CN104198468A - Biochip detector - Google Patents
Biochip detector Download PDFInfo
- Publication number
- CN104198468A CN104198468A CN201410380947.XA CN201410380947A CN104198468A CN 104198468 A CN104198468 A CN 104198468A CN 201410380947 A CN201410380947 A CN 201410380947A CN 104198468 A CN104198468 A CN 104198468A
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- China
- Prior art keywords
- ccd camera
- transmission
- biochip
- objective table
- supplies analysis
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Abstract
The invention relates to a biochip detector. The biochip detector comprises a shell, a bearing device, a transmission device, a collection device, a shading device, a control device and a heat dissipation device, wherein a partition plate is arranged in the shell; a through hole is formed in the partition plate; the partition plate is used for dividing a cavity of the shell into an upper cavity and a lower cavity; an outer side door is arranged below the front end surface of the shell; the bearing device is an objective table; the transmission device arranged at the bottom part of the lower cavity; the collection device is a CCD (Charge Coupled Device) camera; the CCD camera is fixed on the partition plate; a photosensitive port of the CCD camera is arranged above a through hole of the partition plate; an objective lens of the CCD camera is arranged right above the objective table; the shading device comprises two shading covers; the two shading covers are symmetrically mounted between the partition plate and the transmission device; the control device comprises a control circuit board; the heat dissipation device is a fan; a heat dissipation channel is formed in the position, corresponding to the fan, of the shell; a color filter is arranged above the objective lens of the CCD camera; a collection lens is arranged above the color filter.
Description
Technical field
The invention belongs to biological detection equipment technical field, relate to a kind of detector, especially a kind of biochip supplies analysis.
Background technology
Biological chip testing technology comprises protein-chip detection technique and gene chip detecting technique, in fields such as scientific research, medical and health, forensic identification, environmental monitorings, obtains applying more and more widely.
Yet current biological chip testing technology obtains testing result by detecting fluorescence signal mostly, the too busy to get away exciting light of generation due to fluorescence, must cause certainly existing parasitic light in fluorescence, and the existence of parasitic light has limited the sensitivity of fluorescence method.
Yet the appearance along with chemiluminescence, a kind of new biological chip testing technology is provided, utilize the free energy discharging in chemical reaction process to excite intermediate, make it from excited state, get back to ground state, the photon of energy level such as when getting back to ground state from excited state, intermediate can discharge, by photon is measured and carried out quantitative test.
Application number is 200520039761.4 patent of invention file, discloses a kind of biochip supplies analysis, contains following assembly:
Objective table, is positioned under object lens;
One dimension precision surface plate, is positioned at upper strata and installs on dividing plate, by CCD camera;
Shading dividing plate, is positioned at by objective table;
Dividing plate is installed on upper strata, between chip chamber and CCD chamber;
CCD power supply, is positioned at upper strata and installs on dividing plate;
Electric-controlled box, includes central control circuit;
Fan, is positioned at electric control chamber;
Fan power supply, is positioned under object lens, by electric-controlled box;
CCD camera, install on dividing plate on upper strata;
Fan, is positioned at CCD chamber;
Object lens, are assemblied in CCD camera sensitization port;
Software, is installed on computing machine.
In the technical scheme that this patent document is recorded, the photon that intermediate discharges while getting back to ground state by excited state after object lens directly by the sensitization Port detecting of CCD camera, and the photon that intermediate discharges when excited state is got back to ground state has scattering, therefore, part photon possibly cannot be arrived by the sensitization Port detecting of CCD camera, thereby affects final detection analysis result; In addition, in chemical reaction process, other light signals the photon discharging except intermediate may be produced when excited state is got back to ground state, if these light signals are arrived by the sensitization Port detecting of CCD camera, final analysis result may be affected.
Summary of the invention
The object of the invention is to, for the scattering having due to photon existing in above-mentioned prior art, possibly cannot be arrived by the sensitization Port detecting of CCD camera, and the sensitization mouth of CCD camera detects other light signals the photon discharging when excited state is got back to ground state except intermediate and affects the defect of final analysis result, provide design a kind of biochip supplies analysis, to address the above problem, thus the Detection accuracy of raising biochip.
For achieving the above object, the present invention provides following technical scheme:
A biochip supplies analysis, comprising:
-housing, is provided with dividing plate in described housing, on described dividing plate, is provided with through hole, and dividing plate is divided into upper chamber and lower chambers by the cavity in housing, and the below of housing front end face is provided with outer door,
-bogey, described bogey is objective table, for carrying biochip,
-gearing, described gearing is positioned at the bottom of lower chambers, for drive transfer objective table,
-harvester, described harvester is CCD camera, described CCD camera is fixed on dividing plate, the sensitization port of CCD camera is positioned at the top of bulkhead through-hole, the object lens of CCD camera be positioned at objective table directly over, described CCD camera is connected with CCD camera power supply adapter
-shade, described shade is two light shields, two light shield symmetries are arranged between dividing plate and gearing, for the light path between airtight objective table and CCD camera sensitization port,
-control device, described control device comprises control circuit board, in order to realize the control to biochip supplies analysis;
-heat abstractor, described heat abstractor is fan, is positioned at upper chamber, the housing position corresponding with fan is provided with heat dissipation channel;
It is characterized in that: the object lens top of CCD camera is provided with color filter, and the top of described color filter is provided with converging lenses.
Preferably, described converging lenses is convex lens; Adopt convex lens as converging lenses, guaranteeing, under the prerequisite of convergence effect, to save cost.
Preferably, described through hole is manhole.
Preferably, the consistent size of the size of described manhole and CCD camera sensitization port; Avoid CCD camera calibration to extraneous light, thereby testing result is exerted an influence.
Preferably, described gearing comprises transmission platform, motor, transmission accessory whorl and driving belt; Objective table is installed on transmission platform, transmission platform is connected with shadow shield, shadow shield coordinates with outer door, in order to airtight internal light transmission channel, the bottom surface of transmission platform is provided with groove, described groove matches with the rotating shaft of transmission accessory whorl, and transmission accessory whorl is realized transmission by the output shaft of driving belt and motor.
Preferably, a side of described transmission accessory whorl is provided with belt wheel briquetting; Be used for connecting belt and objective table and transmit power.
Preferably, described heat dissipation channel is bar shaped thermovent.
Preferably, on described bar shaped thermovent, screen pack is installed; Screen pack is installed to avoid introduced contaminants to enter in detector housing by heat dissipation channel, to keep cleaning in housing.
Beneficial effect of the present invention is:
1,, by between dividing plate and gearing, light shield being installed, the light path between airtight objective table and CCD camera sensitization port, prevents the collection of external light influence CCD camera sensitization port to the photon discharging in chemical reaction process;
2, utilize the filtering function of color filter, by the impurity photon filtering producing in chemical reaction process, thereby avoid impurity photon to affect final analysis judged result, improve Detection accuracy;
3, utilize the aggregation feature of converging lenses, converge the photon signal discharging in chemical reaction process, prevent that photon from scattering to outside the sensing range of sensitization port of CCD camera, thereby avoid the undetected situation of photon signal to occur, to improve final Detection accuracy;
In addition, design concept of the present invention is reliable, simple in structure, has application prospect very widely.
As can be seen here, the present invention compared with prior art, has outstanding substantive distinguishing features and progressive significantly, and the beneficial effect of its enforcement is also apparent.
Accompanying drawing explanation
Fig. 1 is the stereographic map of a kind of biochip supplies analysis provided by the invention.
Fig. 2 is the right view of a kind of biochip supplies analysis provided by the invention.
Fig. 3 is the left view of a kind of biochip supplies analysis provided by the invention.
Fig. 4 is the vertical view of a kind of biochip supplies analysis provided by the invention.
Fig. 5 is the front elevation of a kind of biochip supplies analysis provided by the invention.
Fig. 6 is the schematic diagram that the heat dissipation channel of a kind of biochip supplies analysis provided by the invention coordinates with screen pack.
Fig. 7 is the path channels schematic diagram of a kind of biochip supplies analysis provided by the invention.
Wherein, 1-housing, 2-dividing plate, 3-CCD camera, 4-light shield, 5-transmission platform, 6-objective table, 7-shadow shield, 8-motor, 9-driving belt, 10-outer door, 11-belt wheel briquetting, 12-heat dissipation channel, 13-CCD power supply adaptor, 14-screen pack, 15-fan, 16-object lens, 17-color filter, 18-converging lenses.
Embodiment
Below in conjunction with accompanying drawing and by specific embodiment, the present invention will be described in detail, and following examples are explanation of the invention, and the present invention is not limited to following embodiment.
As shown in Fig. 1 to 7, a kind of biochip supplies analysis provided by the invention, comprising:
-housing 1, is provided with dividing plate 2 in described housing 1, on described dividing plate 2, is provided with through hole, and dividing plate 2 is divided into upper chamber and lower chambers by the cavity in housing 1, and the below of housing 1 front end face is provided with outer door 10,
-bogey, described bogey is objective table 6, for carrying biochip,
-gearing, described gearing is positioned at the bottom of lower chambers, for drive transfer objective table,
-harvester, described harvester is CCD camera 3, described CCD camera 3 is fixed on dividing plate 2, the sensitization port of CCD camera 3 is positioned at the top of bulkhead through-hole, the object lens of CCD camera 3 be positioned at objective table 6 directly over, described CCD camera 3 is connected with CCD camera power supply adapter 13
-shade, described shade is that 4, two light shield 4 symmetries of two light shields are arranged between dividing plate 2 and gearing, for the light path between airtight objective table 6 and CCD camera 3 sensitization ports,
-control device, described control device comprises control circuit board, in order to realize the control to biochip supplies analysis;
-heat abstractor, described heat abstractor is fan 15, is positioned at upper chamber, housing 1 position corresponding with fan 15 is provided with heat dissipation channel 12;
Wherein, object lens 16 tops of CCD camera 3 are provided with color filter 17, and the top of described color filter 17 is provided with converging lenses 18.
In the present embodiment, described converging lenses 18 is convex lens; Adopt convex lens as converging lenses, guaranteeing, under the prerequisite of convergence effect, to save cost.
In the present embodiment, described through hole is manhole.
In the present embodiment, the consistent size of the size of described manhole and CCD camera sensitization port; Avoid CCD camera calibration to extraneous light, thereby testing result is exerted an influence.
In the present embodiment, described gearing comprises transmission platform 5, motor 8, transmission accessory whorl and driving belt 9; Objective table 6 is installed on transmission platform 5, transmission platform 5 is connected with shadow shield 7, shadow shield 7 coordinates with outer door 10, in order to airtight internal light transmission channel, the bottom surface of transmission platform 5 is provided with groove, described groove matches with the rotating shaft of transmission accessory whorl, and transmission accessory whorl is realized transmission by driving belt 9 and the output shaft of motor 8.
In the present embodiment, a side of described transmission accessory whorl is provided with belt wheel briquetting 11; Be used for connecting belt and objective table and transmit power.
In the present embodiment, described heat dissipation channel 12 is bar shaped thermovent.
In the present embodiment, on described bar shaped thermovent, screen pack 14 is installed; Screen pack 14 is installed to avoid introduced contaminants to enter in detector housing 1 by heat dissipation channel 12, to keep cleaning in housing 1.
Disclosed is above only the preferred embodiment of the present invention; but the present invention is not limited thereto; any those skilled in the art can think there is no a creationary variation, and some improvements and modifications of doing without departing from the principles of the present invention, all should drop in protection scope of the present invention.
Claims (8)
1. a biochip supplies analysis, comprising:
-housing, is provided with dividing plate in described housing, on described dividing plate, is provided with through hole, and dividing plate is divided into upper chamber and lower chambers by the cavity in housing, and the below of housing front end face is provided with outer door,
-bogey, described bogey is objective table, for carrying biochip,
-gearing, described gearing is positioned at the bottom of lower chambers, for drive transfer objective table,
-harvester, described harvester is CCD camera, described CCD camera is fixed on dividing plate, the sensitization port of CCD camera is positioned at the top of bulkhead through-hole, the object lens of CCD camera be positioned at objective table directly over, described CCD camera is connected with CCD camera power supply adapter
-shade, described shade is two light shields, two light shield symmetries are arranged between dividing plate and gearing, for the light path between airtight objective table and CCD camera sensitization port,
-control device, described control device comprises control circuit board, in order to realize the control to biochip supplies analysis;
-heat abstractor, described heat abstractor is fan, is positioned at upper chamber, the housing position corresponding with fan is provided with heat dissipation channel;
It is characterized in that: the object lens top of CCD camera is provided with color filter, and the top of described color filter is provided with converging lenses.
2. biochip supplies analysis according to claim 1, is characterized in that: described converging lenses is convex lens.
3. biochip supplies analysis according to claim 1 and 2, is characterized in that: described through hole is manhole.
4. biochip supplies analysis according to claim 3, is characterized in that: the consistent size of the size of described manhole and CCD camera sensitization port.
5. biochip supplies analysis according to claim 4, is characterized in that: described gearing comprises transmission platform, motor, transmission accessory whorl and driving belt; Objective table is installed on transmission platform, transmission platform is connected with shadow shield, shadow shield coordinates with outer door, in order to airtight internal light transmission channel, the bottom surface of transmission platform is provided with groove, described groove matches with the rotating shaft of transmission accessory whorl, and transmission accessory whorl is realized transmission by the output shaft of driving belt and motor.
6. biochip supplies analysis according to claim 5, is characterized in that: a side of described transmission accessory whorl is provided with belt wheel briquetting.
7. biochip supplies analysis according to claim 6, is characterized in that: described heat dissipation channel is bar shaped thermovent.
8. biochip supplies analysis according to claim 7, is characterized in that: on described bar shaped thermovent, screen pack is installed.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410380947.XA CN104198468A (en) | 2014-08-05 | 2014-08-05 | Biochip detector |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410380947.XA CN104198468A (en) | 2014-08-05 | 2014-08-05 | Biochip detector |
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| CN104198468A true CN104198468A (en) | 2014-12-10 |
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| CN201410380947.XA Pending CN104198468A (en) | 2014-08-05 | 2014-08-05 | Biochip detector |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105181700A (en) * | 2015-09-29 | 2015-12-23 | 宁波大学 | Biochip detector |
| CN105181699A (en) * | 2015-09-29 | 2015-12-23 | 宁波大学 | Onboard seaborne/vehicle-mounted terrestrial biota chip detection system |
| CN105510608A (en) * | 2015-11-25 | 2016-04-20 | 江苏三联生物工程有限公司 | Automatic biochip reading equipment |
| CN107796816A (en) * | 2017-11-22 | 2018-03-13 | 中国农业大学 | A kind of device for detecting safety of foods and method based on image recognition principle |
| CN107843577A (en) * | 2017-09-21 | 2018-03-27 | 丁利 | A kind of integrated glass prism component for surface plasmon resonance detecting system |
| WO2020224363A1 (en) * | 2019-05-06 | 2020-11-12 | 京东方科技集团股份有限公司 | Experimental apparatus for biochip |
| CN112179619A (en) * | 2020-08-28 | 2021-01-05 | 霸州市云谷电子科技有限公司 | Darkroom detection device and detection method |
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| CN1657916A (en) * | 2005-03-03 | 2005-08-24 | 华南师范大学 | Fluorescence correlation spectral detection method and device for transgenosis material |
| CN2816811Y (en) * | 2005-02-24 | 2006-09-13 | 穆海东 | Biological chip detecting instrument |
| CN201514380U (en) * | 2008-11-19 | 2010-06-23 | 苏州纳凯科技有限公司 | Device for quickly detecting protein content in liquid samples based on fluorescent technique |
| CN204028008U (en) * | 2014-08-05 | 2014-12-17 | 曲阜裕隆生物科技有限公司 | Biochip supplies analysis |
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2014
- 2014-08-05 CN CN201410380947.XA patent/CN104198468A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN2816811Y (en) * | 2005-02-24 | 2006-09-13 | 穆海东 | Biological chip detecting instrument |
| CN1657916A (en) * | 2005-03-03 | 2005-08-24 | 华南师范大学 | Fluorescence correlation spectral detection method and device for transgenosis material |
| CN201514380U (en) * | 2008-11-19 | 2010-06-23 | 苏州纳凯科技有限公司 | Device for quickly detecting protein content in liquid samples based on fluorescent technique |
| CN204028008U (en) * | 2014-08-05 | 2014-12-17 | 曲阜裕隆生物科技有限公司 | Biochip supplies analysis |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105181700A (en) * | 2015-09-29 | 2015-12-23 | 宁波大学 | Biochip detector |
| CN105181699A (en) * | 2015-09-29 | 2015-12-23 | 宁波大学 | Onboard seaborne/vehicle-mounted terrestrial biota chip detection system |
| CN105181700B (en) * | 2015-09-29 | 2018-12-07 | 浙江正力安拓生物科技有限公司 | A kind of biochip supplies analysis |
| CN105181699B (en) * | 2015-09-29 | 2019-02-22 | 浙江正力安拓生物科技有限公司 | A kind of marine/vehicle-mounted terrestrial life chip detecting system of boat-carrying |
| CN105510608A (en) * | 2015-11-25 | 2016-04-20 | 江苏三联生物工程有限公司 | Automatic biochip reading equipment |
| CN107843577A (en) * | 2017-09-21 | 2018-03-27 | 丁利 | A kind of integrated glass prism component for surface plasmon resonance detecting system |
| CN107796816A (en) * | 2017-11-22 | 2018-03-13 | 中国农业大学 | A kind of device for detecting safety of foods and method based on image recognition principle |
| WO2020224363A1 (en) * | 2019-05-06 | 2020-11-12 | 京东方科技集团股份有限公司 | Experimental apparatus for biochip |
| CN112179619A (en) * | 2020-08-28 | 2021-01-05 | 霸州市云谷电子科技有限公司 | Darkroom detection device and detection method |
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Application publication date: 20141210 |