CN104168926B - 用于伤口敷料的氟化聚合性水凝胶及其制备方法 - Google Patents

用于伤口敷料的氟化聚合性水凝胶及其制备方法 Download PDF

Info

Publication number
CN104168926B
CN104168926B CN201380014883.5A CN201380014883A CN104168926B CN 104168926 B CN104168926 B CN 104168926B CN 201380014883 A CN201380014883 A CN 201380014883A CN 104168926 B CN104168926 B CN 104168926B
Authority
CN
China
Prior art keywords
group
fluorine
hydrogel
oxygen
groups
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201380014883.5A
Other languages
English (en)
Chinese (zh)
Other versions
CN104168926A (zh
Inventor
N·莱比锡
A·维杰孔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Akron
Original Assignee
University of Akron
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Akron filed Critical University of Akron
Priority to CN201710650215.1A priority Critical patent/CN107522880B/zh
Publication of CN104168926A publication Critical patent/CN104168926A/zh
Application granted granted Critical
Publication of CN104168926B publication Critical patent/CN104168926B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/24—Crosslinking, e.g. vulcanising, of macromolecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/28—Polysaccharides or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/44—Medicaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/60—Liquid-swellable gel-forming materials, e.g. super-absorbents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
    • C08B37/0027—2-Acetamido-2-deoxy-beta-glucans; Derivatives thereof
    • C08B37/003—Chitin, i.e. 2-acetamido-2-deoxy-(beta-1,4)-D-glucan or N-acetyl-beta-1,4-D-glucosamine; Chitosan, i.e. deacetylated product of chitin or (beta-1,4)-D-glucosamine; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F2/00—Processes of polymerisation
    • C08F2/46—Polymerisation initiated by wave energy or particle radiation
    • C08F2/48—Polymerisation initiated by wave energy or particle radiation by ultraviolet or visible light
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/52—Amides or imides
    • C08F220/54—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F299/00—Macromolecular compounds obtained by interreacting polymers involving only carbon-to-carbon unsaturated bond reactions, in the absence of non-macromolecular monomers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/02—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
    • C08J3/03—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
    • C08J3/075—Macromolecular gels
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L33/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • C08L33/24—Homopolymers or copolymers of amides or imides
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2305/00—Characterised by the use of polysaccharides or of their derivatives not provided for in groups C08J2301/00 or C08J2303/00
    • C08J2305/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Materials For Medical Uses (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Medicinal Preparation (AREA)
CN201380014883.5A 2012-01-25 2013-01-25 用于伤口敷料的氟化聚合性水凝胶及其制备方法 Expired - Fee Related CN104168926B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201710650215.1A CN107522880B (zh) 2012-01-25 2013-01-25 水凝胶及其制备方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261590379P 2012-01-25 2012-01-25
US61/590,379 2012-01-25
PCT/US2013/023183 WO2013112863A1 (en) 2012-01-25 2013-01-25 Fluorinated polymerizable hydrogels for wound dressings and methods of making same

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201710650215.1A Division CN107522880B (zh) 2012-01-25 2013-01-25 水凝胶及其制备方法

Publications (2)

Publication Number Publication Date
CN104168926A CN104168926A (zh) 2014-11-26
CN104168926B true CN104168926B (zh) 2017-08-25

Family

ID=48873953

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201380014883.5A Expired - Fee Related CN104168926B (zh) 2012-01-25 2013-01-25 用于伤口敷料的氟化聚合性水凝胶及其制备方法
CN201710650215.1A Expired - Fee Related CN107522880B (zh) 2012-01-25 2013-01-25 水凝胶及其制备方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201710650215.1A Expired - Fee Related CN107522880B (zh) 2012-01-25 2013-01-25 水凝胶及其制备方法

Country Status (10)

Country Link
US (1) US10335490B2 (https=)
EP (1) EP2806908B1 (https=)
CN (2) CN104168926B (https=)
CA (2) CA2862531C (https=)
DK (1) DK2806908T3 (https=)
ES (1) ES2798109T3 (https=)
IN (1) IN2014DN06200A (https=)
PL (1) PL2806908T3 (https=)
PT (1) PT2806908T (https=)
WO (1) WO2013112863A1 (https=)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0808376D0 (en) 2008-05-08 2008-06-18 Bristol Myers Squibb Co Wound dressing
GB0817796D0 (en) 2008-09-29 2008-11-05 Convatec Inc wound dressing
GB201020236D0 (en) 2010-11-30 2011-01-12 Convatec Technologies Inc A composition for detecting biofilms on viable tissues
PL2648795T3 (pl) 2010-12-08 2023-05-08 Convatec Technologies Inc. System do usuwania wysięków z miejsca rany
JP5965409B2 (ja) 2010-12-08 2016-08-03 コンバテック・テクノロジーズ・インコーポレイテッドＣｏｎｖａｔｅｃ Ｔｅｃｈｎｏｌｏｇｉｅｓ Ｉｎｃ 創傷滲出液を評価するための統合システム
CN103347562B (zh) 2010-12-08 2016-08-10 康沃特克科技公司 伤口分泌液系统附件
GB201115182D0 (en) 2011-09-02 2011-10-19 Trio Healthcare Ltd Skin contact material
GB2497406A (en) 2011-11-29 2013-06-12 Webtec Converting Llc Dressing with a perforated binder layer
GB201120693D0 (en) 2011-12-01 2012-01-11 Convatec Technologies Inc Wound dressing for use in vacuum therapy
US9828444B2 (en) * 2012-12-12 2017-11-28 Solvay Specialty Polymers Italy S.P.A. Fluorinated chitosan derivatives
JP2016507663A (ja) 2012-12-20 2016-03-10 コンバテック・テクノロジーズ・インコーポレイテッドＣｏｎｖａｔｅｃ Ｔｅｃｈｎｏｌｏｇｉｅｓ Ｉｎｃ 化学修飾セルロース系繊維の加工
GB2543544A (en) 2015-10-21 2017-04-26 Brightwake Ltd Wound dressing
WO2017173069A1 (en) 2016-03-30 2017-10-05 Convatec Technologies Inc. Detecting microbial infections in wounds
WO2017212345A2 (en) 2016-03-30 2017-12-14 Synovo Gmbh Detecting microbial infection in wounds
GB201608099D0 (en) 2016-05-09 2016-06-22 Convatec Technologies Inc Negative pressure wound dressing
JP7071957B2 (ja) 2016-07-08 2022-05-19 コンバテック・テクノロジーズ・インコーポレイテッド 可撓性陰圧システム
ES2912094T3 (es) 2016-07-08 2022-05-24 Convatec Technologies Inc Detección de flujo de fluidos
BR112019000284A2 (pt) 2016-07-08 2019-04-16 Convatec Technologies Inc. aparelho de coleta de fluido
US12161792B2 (en) 2017-11-16 2024-12-10 Convatec Limited Fluid collection apparatus
WO2019200197A1 (en) * 2018-04-12 2019-10-17 The University Of Akron Multi-functional oxygenating microparticle loaded cell aggregates
CN109847089B (zh) * 2019-01-30 2020-09-22 郑岩 一种高分子材料为载体多种膜构成的伤口供氧敷料
CN111892667B (zh) * 2019-04-30 2024-02-20 苏州大学 含氟化合物修饰的阳离子聚合物在制备医疗美容及保健品中的应用
EP4295869B1 (en) 2019-06-03 2026-01-28 Convatec Limited Devices to disrupt and contain pathogens
US11331221B2 (en) 2019-12-27 2022-05-17 Convatec Limited Negative pressure wound dressing
US11771819B2 (en) 2019-12-27 2023-10-03 Convatec Limited Low profile filter devices suitable for use in negative pressure wound therapy systems
CN111388409B (zh) * 2020-03-25 2023-01-31 牡丹江医学院 一种皮肤止痒抑菌贴剂用水凝胶材料的制备方法
CN112159532B (zh) * 2020-07-03 2022-12-27 中国科学院大学温州研究院(温州生物材料与工程研究所) 一种含氧水凝胶敷料及其制备和用途
US12509542B2 (en) 2021-06-30 2025-12-30 Bausch + Lomb Ireland Limited High water content biomedical devices
CN113801344B (zh) * 2021-09-15 2022-08-12 复旦大学 一种负载氧气的含氟温敏水凝胶及其制备方法和应用
CN116019970B (zh) * 2021-10-27 2024-09-10 曾宪群 高含氧水性凝胶的制造方法
CN113908332B (zh) * 2021-11-15 2022-11-29 中国科学院深圳先进技术研究院 金属过氧化物复合可注射水凝胶及其制备方法和应用
CN115212358B (zh) * 2022-06-16 2023-09-22 健诺维(成都)生物科技有限公司 一种用于眼科治疗的引流管新材料及其制备方法
CN115869458B (zh) * 2022-12-26 2024-07-16 四川大学华西医院 一种用于止血的组合物及其制备方法和用途
CN119281300B (zh) * 2024-11-15 2025-11-07 中国华电科工集团有限公司 一种二氧化碳固体吸附凝胶及其制备方法和应用

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4433111A (en) 1980-10-14 1984-02-21 Kelvin Lenses Limited Fluorine-containing hydrogel-forming polymeric materials
US4618649A (en) * 1983-06-03 1986-10-21 Minnesota Mining And Manufacturing Company Copolymers of poly(vinyl trifluoroacetate) or poly(vinyl alcohol)
ATE127592T1 (de) * 1984-12-18 1995-09-15 Tr Dev Ltd Hydrogelformende polymere.
US4990582A (en) 1986-07-18 1991-02-05 Salamone Joseph C Fluorine containing soft contact lens hydrogels
US4954587A (en) 1988-07-05 1990-09-04 Ciba-Geigy Corporation Dimethylacrylamide-copolymer hydrogels with high oxygen permeability
US5214452A (en) 1988-12-19 1993-05-25 Ciba-Geigy Corporation Hydrogels based on fluorine-containing and saccharide monomers
CA2005659A1 (en) * 1988-12-19 1990-06-19 Jurgen Volkheimer Hydrogels based on fluorine-containing and saccharide monomers
EP0493320B1 (en) 1990-12-20 1996-07-31 Ciba-Geigy Ag Fluorine and/or Silicone containing poly(alkylene-oxide)-block copolymer hydrogels and contact lenses thereof
US5824335A (en) * 1991-12-18 1998-10-20 Dorigatti; Franco Non-woven fabric material comprising auto-crosslinked hyaluronic acid derivatives
GB9325330D0 (en) * 1993-12-10 1994-02-16 Univ Toronto Fluorocyclodextrin drug delivery system
US6630457B1 (en) * 1998-09-18 2003-10-07 Orthogene Llc Functionalized derivatives of hyaluronic acid, formation of hydrogels in situ using same, and methods for making and using same
WO2003087165A2 (en) * 2002-04-11 2003-10-23 Carbomer, Inc. Biocompatible materials and probes
CN101052703A (zh) * 2004-11-05 2007-10-10 庄臣及庄臣视力保护公司 在制造中抑制镜片对表面粘附性的方法
EP2260060A4 (en) * 2008-04-01 2013-01-16 Univ Cornell ORGANIC SOLUBLE CHITOSA SALT AND CHITOSAN DERIVED BIOMATERIALS MANUFACTURED THEREFROM
CN101503491B (zh) 2009-03-10 2011-11-30 海昌隐形眼镜有限公司 一种高透氧氟硅氧烷水凝胶接触镜材料及其制备方法
CA2771389C (en) 2009-08-21 2019-04-09 Novan, Inc. Wound dressings, methods of using the same and methods of forming the same
TWI483996B (zh) 2009-12-08 2015-05-11 Novartis Ag 具有共價貼合塗層之聚矽氧水凝膠鏡片

Also Published As

Publication number Publication date
PL2806908T3 (pl) 2020-10-19
EP2806908A1 (en) 2014-12-03
CA2862531A1 (en) 2013-08-01
IN2014DN06200A (https=) 2015-10-23
US10335490B2 (en) 2019-07-02
CA2862531C (en) 2020-08-11
CN107522880B (zh) 2020-07-24
PT2806908T (pt) 2020-06-22
EP2806908B1 (en) 2020-03-18
EP2806908A4 (en) 2015-09-09
WO2013112863A1 (en) 2013-08-01
DK2806908T3 (da) 2020-06-15
CA3081085A1 (en) 2013-08-01
ES2798109T3 (es) 2020-12-09
CN107522880A (zh) 2017-12-29
CA3081085C (en) 2022-03-22
CN104168926A (zh) 2014-11-26
US20150018433A1 (en) 2015-01-15

Similar Documents

Publication Publication Date Title
CN104168926B (zh) 用于伤口敷料的氟化聚合性水凝胶及其制备方法
Wei et al. Photo-induced adhesive carboxymethyl chitosan-based hydrogels with antibacterial and antioxidant properties for accelerating wound healing
Wu et al. Synthesis and characterization of arginine-NIPAAm hybrid hydrogel as wound dressing: In vitro and in vivo study
Wijekoon et al. Fluorinated methacrylamide chitosan hydrogel systems as adaptable oxygen carriers for wound healing
US7988992B2 (en) Superporous hydrogels for heavy-duty applications
Fan et al. Preparation and characterization of chitosan/gelatin/PVA hydrogel for wound dressings
CN102698313B (zh) 一种纳米银抗菌水凝胶及其制备方法
CN114404649B (zh) 一种具有pH/葡萄糖双响应性释放二甲双胍的水凝胶及制备方法和应用
CN108484936B (zh) 一种接枝改性材料所制备的水凝胶及其制备方法和应用
CN114796620B (zh) 一种用作医用植入材料的互穿网络水凝胶及其制备方法和应用
Liu et al. Multifunctional injectable oxidized sodium alginate/carboxymethyl chitosan hydrogel for rapid hemostasis
CN116271202B (zh) 快速自修复可注射纳米复合抗菌水凝胶敷料及其制备方法
CN117100909B (zh) 一种基于明胶/聚丙烯酰胺载药水凝胶敷料、构建方法及其应用
Sharma et al. The consequence of imine bond origination: Fabrication of rapid self-healing chitosan hydrogel as a drug delivery candidate for water-soluble drug
CN113861447B (zh) 一种改性羟丙基壳聚糖粘附自愈水凝胶及其制备方法和应用
Kılıç Suloğlu et al. Evaluation of kappa carrageenan and gelatin based sponges for dental applications
CN114591473B (zh) 可光固化胶原及其自交联pH敏感型水凝胶的制备方法
EP2147031B1 (en) Stereo photo hydrogel, a process of making said stereo photo hydrogel, polymers for use in making such hydrogel and a pharmaceutical comprising said polymers
CN116549710B (zh) 一种组织胶粘剂及其制备方法、应用
CN118217440B (zh) 一种pam-aa-nhs基多功能创面修复用仿生高分子粘合剂
KR101863293B1 (ko) 자외선을 이용한 하이드로겔 제조방법 및 이의 제조방법으로 제조된 항균성이 향상된 하이드로겔
CN118121753A (zh) 一种促进伤口愈合的CNCs/PAM水凝胶及其用于制备负载药物的敷料的应用
CN119868626A (zh) 一种丙烯酸水凝胶及其制备方法和应用
AU2024295971A1 (en) Improved wound dressing and method to prepare it
CN118217449A (zh) 光固化可注射多糖基多巴胺水凝胶、其制备方法及应用

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20170825

CF01 Termination of patent right due to non-payment of annual fee