CN104171798A - 创伤、感染、手术及其他应激状态全营养配方食品 - Google Patents
创伤、感染、手术及其他应激状态全营养配方食品 Download PDFInfo
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- CN104171798A CN104171798A CN201410362400.7A CN201410362400A CN104171798A CN 104171798 A CN104171798 A CN 104171798A CN 201410362400 A CN201410362400 A CN 201410362400A CN 104171798 A CN104171798 A CN 104171798A
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- lactobacillus
- bifidobacterium
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- vitamin
- food
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Abstract
本发明提供了供创伤、感染、手术及其他应激状态患者食用的全营养配方食品、特定全营养配方食品或非全营养配方食品。该配方根据《特殊医学用途配方食品通则》的要求,结合创伤、感染、手术及其他应激状态患者的体质特征,综合当今美国哈佛大学的先进生理学、医药、营养学及临床应用等研究成果,依据“消中寓补”、“均衡调养”的传统中医的精髓理论(肝、脾、肾三脏同调为主原则)研制而成。该产品采用10种以上药食两用的中药提取物精华、多种益生菌、益生元为主要原料,以短肽、氨基酸、水溶性膳食纤维、复合维生素、复合矿物质辅料,不仅可作为单一营养来源满足创伤、感染、手术及其他应激状态患者的营养需求,还有起到活血化瘀、去腐生肌、补中理气、痛经活络的功效。
Description
技术领域
本发明属于药食同源类配方与食品技术领域,具体是将 “药食同源之中药”的传统中医精髓理论和“多重益生菌”有机结合起来,添加以短肽、益生元、氨基酸、水溶性膳食纤维、复合维生素、复合矿物质为辅料制成的防治创伤、感染、手术及其他应激状态的全营养配方食品、特定全营养配方食品或非全营养配方食品。
背景技术
创伤为机械因素加于人体所造成的组织或器官的破坏,创伤根据其形式的不同分为交通伤、坠落伤、机械伤、锐器伤和跌伤交通伤占创伤的首要位置,现代创伤中交通伤以高能创伤(高速行驶所发生的交通伤)为特点,常造成多发伤、多发骨折、脊柱脊髓损伤、脏器损伤、开放伤等严重损伤,随着高层建筑增多,坠落伤的比重逐渐加大,坠落伤通过着地部位直接摔伤和力的传导致伤,以脊柱和脊髓损伤、骨盆骨折为主,也可造成多发骨折、颅脑损伤、肝脾破裂,机械伤以绞伤、挤压伤为主,常导致单肢体开放性损伤或断肢、断指,组织挫伤血管、神经、肌腱损伤和骨折,伤口深,易出现深部组织损伤,胸腹部锐器伤可导致内脏或大血管损伤,出血多。跌伤常见于老年人,造成前臂、骨盆、脊柱压缩性骨折和髋部骨折,青壮年跌伤也可造成骨折, 感染是指细菌、病毒、真菌、寄生虫等病原体侵入人体所引起的局部组织和全身性炎症反应,病因原因可以是感染性的或非感染性的(如炎症,肿瘤,免疫紊乱),热型可以是间隙性的,即每天上升后再降到正常水平,或为潜留热,即上升后不回到正常水平,老年人对热的反应常下降,某些病人如嗜酒者、老人或小孩,在严重感染时,发热反应可变低,热原质是引起发热的物质,有外源性和内源性两种,外源性热原质是指从宿主体外得到的,主要是微生物及其产物和毒素,研究较深入的是革兰氏阴性菌的脂多糖(常称内毒素)和从毒性休克综合征病人分离到的金黄色葡萄球菌毒素,外源性热原质常通过诱导内源性热源质(或称内源性发热细胞因子)的释放而引起发热,内源性热原质是由宿主多种细胞,特别是单核-巨噬细胞产生的多肽。其他能产生发热细胞因子的细胞有角质细胞、内皮细胞、B细胞、肾小球间膜细胞、上皮细胞和神经胶质细胞,内源性热原质(白介素-1,肿瘤坏死因子,干扰素,gp130受体-活化家族:白介素-6,白介素-11,白血病抑制因子,纤毛嗜神经因子和制瘤蛋白-M)通过改变热调体中枢的代谢引起发热,前列腺素E2的合成好像起了关键作用,手术指医生用医疗器械对病人身体进行的切除、缝合等治疗,以刀、剪、针等器械在人体局部进行的操作,是外科的主要治疗方法,俗称“开刀”,“药食同源”是中华原创医学之中对人类最有价值的贡献之一;中医历来强调“药疗不如食疗”,食疗成为现代人追求返璞归真、健康饮食的最佳选择;让人们在享受美食的过程中祛除病痛,避免了打针、吃药,甚至手术之苦。
对于特殊营养食品,在美国、欧盟等发达国家都有相应的规定和开发应用;而我国GB29922-2013《特殊医学用途配方食品通则》食品安全国家标准中全营养食品明确规定:2.1.1全营养配方食品:可作为单一营养来源满足目标人群营养需求的特殊医学用途配方食品;2.1.2特定全营养配方食品:可作为单一营养来源满足目标人群在特定疾病或医学状况下营养需求的特殊医学用途配方食品。
中医传统医学认为:“脾(即消化系统)为后天之本”,肠胃健康是健康之本,人体营养的99%需要靠肠道吸收,肠内疾病也是万病之源;但随着年龄越大,肠道中有益菌群(益生菌)比例逐渐减少;如双岐杆菌在婴幼儿时期占98%,到中年时降至10%,65岁以后仅占5%;人越老,益生菌越少,肠道功能也随之逐渐下降,越来越多的研究显示,正常菌群在人体消化、免疫和抗病等方面有诸多不可替代的作用;肠道菌群组成的改变与多种疾病,特别是肠道疾病的发生发展密切相关,而从已有临床研究发现:益生菌能起到调节肠道菌群,控制肠道炎症作用,是一种安全有效的干预调节方法。
肠道微生态系统与创伤、手术、感染及其他应激状态的联系:肠道菌群是人体最大和最复杂的微生态系统,是肠粘膜屏障的重要组成部分,对抵抗病原菌感染具有重要意义,正常情况下,肠道菌群具有特定的定位、定性和定量结构,种群间处于一种有利于机体的动态平衡状态,当机体免疫力低下或长期使用激素,同位素、免疫抑制剂、放化疗或遭受严重创伤时,可能导致肠道微生态失调,肠道微生态失调可使肠粘膜屏障功能受损,引发细菌易位,进一步造成局部感染、诱发内毒素休克,引起全身败血症或远端感染,还可诱发系统性炎症反应综合症,以致多脏器衰竭、对创伤患者的预后造成不良影响,有研究表明,益生菌能通过与肠上皮细胞的特异性受体结合,有序地定植在肠上皮细胞表面,构成有层次的厌氧菌膜,并与其他厌氧菌一起构成菌膜群,一方面起占位性保护作用,保护肠粘膜免受其他病原菌的黏附和入侵;另一方面,通过产生有机酸,过氧化氢等其他物质,抑制病原菌的黏附、生长和繁殖,从而发挥屏障效应,另外,益生菌还能以争夺营养和分泌有毒代谢产物的方式,抑制其他有害的细菌在肠道中过度繁殖,并通过竞争性占位抑制其他有害菌结合到粘膜表面,Cano等实验结果显示,乳酸菌能有效地抑制鼠伤寒沙门菌、金黄色葡萄球菌、大肠杆菌、产气荚膜梭菌、艰难梭菌等致病菌的繁殖,而肠内免疫微生态营养可通过减轻肠道内毒素易位,减轻全身性炎症反应。
直接口服益生菌虽有一定效果,但是由于益生菌一在肠道内无法定植,且停留、占位很少,易流失,停服后有害菌易复发,相关患者需要长期服用,治疗周期长,往往使用后复发率非常高;为缩短相关患者的治疗周期,减少停药后复发率,本团队通过近叁年来对益生菌在肠道内定植机理的关健技术研究,努力寻求改进益生菌在肠道内定植的“药食同源之中药”复方,考虑到益生菌在肠道内定植的几个关键要素:益生元的存在能起到定植作用、肠道pH环境的降低和提高益生菌细胞的肠道粘附能力等,基于上述要素,本课题组从数十种“药食同源之中药”中筛选合适的食材,首次发现了添加山药、薏仁、鸡内金、芡实和菊芋等药食同源之中药成分的提取物及水苏糖,酵母、L-谷氨酰胺等后,对外源益生菌有很强的定植作用,为肠道微生态制剂中益生菌的组方选择提供实验依据。
目前市场上有利用以食源性短肽为主要原料,添加药食两用的川芎、当归、没药、黄芪等的提取物、复合维生素和矿物质,组成复合配方,还有利用益生菌为主要原料的产品,但还没有发现结合创伤、感染、手术及其他应激状态患者的体质特征,依据传统中医的精髓理论,因人而异,黄金配伍以十种以上药食两用的中药提取物精华、多种益生菌、益生元为主要原料,以短肽、氨基酸、水溶性膳食纤维、复合维生素、复合矿物质辅料制成的全营养配方食品、特定全营养配方食品或类似产品。
发明目的
本发明的目的是在继承中医精髓理论治病方法上,开创性将多种抗肝炎益生菌与“药食同源之中药”复方的提取物有机结合起来, 添加以短肽、氨基酸、水溶性膳食纤维、复合维生素、复合矿物质为辅料,不仅能够补充创伤、感染、手术及其他应激状态患者所必需营养素,改善机体营养状况,还能并利用药食两用中草药中的功能因子调节机体功能,益生菌能起到调节肠道菌群,毒副作用小、安全有效,且人们容易接受的适合创伤、感染、手术及其他应激状态患者食用的全营养配方食品、特定全营养配方食品或非全营养配方食品。
发明内容:
本研发团队根据《特殊医学用途配方食品通则》的要求,结合创伤、感染、手术及其他应激状态患者的体质特征,综合当今美国哈佛大学的先进生理学、医药、营养学及临床应用等研究成果,依据“消中寓补”、“均衡调养”的传统中医的精髓理论(肝、脾、肾三脏同调为主原则),采用10种以上药食两用的中药提取物精华、多种益生菌、短肽、益生元为主要原料,以氨基酸、水溶性膳食纤维、
复合维生素、复合矿物质辅料,不仅可作为单一营养来源满足创伤、感染、手术及其他应激状态患者的营养需求,还有活血化瘀、去腐生肌、补中理气、痛经活络及防治创伤、感染、手术及其他应激状态的全营养配方食品、特定全营养配方食品或非全营养配方食品(组合成的复合配方)。
本发明配方的主要成分为:
1. 中药提取物是根据创伤、感染、手术及其他应激状态患者的体质特征从中医理论中的肝、脾、肾三脏同调为主原则,利用药食两用中草药中的功能因子调节机体功能防治创伤、感染、手术及其他应激状态,并选取以下几大类药物进行配伍;其中:
川芎是一种中药植物,常用于活血行气,祛风止痛,川芎辛温香燥,走而不守,既能行散,上行可达巅顶;又入血分,下行可达血海,活血祛瘀作用广泛,适宜瘀血阻滞各种病症;祛风止痛,效用甚佳,可治头风头痛、风湿痹痛等症,昔人谓川芎为血中之气药,殆言其寓辛散、解郁、通达、止痛等功能,当归味甘而重,故专能补血,其气轻而辛,故又能行血,补中有动,行中有补,为血中之要药,因而,它既能补血,又能活血,既可通经,又可活络,没药散血消肿,定痛生肌,黄芪有益气固表、敛汗固脱、托疮生肌、利水消肿之功效,蒲公英性寒、味甘苦,有清热解毒、消肿散结、利湿退黄之功效,鱼腥草具有抗菌、抗病毒、提高机体免疫力、利尿等作用,牡丹皮具有清热凉血、活血化淤、退虚热等功效,赤芍具有行瘀、止痛、凉血、消肿等功能,防风具有祛风解表、胜湿止痛、解痉、止痒的功效,厚朴具有行气化湿、温中止痛、降逆平喘的功效,人参具有大补元气,复脉固脱,补脾益肺,生津止渴,安神益智的功效,三七具有止血,散瘀,消肿,定痛的功效,
本发明所述的药食两用中药提取物是指川芎、当归、没药、黄芪、蒲公英、鱼腥草、牡丹皮、赤芍、防风、桔梗、厚朴、陈皮、桂枝、白芷、甘草、人参、赤小豆、槐花、三七、藕节、花生衣、桃仁其中的10种以上采用生物酶解或预水解SBE提取并微胶囊化,经喷雾干燥及冷冻干燥的提取物全部混合。
2. 多种益生菌: 使益生菌能大部分通过胃的强酸环境到达肠道,以促进益生菌的增殖,调节肠内微生态平衡,促进对微量元素的吸收,增强脾胃运动功能,加速药效的吸收,改善黏膜表面的微生物群或酶的平衡,或刺激机体特异性或非特异性免疫机制,提高机体定植抗力或免疫力;Xing等用双歧杆菌和乳酸杆菌预处理肝缺血再灌注大鼠,可以明显降低肠源性内毒素血症的水平并预防肝损伤的发生;选择性肠道脱污染也是调整肠道微生态的重要措施,有研究应用肠道不吸收抗生素利福昔明(rifaximin),通过抑制肠道中产尿素酶及产氨细菌的生长,来防治肝性脑病的发生;
本发明所述的多种益生菌是指微胶囊化后的双歧杆菌(青春双歧杆菌、乳双歧杆菌、两歧双歧杆菌、短双歧杆菌、婴儿双歧杆菌、长双歧杆菌)、乳杆菌(嗜酸乳杆菌粉、干酪乳杆菌、保加利亚乳杆菌、德氏乳杆菌、乳亚种格氏乳杆菌、发酵乳杆菌、瑞士乳杆菌、唾液乳杆菌、鼠李糖乳杆菌、罗伊氏乳杆菌、植物乳杆菌、副干酪乳杆菌、约氏乳杆菌)、嗜热链球菌其中的四种以上或全部混合。
3. 短肽:即为低聚肽,是指利用生物酶工程技术从动物或植物蛋白中分离提取的一类小分子蛋白质,其平均分子量在1000Dalton以下,易溶于水,对酸、热稳定,可以不需经过消化而直接吸收,生物利用率高,在吸收和利用上优于游离的氨基酸和完整的蛋白质,可应用于蛋白质补充食品中,尤其对于消化吸收能力低下的人群,短肽是极佳的氮源,除营养功能外,短肽还具有一系列的生理活性功能:提高小肠的消化吸收功能, 增强机体免疫力,抗氧化, 辅助调节血糖,辅助调节血脂,辅助降血压,抗辐射, 促进矿物质吸收, 增强药食两用中草药中功能因子的作用效果;
本发明所述的短肽是指海洋胶原肽、海洋骨原肽、大豆蛋白肽、乳清蛋白肽、卵白蛋白肽其中一种、几种或全部混合。
4. 益生元: 以促益生菌肠道定植、肠道收敛、降低肠道pH环境,也不被大多数的肠道腐败菌利用,但可以促进人体内有益细菌——乳杆菌、双歧 杆菌的生长繁殖,从而可以抑制腐败菌生长,有助于改善和维持肠道正常功能;长期食用可以延缓衰老、通便、提高免疫力、减轻肝脏负担、提高营养素的吸收率,特别是能够改善机体对钙、铁、锌等金属离子 的吸收;可选择性地促进有益菌(双歧、乳酸)的生长繁殖外,还可代谢为酸性产物如乳酸等有机酸,使结肠内pH值降低,抑制肠道有害细菌的生长;使小肠内水电解质滞留在肠腔,产生高渗效果,刺激肠蠕动引起缓泻,从而促进肠道内毒素及其他毒性物质的排出,乳果糖还可直接灭活肠道中内毒素、降低肠道pH值,已广范应用于肝性脑病的治疗;
本发明所述的益生元本是指低聚异麦芽糖、水苏糖、低聚果糖、大豆低聚糖、低聚木糖其中的一种、几种或全部混合。
5.氨基酸:分为必需氨基酸与非必需氨基酸,是构成蛋白质的基本单位,赋予蛋白质特定的分子结构形态,使其具有生化活性;摄取适量的蛋氨酸有助于人体内各种含硫化合物的代谢并且其所含的甲基对有毒物或药物进行甲基化而起到解毒的作用;亮氨酸能够修复肌肉,控制血糖,并给身体组织提供能量,必需氨基酸苯丙氨酸可以抑制癌瘤生长,又可以降低药物的毒副作用,赖氨酸可提高食物蛋白质的吸收和利用,达到均衡营养,促进生长发育;精氨酸有助于将血液中的氨转变为尿素而排泄出去;对于高氨血症,肝脏机能障碍等均有功效;组氨酸降低胃液酸度,缓和胃肠手术的疼痛,减轻妊娠期呕吐及胃部灼热感,抑制由植物神经紧张而引起的消化道溃烂,对过敏性疾病,如哮喘等也有功效;色氨酸可以预防糙皮病、抑郁症,改善睡眠和调节情绪;
本发明所述的氨基酸是指L-谷氨酰胺、蛋氨酸、异亮氨酸、酪氨酸、苯丙氨酸、赖氨酸、精氨酸、组氨酸、色氨酸、瓜氨酸、鸟氨酸、牛磺酸其中的一种、几种或全部混合。
6.维生素和矿物质:
维生素和矿物质是人体必需的营养素,本发明中添加的维生素为维生素和矿物质是人体必需的营养素;
本发明中添加的维生素为维生素A、维生素D、维生素E、维生素K、维生素K1、维生素C、维生素B1、维生素B2、维生素B6、维生素B12、维生素Be、维生素Bu、烟酸、叶酸、泛酸、胆碱、生物素其中的 一种、几种或全部混合;
本发明中添加的矿物质为钙、磷、钾、钠、镁、氯、铁、锌、硒、铜、锰、碘、氟、铬、钼其中的一种、几种或全部混合,本发明所述的矿物质添加为该矿物质的有机或无机化合物;
本发明中维生素矿物质的添加量参照GB14880《食品营养强化剂使用卫生标准》、GB2760《食品添加剂使用标准》执行。
7.本发明以微胶囊、生物酶解、预水解SBE、喷雾干燥及冷冻干燥集成创新,构成的产业化生产的关键技术;微囊化保护技术,有效解决了口服过程中高温以及强酸胃液对益生菌的灭活;采用三层蛋白质深埋微胶囊技术,再与经生物酶解或预水解SBE技术提取并微囊化处理后的中药提取物混合均匀,以解决“多重益生菌”与“药食同源之中药”组分的共存问题,具有一定的抗高温和强酸特性,有利于益生菌通过口服顺利通过胃液到达肠道内停留定植,使产品防治创伤、感染、手术及其他应激状态功效与市场同类产品相比大幅提高;
8.采用上述集成创新工艺将各种配料混合均匀制成粉状的固体饮料、颗粒剂,并分装成10g/包,用约150ml温开水(45度)溶解后,直接饮用或经鼻饲摄入;也可以加入适量附料制成胶囊、片剂或加入甜味剂和黑芝麻粉制成饼干等快速、方便食品便于外出携带食用,若做成饮料则省去经喷雾干燥,少添加黑芝麻粉等,分装成10-65ml/瓶,每日早、中、晚饭后0.5小时各饮1瓶,所有操作均在洁净干燥环境内进行;
本配方全营养配方食品的特性及其对机体的作用主要表现在以下几个方面:
1.本发明是根据《特殊医学用途配方食品通则》的要求,结合创伤、感染、手术及其他应激状态患者的体质特征,综合当今美国哈佛大学的先进生理学、医药、营养学及临床应用等研究成果研制的,因人而异,黄金配伍;
2.本发明依据“消中寓补”、“均衡调养”的传统中医的精髓理论(肝、脾、肾三脏同调为主原则),采用10种以上药食两用的中药提取物精华、多种益生菌、益生元为主要原料,以短肽、氨基酸、复合维生素、复合矿物质辅料,各种配料的有机组合,将各种功能进行融合,并通过有效成分之间的协同作用,增强作用效果;
3. 具有高效吸收性,利用本发明配方,各种组分采用适宜的比例搭配制备的食品,经一定量水溶解后呈等渗状态,能快速 通过胃到达小肠,吸收快速、完全,可以迅速补充创伤、感染、手术及其他应激状态患者所需营养,不增加肝肾负担;
4. 本发明配方中采用各种药食两用中草药的提取物,含有多种功能活性成分,不仅提高了功能因子的浓度,减少各种杂质的摄入,有助于减轻肝肾负担,具有增强人体抵抗力的作用,还有活血化瘀、去腐生肌、补中理气、痛经活络及防治创伤、感染、手术及其他应激状态的功效;
5.本发明配方中所含的益生菌,多种益生菌能够维护肠道正常细菌菌群平衡,抑制病原菌的生长,防止胃肠障碍等,在肠道内合成维生素、氨基酸和提高机体对钙离子的吸收,增强人体免疫机能,预防抗生素的副作用,提高宿主对放射线的耐受性,乳杆菌显著增加肠粘膜免疫球蛋白A(SIgA)含量,对机体肠粘膜局部免疫具有调节作用,调节胃、肠微生态,能提高钙、磷、铁的利用率,促进铁和维生素D的吸收,产生维生素K及维生素B,还可以减少胆固醇的吸收;
6. 本发明配方食品以多种来源的食源性生物活性短肽为氮源,因为短肽不需消化即可吸收,更有利于机体的利用,可以有效改善创伤、感染、手术及其他应激状态患者负氮平衡,而且食源性短肽能够改善肠粘膜上皮细胞的结构和功能,提高肠粘膜的吸收能力;
7.本组方采用了本团队通过近叁年来对益生菌在肠道内定植机理的关健技术研究的成果, 改进益生菌在肠道内定植的“药食同源之中药”复方,结合了益生元的存在能起到定植作用、肠道pH环境的降低和提高益生菌细胞的肠道粘附能力等要素,因此该食品配方的组成大大增强了对外源益生菌的定植作用;
8.本发明配方中所含的益生元,通过促进肠内益生菌的生长繁殖,抑制腐败菌的生长,同时在肠粘膜表面形成一道保护屏障,可以抵御肠道腐败菌对肠粘膜的损伤,减少肠内有害物质的吸收,还可以促进肠道蠕动,加速肠内残留物质的排出,可以防止便秘,而且通过促进肠道益生菌的生长繁殖也可以增强机体免疫力,短肽 与活性多糖等生物活性物质具有协同作用;
9、本发明配方中所含的氨基酸,是构成蛋白质的基本单位,赋予蛋白质特定的分子结构形态,使其具有生化活性,有助于人体内各种含硫化合物的代谢并且其所含的甲基对有毒物或药物进行甲基化而起到解毒的作用,能够修复肌肉,控制血糖,并给身体组织提供能量,还可提高食物蛋白质的吸收和利用,达到均衡营养,促进生长发育;
10、本发明配方食品含多种维生素和矿物质,可迅速补充创伤、感染、手术及其他应激状态患者所需的微量营养素,短肽通过与钙、铁、锌等的螯合后,更增加了矿物质元素的吸收率;
11、本发明配方中不含脂肪和胆固醇,能够在补充蛋白质、微量营养素的同时,不会增加脂肪、胆固醇的摄入,避免了肉、蛋等髙蛋白食物的不利影响。
具体实施方式
下面通过以下实施例对本发明作进一步说明,它将有助于理解本发明。
实施例一
实施案例一 实现本发明目的创伤、感染、手术及其他应激状态全营养配方食品其包括以重量计的下列组分: 药食两用的提取物: 川芎14g、当归14g、没药14g、黄芪12g、蒲公英12g、鱼腥草12g、牡丹皮12g、赤芍10g、防风10g、桔梗10g、厚朴10g、陈皮8g、桂枝8g、白芷8g、甘草8g、人参8g、赤小豆6g、槐花6g、三七6g、藕节4g、花生衣4g、桃仁4g、微胶囊化后的双歧杆菌(青春双歧杆菌、乳双歧杆菌、两歧双歧杆菌、短双歧杆菌、婴儿双歧杆菌、长双歧杆菌)100g、乳杆菌(嗜酸乳杆菌粉、干酪乳杆菌、保加利亚乳杆菌、德氏乳杆菌、乳亚种格氏乳杆菌、发酵乳杆菌、瑞士乳杆菌、唾液乳杆菌、鼠李糖乳杆菌、罗伊氏乳杆菌、植物乳杆菌、副干酪乳杆菌、约氏乳杆菌)100g、嗜热链球菌50g、短肽(海洋胶原肽、海洋骨原肽、大豆蛋白肽、乳清蛋白肽、卵白蛋白肽)200g、益生元(低聚异麦芽糖、水苏糖、低聚果糖、大豆低聚糖、低聚木糖)150g、复合氨基酸(L-谷氨酰胺、蛋氨酸、异亮氨酸、酪氨酸、苯丙氨酸、赖氨酸、精氨酸、组氨酸、色氨酸、瓜氨酸、鸟氨酸、牛磺酸)100g、水溶性膳食纤维50g、维生素A0.01g、维生素D0.000015g、维生素E0.12g、维生素K0.0075g、维生素K10.00001g、维生素C10.625g、维生素B10.016g、维生素B20.016g、维生素B60.015g、维生素B0.0023g、维生素Be、维生素Bu、烟酸0.2g、叶酸0.003g、泛酸0.051g、胆碱2.5g、生物素0.000057g、钙6.2g、磷4.5g、钾10g、钠16.17g、镁1.7g、氯、铁0.15g、锌6.2g、硒0.00012g、铜0.007g、锰0.018g、碘0.00001g、氟0.00001g、铬0.00001g、钼0.00001g;
制作时先将以是川芎、当归、没药、黄芪、蒲公英、鱼腥草、牡丹皮、赤芍、防风、桔梗、厚朴、陈皮、桂枝、白芷、甘草、人参、槐花、三七、藕节、花生衣浸泡后加入β-环状糊精,用预水解SBE技术提取后,经喷雾干燥而制备的粉状物质,再添加生物酶解提取的短肽、益生元、氨基酸、赤小豆、桃仁、水溶性膳食纤维、多种维生素及矿物质混合后进行巴氏灭菌1小时,然后添加微胶囊化后的双歧杆菌(青春双歧杆菌、乳双歧杆菌、两歧双歧杆菌、短双歧杆菌、婴儿双歧杆菌、长双歧杆菌)、乳杆菌(嗜酸乳杆菌粉、干酪乳杆菌、保加利亚乳杆菌、德氏乳杆菌、乳亚种格氏乳杆菌、发酵乳杆菌、瑞士乳杆菌、唾液乳杆菌、鼠李糖乳杆菌、罗伊氏乳杆菌、植物乳杆菌、副干酪乳杆菌、约氏乳杆菌)、嗜热链球菌并混合的各种配料混合均匀制成粉状的固体饮料、颗粒剂,并分装成10g/包,用约150ml温开水(45度)溶解后,直接饮用或经鼻饲摄入;也可以加入适量附料制成胶囊、片剂或加入甜味剂和黑芝麻粉制成饼干等快速、方便食品便于外出携带食用,若做成饮料则省去经喷雾干燥,少添加黑芝麻粉等,分装成10-65ml/瓶,每日早、中、晚饭后0.5小时各饮1瓶,所有操作均在洁净干燥环境内进行。
实施例二
上述创伤、感染、手术及其他应激状态全营养配方食品还包括以重量计的下列组分: 药食两用的提取物: 川芎16g、当归16g、黄芪16g、蒲公英14g、鱼腥草14g、牡丹皮14g、防风12g、桔梗12g、厚朴12g、陈皮10g、白芷10g、甘草10g、槐花8g、藕节8g、花生衣8g、桃仁8g、人参6g、赤小豆6g、微胶囊化后的双歧杆菌(青春双歧杆菌、乳双歧杆菌、两歧双歧杆菌、短双歧杆菌、婴儿双歧杆菌、长双歧杆菌)100g、乳杆菌(嗜酸乳杆菌粉、干酪乳杆菌、保加利亚乳杆菌、德氏乳杆菌、乳亚种格氏乳杆菌、发酵乳杆菌、瑞士乳杆菌、唾液乳杆菌、鼠李糖乳杆菌、罗伊氏乳杆菌、植物乳杆菌、副干酪乳杆菌、约氏乳杆菌)100g、嗜热链球菌50g、短肽(海洋胶原肽、海洋骨原肽、大豆蛋白肽、乳清蛋白肽、卵白蛋白肽)200g、益生元(低聚异麦芽糖、水苏糖、低聚果糖、大豆低聚糖、低聚木糖)150g、复合氨基酸(L-谷氨酰胺、蛋氨酸、异亮氨酸、酪氨酸、苯丙氨酸、赖氨酸、精氨酸、组氨酸、色氨酸、瓜氨酸、鸟氨酸、牛磺酸)100g、水溶性膳食纤维50g、维生素A0.01g、维生素D0.000015g、维生素E0.12g、维生素K0.0075g、维生素K10.00001g、维生素C10.625g、维生素B10.016g、维生素B20.016g、维生素B60.015g、维生素B0.0023g、维生素Be、维生素Bu、烟酸0.2g、叶酸0.003g、泛酸0.051g、胆碱2.5g、生物素0.000057g、钙6.2g、磷4.5g、钾10g、钠16.17g、镁1.7g、氯、铁0.15g、锌6.2g、硒0.00012g、铜0.007g、锰0.018g、碘0.00001g、氟0.00001g、铬0.00001g、钼0.00001g。
实施例三
上述创伤、感染、手术及其他应激状态全营养配方食品还包括以重量计的下列组分: 药食两用的提取物: 蒲公英20g、鱼腥草20g、槐花18g、藕节18g、桔梗18g、陈皮16g、白芷16g、甘草16g、花生衣16g、桃仁14g、赤小豆14g、人参14g、微胶囊化后的双歧杆菌(青春双歧杆菌、乳双歧杆菌、两歧双歧杆菌、短双歧杆菌、婴儿双歧杆菌、长双歧杆菌)100g、乳杆菌(嗜酸乳杆菌粉、干酪乳杆菌、保加利亚乳杆菌、德氏乳杆菌、乳亚种格氏乳杆菌、发酵乳杆菌、瑞士乳杆菌、唾液乳杆菌、鼠李糖乳杆菌、罗伊氏乳杆菌、植物乳杆菌、副干酪乳杆菌、约氏乳杆菌)100g、嗜热链球菌50g、短肽(海洋胶原肽、海洋骨原肽、大豆蛋白肽、乳清蛋白肽、卵白蛋白肽)200g、益生元(低聚异麦芽糖、水苏糖、低聚果糖、大豆低聚糖、低聚木糖)150g、复合氨基酸(L-谷氨酰胺、蛋氨酸、异亮氨酸、酪氨酸、苯丙氨酸、赖氨酸、精氨酸、组氨酸、色氨酸、瓜氨酸、鸟氨酸、牛磺酸)100g、水溶性膳食纤维50g、维生素A0.01g、维生素D0.000015g、维生素E0.12g、维生素K0.0075g、维生素K10.00001g、维生素C10.625g、维生素B10.016g、维生素B20.016g、维生素B60.015g、维生素B0.0023g、维生素Be、维生素Bu、烟酸0.2g、叶酸0.003g、泛酸0.051g、胆碱2.5g、生物素0.000057g、钙6.2g、磷4.5g、钾10g、钠16.17g、镁1.7g、氯、铁0.15g、锌6.2g、硒0.00012g、铜0.007g、锰0.018g、碘0.00001g、氟0.00001g、铬0.00001g、钼0.00001g。
实施例四
上述创伤、感染、手术及其他应激状态全营养配方食品还包括以重量计的下列组分: 药食两用的提取物: 蒲公英20g、鱼腥草20g、槐花18g、藕节18g、桔梗18g、陈皮16g、白芷16g、甘草16g、花生衣16g、桃仁14g、赤小豆14g、人参14g、微胶囊化后的双歧杆菌(青春双歧杆菌、乳双歧杆菌、两歧双歧杆菌、短双歧杆菌、婴儿双歧杆菌、长双歧杆菌)100g、乳杆菌(嗜酸乳杆菌粉、干酪乳杆菌、保加利亚乳杆菌、德氏乳杆菌、乳亚种格氏乳杆菌、发酵乳杆菌、瑞士乳杆菌、唾液乳杆菌、鼠李糖乳杆菌、罗伊氏乳杆菌、植物乳杆菌、副干酪乳杆菌、约氏乳杆菌)100g、嗜热链球菌50g、短肽(海洋胶原肽、海洋骨原肽、大豆蛋白肽、乳清蛋白肽、卵白蛋白肽)200g、益生元(低聚异麦芽糖、水苏糖、低聚果糖、大豆低聚糖、低聚木糖)250g、复合氨基酸(L-谷氨酰胺、蛋氨酸、异亮氨酸、酪氨酸、苯丙氨酸、赖氨酸、精氨酸、组氨酸、色氨酸、瓜氨酸、鸟氨酸、牛磺酸)100g、水溶性膳食纤维50g。
实施例五
上述创伤、感染、手术及其他应激状态全营养配方食品还包括以重量计的下列组分: 药食两用的提取物: 蒲公英22g、鱼腥草22g、槐花20g、藕节20g、桔梗20g、陈皮18g、白芷18g、甘草16g、桃仁16g、赤小豆14g、人参14g、微胶囊化后的双歧杆菌(青春双歧杆菌、乳双歧杆菌、两歧双歧杆菌、短双歧杆菌、婴儿双歧杆菌、长双歧杆菌)100g、乳杆菌(嗜酸乳杆菌粉、干酪乳杆菌、保加利亚乳杆菌、德氏乳杆菌、乳亚种格氏乳杆菌、发酵乳杆菌、瑞士乳杆菌、唾液乳杆菌、鼠李糖乳杆菌、罗伊氏乳杆菌、植物乳杆菌、副干酪乳杆菌、约氏乳杆菌)100g、嗜热链球菌50g、短肽(海洋胶原肽、海洋骨原肽、大豆蛋白肽、乳清蛋白肽、卵白蛋白肽)200g、益生元(低聚异麦芽糖、水苏糖、低聚果糖、大豆低聚糖、低聚木糖)250g、复合氨基酸(L-谷氨酰胺、蛋氨酸、异亮氨酸、酪氨酸、苯丙氨酸、赖氨酸、精氨酸、组氨酸、色氨酸、瓜氨酸、鸟氨酸、牛磺酸)100g、水溶性膳食纤维50g。
本发明以微胶囊、生物酶解、预水解SBE、喷雾干燥及冷冻干燥集成创新,构成的产业化生产的关键技术;微囊化保护技术,有效解决了口服过程中高温以及强酸胃液对益生菌的灭活;采用三层蛋白质深埋微胶囊技术,再与经生物酶解或预水解SBE技术提取并微囊化处理后的中药提取物混合均匀,以解决“多重益生菌”与“药食同源之中药”组分的共存问题,具有一定的抗高温和强酸特性,有利于益生菌通过口服顺利通过胃液到达肠道内停留定植,使产品防治创伤、感染、手术及其他应激状态功效与市场同类产品相比大幅提高。
Claims (6)
1.创伤、感染、手术及其他应激状态全营养配方食品,其特征在于其原料成分含量包括以重量计的下列组分:药食两用的提取物: 川芎14g、当归14g、没药14g、黄芪12g、蒲公英12g、鱼腥草12g、牡丹皮12g、赤芍10g、防风10g、桔梗10g、厚朴10g、陈皮8g、桂枝8g、白芷8g、甘草8g、人参8g、赤小豆6g、槐花6g、三七6g、藕节4g、花生衣4g、桃仁4g、微胶囊化后的双歧杆菌(青春双歧杆菌、乳双歧杆菌、两歧双歧杆菌、短双歧杆菌、婴儿双歧杆菌、长双歧杆菌)100g、乳杆菌(嗜酸乳杆菌粉、干酪乳杆菌、保加利亚乳杆菌、德氏乳杆菌、乳亚种格氏乳杆菌、发酵乳杆菌、瑞士乳杆菌、唾液乳杆菌、鼠李糖乳杆菌、罗伊氏乳杆菌、植物乳杆菌、副干酪乳杆菌、约氏乳杆菌)100g、嗜热链球菌50g、短肽(海洋胶原肽、海洋骨原肽、大豆蛋白肽、乳清蛋白肽、卵白蛋白肽)200g、益生元(低聚异麦芽糖、水苏糖、低聚果糖、大豆低聚糖、低聚木糖)150g、复合氨基酸(L-谷氨酰胺、蛋氨酸、异亮氨酸、酪氨酸、苯丙氨酸、赖氨酸、精氨酸、组氨酸、色氨酸、瓜氨酸、鸟氨酸、牛磺酸)100g、水溶性膳食纤维50g、维生素A0.01g、维生素D0.000015g、维生素E0.12g、维生素K0.0075g、维生素K10.00001g、维生素C10.625g、维生素B10.016g、维生素B20.016g、维生素B60.015g、维生素B0.0023g、维生素Be、维生素Bu、烟酸0.2g、叶酸0.003g、泛酸0.051g、胆碱2.5g、生物素0.000057g、钙6.2g、磷4.5g、钾10g、钠16.17g、镁1.7g、氯、铁0.15g、锌6.2g、硒0.00012g、铜0.007g、锰0.018g、碘0.00001g、氟0.00001g、铬0.00001g、钼0.00001g;
制作时先将以是川芎、当归、没药、黄芪、蒲公英、鱼腥草、牡丹皮、赤芍、防风、桔梗、厚朴、陈皮、桂枝、白芷、甘草、人参、槐花、三七、藕节、花生衣浸泡后加入β-环状糊精,用预水解SBE技术提取后,经喷雾干燥而制备的粉状物质,再添加生物酶解提取的短肽、益生元、氨基酸、赤小豆、桃仁、水溶性膳食纤维、多种维生素及矿物质混合后进行巴氏灭菌1小时,然后添加微胶囊化后的双歧杆菌(青春双歧杆菌、乳双歧杆菌、两歧双歧杆菌、短双歧杆菌、婴儿双歧杆菌、长双歧杆菌)、乳杆菌(嗜酸乳杆菌粉、干酪乳杆菌、保加利亚乳杆菌、德氏乳杆菌、乳亚种格氏乳杆菌、发酵乳杆菌、瑞士乳杆菌、唾液乳杆菌、鼠李糖乳杆菌、罗伊氏乳杆菌、植物乳杆菌、副干酪乳杆菌、约氏乳杆菌)、嗜热链球菌并混合的各种配料混合均匀制成粉状的固体饮料、颗粒剂,并分装成10g/包,用约150ml温开水(45度)溶解后,直接饮用或经鼻饲摄入;也可以加入适量附料制成胶囊、片剂或加入甜味剂和黑芝麻粉制成饼干等快速、方便食品便于外出携带食用,若做成饮料则省去经喷雾干燥,少添加黑芝麻粉等,分装成10-65ml/瓶,每日早、中、晚饭后0.5小时各饮1瓶,所有操作均在洁净干燥环境内进行。
2.根据权利要求1所述的创伤、感染、手术及其他应激状态全营养配方食品还包括以重量计的下列组分: 药食两用的提取物: 川芎16g、当归16g、黄芪16g、蒲公英14g、鱼腥草14g、牡丹皮14g、防风12g、桔梗12g、厚朴12g、陈皮10g、白芷10g、甘草10g、槐花8g、藕节8g、花生衣8g、桃仁8g、人参6g、赤小豆6g、微胶囊化后的双歧杆菌(青春双歧杆菌、乳双歧杆菌、两歧双歧杆菌、短双歧杆菌、婴儿双歧杆菌、长双歧杆菌)100g、乳杆菌(嗜酸乳杆菌粉、干酪乳杆菌、保加利亚乳杆菌、德氏乳杆菌、乳亚种格氏乳杆菌、发酵乳杆菌、瑞士乳杆菌、唾液乳杆菌、鼠李糖乳杆菌、罗伊氏乳杆菌、植物乳杆菌、副干酪乳杆菌、约氏乳杆菌)100g、嗜热链球菌50g、短肽(海洋胶原肽、海洋骨原肽、大豆蛋白肽、乳清蛋白肽、卵白蛋白肽)200g、益生元(低聚异麦芽糖、水苏糖、低聚果糖、大豆低聚糖、低聚木糖)150g、复合氨基酸(L-谷氨酰胺、蛋氨酸、异亮氨酸、酪氨酸、苯丙氨酸、赖氨酸、精氨酸、组氨酸、色氨酸、瓜氨酸、鸟氨酸、牛磺酸)100g、水溶性膳食纤维50g、维生素A0.01g、维生素D0.000015g、维生素E0.12g、维生素K0.0075g、维生素K10.00001g、维生素C10.625g、维生素B10.016g、维生素B20.016g、维生素B60.015g、维生素B0.0023g、维生素Be、维生素Bu、烟酸0.2g、叶酸0.003g、泛酸0.051g、胆碱2.5g、生物素0.000057g、钙6.2g、磷4.5g、钾10g、钠16.17g、镁1.7g、氯、铁0.15g、锌6.2g、硒0.00012g、铜0.007g、锰0.018g、碘0.00001g、氟0.00001g、铬0.00001g、钼0.00001g。
3.根据权利要求1所述的创伤、感染、手术及其他应激状态全营养配方食品还包括以重量计的下列组分: 药食两用的提取物: 蒲公英20g、鱼腥草20g、槐花18g、藕节18g、桔梗18g、陈皮16g、白芷16g、甘草16g、花生衣16g、桃仁14g、赤小豆14g、人参14g、微胶囊化后的双歧杆菌(青春双歧杆菌、乳双歧杆菌、两歧双歧杆菌、短双歧杆菌、婴儿双歧杆菌、长双歧杆菌)100g、乳杆菌(嗜酸乳杆菌粉、干酪乳杆菌、保加利亚乳杆菌、德氏乳杆菌、乳亚种格氏乳杆菌、发酵乳杆菌、瑞士乳杆菌、唾液乳杆菌、鼠李糖乳杆菌、罗伊氏乳杆菌、植物乳杆菌、副干酪乳杆菌、约氏乳杆菌)100g、嗜热链球菌50g、短肽(海洋胶原肽、海洋骨原肽、大豆蛋白肽、乳清蛋白肽、卵白蛋白肽)200g、益生元(低聚异麦芽糖、水苏糖、低聚果糖、大豆低聚糖、低聚木糖)150g、复合氨基酸(L-谷氨酰胺、蛋氨酸、异亮氨酸、酪氨酸、苯丙氨酸、赖氨酸、精氨酸、组氨酸、色氨酸、瓜氨酸、鸟氨酸、牛磺酸)100g、水溶性膳食纤维50g、维生素A0.01g、维生素D0.000015g、维生素E0.12g、维生素K0.0075g、维生素K10.00001g、维生素C10.625g、维生素B10.016g、维生素B20.016g、维生素B60.015g、维生素B0.0023g、维生素Be、维生素Bu、烟酸0.2g、叶酸0.003g、泛酸0.051g、胆碱2.5g、生物素0.000057g、钙6.2g、磷4.5g、钾10g、钠16.17g、镁1.7g、氯、铁0.15g、锌6.2g、硒0.00012g、铜0.007g、锰0.018g、碘0.00001g、氟0.00001g、铬0.00001g、钼0.00001g。
4.根据权利要求1所述的创伤、感染、手术及其他应激状态全营养配方食品还包括以重量计的下列组分: 药食两用的提取物: 蒲公英20g、鱼腥草20g、槐花18g、藕节18g、桔梗18g、陈皮16g、白芷16g、甘草16g、花生衣16g、桃仁14g、赤小豆14g、人参14g、微胶囊化后的双歧杆菌(青春双歧杆菌、乳双歧杆菌、两歧双歧杆菌、短双歧杆菌、婴儿双歧杆菌、长双歧杆菌)100g、乳杆菌(嗜酸乳杆菌粉、干酪乳杆菌、保加利亚乳杆菌、德氏乳杆菌、乳亚种格氏乳杆菌、发酵乳杆菌、瑞士乳杆菌、唾液乳杆菌、鼠李糖乳杆菌、罗伊氏乳杆菌、植物乳杆菌、副干酪乳杆菌、约氏乳杆菌)100g、嗜热链球菌50g、短肽(海洋胶原肽、海洋骨原肽、大豆蛋白肽、乳清蛋白肽、卵白蛋白肽)200g、益生元(低聚异麦芽糖、水苏糖、低聚果糖、大豆低聚糖、低聚木糖)250g、复合氨基酸(L-谷氨酰胺、蛋氨酸、异亮氨酸、酪氨酸、苯丙氨酸、赖氨酸、精氨酸、组氨酸、色氨酸、瓜氨酸、鸟氨酸、牛磺酸)100g、水溶性膳食纤维50g。
5.根据权利要求1所述的创伤、感染、手术及其他应激状态全营养配方食品还包括以重量计的下列组分: 药食两用的提取物: 蒲公英22g、鱼腥草22g、槐花20g、藕节20g、桔梗20g、陈皮18g、白芷18g、甘草16g、桃仁16g、赤小豆14g、人参14g、微胶囊化后的双歧杆菌(青春双歧杆菌、乳双歧杆菌、两歧双歧杆菌、短双歧杆菌、婴儿双歧杆菌、长双歧杆菌)100g、乳杆菌(嗜酸乳杆菌粉、干酪乳杆菌、保加利亚乳杆菌、德氏乳杆菌、乳亚种格氏乳杆菌、发酵乳杆菌、瑞士乳杆菌、唾液乳杆菌、鼠李糖乳杆菌、罗伊氏乳杆菌、植物乳杆菌、副干酪乳杆菌、约氏乳杆菌)100g、嗜热链球菌50g、短肽(海洋胶原肽、海洋骨原肽、大豆蛋白肽、乳清蛋白肽、卵白蛋白肽)200g、益生元(低聚异麦芽糖、水苏糖、低聚果糖、大豆低聚糖、低聚木糖)250g、复合氨基酸(L-谷氨酰胺、蛋氨酸、异亮氨酸、酪氨酸、苯丙氨酸、赖氨酸、精氨酸、组氨酸、色氨酸、瓜氨酸、鸟氨酸、牛磺酸)100g、水溶性膳食纤维50g。
6.本发明以微胶囊、生物酶解、预水解SBE、喷雾干燥及冷冻干燥集成创新,构成的产业化生产的关键技术;微囊化保护技术,有效解决了口服过程中高温以及强酸胃液对益生菌的灭活;采用三层蛋白质深埋微胶囊技术,再与经生物酶解或预水解SBE技术提取并微囊化处理后的中药提取物混合均匀,以解决“多重益生菌”与“药食同源之中药”组分的共存问题,具有一定的抗高温和强酸特性,有利于益生菌通过口服顺利通过胃液到达肠道内停留定植,使产品防治创伤、感染、手术及其他应激状态功效与市场同类产品相比大幅提高。
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