CN104187739B - A kind of nutritional preparation and preparation method and application - Google Patents
A kind of nutritional preparation and preparation method and application Download PDFInfo
- Publication number
- CN104187739B CN104187739B CN201410466688.2A CN201410466688A CN104187739B CN 104187739 B CN104187739 B CN 104187739B CN 201410466688 A CN201410466688 A CN 201410466688A CN 104187739 B CN104187739 B CN 104187739B
- Authority
- CN
- China
- Prior art keywords
- preparation
- nutritional preparation
- nutritional
- small molecular
- edible fungi
- Prior art date
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- 239000000843 powder Substances 0.000 claims abstract description 37
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- 230000007062 hydrolysis Effects 0.000 claims abstract description 34
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
- A23L33/155—Vitamins A or D
-
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- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/18—Peptides; Protein hydrolysates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/185—Vegetable proteins
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- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
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- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/525—Isoalloxazines, e.g. riboflavins, vitamin B2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7135—Compounds containing heavy metals
- A61K31/714—Cobalamins, e.g. cyanocobalamin, i.e. vitamin B12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/01—Hydrolysed proteins; Derivatives thereof
- A61K38/011—Hydrolysed proteins; Derivatives thereof from plants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/01—Hydrolysed proteins; Derivatives thereof
- A61K38/012—Hydrolysed proteins; Derivatives thereof from animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/02—Peptides of undefined number of amino acids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
Abstract
The present invention relates to a kind of nutritional preparation and preparation method and application, this nutritional preparation is used for treating Refractory Pulmonary Infection.The nutritional preparation of the present invention is made up of the component of following weight portion: 35～45 parts of hydrolysis small molecular protein powder, 45～60 parts of edible fungi polysaccharide peptides and 0.73～1.25 part of vitamin；This nutritional preparation is prepared by mixing small molecular protein powder, edible fungi polysaccharide peptide and vitamin in proportion.The nutritional preparation of the present invention can improve the nutrition condition of Refractory Pulmonary Infection patient, can improve again the immunologic function of Refractory Pulmonary Infection patient.
Description
Technical field
The present invention relates to a kind of nutritional preparation and preparation method and application, be specifically related to one and treat the sense of intractable lung
Nutritional preparation of dye and preparation method and application.
Background technology
Pulmonary infection occupies bigger proportion in respiratory disease or infectious diseases.Due to current medical condition
Limiting, the probability that iatrogenic and secondary pulmonary infects is on the rise.Refractory Pulmonary Infection is mainly caused a disease micro-by Various Complex
Biology causes, and is difficult to the most real pathogenic microorganisms in diagnosis, uses and it has been generally acknowledged that the intractable lung of effective drug therapy
Portion infects, though lose effect through suitable time, or symptom is slightly alleviated and the most repeatedly, so causes course of disease delay, complication
Wait harmful effect more.
In recent years, antibiotic and the application of other antimicrobial agents, effectively control the development of the pulmonary infection state of an illness, but
It is that patient's drug sensitivity is gradually lowered, and Long-Time Service antibiotics has more significantly toxic and side effect.Further, since it is anti-
The problems such as raw element abuse, cause patient's multidrug resistant and extensive resistance, and patient's prolonged illness body's immunity are low.Conventional medicine
Treatment pulmonary infection delay difficulty more, causes serious challenge to treatment so that pulmonary infection medicine for treatment cycle stretch-out, treatment effect
Fruit declines, and the death rate increases.
Treatment pulmonary infection mainly uses drug therapy at present, but Western medicine easily brings side effect, and Chinese medicine onset is slow, opens
The new method sending out treatment pulmonary infection is significant.In prior art, treat Refractory Pulmonary Infection without nutritional preparation temporarily
Relevant report.
Summary of the invention
It is an object of the invention to overcome above-mentioned the deficiencies in the prior art to provide one can improve Refractory Pulmonary Infection
Nutritional Status of Patients, improve its immunologic function thus treat the nutritional preparation of Refractory Pulmonary Infection.
Corresponding to this, another object of the present invention is to provide the preparation method of above-mentioned nutritional preparation and at treatment refractory
Application in property pulmonary infection.
For achieving the above object, the technical scheme that the present invention takes is: a kind of nutritional preparation, by the component of following weight portion
Composition:
Hydrolysis small molecular protein powder 35～45 parts
Edible fungi polysaccharide peptide 45～60 parts
Vitamin 0.73～1.25 parts.
As the preferred embodiment of nutritional preparation of the present invention, described vitamin includes the component of following weight portion:
As the more preferably embodiment of nutritional preparation of the present invention, described nutritional preparation is by the component of following weight portion
Composition:
As the preferred embodiment of nutritional preparation of the present invention, described hydrolysis small molecular protein powder with soybean, corn,
Ovalbumin, wheat, more than one materials of Fish protein are that gained prepared by raw material.More excellent as nutritional preparation of the present invention
The embodiment, the preparation method of described hydrolysis small molecular protein powder is selected to be: to weigh soybean, corn, ovalbumin, wheat and fish egg
In Bai, at least one material is as raw material, adds water, sizes mixing under conditions of pH is 7.3～7.8；The slurries of gained after sizing mixing
Middle addition protease, enzymolysis 3 hours at a temperature of 45～55 DEG C；Being again heated to temperature is 110～120 DEG C, makes enzyme-deactivating；Film mistake
Filter enzyme-deactivating processes products therefrom, is concentrated in vacuo after filtrate in 120～130 DEG C of instantaneous sterilizings；Finally, it is 170 in inlet temperature
DEG C, outlet temperature be spray-dried under conditions of being 80 DEG C, prepare hydrolysis small molecular protein powder.Preparation hydrolysis small molecular protein
During powder, the protease of addition is papain, bromelain and the ficin that GB2760 allows to use
Mixture.
As the preferred embodiment of nutritional preparation of the present invention, described edible fungi polysaccharide peptide is with mushroom, Hericium erinaceus, a Ji
More than one materials in matsutake, asparagus are that gained prepared by raw material.More preferably enforcement as nutritional preparation of the present invention
Mode, the preparation method of described edible fungi polysaccharide peptide is: weigh at least one material in mushroom, Hericium erinaceus, Agricus blazei, asparagus
As raw material, add water, after dissolving, use membrane filtration, temperature be 60～85 DEG C, vacuum be-0.06～-0.08Mpa condition
Under filtrate is concentrated in vacuo；Finally, inlet temperature be 180 DEG C, outlet temperature be 90 DEG C under conditions of be spray-dried, prepare
Edible fungi polysaccharide peptide.
In the above-mentioned nutritional preparation of the present invention, described niacinamide is Cobastab3, described folic acid is Cobastab9, institute
State pantothenic acid and be Cobastab5.In the nutritional preparation of the present invention, effect of each component is:
Hydrolysis small molecular protein powder: small protein, rich in essential amino acid, is the weight of human body protein nutrition
Want composition；Meanwhile, small protein can be absorbed by human body intestinal canal rapidly, supplements body nutrition, thus improves rapidly body
Immunologic function also improves the nutrition condition of Refractory Pulmonary Infection patient.
Edible fungi polysaccharide peptide: can strengthen T cell, B cell, K cell, NK cell and the activity of mononuclear macrophage, improves
Immunity of organisms.
Vitamin: supplement trace element necessary to human body, reduces the impact lacking trace element to person rehabilitation.
The preparation method of above-mentioned nutritional preparation that the present invention provides is: mixing small molecular protein powder, edible mushroom are many in proportion
Glycopeptide and vitamin, prepare described nutritional preparation；Wherein, hydrolysis small molecular protein powder is 35～45 weight portions, edible fungi polysaccharide
Peptide is 45～60 weight portions, and vitamin is 0.73～1.25 weight portions.Certainly, we can be by hydrolysis small molecular protein powder, food
Putting in proportion in water with granulose peptide and vitamin, canned after being completely dissolved, sterilization treatment prepares liquid state nutritional preparation.
Additionally, present invention also offers the application in treatment Refractory Pulmonary Infection of the described nutritional preparation.As this
The preferred embodiment of bright described nutritional preparation application in treatment Refractory Pulmonary Infection, described nutritional preparation can improve
The nutrition condition of Refractory Pulmonary Infection patient, can improve again the immunologic function of Refractory Pulmonary Infection patient.
The invention have the benefit that the nutritional preparation of the present invention can improve the nutrition shape of Refractory Pulmonary Infection patient
Condition.Most Refractory Pulmonary Infection patients, have digestion and absorption function obstacle, are usually in malnutrition, and now nutrition is propped up
It is necessary for holding.Small protein in the nutritional preparation of the present invention, rich in essential amino acid, is human body protein battalion
The important component supported；Meanwhile, small protein can be absorbed by human body intestinal canal rapidly, supplements body nutrition, thus carries rapidly
High immunity of organisms also improves the nutrition condition of Refractory Pulmonary Infection patient.
The nutritional preparation of the present invention also can improve the immunologic function of Refractory Pulmonary Infection patient.Refractory Pulmonary Infection master
To be caused by Various Complex pathogenic microorganisms, to add the problems such as abuse of antibiotics, cause multidrug resistant and extensive resistance, and patient
Prolonged illness body's immunity is low.Conventional drug therapy delay difficulty more, causes serious challenge to treatment so that pulmonary infection
Medicine for treatment cycle stretch-out, result for the treatment of declines, and the death rate increases.Thus, the supportive treatment that has additional nutrients is necessary, and nutrition is propped up
Hold and can improve body malnutrition, and body's immunity can be improved rapidly, strengthen Immune Organs of Body and immunity is thin
Born of the same parents (such as: T, B, K, NK, MNP etc.) get rid of antigenicity foreign matter, swallow and eliminate all kinds of pathogen microorganism and body
Aging death cell and the ability of tumour cell, moreover it is possible to maintain body's immunity balance, play anti-infectious function.Therefore, change
Kind nutrition condition, to improving Refractory Pulmonary Infection cure rate, shortens treatment time, reduces the death rate and has great importance.
The nutritional preparation of the present invention can elevator body immunity function rapidly, play anti-infectious function, improve and cure cough,
Expectoration, have difficulty in breathing, the pulmonary infection symptom such as heating；Described nutritional preparation not only coordinates the intractable lung of routine medication to feel
Dye effect is notable, is used alone treatment pulmonary infection and also obtains promising result.
Accompanying drawing explanation
Fig. 1 is the preparation technology flow chart of hydrolysis small molecular protein powder of the present invention；
Fig. 2 is the preparation technology flow chart of edible fungi polysaccharide peptide of the present invention.
Detailed description of the invention
In order to the object, technical solutions and advantages of the present invention are better described, below in conjunction with specific embodiment to the present invention
It is described further.
In embodiment, the water used in the process of preparation hydrolysis small molecular protein powder, edible fungi polysaccharide peptide is industrial water；
During preparation hydrolysis small molecular protein powder, the protease of addition is papain, the bromelain that GB2760 allows to use
Enzyme and the mixture of ficin, and the quality of papain, bromelain and ficin in mixture
Ratio is 1:1:1.Certainly, papain, bromelain are not limited to 1:1:1 with the mass ratio of ficin, can basis
It is actually needed and selects.
In embodiment, the preparation technology flow process of hydrolysis small molecular protein powder is as shown in Figure 1；The preparation work of edible fungi polysaccharide peptide
Process flow is as shown in Figure 2.
Embodiment 1
A kind of embodiment of nutritional preparation of the present invention, nutritional preparation described in the present embodiment is by the component group of following weight portion
Become:
In above-mentioned nutritional preparation, the preparation method of hydrolysis small molecular protein powder is: weigh soybean as raw material, in soybean
Add industrial water, size mixing under conditions of pH is 7.3；The slurries of gained add after sizing mixing protease, in 55 DEG C of temperature
Lower enzymolysis 3 hours；Being again heated to temperature is 115 DEG C, makes enzyme-deactivating；Membrane filtration enzyme-deactivating processes products therefrom, and filter is concentrated in vacuo
In 125 DEG C of instantaneous sterilizings after liquid；Finally, inlet temperature be 170 DEG C, outlet temperature be 80 DEG C under conditions of to carry out spraying dry
Dry, prepare hydrolysis small molecular protein powder.
In above-mentioned nutritional preparation, the preparation method of edible fungi polysaccharide peptide is: weigh mushroom as raw material, adds in mushroom
Industrial water, uses membrane filtration after dissolving, temperature be 60 DEG C, vacuum for-0.08Mpa under the conditions of filtrate is concentrated in vacuo；?
After, inlet temperature be 180 DEG C, outlet temperature be 90 DEG C under conditions of be spray-dried, prepare edible fungi polysaccharide peptide.
The preparation method of the nutritional preparation of the present embodiment is: prepares hydrolysis small molecular protein powder according to the method described above, eat
After granulose peptide, by 40 parts of hydrolysis small molecular protein powder, 55 parts of edible fungi polysaccharide peptides, 0.8 part of vitamin A, 0.01 part of vitamin
E, 0.12 part of vitamin C, 0.001 part of Cobastab1, 0.001 part of Cobastab2, 0.016 part of niacinamide, 0.001 part of Cobastab6、
0.00045 part of folic acid, 0.000003 part of Cobastab12, 0.0047 part of pantothenic acid mix, can be prepared by nutritional preparation；Wherein,
Described part all represents weight portion.
Embodiment 2
A kind of embodiment of nutritional preparation of the present invention, nutritional preparation described in the present embodiment is by the component group of following weight portion
Become:
In above-mentioned nutritional preparation, the preparation method of hydrolysis small molecular protein powder is: weigh corn and little by the mass ratio of 1:1
Wheat, as raw material, adds industrial water in corn and wheat, sizes mixing under conditions of pH is 7.8；The slurry of gained after sizing mixing
Liquid adds protease, enzymolysis 3 hours at a temperature of 50 DEG C；Being again heated to temperature is 110 DEG C, makes enzyme-deactivating；Membrane filtration enzyme goes out
Live and process products therefrom, be concentrated in vacuo after filtrate in 120 DEG C of instantaneous sterilizings；Finally, it is 170 DEG C, outlet temperature in inlet temperature
It is spray-dried under conditions of being 80 DEG C, prepares hydrolysis small molecular protein powder.
In above-mentioned nutritional preparation, the preparation method of edible fungi polysaccharide peptide is: weigh Hericium erinaceus as raw material, in Hericium erinaceus
Add industrial water, after dissolving, use membrane filtration, temperature be 70 DEG C, vacuum for-0.07Mpa under the conditions of filter is concentrated in vacuo
Liquid；Finally, inlet temperature be 180 DEG C, outlet temperature be 90 DEG C under conditions of be spray-dried, prepare edible fungi polysaccharide
Peptide.
The preparation method of the nutritional preparation of the present embodiment is: prepares hydrolysis small molecular protein powder according to the method described above, eat
After granulose peptide, by 35 parts of hydrolysis small molecular protein powder, 60 parts of edible fungi polysaccharide peptides, 0.6 part of vitamin A, 0.008 part of vitamin
E, 0.1 part of vitamin C, 0.0008 part of Cobastab1, 0.0008 part of Cobastab2, 0.012 part of niacinamide, 0.0008 part of vitamin
B6, 0.0003 part of folic acid, 0.000001 part of Cobastab12, 0.003 part of pantothenic acid mix, can be prepared by nutritional preparation；Wherein,
Described part all represents weight portion.
Embodiment 3
A kind of embodiment of nutritional preparation of the present invention, nutritional preparation described in the present embodiment is by the component group of following weight portion
Become:
In above-mentioned nutritional preparation, the preparation method of hydrolysis small molecular protein powder is: weigh ovalbumin as raw material, to ovum
Albumin adds industrial water, sizes mixing under conditions of pH is 7.5；The slurries of gained add after sizing mixing protease, in
Enzymolysis 3 hours at a temperature of 45 DEG C；Being again heated to temperature is 120 DEG C, makes enzyme-deactivating；Membrane filtration enzyme-deactivating processes products therefrom, very
In 130 DEG C of instantaneous sterilizings after empty concentrated filtrate；Finally, inlet temperature be 170 DEG C, outlet temperature be 80 DEG C under conditions of carry out
It is spray-dried, prepares hydrolysis small molecular protein powder.
In above-mentioned nutritional preparation, the preparation method of edible fungi polysaccharide peptide is: weigh Agricus blazei as raw material, in Agricus blazei
Add industrial water, after dissolving, use membrane filtration, temperature be 75 DEG C, vacuum for-0.07Mpa under the conditions of filter is concentrated in vacuo
Liquid；Finally, inlet temperature be 180 DEG C, outlet temperature be 90 DEG C under conditions of be spray-dried, prepare edible fungi polysaccharide
Peptide.
The preparation method of the nutritional preparation of the present embodiment is: prepares hydrolysis small molecular protein powder according to the method described above, eat
After granulose peptide, by 45 parts of hydrolysis small molecular protein powder, 52 parts of edible fungi polysaccharide peptides, 0.6 part of vitamin A, 0.012 part of vitamin
E, 0.14 part of vitamin C, 0.0015 part of Cobastab1, 0.0015 part of Cobastab2, 0.02 part of niacinamide, 0.0016 part of vitamin
B6, 0.0003 part of folic acid, 0.000001 part of Cobastab12, 0.005 part of pantothenic acid mix, can be prepared by nutritional preparation；Wherein,
Described part all represents weight portion.
Embodiment 4
A kind of embodiment of nutritional preparation of the present invention, nutritional preparation described in the present embodiment is by the component group of following weight portion
Become:
In above-mentioned nutritional preparation, the preparation method of hydrolysis small molecular protein powder is: weigh Fish protein as raw material, to fish egg
Add industrial water in white, size mixing under conditions of pH is 7.5；The slurries of gained add after sizing mixing protease, in 50 DEG C
At a temperature of enzymolysis 3 hours；Being again heated to temperature is 115 DEG C, makes enzyme-deactivating；Membrane filtration enzyme-deactivating processes products therefrom, and vacuum is dense
In 125 DEG C of instantaneous sterilizings after contracting filtrate；Finally, inlet temperature be 170 DEG C, outlet temperature be 80 DEG C under conditions of spray
It is dried, prepares hydrolysis small molecular protein powder.
In above-mentioned nutritional preparation, the preparation method of edible fungi polysaccharide peptide is: weigh asparagus as raw material, in asparagus
Add industrial water, after dissolving, use membrane filtration, temperature be 85 DEG C, vacuum for-0.06Mpa under the conditions of filter is concentrated in vacuo
Liquid；Finally, inlet temperature be 180 DEG C, outlet temperature be 90 DEG C under conditions of be spray-dried, prepare edible fungi polysaccharide
Peptide.
The preparation method of the nutritional preparation of the present embodiment is: prepares hydrolysis small molecular protein powder according to the method described above, eat
After granulose peptide, by 45 parts of hydrolysis small molecular protein powder, 45 parts of edible fungi polysaccharide peptides, 1 part of vitamin A, 0.016 part of vitamin E,
0.19 part of vitamin C, 0.0022 part of Cobastab1, 0.0022 part of Cobastab2, 0.028 part of niacinamide, 0.0025 part of vitamin
B6, 0.00055 part of folic acid, 0.000005 part of Cobastab12, 0.007 part of pantothenic acid mix, can be prepared by nutritional preparation；Its
In, described part all represents weight portion.
Embodiment 5
The using method of the nutritional preparation of the present invention is: oral, once a day, and each 2 bags (nutritional preparation every bag 15g).
The nutritional preparation of the present invention not only can improve the nutrition condition of Refractory Pulmonary Infection patient, moreover it is possible to improves the sense of intractable lung
The immunologic function of dye patient, can be used for treating Refractory Pulmonary Infection.
In order to the nutritional preparation of present invention effect in treatment Refractory Pulmonary Infection is better described, we are by this
Bright nutritional preparation and conventional antimicrobial medicine are respectively used to treatment delay difficulty patients with pulmonary infection more, observe its curative effect simultaneously；
The conventional antimicrobial medicine that we select is the two kinds of antibiotic being usually used in pulmonary infection: lavo-ofloxacin sodium chloride injection (can
Pleasure must be appropriate) and cefmetazole sodium injection (knowing smooth), the usage and dosage of lavo-ofloxacin sodium chloride injection (Cravit) is:
Intravenous injection every day once, each 0.6g (0.6g qd drip)；The usage and dosage of cefmetazole sodium injection (knowing smooth) is:
0.9% salt solution 100ml+ knows quiet of smooth 2g, and every day, 2 times (0.9%NS100ml+ knows smooth 2g iv drip bid, and (NS represented chlorination
Sodium injection))；The usage and dosage of nutritional preparation is: oral, once a day, and each 30g (30g qd po)；Use above-mentioned medicine
The efficacy result of thing/nutritional preparation is respectively as shown in table 1, table 2.
Table 1
In table 1, patient's totally 60 example, the antibacterials of selection are lavo-ofloxacin sodium chloride injection (Cravit), this
The specification of parenteral solution is: lavo-ofloxacin sodium chloride injection (Cravit) 100ml, 0.3g/ prop up (i.e. every 100ml parenteral solution
In containing 0.3g lavo-ofloxacin).Use Cravit treat the patient for the treatment of, the patient of Cravit and nutritional preparation treatment,
It is used alone each 20 examples of patient of nutritional preparation treatment, accounts for 33.% (i.e. constituting ratio is 33.3%) of total patient respectively.
Table 2
In table 2, patient's totally 60 example, the antibacterials of selection are cefmetazole sodium injection (knowing smooth) (1g/ bottle).Use is known
The patient of smooth treatment, know smooth patient with nutritional preparation treatment, be used alone each 20 examples of patient that nutritional preparation is treated, account for respectively
33.% (i.e. constituting ratio is 33.3%) of total patient.
From table 1, table 2 result, with the cure rate that lavo-ofloxacin sodium chloride injection (Cravit) is treated it is
25%, the cure rate treated with cefmetazole sodium injection (know smooth) is for 30%；Control with nutritional preparation with above two antibiotic
Treat or individually with the cure rate equal 100% of nutritional preparation treatment, with the use of or to be used alone the cure rate of nutritional preparation bright
Aobvious higher than being used alone antibacterials.On treatment time, Cravit, know smooth monotherapy and be both needed to more than 15 days, coordinate battalion
Supporting preparation or be used alone nutritional preparation treatment, within average 3-7 days, can improving or fully recover, treatment time is substantially than independent antimicrobial
Thing treatment time shortens.In result for the treatment of, coordinate nutritional preparation or be used alone nutritional preparation treatment be superior to be used alone
Antibiotic.As can be seen here, nutritional preparation treatment Refractory Pulmonary Infection effect is notable, not only improves patient's cure rate, improves machine
Body nutrition, immunity, and shorten healing time, and alleviate patient economy burden.Therefore, this nutritional preparation be a kind of green,
Safe and effective nutritional preparation.
Last institute is it should be noted that, the present invention is only protected by above example in order to technical scheme to be described
Protecting the restriction of scope, although being explained in detail the present invention with reference to preferred embodiment, those of ordinary skill in the art should
Understand, technical scheme can be modified or equivalent, without deviating from the essence of technical solution of the present invention
And scope.
Claims (7)
1. a nutritional preparation, it is characterised in that: described nutritional preparation is made up of the component of following weight portion:
Hydrolysis small molecular protein powder 35～45 parts
Edible fungi polysaccharide peptide 45～60 parts
Vitamin 0.73～1.25 parts；
Wherein, described hydrolysis small molecular protein powder is with at least one material in soybean, corn, ovalbumin, wheat as raw material
Prepare gained；Described edible fungi polysaccharide peptide prepares institute with more than one materials in Hericium erinaceus, Agricus blazei, asparagus for raw material
?.
2. nutritional preparation as claimed in claim 1, it is characterised in that: described vitamin includes the component of following weight portion:
3. nutritional preparation as claimed in claim 2, it is characterised in that: described nutritional preparation is by the component group of following weight portion
Become:
4. nutritional preparation as claimed in claim 1, it is characterised in that: the preparation method of described hydrolysis small molecular protein powder is:
Weigh at least one material in soybean, corn, ovalbumin, wheat and, as raw material, add water, in the condition that pH is 7.3～7.8
Under size mixing；The slurries of gained add after sizing mixing protease, enzymolysis 3 hours at a temperature of 45～55 DEG C；It is again heated to temperature
It is 110～120 DEG C, makes enzyme-deactivating；Membrane filtration enzyme-deactivating processes products therefrom, instantaneous in 120～130 DEG C after filtrate is concentrated in vacuo
Sterilizing；Finally, inlet temperature be 170 DEG C, outlet temperature be 80 DEG C under conditions of be spray-dried, prepare and hydrolyze little molecule
Albumen powder.
5. nutritional preparation as claimed in claim 1, it is characterised in that: the preparation method of described edible fungi polysaccharide peptide is: weigh
In Hericium erinaceus, Agricus blazei, asparagus, at least one material is as raw material, adds water, uses membrane filtration, be 60 in temperature after dissolving
～85 DEG C, vacuum is for being concentrated in vacuo filtrate under the conditions of-0.06～-0.08Mpa；Finally, it is 180 DEG C in inlet temperature, exports
Temperature is spray-dried under conditions of being 90 DEG C, prepares edible fungi polysaccharide peptide.
6. the preparation method of a nutritional preparation as claimed in claim 1, it is characterised in that: the preparation method of described nutritional preparation
For: mixed hydrolysis small molecular protein powder, edible fungi polysaccharide peptide and vitamin in proportion, prepare described nutritional preparation；Wherein, hydrolysis
Small molecular protein powder is 35～45 weight portions, and edible fungi polysaccharide peptide is 45～60 weight portions, and vitamin is 0.73～1.25 weight
Part.
7. a nutritional preparation as claimed in claim 1 is preparation answering in the health food treating Refractory Pulmonary Infection
With.
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