CN104159913A - 针对细胞内靶分子的结合剂 - Google Patents

针对细胞内靶分子的结合剂 Download PDF

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Publication number
CN104159913A
CN104159913A CN201380009041.0A CN201380009041A CN104159913A CN 104159913 A CN104159913 A CN 104159913A CN 201380009041 A CN201380009041 A CN 201380009041A CN 104159913 A CN104159913 A CN 104159913A
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alphabody
cell
cells
polypeptide
intracellular
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CN201380009041.0A
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Chinese (zh)
Inventor
I·拉斯特斯
M·万克
J·戴斯迈特
J·德巴韦耶
S·德罗
S·洛贝里克斯
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Complix NV
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Complix NV
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K16/1002—Coronaviridae
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C07K2317/00—Immunoglobulins specific features
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    • C—CHEMISTRY; METALLURGY
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    • C07K2319/00—Fusion polypeptide
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    • C07K2319/10—Fusion polypeptide containing a localisation/targetting motif containing a tag for extracellular membrane crossing, e.g. TAT or VP22

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CN201380009041.0A 2012-01-06 2013-01-04 针对细胞内靶分子的结合剂 Pending CN104159913A (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201261583761P 2012-01-06 2012-01-06
EP12150406.2 2012-01-06
US61/583,761 2012-01-06
EP12150406 2012-01-06
US201261716893P 2012-10-22 2012-10-22
US61/716,893 2012-10-22
PCT/EP2013/050101 WO2013102659A2 (en) 2012-01-06 2013-01-04 Binding agents to intracellular target molecules

Publications (1)

Publication Number Publication Date
CN104159913A true CN104159913A (zh) 2014-11-19

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ID=48745494

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Application Number Title Priority Date Filing Date
CN201380009041.0A Pending CN104159913A (zh) 2012-01-06 2013-01-04 针对细胞内靶分子的结合剂

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Country Link
US (1) US20140363434A1 (enExample)
EP (1) EP2800759B1 (enExample)
JP (1) JP2015504064A (enExample)
CN (1) CN104159913A (enExample)
AU (1) AU2013207209B2 (enExample)
BR (1) BR112014016744A2 (enExample)
CA (1) CA2860666A1 (enExample)
IN (1) IN2014MN01562A (enExample)
WO (1) WO2013102659A2 (enExample)

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EP2909235B1 (en) * 2012-10-22 2017-03-29 Complix NV Polypeptides specifically binding to il-23
AU2013336753B2 (en) * 2012-10-22 2018-02-01 Complix Nv Polypeptides capable of cellular internalization
EP3065758B1 (en) * 2013-11-06 2019-09-25 Merck Sharp & Dohme Corp. Peptide containing conjugates for dual molecular delivery of oligonucleotides
AU2016232833A1 (en) 2015-03-18 2017-10-12 Dana-Farber Cancer Institute, Inc. Selective Mcl-1 binding peptides
US11078246B2 (en) 2015-08-28 2021-08-03 Dana-Farber Cancer Institute, Inc. Peptides binding to Bfl-1
WO2018017922A2 (en) * 2016-07-22 2018-01-25 Massachusetts Institute Of Technology Selective bfl-1 peptides
US11834520B2 (en) 2017-12-15 2023-12-05 Dana-Farber Cancer Institute, Inc. Selective targeting of apoptosis proteins by structurally-stabilized and/or cysteine-reactive NOXA peptides
EP3805400A4 (en) 2018-06-04 2022-06-29 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecule showing changed half-life in cytoplasm
US11286299B2 (en) 2018-09-17 2022-03-29 Massachusetts Institute Of Technology Peptides selective for Bcl-2 family proteins
EP4036117A1 (en) * 2021-01-27 2022-08-03 Complix NV Mcl-1 binding alphabodies and uses thereof
WO2023203127A1 (en) * 2022-04-20 2023-10-26 Vib Vzw Alphabody-based degrader molecules

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EP2161278A1 (en) * 2008-09-08 2010-03-10 Complix N.V. Single-chain coiled coil scaffold
WO2011003935A1 (en) * 2009-07-08 2011-01-13 Complix Nv Parathyroid hormone related protein antagonists
WO2011003936A1 (en) * 2009-07-08 2011-01-13 Complix Nv Alphabodies for hiv entry inhibition
CN102245623A (zh) * 2008-12-08 2011-11-16 康普里斯有限公司 单链反向平行卷曲型螺旋蛋白

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JP2006519763A (ja) * 2002-11-08 2006-08-31 アブリンクス エン．ヴェー． 治療用ポリペプチドの投与法およびそのためのポリペプチド
WO2010108824A1 (en) * 2009-03-23 2010-09-30 Vib Vzw L-plastin antibodies and their use
JP2014504869A (ja) 2011-01-06 2014-02-27 コンプリクス エン ヴェー サイトカインもしくは成長因子および／またはサイトカイン受容体もしくは成長因子受容体に特異的に結合するアルファボディー
BR112013017363A2 (pt) 2011-01-06 2016-08-30 Complix Sa biblioteca de alphabody de cadeia única, mistura de bibliotecas de alphabody, ácido nucleico ou biblioteca de vetor, biblioteca de células hospedeiras, uso de uma biblioteca de alphabody de cadeia única, método para a produção de uma biblioteca de alphabody de cadeia única, método para a produção de um ou mais polipeptídeos de alphabody de cadeia única, polipeptíceo de alphabody de cadeia única, ácido nucleico, vetor e célula hospedeira
US20130261049A1 (en) 2011-01-06 2013-10-03 Complix Sa Alphabodies specifically binding to class-i viral fusion proteins and methods for producing the same
US20140294828A1 (en) 2011-01-06 2014-10-02 Complix Sa Alphabodies specifically binding to viral proteins and methods for producing the same

Patent Citations (4)

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Publication number Priority date Publication date Assignee Title
EP2161278A1 (en) * 2008-09-08 2010-03-10 Complix N.V. Single-chain coiled coil scaffold
CN102245623A (zh) * 2008-12-08 2011-11-16 康普里斯有限公司 单链反向平行卷曲型螺旋蛋白
WO2011003935A1 (en) * 2009-07-08 2011-01-13 Complix Nv Parathyroid hormone related protein antagonists
WO2011003936A1 (en) * 2009-07-08 2011-01-13 Complix Nv Alphabodies for hiv entry inhibition

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AU2013207209B2 (en) 2017-02-16
JP2015504064A (ja) 2015-02-05
BR112014016744A2 (pt) 2018-09-04
EP2800759A2 (en) 2014-11-12
AU2013207209A1 (en) 2014-08-07
EP2800759B1 (en) 2018-07-18
WO2013102659A2 (en) 2013-07-11
IN2014MN01562A (enExample) 2015-05-08
CA2860666A1 (en) 2013-07-11
BR112014016744A8 (pt) 2017-07-04
WO2013102659A3 (en) 2013-08-29
US20140363434A1 (en) 2014-12-11

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Application publication date: 20141119