CN104173223A - Medical toothpaste containing long pepper oil and long pepper ethanol extract at the same time - Google Patents
Medical toothpaste containing long pepper oil and long pepper ethanol extract at the same time Download PDFInfo
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- CN104173223A CN104173223A CN201310213725.4A CN201310213725A CN104173223A CN 104173223 A CN104173223 A CN 104173223A CN 201310213725 A CN201310213725 A CN 201310213725A CN 104173223 A CN104173223 A CN 104173223A
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- fructus piperis
- piperis longi
- long pepper
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Abstract
A medical toothpaste containing long pepper oil and long pepper ethanol extract is characterized by comprising long pepper oil and long pepper ethanol extract at the same time, and other commonly used raw materials for toothpaste. The toothpaste comprises the following raw materials by weight: 5.0-10.0% of a long pepper ethanol extract, 2.5-5.0% of long pepper oil obtained by steam distillation, 20-50% of a friction agent, 10-20% of a humectant, 0.5-2.5% of a binder, 0.3-3.0% of a foaming agent, 0.1-0.3% of a sweetener, 0.1-0.5% of a preservative, 0.1-0.5% of an auxiliary agent, 0.8-2% of an essence and the balance of deionized water. The invention has the advantages that two different extraction processes are employed to obtain different effective components, long pepper oil obtained by steam distillation and long pepper ethanol extract, which are also added to the toothpaste at the same time, so that the toothpaste has comprehensive effects of preventing dental caries and reliving pain, and the utilization rate of effective components of long pepper is higher.
Description
Technical field
The present invention relates to a kind of medicated toothpaste that simultaneously contains Fructus Piperis Longi oil and Fructus Piperis Longi alcohol-extracted extract, Fructus Piperis Longi oil and Fructus Piperis Longi alcohol-extracted extract are the different effective ingredient that obtain by two kinds of different extraction processes by Fructus Piperis Longi Fruit, and the two adds simultaneously and in toothpaste, has good anti-caries effect.
Background technology
In toothpaste, applying some effect Chinese herbal medicine and can prevent oral health issue, is also that the one of current Chinese medicine in article of everyday use effectively applied.Fructus Piperis Longi is powerful statement in pharmacopeia, but the application in oral cavity, and the application of the different chemical composition of especially different extraction processes in oral cavity also do not have at present.
Compendium of Material Medica: " Fructus Piperis Longi, is headache, nasal sinusitis, toothache key medicine, gets it and hotly can enter the loose superficial heat of Yangming Channel also.”
" book on Chinese herbal medicine is just read ": " taste class Fructus Piperis, enters stomach and large intestine for Fructus Piperis Longi, the large heat of great Xin, and positive bright medicine also.Warming spleen and stomach for dispelling cold, broken stagnant gas, relieving stagnation, therapeutic method to keep the adverse QI flowing downwards expectorant, the superficial heat of the part of the body cavity above the diaphragm housing the heart and lungs that can fall apart again, the diseases such as all toothache, wind syndrome of head, acid regurgitation, belong to the bright wet fiery person of sun, all can be with this to control it.”
Summary of the invention
Object of the present invention is just to provide a kind of medicated toothpaste containing Fructus Piperis Longi oil and Fructus Piperis Longi alcohol-extracted extract simultaneously, Fructus Piperis Longi has warming spleen and stomach for dispelling cold, preventing decayed tooth analgesic effect, but the different extraction processes of Fructus Piperis Longi obtain different chemical compositions, the effect difference of heterogeneity in oral cavity, the present invention uses the extract of two kinds of different extraction processes to carry out composite usage in toothpaste Fructus Piperis Longi, reaches analgesia and antiulcer effect.Two kinds of different extraction processes are respectively the Fructus Piperis Longi oil after Fructus Piperis Longi ethanol extraction extractum and Fructus Piperis Longi steam distillation.Alcohol-extracted extract is mainly 4-10% piperine containing effective ingredient, is a kind of effects on neural system medicine, has powerful analgesic activity, the Fructus Piperis Longi oil after Fructus Piperis Longi steam distillation, and main component is terpene compound and long chain alkane compound, has antiulcer effect.The two is each powerful in toothpaste, by it the two different amounts in toothpaste composite, carry out many experiments, verified that its two composite effect is better than independent use.Advantage of the present invention is: utilize two kinds of different extraction processes to obtain different Fructus Piperis Longi extracts, Fructus Piperis Longi oil and roots of grass Bi extractum are different efficacies composition, and combination is added into after toothpaste, and more comprehensively, Fructus Piperis Longi utilization rate of active components is higher for anti-caries analgesic effect.
Fructus Piperis Longi oil and Fructus Piperis Longi alcohol-extracted extract are applied representative experimental data and are in toothpaste: by Fructus Piperis Longi alcohol-extracted extract, Fructus Piperis Longi oil, Fructus Piperis Longi alcohol-extracted extract and Fructus Piperis Longi oil compound three carry out respectively bacteriostatic experiment, carry out liquid processes bacteriostatic test with oral cavity dental caries Main Pathogenic Bacteria-Streptococcus mutans and observe its effect (indirectly showing anti-caries effect), concrete data are in table 1, the visible Fructus Piperis Longi alcohol-extracted extract of result minimum bactericidal concentration is 5.0%, Fructus Piperis Longi oil minimum bactericidal concentration is 2.5%, the two is mixed into compound in 1: 1 ratio and adds, in the obviously a small amount of growth of the just visible antibacterial of very low concentration 1.25%, minimum bactericidal concentration is 5.0%, visible the two complex role better effects if, in oral mucosa, to help osmosis relevant to the terpene compound in Fructus Piperis Longi oil for this.
Table 1 three bacteriostasis result
Note: " +++ " represents obviously growth, "+" represents growth on a small quantity, " 0 " represents that getting culture fluid inoculates rear asepsis growth
Based on the preliminary conclusion of table 1, by Fructus Piperis Longi alcohol-extracted extract, the two different amounts of Fructus Piperis Longi oil are added in toothpaste simultaneously, carried out the full orthogonal experiment of two factor four levels with toothpaste finished product, experiment adopts toothpaste aqueous solution centrifuging and taking filtrate to carry out toothpaste fluid inhibition zone Experimental Comparison effect, and experimental bacteria still adopts Streptococcus mutans.As table 2 visible result.
The comparison of table 2 antibacterial circle diameter effect
Toothpaste of the present invention is except Fructus Piperis Longi oil and Fructus Piperis Longi alcohol-extracted extract, and other raw materials are the conventional raw material of tooth paste product and ratio.It is achieved in that it is made up of the raw material of following percetage by weight: Fructus Piperis Longi ethanol extraction extractum: 5.0～10.0%, the Fructus Piperis Longi oil after Fructus Piperis Longi steam distillation: 2.5～5.0%, and abrasive 20～50%, wetting agent 10～20%, binding agent 0.5～2.5%, foaming agent 0.3～3.0%, sweeting agent 0.1～0.3%, antiseptic 0.1～0.5%, auxiliary agent 0.1～0.5%, essence 0.8～2.0%, deionized water surplus.
Fructus Piperis Longi ethanol extraction extractum of the present invention is: Fructus Piperis Longi dry fruit is crushed to 40 orders, adds 75% ethanol of specific factor to return to heat up in a steamer and extract after 1-2 hour, after filtrate merges, evaporation is removed ethanol and is condensed into extractum.
Fructus Piperis Longi oil of the present invention is: Fructus Piperis Longi dry fruit is crushed to 40 orders, adds the distilled water of specific factor to distill after 1-2 hour, ethereal oil is distillated in the lump with steam, collect distillate after condensation, separatory is removed moisture and obtained.
Other described raw materials of this discovery are the conventional raw material of tooth paste product and ratio.
Detailed description of the invention
Embodiment 1:
A kind of when being formed by following percetage by weight raw material containing the medicated toothpaste of Fructus Piperis Longi oil and Fructus Piperis Longi alcohol-extracted extract:
Fructus Piperis Longi alcohol-extracted extract 5, Fructus Piperis Longi oil 2.5, calcite 45, silicon dioxide 3, PEG400 3, sorbitol 15, sodium carboxymethyl cellulose 1.0, glucide 0.2, essence 0.8, sodium lauryl sulphate 2.0, tetrasodium pyrophosphate 0.5, deionized water surplus.
Embodiment 2:
A kind of when being formed by following percetage by weight raw material containing the medicated toothpaste of Fructus Piperis Longi oil and Fructus Piperis Longi alcohol-extracted extract:
Fructus Piperis Longi alcohol-extracted extract 5, Fructus Piperis Longi oil 2.5, calcite 35, aluminium hydroxide 5, glycerol 5, sorbitol 15, xanthan gum 1.0, glucide 0.2, essence 0.8, sodium lauryl sulphate 2.0, deionized water surplus.
Embodiment 3:
A kind of when being formed by following percetage by weight raw material containing the medicated toothpaste of Fructus Piperis Longi oil and Fructus Piperis Longi alcohol-extracted extract:
Fructus Piperis Longi alcohol-extracted extract 8, Fructus Piperis Longi oil 2.5, silicon dioxide 20, glycerol 3, sorbitol 15, sodium carboxymethyl cellulose 1.0, glucide 0.2, essence 0.8, sodium lauryl sulphate 2.0, tetrasodium pyrophosphate 0.3, deionized water surplus.
Embodiment 4:
A kind of when being formed by following percetage by weight raw material containing the medicated toothpaste of Fructus Piperis Longi oil and Fructus Piperis Longi alcohol-extracted extract:
Fructus Piperis Longi alcohol-extracted extract 8.0, Fructus Piperis Longi oil 2.5, calcite 50, silica 1 .5, glycerol 15, Polyethylene Glycol 3, sodium carboxymethyl cellulose 1.0, glucide 0.2, essence 0.8, sodium lauryl sulphate 2.0, deionized water surplus.
Claims (1)
1. one kind contains the medicated toothpaste of Fructus Piperis Longi oil and alcohol-extracted extract simultaneously, it is characterized in that: the Fructus Piperis Longi oil and the ethanol extraction Fructus Piperis Longi extractum that in toothpaste, contain steam distillation simultaneously, in toothpaste, other raw materials are the conventional raw material of toothpaste and ratio, toothpaste is made up of the raw material of following percetage by weight: Fructus Piperis Longi ethanol extraction extractum: 5.0～10.0%, Fructus Piperis Longi oil after Fructus Piperis Longi steam distillation: 2.5～5.0%, abrasive 20～50%, wetting agent 10～20%, binding agent 0.5～2.5%, foaming agent 0.3～3.0%, sweeting agent 0.1～0.3%, antiseptic 0.1～0.5%, auxiliary agent 0.1～0.5%, essence 0.8～2.0%, deionized water surplus.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201310213725.4A CN104173223A (en) | 2013-05-28 | 2013-05-28 | Medical toothpaste containing long pepper oil and long pepper ethanol extract at the same time |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201310213725.4A CN104173223A (en) | 2013-05-28 | 2013-05-28 | Medical toothpaste containing long pepper oil and long pepper ethanol extract at the same time |
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| CN104173223A true CN104173223A (en) | 2014-12-03 |
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| CN201310213725.4A Pending CN104173223A (en) | 2013-05-28 | 2013-05-28 | Medical toothpaste containing long pepper oil and long pepper ethanol extract at the same time |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020212099A1 (en) | 2019-04-15 | 2020-10-22 | Unilever Plc | A personal care composition comprising piperlongumine and process for producing the composition |
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| CN101396329A (en) * | 2008-09-23 | 2009-04-01 | 江西诚志日化有限公司 | Sarcandra glabra ice hard-effective toothpaste |
| CN101703456A (en) * | 2009-12-11 | 2010-05-12 | 江西诚志日化有限公司 | Combined chloranthus glaber whitening gelatin with anti-allergic agent and preparation method thereof |
| CN101926738A (en) * | 2010-08-06 | 2010-12-29 | 江西诚志日化有限公司 | Toothpaste containing fumed silica and sodium tripolyphosphate |
| CN102389388A (en) * | 2011-11-28 | 2012-03-28 | 江西诚志日化有限公司 | Piper longum toothpaste and preparation method thereof |
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2013
- 2013-05-28 CN CN201310213725.4A patent/CN104173223A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101396329A (en) * | 2008-09-23 | 2009-04-01 | 江西诚志日化有限公司 | Sarcandra glabra ice hard-effective toothpaste |
| CN101703456A (en) * | 2009-12-11 | 2010-05-12 | 江西诚志日化有限公司 | Combined chloranthus glaber whitening gelatin with anti-allergic agent and preparation method thereof |
| CN101926738A (en) * | 2010-08-06 | 2010-12-29 | 江西诚志日化有限公司 | Toothpaste containing fumed silica and sodium tripolyphosphate |
| CN102389388A (en) * | 2011-11-28 | 2012-03-28 | 江西诚志日化有限公司 | Piper longum toothpaste and preparation method thereof |
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| 阚全程等: "牙复康膏治疗牙本质过敏症临床观察", 《中国药业》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020212099A1 (en) | 2019-04-15 | 2020-10-22 | Unilever Plc | A personal care composition comprising piperlongumine and process for producing the composition |
| CN113710223A (en) * | 2019-04-15 | 2021-11-26 | 联合利华知识产权控股有限公司 | Personal care compositions comprising piperlongumine and methods of making the same |
| CN113710223B (en) * | 2019-04-15 | 2023-08-01 | 联合利华知识产权控股有限公司 | Personal care compositions comprising piperlonglamide and methods of making the same |
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Application publication date: 20141203 |