CN104162098A - Thyroid nodule eliminating paste preparation for treating benign non-toxic thyroid nodules and preparation method thereof - Google Patents

Abstract

The invention discloses a thyroid nodule eliminating paste preparation for treating benign non-toxic thyroid nodules. The preparation is composed of the following medicinal raw materials in parts by weight: 6 to 11 parts of radix bupleuri, 10 to 15 parts of curcuma rhizome processed with vinegar, 15 to 20 parts of dioscorea bulbifera, 15 to 20 parts of fried semen brassicae, 6 to 11 parts of processed rhizoma cyperi, 30 to 35 parts of ternate buttercup root, 20 to 25 parts of prunella vulgaris, 10 to 15 parts of salt cake, 10 to 15 parts of rhizoma pinelliae preparata, 15 to 20 parts of laminaria, 15 to 20 parts of alga, and 30 to 35 parts of live oyster.

Description

Treat optimum non-toxic thyroid nodule the flat paste formulation of knot first, and preparation method thereof

Technical field

The present invention relates to engineering of traditional Chinese medicine technical field, be specifically related to a kind of flat paste formulation of knot first for the treatment of optimum non-toxic thyroid nodule, and preparation method thereof.

Background technology

Thyroid nodule refers to that thyroid cell is in the caused pathological changes that is dispersed in of local anomaly growth, can be single-shot or multiple nodules sexually transmitted disease (STD) becomes, it is a kind of common clinical, palpation finds that the sickness rate of thyroid nodule is 3%-7%, ultrasound diagnosis finds that the prevalence of tuberosity reaches 20%-70%, clinically, can be divided into thyroid nodule benign protuberance and thyroid carcinoma two classes, wherein optimum thyroid nodule accounts for 95% left and right, and non-toxic thyroid nodule in optimum thyroid nodule, to occupy ratio higher.Optimum non-toxic thyroid nodule is at tuberosity hour non-evident sympton.But if treatment not in time, tuberosity can increase day by day, even can oppress trachea, esophagus and recurrent laryngeal nerve and occur the symptoms such as dyspnea, dysphagia, hoarseness.In addition, optimum thyroid nodule has 10%～20% the rate that cancerates.Therefore, should after discovery, treat as early as possible, prevent its increase or cancerate.

Doctor trained in Western medicine is to the effective Therapeutic Method of this sick shortage at present, for the optimum non-toxic thyroid nodule patient of the overwhelming majority, do not advise using non-operative treatment treatment, comprise: TSH suppression therapy, 131I treatment, the injection of ultrasound-guided percutaneous anhydrous alcohol, percutaneous laser ablation and radio-frequency (RF) ablation etc., only give with examining.Only have when tuberosity increases and occur that hyperthyroidism is improved looks, merged in pressure symptom or obvious impact, tuberosity has in the situation of the tendency that cancerates, just consider surgical resection therapy.Therefore,, for optimum non-toxic thyroid nodule, at its tuberosity, increase to and need before operative treatment, there is no effective western medicine method.Even if it is very easily to recur that operative treatment brings maximum problem, the tuberosity relapse rate of single-shot is large 70%, and multiple nodules relapse rate almost reaches 100%, repeatedly performs the operation and brings great misery to patient's spirit and the human body.

Optimum non-toxic thyroid nodule is known as " goiter " in traditional Chinese medical science ancient literature.On pathogenesis, < < Shengji Zonglu. goiter door > > say " interior seven emotions, the institute of feelings extremely ... gas is thereupon, or upper and not, or knot and loose "; The < < General Treatise on the Cause and Symptoms of Diseases. wart is waited > > and is pointed out that goiter is due to due to " melancholy is angerd depressed ", " take offence to increase and suffer from "; < < Prescriptions for Succouring the Sick. goiter opinion is controlled > > and is said: " being worried excessively ... airsetting stasis, for wart is tumor ".Therefore ancient Chinese medicine doctor think that primary disease mainly blames in irritability stasis.The liver failing to maintain the normal flow of QI, mechanism of qi retardance, with the passing of time gathers shaping; Disorder of movement of QI, the defeated cloth acatharsia of water liquid, retention of water-damp in the body, condenses into expectorant; Transverse invasion of hyperactive liver-QI is violated spleen again, and dysfunction of the spleen in transportation is raw in phlegm-damp, body fluid phlegm caused by accumulation of body fluid, and the expectorant core that congeals into is sent out as wart; Qi being the governor of blood, the stagnation of QI is blood stasis.Liver channel of foot-Jueyin is up enters neck, after following throat, above enters neck forehead, thus stagnation of liver-QI solidifying, the blood stasis of the stagnation of QI, expectorant can follow through up, stop up and tie in throat, send out as goiter.To sum up, stagnation of liver-QI with deficiency of the spleen is the basis of morbidity, and the stagnation of QI, expectorant are solidifying, blood stasis is main pathological factor.

Modern doctor adopts the disappear oral medicinal herb treatment of wart of soothing liver and strengthening spleen, dissipating phlegm and removing blood stasis, eliminating stagnation to primary disease more.Although Chinese medicine can be seen effective report, still there are the following problems: (1) optimum non-toxic thyroid nodule inside and peripheral blood be not for abundant.Therefore only depend on its efficacy of a drug for oral administration to be difficult to through diseased region, therefore simple oral medicinal herb curative effect is poor.(2) therefore a little less than the effect of simple interior oral administration hard masses softening and resolving, the course for the treatment of is long, has increased treatment cost and patient burden.(3) the disappear medicine of Disorder, hard masses softening and resolving of some removing blood stasis has certain toxicity, and prolonged application has more increased risk and the gastrointestinal irritation that causes hepatic and kidney function obstacle.And the topical application of application compress is expected to improve the worth further research and extension of the problems referred to above.

Summary of the invention

For the problems referred to above, the invention provides a kind of flat paste formulation of knot first and preparation method for the treatment of optimum non-toxic thyroid nodule.

Concrete preparation one: the present invention treats the flat paste formulation of knot first of optimum non-toxic thyroid nodule, and described preparation is made by the raw medicinal material of following weight proportion umber: Radix Bupleuri 6-11 part, stir-baked RHIIZOMA CURCUMAE with vinegar 10-15 part, Rhizoma Dioscoreae Bulbiferae 15-20 part, Semen Sinapis Albae (parched) 15-20 part, Rhizoma Cyperi (processed) 6-11 part, Radix Ranunculi Ternati 30-35 part, Spica Prunellae 20-25 part, Natrii Sulfas 10-15 part, Rhizoma Pinelliae 10-15 part, Thallus Laminariae (Thallus Eckloniae) 15-20 part, Sargassum 15-20 part, Concha Ostreae 30-35 part.

Concrete preparation two: the present invention treats the flat paste formulation of knot first of optimum non-toxic thyroid nodule, and described preparation is made by the raw medicinal material of following weight proportion umber: Radix Bupleuri 6-11 part, stir-baked RHIIZOMA CURCUMAE with vinegar 10-15 part, Rhizoma Dioscoreae Bulbiferae 15-20 part, Semen Sinapis Albae (parched) 15-20 part, Rhizoma Pinelliae 6-11 part, Radix Ranunculi Ternati 30-35 part, Medulla Tetrapanacis 20-25 part, Natrii Sulfas 10-15 part, Radix Angelicae Sinensis 10-15 part, Thallus Laminariae (Thallus Eckloniae) 15-20 part, Sargassum 15-20 part, stir-baked RHIZOMA SPARGANII with vinegar 10-15 part.

Concrete preparation three: the present invention treats the flat paste formulation of knot first of optimum non-toxic thyroid nodule, and described preparation is made by the raw medicinal material of following weight proportion umber: Radix Bupleuri 6-11 part, stir-baked RHIIZOMA CURCUMAE with vinegar 10-15 part, Semen Sinapis Albae (parched) 15-20 part, Rhizoma Cyperi (processed) 6-11 part, Radix Ranunculi Ternati 30-35 part, Spica Prunellae 20-25 part, Rhizoma Pinelliae 10-15 part, Thallus Laminariae (Thallus Eckloniae) 15-20 part, Sargassum 15-20 part, Concha Ostreae 30-35 part.

Concrete preparation four: the present invention treats the flat paste formulation of knot first of optimum non-toxic thyroid nodule, and described preparation is made by the raw medicinal material of following weight proportion umber: Radix Bupleuri 6-11 part, Radix Scutellariae 10-15 part, stir-baked RHIIZOMA CURCUMAE with vinegar 10-15 part, Semen Sinapis Albae (parched) 15-20 part, Rhizoma Cyperi (processed) 6-11 part, Radix Ranunculi Ternati 30-35 part, Spica Prunellae 20-25 part, Rhizoma Pinelliae 10-15 part, Thallus Laminariae (Thallus Eckloniae) 15-20 part, Sargassum 15-20 part, Concha Ostreae 30-35 part.

The preparation method of the flat paste formulation of knot first of the optimum non-toxic thyroid nodule for the treatment of that the present invention is above-mentioned, described method comprises:

Step 1: proportionally take various described raw medicinal materials, fully mix;

Step 2: mixed various raw medicinal materials are pulverized, be ground into 80 order～400 object medicated powder;

Step 3: the medicated powder of step 2 is put into boil and carry tank, extract at twice medicinal liquid;

Step 4: extracted twice medicinal liquid is put into concentration tank, be concentrated into the concentrated solution of 1.05-1.2 proportion;

Step 5: be crushed to 80 order～400 object medicated powder described in adding, fully dissolve, mix;

Step 6: by above-mentioned concentrated solution and medical water-borne pressure sensitive adhesive, mix and blend, adjustment pH value is 5.5-7, crosses 80 mesh filter screens;

Step 7: mixed liquor is paved on non-woven fabrics, remove excessive moisture, cut into patch.

The preparation method of the flat paste formulation of knot first of the above-mentioned optimum non-toxic thyroid nodule for the treatment of, described method comprises:

Step 1: get stir-baked RHIIZOMA CURCUMAE with vinegar, Rhizoma Dioscoreae Bulbiferae, Rhizoma Cyperi (processed), Radix Ranunculi Ternati, Rhizoma Pinelliae and Sargassum, Thallus Laminariae (Thallus Eckloniae), Spica Prunellae, Radix Bupleuri, Semen Sinapis Albae (parched), Concha Ostreae, mix according to following weight proportion umber: Radix Bupleuri 6-11 part, stir-baked RHIIZOMA CURCUMAE with vinegar 10-15 part, Rhizoma Dioscoreae Bulbiferae 15-20 part, Semen Sinapis Albae (parched) 15-20 part, Rhizoma Cyperi (processed) 6-11 part, Radix Ranunculi Ternati 30-35 part, Spica Prunellae 20-25 part, Natrii Sulfas 10-15 part, Rhizoma Pinelliae 10-15 part, Thallus Laminariae (Thallus Eckloniae) 15-20 part, Sargassum 15-20 part, Concha Ostreae 30-35 part;

Step 2: mixed above-mentioned raw materials medical material is pulverized, and pulverizing is 80 order medicated powder, soaks 12 hours;

Step 3: it is 80 order medicated powder that Natrii Sulfas is pulverized, it is 400 order medicated powder that Semen Sinapis Albae (parched), Concha Ostreae are pulverized;

Step 4: the medicated powder of step 2 is put into boil and carry tank, add 4 times of water of medical material total amount, equivalent ethanol to boil and carry for the first time.Seethe with excitement and within latter 3 hours, extract first medicinal liquid.Add 2 times of water of medical material total amount, seethe with excitement and within latter 2 hours, extract second medicinal liquid;

Step 5: medical filtration 120 eye mesh screens that step 4 is extracted, then add concentration tank.Medicinal liquid is concentrated to 1.0 and concentrated solution is taken out during to 1.2 proportion;

Step 6: the concentrated solution in step 5 is fully mixed, dissolved with the Natrii Sulfas medicated powder in step 3;

Step 7: the mixed solution in step 6 is fully mixed and adds medical water-borne pressure sensitive adhesive with 400 order medicated powder in step 3, mix and blend, adjustment pH value is 5.5-7, crosses 80 mesh filter screens, viscosity is viscosity 90-110mPa.s;

Step 7: above-mentioned mixed liquor is paved on non-woven fabrics, and upper strata covers silicone oil release paper, dries and removes excessive moisture, cuts into patch.

Beneficial effect of the present invention:

The present invention adopts pure Chinese medicinal preparation, and determined curative effect is lasting rapidly, without Liver and kidney first pass effect, use safety, have no side effect, the blood drug level peak valley phenomenon of avoiding oral administration etc. to cause, maintain constant blood concentration, can be used in conjunction with oral agents, injection or other Therapeutic Method, without incompatibility, easy to use, interruption of the administration at any time, improves the compliance of patient's medication, economical and practical.

The specific embodiment

The present invention with activating QI to eliminate phlegm, the method treatment of wart, hard masses softening and resolving of disappearing of invigorating blood circulation, get the meaning of " disease caused by accumulations of pathogen should be treated with therapy of dispersion, disease with retention of pathogen in the body should be treated by elimination therapy ".The disease that optimum non-toxic thyroid nodule is deficiency in origin and excess in superficiality, treating both the principal and secondary aspects of a disease.Its " basis " mainly refers to the visceral dysfunction of stagnation of liver-QI with deficiency of the spleen; " mark " leading indicator is real, i.e. solidifying, the blood stasis of the stagnation of QI, expectorant.When taking stopgap measures, all the time do not forget the Therapeutic Principle of effecting a permanent cure, a kind of flat paste formulation of knot first for the treatment of optimum non-toxic thyroid nodule is provided, and wherein Chinese herbs paste comprises following raw medicinal material: Radix Bupleuri, stir-baked RHIIZOMA CURCUMAE with vinegar, Rhizoma Dioscoreae Bulbiferae, Semen Sinapis Albae (parched), Rhizoma Cyperi (processed), Radix Ranunculi Ternati, Spica Prunellae, Natrii Sulfas, Rhizoma Pinelliae, Thallus Laminariae (Thallus Eckloniae), Sargassum, Concha Ostreae.

The present invention with activating QI to eliminate phlegm, the method treatment of wart, hard masses softening and resolving of disappearing of invigorating blood circulation, get the meaning of " disease caused by accumulations of pathogen should be treated with therapy of dispersion, disease with retention of pathogen in the body should be treated by elimination therapy ".The disease that optimum non-toxic thyroid nodule is deficiency in origin and excess in superficiality, treating both the principal and secondary aspects of a disease.Its " basis " mainly refers to the visceral dysfunction of stagnation of liver-QI with deficiency of the spleen; " mark " leading indicator is real, i.e. solidifying, the blood stasis of the stagnation of QI, expectorant.When taking stopgap measures, all the time do not forget the Therapeutic Principle of effecting a permanent cure, a kind of flat paste formulation of knot first for the treatment of optimum non-toxic thyroid nodule is provided, and wherein Chinese herbs paste comprises following raw medicinal material: Radix Bupleuri, stir-baked RHIIZOMA CURCUMAE with vinegar, Rhizoma Dioscoreae Bulbiferae, Semen Sinapis Albae (parched), Rhizoma Cyperi (processed), Radix Ranunculi Ternati, Spica Prunellae, Natrii Sulfas, Rhizoma Pinelliae, Thallus Laminariae (Thallus Eckloniae), Sargassum, Concha Ostreae.

In described Chinese herbs paste, the weight fraction of various raw medicinal materials ratio is preferably: Radix Bupleuri 6 weight portions, stir-baked RHIIZOMA CURCUMAE with vinegar 10 weight portions, Rhizoma Dioscoreae Bulbiferae 15 weight portions, Semen Sinapis Albae (parched) 15 weight portions, Rhizoma Cyperi (processed) 6 weight portions, Radix Ranunculi Ternati 30 weight portions, Spica Prunellae 20 weight portions, Natrii Sulfas 10 weight portions, Rhizoma Pinelliae 10 weight portions, Thallus Laminariae (Thallus Eckloniae) 15 weight portions, Sargassum 15 weight portions, Concha Ostreae 30 weight portions.Radix Bupleuri 6g, stir-baked RHIIZOMA CURCUMAE with vinegar 10g, Rhizoma Dioscoreae Bulbiferae 15g, Semen Sinapis Albae (parched) 15g, Rhizoma Cyperi (processed) 6g, Radix Ranunculi Ternati 30g Spica Prunellae 20g, Natrii Sulfas 10g, Rhizoma Pinelliae 10g, Thallus Laminariae (Thallus Eckloniae) 15g, Sargassum 15g, Concha Ostreae 30g.

Described Chinese herbs paste can also comprise following raw medicinal material: Radix Bupleuri, stir-baked RHIIZOMA CURCUMAE with vinegar, Rhizoma Dioscoreae Bulbiferae, Semen Sinapis Albae (parched), Rhizoma Pinelliae, Radix Ranunculi Ternati, Medulla Tetrapanacis, Natrii Sulfas, Radix Angelicae Sinensis, Thallus Laminariae (Thallus Eckloniae), Sargassum, stir-baked RHIZOMA SPARGANII with vinegar.

The weight fraction ratio of above-mentioned various raw medicinal materials is: Radix Bupleuri 6 weight portions, stir-baked RHIIZOMA CURCUMAE with vinegar 10 weight portions, Rhizoma Dioscoreae Bulbiferae 15 weight portions, Semen Sinapis Albae (parched) 15 weight portions, Rhizoma Pinelliae 10 weight portions, Radix Ranunculi Ternati 30 weight portions, Medulla Tetrapanacis 20 weight portions, Natrii Sulfas 10 weight portions, Radix Angelicae Sinensis 10 weight portions, Thallus Laminariae (Thallus Eckloniae) 15 weight portions, Sargassum 15 weight portions, stir-baked RHIZOMA SPARGANII with vinegar 10 weight portions.

In described Chinese herbs paste, the weight fraction of various raw medicinal materials is than being also preferably: Radix Bupleuri 6 weight portions, stir-baked RHIIZOMA CURCUMAE with vinegar 10 weight portions, Rhizoma Dioscoreae Bulbiferae 15 weight portions, Semen Sinapis Albae (parched) 15 weight portions, Rhizoma Pinelliae 10 weight portions, Radix Ranunculi Ternati 30 weight portions, Medulla Tetrapanacis 20 weight portions, Natrii Sulfas 10 weight portions, Radix Angelicae Sinensis 10 weight portions, Thallus Laminariae (Thallus Eckloniae) 15 weight portions, Sargassum 15 weight portions, stir-baked RHIZOMA SPARGANII with vinegar 10 weight portions.

In described Chinese herbs paste, the weight fraction of various raw medicinal materials ratio can also be more preferably: Radix Bupleuri 6 weight portions, Radix Scutellariae 10 weight portions, stir-baked RHIIZOMA CURCUMAE with vinegar 10 weight portions, Semen Sinapis Albae (parched) 15 weight portions, Rhizoma Cyperi (processed) 6 weight portions, Radix Ranunculi Ternati 30 weight portions, Spica Prunellae 20 weight portions, Rhizoma Pinelliae 10 weight portions, Thallus Laminariae (Thallus Eckloniae) 15 weight portions, Sargassum 15 weight portions, Concha Ostreae 30 weight portions.

In Chinese herbs paste of the present invention, the pharmacology of each raw medicinal material is as follows:

Radix Bupleuri: bitter in the mouth is flat, enters liver, gallbladder meridian.There is delivering, bring down a fever, the effect of soothing the liver, resolving depression, yang invigorating.Cure mainly alternate attack of chill and fever, malaria, side of body distending pain, menoxenia.

Stir-baked RHIIZOMA CURCUMAE with vinegar: acrid in the mouth is bitter, temperature.Enter liver, spleen channel.Stir-baked RHIIZOMA CURCUMAE with vinegar is as the term suggests be exactly, with vinegar, Rhizoma Curcumae was fried to Rhizoma Curcumae finished product afterwards, and stir-baked RHIIZOMA CURCUMAE with vinegar Ke Yi lumps in the chest and abdomen, amenorrhea and trusted subordinate's stasis of blood are bitterly.It is logical that Rhizoma Curcumae hardship is let out pungent loose temperature, both entered blood system, enters again edema caused by disorder of QI, can removing blood stasis dissipating blood stasis ， Xiao Disorder eliminate indigestion, and promoting the circulation of QI to relieve pain, are applicable to that with the passing of time qi depression to blood stasis, food stagnation form that lumps in the chest and abdomen and the stagnation of QI, blood stasis, food stop, pain card as all due to cold coagulation.

Rhizoma Dioscoreae Bulbiferae: bitter in the mouth is flat.Enter liver, heart channel.Removing heat from blood, pathogenic fire reducing, the wart that disappears, removing toxic substances.Control haematemesis, epistaxis, sore throat, goiter, carbuncle sore scrofula.

Semen Sinapis Albae (parched): acrid in the mouth, temperature.Enter lung meridian.Reduce phlegm by drink, mass dissipating and swelling eliminating.Cure mainly cough with asthma abundant expectoration; Fullness in the chest and hypochondriac pain; Numb limbs and tense tendons; Arthralgia; Multiple abscess caused by damp-phlegm; Carbuncle of yin nature toxic swelling.< < Elementary Medicine > >: sharp chest and diaphragm expectorant, only regurgitation of food from the stomach is told food, gas on phlegmatic cough, aphasia due to apoplexy, appearance yellow skin, settling five organs, stops many urine at night.Control again and flutter damage blood stasis.< < detailed outline > >: promoting the circulation of QI eliminating phlegm, in cold warming up, loose swollen pain relieving.Control and breathe heavily the regurgitation of coughing, numbness wood beriberi, muscles and bones waist saves all pains.The modern Practical Chinese medicinal > of < < >: mash as mud, outward as skin irritation rubefacient.

Rhizoma Cyperi (processed): the micro-hardship of acrid in the mouth is sweet is flat.Enter liver, spleen, tri-jiao channel.Effect: the resolving depression of regulating the flow of vital energy, menstruction regulating and pain relieving.Cure mainly: stagnation of QI due to depression of the liver, breast, the side of body, abdominal distention, dyspepsia, menoxenia, amenorrhea dysmenorrhea, colic of cold type stomachache, distending pain of the breast.

Radix Ranunculi Ternati: taste sweet, acrid, warm.Enter liver, lung meridian.Eliminating stagnation, detumescence.Control scrofula, pulmonary tuberculosis, malaria.

Spica Prunellae: taste bitter, acrid, cold, enters liver, gallbladder meridian.Liver heat removing and eyesight improving, mass dissipating and swelling eliminating.Cure mainly conjunctival congestion and swelling pain, headache, scrofula, goiter, acute mastitis swell and ache.

Natrii Sulfas: salty in the mouth, micro-hardship, cold in nature.Enter stomach, large intestine channel.Under rushing down, heat clearing away, softening the hard mass.Cure mainly fever accumulation and constipation, abdominal distention distending pain, lumps in the chest and abdomen, carbuncle, conjunctival congestion, aphtha, erysipelas etc.Control excess-heat stagnant, abdominal distention constipation, retention of phlegm gathers, mouthful red hiding from view, erysipelas, carbuncle.< < does not record > >: main the five internal organs gather, and hot stomach of a specified duration closes, except pathogen, and broken stagnant blood, in abdomen, the real knot of expectorant is fought, qualcomm meridian, sharp defecation and Yue Shui, drench the fifth day of the first lunar month, pushes away Chen Zhixin.

Rhizoma Pinelliae: acrid in the mouth, temperature, poisonous.Enter spleen, stomach, lung meridian.Drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass; Externally used detumescence pain relieving.This product acrid in the mouth is warm in nature and dry, is drying dampness to eliminate phlegm, the key medicine of warming for resolving cold-phlegm.The outstanding kind damp-phlegm of controlling internal organs.Goiter, sucutaneous nodule, swollen ulcer drug and venom.Energy vanishing sputum and dispelling knot for oral administration, external energy reducing swelling and alleviating pain.Control gall subcutaneous nodule, often join Thallus Laminariae (Thallus Eckloniae), Sargassum, Bulbus Fritillariae Uninbracteatae etc.;

Thallus Laminariae (Thallus Eckloniae): salty in the mouth is cold, enters liver, stomach, kidney channel.Eliminating phlegm and softening indurated mass, the diuretic that expels the heat-evil, relieving cough and asthma, eliminating stagnation are anticancer.For under goiter, scrofula, hernia, fall, cough with asthma, edema, hypertension, coronary heart disease, obesity.Be used for the treatment of goiter, may be relevant with its contained iodide, because iodine is thyroxine main component, iodine Deficiency of Intake can cause thyroxine not enough, cause thyromegaly (goiter), and the intake of Thallus Laminariae (Thallus Eckloniae) energy supplementing iodine for oral administration is corrected thyroxine not enough, thereby the body of gland of enlargement is dwindled gradually, even dissipate, for goiter, early stage hypertrophy enlargement has certain effect, but needs long-term (March～half a year) to adhere to taking medicine, often join Sargassum, side's kettle ball plus-minus as beautiful in Sargassum.

Sargassum: bitter in the mouth, salty, cold.Enter liver, kidney, stomach warp.Softening the hard mass, expectorant, clearing away heat and promoting diuresis.Goiter scrofula, hernia, painful and swollen testis, phlegm retention edema.< < herbal classic > >: " main goiter gas, core under neck, broken eliminating stagnation gas, the hard gas of Yong Zhong mass in the abdomen." < < is interior through > > cloud, salty energy softening the hard mass.Stagnation of nutrient QI, is outward edema, with the medicine of each tying-in, controls it, without swollen, does not disappear, and gas also sluices." < < detailed outline > >: " Sargassum, salty can relaxing the bowels with lubricant drugs, the cold diversion that can expel the heat-evil, therefore the goiter that can disappear, tuberculosis, cloudy heavily fortified point of bursting are gathered, and damp and hot except edema, beriberi, prolonged fluid-retention, mental disorder makes pathogen go out also from urine." " by eastern wall Li Shi, controls the loose swollen hard soup of bursting of scrofula Concha Solen gouldii, Sargassum, Radix Glycyrrhizae dual-purpose it, the disease that Gai Yijian is long-pending, non-gentle medicine can be got victory, must make counter taking by force, with Cheng Qigong also." the high former > > of < < book on Chinese herbal medicine: " Sargassum, its bitter in the mouth is salty, and it is cold in nature clean, therefore cure mainly the outer interior heavily fortified point knot of passages through which vital energy circulates.Goiter stagnation of QI, stone pain carbuncle under neck is through abnormal pulse and disease is tied in outward also.The hard gas of mass in the abdomen, thunderous up and down in abdomen, be through abnormal pulse and disease is tied in also interior.Sargassum ... main qualcomm meridian, therefore control 12 through edema, personal twelve regular channels circulation, edema spontaneous recovery.

Concha Ostreae: salty in the mouth is wet is flat.Enter liver, kidney channel.Yin fluid astringing, YANG hyperactivity suppressing, hidroschesis, arresting seminal emission, reduces phlegm, softening the hard mass.Cure mainly palpitation with fear insomnia, vertigo and tinnitus, tuberculous lymphadenitis, abdominal mass abdominal mass mass in the abdomen, spontaneous sweating, seminal emission metrorrhagia and leukorrhagia, stomachache pantothenic acid.< < detailed outline > >: resolving phlegm and softening hard masses, removing damp-heat, stops heart temper pain, under dysentery, reddish and whitish turbid urine, the hernia that disappears abdominal mass is amassed piece, wart disease tuberculosis.

We are local external application in affected part, real mainly for the stagnation of QI, expectorant mark solidifying, blood stasis, controls to regulate the flow of vital energy, reduces phlegm, invigorates blood circulation, and reach the disappear object of wart of eliminating stagnation.Cervical region both sides are the Liver Channel part of go the rounds, and depression of liver-QI is sent out as goiter in this, and in side, Radix Bupleuri, Rhizoma Cyperi (processed), Rhizoma Dioscoreae Bulbiferae, Spica Prunellae all enter Liver Channel, Radix Bupleuri, Rhizoma Cyperi (processed) depressed liver-energy dispersing and QI regulating, and liver-fire falls in Rhizoma Dioscoreae Bulbiferae, Spica Prunellae, plays altogether the merit of resolving depression eliminating stagnation.The Rhizoma Pinelliae, Semen Sinapis Albae acrid in the mouth are warm in nature, Rhizoma Pinelliae drying dampness to eliminate phlegm, and Semen Sinapis Albae warming YANG is by drink, and two medicines share the drink that can temperature reduces phlegm.Natrii Sulfas, Thallus Laminariae (Thallus Eckloniae), Sargassum, Concha Ostreae are salty-cold product, softening the hard mass vanishing sputum and dispelling knot.We's medicine reducing phlegm used, pungent salty and use, cold temperature is executed altogether, and the lifting people having the same aspiration and interest is played the merit of dissipating phlegm and resolving masses altogether.Stir-baked RHIIZOMA CURCUMAE with vinegar removing blood stasis Xiao Disorder is with eliminating stagnation.Full side plays activating QI to eliminate phlegm, the merit of blood circulation promoting and dispersing pathogen accumulation altogether.

In described Chinese herbs paste, the weight fraction of various raw medicinal materials is than being also preferably: Radix Bupleuri 6-11 weight portion, stir-baked RHIIZOMA CURCUMAE with vinegar 10-15 weight portion, Semen Sinapis Albae (parched) 15-20 weight portion, Rhizoma Cyperi (processed) 6-11 weight portion, Radix Ranunculi Ternati 30-35 weight portion, Spica Prunellae 20-25 weight portion, Rhizoma Pinelliae 10-15 weight portion, Thallus Laminariae (Thallus Eckloniae) 15-20 weight portion, Sargassum 15-20 weight portion, Concha Ostreae 30-35 weight portion.

In described Chinese herbs paste, the weight fraction of various raw medicinal materials ratio can also be more preferably: Radix Bupleuri 6-11 weight portion, Radix Scutellariae 10-15 weight portion, stir-baked RHIIZOMA CURCUMAE with vinegar 10-15 weight portion, Semen Sinapis Albae (parched) 15-20 weight portion, Rhizoma Cyperi (processed) 6-11 weight portion, Radix Ranunculi Ternati 30-35 weight portion, Spica Prunellae 20-25 weight portion, Rhizoma Pinelliae 10-15 weight portion, Thallus Laminariae (Thallus Eckloniae) 15-20 weight portion, Sargassum 15-20 weight portion, Concha Ostreae 30-35 weight portion.

The present invention provides again a kind of preparation method of above-mentioned Chinese herbs paste, and wherein prepared method comprises the following steps:

Step 1: proportionally take various raw medicinal materials in described Chinese herbs paste, fully mix;

Step 2: mixed various raw medicinal materials are pulverized, be ground into 80 order～400 object medicated powder;

Step 3: the medicated powder of step 2 is put into boil and carry tank, extract at twice medicinal liquid;

Step 4: extracted twice medicinal liquid is put into concentration tank, be concentrated into the concentrated solution of 1.05-1.2 proportion;

Step 5: add the above-mentioned 80 order～400 object medicated powder that are crushed to, fully dissolve, mix;

Step 6: by above-mentioned concentrated solution and medical water-borne pressure sensitive adhesive, mix and blend, adjustment pH value is 5.5-7, crosses 80 mesh filter screens.

Step 7: above-mentioned mixed liquor is paved on non-woven fabrics, remove excessive moisture, cut into patch.

For solving the problems of the technologies described above, the present invention provides a kind of preparation method of above-mentioned Chinese herbs paste again, and wherein said preparation method comprises the following steps:

Step 1: get stir-baked RHIIZOMA CURCUMAE with vinegar, Rhizoma Dioscoreae Bulbiferae, Rhizoma Cyperi (processed), Radix Ranunculi Ternati, Rhizoma Pinelliae and Sargassum, Thallus Laminariae (Thallus Eckloniae), Spica Prunellae, Radix Bupleuri, Semen Sinapis Albae (parched), Concha Ostreae: proportionally mix.

Step 2: mixed above-mentioned raw materials medical material is pulverized, and pulverizing is 80 order medicated powder, soaks 12 hours;

Step 3: it is 80 order medicated powder that Natrii Sulfas is pulverized, it is 400 order medicated powder that Semen Sinapis Albae (parched), Concha Ostreae are pulverized;

Step 4: the medicated powder of step 2 is put into boil and carry tank, add 4 times of water of medical material total amount, equivalent ethanol to boil and carry for the first time.Seethe with excitement and within latter 3 hours, extract first medicinal liquid.Add 2 times of water of medical material total amount, seethe with excitement and within latter 2 hours, extract second medicinal liquid;

Step 5: medical filtration 120 eye mesh screens that step 4 is extracted, then add concentration tank.Medicinal liquid while being concentrated to 1.1 (± 10%) proportion takes out concentrated solution;

Step 6: the concentrated solution in step 5 is fully mixed, dissolved with the Natrii Sulfas medicated powder in step 3;

Step 7: the mixed solution in step 6 is fully mixed with 400 order medicated powder in step 3 and add medical water-borne pressure sensitive adhesive,, mix and blend, adjustment pH value is 5.5-7, crosses 80 mesh filter screens, viscosity is viscosity 90-110mPa.s; Above-mentioned mixed liquor is paved on non-woven fabrics, and upper strata covers silicone oil release paper, dries and removes excessive moisture, cuts into patch.Patient is applied to bilateral thyroid, subsides in a day.

Pharmacology's toxicity test

1. irritation test

Get rabbit and shave hair, with medicine of the present invention, induce and excite contact test, viewing test rabbit after 24 hours and 48 hours, all loseing skin has the phenomenons such as erythema and edema, with negative control group zero difference.Result shows, Chinese herbs paste of the present invention is bordering on zero to dermoreaction intensity, without skin allergic reaction.

2. endo-medicine cumulative toxicity test report

Test method: select 20 healthy mices, female, male each 10, it is first phase that dosage designs every 5 days, each issue dosage is respectively 0.10LD50,0.15LD50,0.22LD50,0.34LD50,0.50LD50, and the LD50 female, male mice of this sample is 5000m part/k part BW (five dosage be 500,750,1100,1700,2500m part/k part BW).Within every 5 days, weigh once, adjust dosage, by 0.1ml/10 part BW per os gavage.After 20 days, animal occurs without death condition, off-test, and by ascending-dose, to tested material after 20 days, female, buck all occurs without death condition.

3. acute toxicity test

Give from Mus oral administration medicine supplying with 300 times of the clinical consumption per day of Chinese medicine of the present invention, observe 5.The all animals of result are strong deposits, and its activity, diet, hair, Excreta are no abnormal, have no toxic reaction.White mouse damaged skin is carried out to irritation test, there are no irritative response and other untoward reaction.

Toxicity test proves, the not toxic effect of this medicine and untoward reaction, and clinical practice is safe and reliable.

4. long term toxicity test:

Chinese medicine preparation of the present invention to mice by 7.69,19.18 and 15 weeks (1.0ml/100g body weight of 43.21g crude drug/kg continuous use, every day 2 times) and drug withdrawal after 3 weeks, result shows: Chinese medicine preparation of the present invention all has no significant effect indexs such as the hair of rat, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat, internal organs naked eyes do not find that difference changes and histological examination result shows, medication 15 weeks and drug withdrawal are after 3 weeks, and each internal organs of rat are all without obviously changing.Illustrate that toxicity is little after Chinese medicine preparation of the present invention is to rat long-term prescription, after drug withdrawal, also there is no difference reaction, application safety.

The present invention be should be understood that; above-described embodiment; object of the present invention, technical scheme and beneficial effect have been carried out to further detailed explanation; these are only embodiments of the invention; be not intended to limit the present invention, every within spiritual principles of the present invention, any modification of having done, be equal to replacement, improvement etc.; within all should being included in protection scope of the present invention, protection scope of the present invention should be as the criterion with the protection domain that claim was defined.

Claims (6)

1. the flat paste formulation of knot first for the treatment of optimum non-toxic thyroid nodule, it is characterized in that, described preparation is made by the raw medicinal material of following weight proportion umber: Radix Bupleuri 6-11 part, stir-baked RHIIZOMA CURCUMAE with vinegar 10-15 part, Rhizoma Dioscoreae Bulbiferae 15-20 part, Semen Sinapis Albae (parched) 15-20 part, Rhizoma Cyperi (processed) 6-11 part, Radix Ranunculi Ternati 30-35 part, Spica Prunellae 20-25 part, Natrii Sulfas 10-15 part, Rhizoma Pinelliae 10-15 part, Thallus Laminariae (Thallus Eckloniae) 15-20 part, Sargassum 15-20 part, Concha Ostreae 30-35 part.

2. the flat paste formulation of knot first for the treatment of optimum non-toxic thyroid nodule, it is characterized in that, described preparation is made by the raw medicinal material of following weight proportion umber: Radix Bupleuri 6-11 part, stir-baked RHIIZOMA CURCUMAE with vinegar 10-15 part, Rhizoma Dioscoreae Bulbiferae 15-20 part, Semen Sinapis Albae (parched) 15-20 part, Rhizoma Pinelliae 6-11 part, Radix Ranunculi Ternati 30-35 part, Medulla Tetrapanacis 20-25 part, Natrii Sulfas 10-15 part, Radix Angelicae Sinensis 10-15 part, Thallus Laminariae (Thallus Eckloniae) 15-20 part, Sargassum 15-20 part, stir-baked RHIZOMA SPARGANII with vinegar 10-15 part.

3. the flat paste formulation of knot first for the treatment of optimum non-toxic thyroid nodule, it is characterized in that, described preparation is made by the raw medicinal material of following weight proportion umber: Radix Bupleuri 6-11 part, stir-baked RHIIZOMA CURCUMAE with vinegar 10-15 part, Semen Sinapis Albae (parched) 15-20 part, Rhizoma Cyperi (processed) 6-11 part, Radix Ranunculi Ternati 30-35 part, Spica Prunellae 20-25 part, Rhizoma Pinelliae 10-15 part, Thallus Laminariae (Thallus Eckloniae) 15-20 part, Sargassum 15-20 part, Concha Ostreae 30-35 part.

4. the flat paste formulation of knot first for the treatment of optimum non-toxic thyroid nodule, it is characterized in that, described preparation is made by the raw medicinal material of following weight proportion umber: Radix Bupleuri 6-11 part, Radix Scutellariae 10-15 part, stir-baked RHIIZOMA CURCUMAE with vinegar 10-15 part, Semen Sinapis Albae (parched) 15-20 part, Rhizoma Cyperi (processed) 6-11 part, Radix Ranunculi Ternati 30-35 part, Spica Prunellae 20-25 part, Rhizoma Pinelliae 10-15 part, Thallus Laminariae (Thallus Eckloniae) 15-20 part, Sargassum 15-20 part, Concha Ostreae 30-35 part.

5. the preparation method of the flat paste formulation of knot first of the arbitrary described optimum non-toxic thyroid nodule for the treatment of of claim 1 to 4, is characterized in that, described method comprises:

Step 1: proportionally take various described raw medicinal materials, fully mix;

Step 2: mixed various raw medicinal materials are pulverized, be ground into 80 order～400 object medicated powder;

Step 3: the medicated powder of step 2 is put into boil and carry tank, extract at twice medicinal liquid;

Step 4: extracted twice medicinal liquid is put into concentration tank, be concentrated into the concentrated solution of 1.05-1.2 proportion;

Step 5: be crushed to 80 order～400 object medicated powder described in adding, fully dissolve, mix;

Step 6: by above-mentioned concentrated solution and medical water-borne pressure sensitive adhesive, mix and blend, adjustment pH value is 5.5-7, crosses 80 mesh filter screens;

Step 7: mixed liquor is paved on non-woven fabrics, remove excessive moisture, cut into patch.

6. the preparation method of the flat paste formulation of knot first of the optimum non-toxic thyroid nodule for the treatment of claimed in claim 1, is characterized in that, described method comprises:

Step 1: get stir-baked RHIIZOMA CURCUMAE with vinegar, Rhizoma Dioscoreae Bulbiferae, Rhizoma Cyperi (processed), Radix Ranunculi Ternati, Rhizoma Pinelliae and Sargassum, Thallus Laminariae (Thallus Eckloniae), Spica Prunellae, Radix Bupleuri, Semen Sinapis Albae (parched), Concha Ostreae, mix according to following weight proportion umber: Radix Bupleuri 6-11 part, stir-baked RHIIZOMA CURCUMAE with vinegar 10-15 part, Rhizoma Dioscoreae Bulbiferae 15-20 part, Semen Sinapis Albae (parched) 15-20 part, Rhizoma Cyperi (processed) 6-11 part, Radix Ranunculi Ternati 30-35 part, Spica Prunellae 20-25 part, Natrii Sulfas 10-15 part, Rhizoma Pinelliae 10-15 part, Thallus Laminariae (Thallus Eckloniae) 15-20 part, Sargassum 15-20 part, Concha Ostreae 30-35 part;

Step 2: mixed above-mentioned raw materials medical material is pulverized, and pulverizing is 80 order medicated powder, soaks 12 hours;

Step 3: it is 80 order medicated powder that Natrii Sulfas is pulverized, it is 400 order medicated powder that Semen Sinapis Albae (parched), Concha Ostreae are pulverized;

Step 4: the medicated powder of step 2 is put into boil and carry tank, add 4 times of water of medical material total amount, equivalent ethanol to boil and carry for the first time, seethe with excitement and extract first medicinal liquid in latter 3 hours, add 2 times of water of medical material total amount, seethe with excitement and extract second medicinal liquid for latter 2 hours;

Step 5: medical filtration 120 eye mesh screens that step 4 is extracted, then add concentration tank, medicinal liquid to be concentrated to 1.0 concentrated solution to be taken out during to 1.2 proportion;

Step 6: the concentrated solution in step 5 is fully mixed, dissolved with the Natrii Sulfas medicated powder in step 3;

Step 7: the mixed solution in step 6 is fully mixed and adds medical water-borne pressure sensitive adhesive with 400 order medicated powder in step 3, mix and blend, adjustment pH value is 5.5-7, crosses 80 mesh filter screens, viscosity is viscosity 90-110mPa.s;

Step 8: above-mentioned mixed liquor is paved on non-woven fabrics, and upper strata covers silicone oil release paper, dries and removes excessive moisture, cuts into patch.