless, do not produce poisoning to crops, non agricultural chemical residuum, free from environmental pollution, has drug substance stable, strong drug action, the feature that the lasting period is long.The insect that can effectively kill comprises Lepidoptera, diptera and Thysanoptera, also has certain toxic action to the insect of coleoptera, orthoptera, Hymenoptera, Isoptera, Siphonaptera, Dermaptera and some particular types psocopteran simultaneously.
Embodiment
Below in conjunction with embodiment, the present invention is further described.
Number involved in prescription of the present invention is parts by weight.
Embodiment 1:
Prescription: 10 parts of pleocidin, 10 parts of griseofulvin, 150 parts of gelatin, 1.5 parts of ethanol, 0.8 part of formaldehyde, 1.5 parts of sorbierites
Above-mentioned pleocidin and griseofulvin composite microcapsule method for producing insecticide, it comprises the steps:
(1) by Gelatin in water, make carrier solution;
(2) pleocidin and griseofulvin are mixed, join in above-mentioned carrier solution, stir and make suspension, the pH regulating suspension is 8.5;
(3) ethanol is dissolved in the water, joins in above-mentioned suspension, be incubated 25 DEG C, stir 0.8 hour;
(4) finally add sorbierite and formaldehyde, stir, obtain product.
Pleocidin obtained in the present embodiment and griseofulvin composite microcapsule insecticide, drug substance stable, kill pests effect is strong, and the lasting period is permanent.
Embodiment 2:
Prescription: 10 parts of pleocidin, 5 parts of griseofulvin, 40 parts of gelatin, 60 parts of sodium alginates, 1 part of isopropyl alcohol, 0.5 part of formaldehyde, 1 part of polyethylene glycol
Above-mentioned pleocidin and griseofulvin composite microcapsule method for producing insecticide, it comprises the steps:
(1) gelatin and sodium alginate are dissolved in the water, make carrier solution;
(2) pleocidin and griseofulvin are mixed, join in above-mentioned carrier solution, stir and make suspension,
The pH regulating suspension is 8;
(3) isopropyl alcohol is dissolved in the water, joins in above-mentioned suspension, be incubated 20 DEG C, stir 0.5 hour;
(4) finally add polyethylene glycol and formaldehyde, stir, obtain product.
Pleocidin obtained in the present embodiment and griseofulvin composite microcapsule insecticide, drug substance stable, kill pests effect is strong, and the lasting period is permanent.
Embodiment 3:
Prescription: 10 parts of pleocidin, 15 parts of griseofulvin, 200 parts of shitosans, 1 part of tert-butyl alcohol, 1 part of ethanol, 1 part of formaldehyde, 2 parts of propane diols
Above-mentioned pleocidin and griseofulvin composite microcapsule method for producing insecticide, it comprises the steps:
(1) shitosan is dissolved in the water, makes carrier solution;
(2) pleocidin and griseofulvin are mixed, join in above-mentioned carrier solution, stir and make suspension, the pH regulating suspension is 9;
(3) tert-butyl alcohol and ethanol are dissolved in the water, join in above-mentioned suspension, be incubated 30 DEG C, stir 1 hour;
(4) finally add propane diols and formaldehyde, stir, obtain product.
Pleocidin obtained in the present embodiment and griseofulvin composite microcapsule insecticide, drug substance stable, kill pests effect is strong, and the lasting period is permanent.
Embodiment 4:
Prescription: 10 parts of pleocidin, 8 parts of griseofulvin, 140 parts of sodium carboxymethylcelluloses, 1.4 parts of sodium sulphate, 0.6 part of formaldehyde, 1.0 parts of propane diols, 0.2 part of glycerine
Above-mentioned pleocidin and griseofulvin composite microcapsule method for producing insecticide, it comprises the steps:
(1) sodium carboxymethylcellulose is dissolved in the water, makes carrier solution;
(2) pleocidin and griseofulvin are mixed, join in above-mentioned carrier solution, stir and make suspension, the pH regulating suspension is 8;
(3) sodium sulphate is dissolved in the water, joins in above-mentioned suspension, be incubated 30 DEG C, stir 0.5 hour;
(4) finally add propane diols, glycerine and formaldehyde, stir, obtain product.
Pleocidin obtained in the present embodiment and griseofulvin composite microcapsule insecticide, drug substance stable, kill pests effect is strong, and the lasting period is permanent.
Embodiment 5:
Prescription: 10 parts of pleocidin, 12 parts of griseofulvin, 160 parts of gelatin, 1.8 parts of sodium sulphate, 0.8 part of formaldehyde, 1.6 parts of propane diols
Above-mentioned pleocidin and griseofulvin composite microcapsule method for producing insecticide, it comprises the steps:
(1) by Gelatin in water, make carrier solution;
(2) pleocidin and griseofulvin are mixed, join in above-mentioned carrier solution, stir and make suspension, the pH regulating suspension is 9;
(3) sodium sulphate is dissolved in the water, joins in above-mentioned suspension, be incubated 20 DEG C, stir 1 hour;
(4) finally add propane diols and formaldehyde, stir, obtain product.
Pleocidin obtained in the present embodiment and griseofulvin composite microcapsule insecticide, drug substance stable, kill pests effect is strong, and the lasting period is permanent.
The effect experiment of experimental example gained insecticide of the present invention to diamondback moth larvae the results are shown in Table 1
Test is the diamond-back moth raised in indoor continuous generation for examination worm source, and test method adopts blade infusion process;
Common pleocidin supensoid agent, common griseofulvin supensoid agent, common pleocidin and griseofulvin supensoid agent all refer to formulation method routinely, add the supensoid agent made by customary adjuvant, are set to A control group, B control group and C control group respectively.
Drug dose is the recommended dose of pleocidin field control;
Median lethal concentration (LC
50): represent and make the lethal required drug concentration of the tested animal of half (insect) in an experiment, with mg/m
3represent.Its value is less, and show that the toxicity of medicine is larger, effect is stronger.
Lethality after medicine: refer to after drug administration after certain hour, death toll accounts for the percentage of total test number.
Drug degradation rate: high-temperature storage is after 3 months, and the amount of pleocidin and griseofulvin degraded accounts for the percentage of total content.Adopt the content of high effective liquid chromatography for measuring pleocidin and griseofulvin.
Table 1 gained insecticide of the present invention is to the effect experiment result of diamondback moth larvae
Note: compare with A control group, B control group and C control group, * P<0.05
As seen from the above table, C control group is compared with A control group, B control group, and after median lethal concentration, medicine, after 3 days lethality, medicine, 7 days lethality and drug degradation rate all do not have marked change.And the pleocidin of gained of the present invention and griseofulvin composite microcapsule insecticide, compared with three control groups, LC
50obvious reduction, insecticidal effect improves; After medicine, 7 days lethality after 3 days lethality and medicine, compared with three control groups, significantly improve, illustrate that the insecticide desinsection lasting period of the present invention is permanent; Medicine high-temperature storage is after 3 months, and three control groups of comparing, the degradation rate of medicine obviously reduces, and gained preparation stabilization of the present invention is described, can preserves for a long time.
The above is only the preferred embodiment of the present invention, is noted that for those skilled in the art, in scope disclosed by the invention, carries out some improvement and modification, also should be considered as protection scope of the present invention.
Claims (2)
1. a pleocidin and griseofulvin composite microcapsule insecticide, it is characterized in that, it is primarily of made by following component: 10 parts of pleocidin, 5-15 part griseofulvin, 100-200 part carrier material, 1-2 part flocculating agent, 0.5-1 part crosslinking agent, 1-2 part plasticizer;
Described carrier material is shitosan, sodium carboxymethylcellulose or gelatin;
Described flocculating agent is the tert-butyl alcohol and alcohol mixture, or is only sodium sulphate;
Described crosslinking agent is formaldehyde;
Described plasticizer is propane diols and glycerol mixture, or is only propane diols.
2. a kind of pleocidin according to claim 1 and griseofulvin composite microcapsule insecticide, is characterized in that: it is primarily of made by following component: 10 parts of pleocidin, 8-12 part griseofulvin, 140-160 part carrier material, 1.4-1.8 part flocculating agent, 0.6-0.8 part crosslinking agent, 1.2-1.6 part plasticizer.
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| CN201310445290.6A CN103461336B (en) | 2013-09-26 | 2013-09-26 | A kind of pleocidin and griseofulvin composite microcapsule insecticide |
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| CN201310445290.6A CN103461336B (en) | 2013-09-26 | 2013-09-26 | A kind of pleocidin and griseofulvin composite microcapsule insecticide |
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| CN103461336B true CN103461336B (en) | 2015-08-05 |
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2013
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|---|---|---|---|---|
| CN1170346A (en) * | 1994-12-16 | 1998-01-14 | 沃尼尔·朗伯公司 | Process for encapsulation of caplets in capsule and solid dasage forms obtainable by such process |
| CN1411727A (en) * | 2002-10-09 | 2003-04-23 | 华南农业大学 | Nimbin and antibiotic bacteriocide mixed pesticide preparation |
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| WO2010032135A2 (en) * | 2008-09-22 | 2010-03-25 | Kritikou, Christine | Spinosyn antifouling compositions, methods of use thereof and articles protected from attachment of biofouling organisms |
| CN101461358A (en) * | 2008-12-30 | 2009-06-24 | 南京师范大学 | Oil-soluble pesticide nano capsules and preparation method thereof |
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| Title |
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