CN104155461B - A kind of biological detection analytical equipment and its application method with air-dried module - Google Patents
A kind of biological detection analytical equipment and its application method with air-dried module Download PDFInfo
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- CN104155461B CN104155461B CN201410398764.0A CN201410398764A CN104155461B CN 104155461 B CN104155461 B CN 104155461B CN 201410398764 A CN201410398764 A CN 201410398764A CN 104155461 B CN104155461 B CN 104155461B
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Abstract
The application is related to a kind of biological detection analytical equipment, and it includes air-drying module, and this, which air-dries module, includes film groove, bearing test film bar is configured as, wherein the film bar is face-up placed among the film groove；Wind regime, is configured as producing parallel to the film bar is positive, with uniform flow field, wind for air-drying the film bar；And lamina of septum pellucidum, above the film groove, the sealing air flue from the wind regime to the film groove is formed together with the film groove；The equipment also includes scanner, for being scanned through the lamina of septum pellucidum to the film bar.The application further relates to a kind of method for being used to the progress of biological test film bar is air-dried and read.
Description
Technical field
The application is related to a kind of biological detection analytical equipment, especially, is related to the biological detection analysis for air-drying module
Equipment and its application method.
Background technology
Clinical medicine laboratory and biology laboratory are frequently necessary to detect batch sample.It is past when being detected
Toward needing to add different reagents or liquid into sample in different time points, the processing such as dilution, mixing, reaction and cleaning are completed
Step.For example, Western blot analysis equipment is exactly a kind of conventional biological detection analytical equipment, it utilizes antibody and attachment
The specific immune response occurred in the target protein on test film bar is detected.
The process tested using film bar can substantially be divided into, and film bar is placed in film groove and reacted, reaction is finished
Film bar is cleaned afterwards, air-drying for film bar is read out and analyzed to film bar.The air-dried speed of existing film bar is slower, for example
Up to 2 hours are taken to 50 air-drying for film bar.Also, the temperature air-dried to film bar by experimental nature limitation and
What can not be set is too high, because temperature is too high may to destroy reaction result.Meanwhile, biological detection and analytical technology it is automatic
The corresponding detection of change trend requirement and analytical equipment can carry out automatically scanning and interpretation to detection film bar, and this requires that film bar can be with
Directly it is scanned and interpretation in film groove.
The content of the invention
For the above-mentioned problems in the prior art, it is necessary to which a kind of biological detection analytical equipment, can not only improve film
The air-dried efficiency of bar, also with compact device structure, and can realize the automatic reading and analysis to film bar.
A kind of biological detection analytical equipment is provided according to the one side of the application, it includes air-drying module, and this is air-dried
Module includes film groove, bearing test film bar is configured as, wherein the film bar is face-up placed among the film groove；Wind regime,
It is configured as producing parallel to the film bar is positive, with uniform flow field, wind for air-drying the film bar；With
And lamina of septum pellucidum, above the film groove, the sealing air flue from the wind regime to the film groove is formed together with the film groove；
The equipment also includes scanner, for being scanned through the lamina of septum pellucidum to the film bar.
Particularly, the air-dried module also includes the runner being sealably engaged between the wind regime and the film groove, described
Runner forms the sealing air flue together with the lamina of septum pellucidum and film groove.
Particularly, the distance between upper edge of the lamina of septum pellucidum and the film groove about 5mm-20mm.
Particularly, the wind regime includes cross flow fan, and the fan is configured to produce air quantity about 2-5m3/ min's is described
Wind with uniform flow field.
Particularly, the wind regime includes non-cross flow fan and rectification leaf grating, to produce the wind with uniform flow field,
Its air quantity is about 2-5m3/min。
Particularly, the length of the runner is not more than 15cm.
Particularly, described equipment also includes timer, is configured as counting the air dry operation of the air-dried module
When and control.
A kind of side for being used to the progress of biological test film bar is air-dried and read is additionally provided according to the another aspect of the application
Method, including make parallel to film bar it is positive, blow air over film bar front with uniform flow field to be air-dried；It is wherein described
Film bar is face-up placed in film groove.
Particularly, methods described also passes through dividing plate be located above the film groove, transparent to wind using scanner
The film bar after dry is scanned and read.
Particularly, the wind with uniform flow field is about 2-5m by air quantity3/ min wind regimes are produced.
The air-dried module that the application patent is provided uses wind parallel to film bar surface, with uniform plane flow field to film
Bar is air-dried, because film groove and the distance between lamina of septum pellucidum are very narrow and small, so wind speed can faster, so as to significantly improve
The air-dried efficiency of film bar, saves air-dry time, reduces the physical space that air-dried module is occupied.Further, since the chi of film bar
It is very little smaller, and wind speed is significantly increased, therefore the air-dried degree between multiple film bars is more uniform.
Brief description of the drawings
Below, the preferred embodiment of the application will be described in more detail with reference to accompanying drawing, wherein：
The solid that Fig. 1 show air-dried module in biological detection and analytical equipment according to one embodiment of the application is shown
It is intended to；
Fig. 2 show the side sectional view of the air-dried module shown in Fig. 1；
Fig. 3 show the schematic perspective view of fan in the air-dried module shown in Fig. 1；
Fig. 4 show the schematic top plan view of film groove in the air-dried module shown in Fig. 1；
Fig. 5 show the schematic perspective view of runner in the air-dried module shown in Fig. 1；
Cut open the side that Fig. 6 show air-dried module in biological detection and analytical equipment according to another embodiment of the application
View；
Fig. 7 (a) show the vertical view according to the biological detection of the application one embodiment and the air-dried module of analytical equipment
Schematic diagram；
Fig. 7 (b) show the air-dried module in the equipment shown in Fig. 7 (a) and the schematic top plan view of scanner；And
Fig. 8 is shown carries out method flow that is air-dried and reading to biological test film bar according to the application one embodiment
Figure.
Embodiment
To make the purpose, technical scheme and advantage of the embodiment of the present application clearer, below in conjunction with the embodiment of the present application
In accompanying drawing, the technical scheme in the embodiment of the present application is clearly and completely described, it is clear that described embodiment is
Some embodiments of the present application, rather than whole embodiments.Based on the embodiment in the application, those of ordinary skill in the art
The every other embodiment obtained under the premise of creative work is not made, belongs to the scope of the application protection.
Fig. 1 is the schematic perspective view of air-dried module 100 in biology and detection device according to the application one embodiment.One
Individual or multiple film bars can lie in the bottom of film groove 102 in face-up mode.It is transparent provided with one piece on the top of film groove 102
Dividing plate 106, by the side wall support of runner 104, along maintaining a certain distance d on lamina of septum pellucidum 106 and film groove 102.According to this
One embodiment of application, d span can be 5-20mm.Fan 108 be used for produce parallel to film bar it is positive, have
The wind in uniform plane flow field, so as to be air-dried to the film bar in film groove 102.Runner 104 can be engaged on fan 108 and film groove
Between 102, the wind that fan 108 is produced can be directed to film groove 102 by runner 104, so as to enter to the film bar in film groove 102
Sector-style is done.
Fig. 2 is the side sectional view of the air-dried module 100 shown in Fig. 1.Fig. 3 is fan in the air-dried module 100 shown in Fig. 1
108 schematic perspective view.Fan 108 can be cross flow fan, can produce such as 2-5m3/ min air quantity.Fan 108 can be with
Fan outlet 108B with motor 108A and strip, to provide a uniform Plane Fluid Field.According to another embodiment,
For example non-cross flow fan (not shown) of other wind regimes can be used, coordinates rectification leaf grating (not shown) to produced by non-cross flow fan
Wind carry out rectification, so as to produce the wind with uniform plane flow field for blowing to film groove 102.
Fig. 4 be Fig. 1 shown in air-dried module 100 in film groove 102 schematic top plan view.According to one embodiment, such as Fig. 2 institutes
Show, the side section of film groove 102 can be inverted trapezoidal, and such shape contributes to follow-up scan operation.According to other realities
Example is applied, the side section of film groove 102 can also be such as rectangle.As shown in Fig. 2 sidewall upper of the film groove 102 close to fan 108
It can be sealingly engaged with runner 104, so that the space in film groove 102 is connected with runner 104.The remote fan 108 of film groove 102
Sidewall upper can be coupled with the air outlet of air-dried module 100.According to one embodiment, the long side of multiple film bars can be along wind
Dynamic direction arrangement, so contributes to the stability of film bar position in air drying process, it might even be possible to be not used in the painting of film bar bottom
Adhesive is smeared to be fixed.According to other embodiment, film bar can also along with wind direction or other directions that to blow direction vertical
Arrangement.
Fig. 5 be Fig. 1 shown in air-dried module 100 in runner 104 schematic diagram.The side wall 104A of runner 104 can with it is saturating
Bright dividing plate 106 is sealingly engaged and dividing plate 106 is supported, and makes to keep such as institute above between lamina of septum pellucidum 106 and film groove 102
State apart from d.The bottom 104B of runner 104 extends to film groove below 102, so as to be supported to film groove 102.Runner 104
One end 104C of water diversion part is sealingly engaged with film groove 102, and other end 104D and fan 108 air outlet are sealingly engaged so as to shape
Into the air channel being made up of runner 104, dividing plate 106 and film groove 102, this air channel is sealed, so that produced by ensureing fan 108
Wind will not be leaked in transmitting procedure, can be completely used for air-drying film bar.The shape and material of runner can roots
Choose and design the need for according to user, this be to those skilled in the art it is conceivable that.For example, needing wind
In the case of doing such as 50 film bars, the length of runner can in the range of no more than 15cm value as needed.
Fig. 6 show the side sectional view of the air-dried module 200 according to the application one embodiment.With air-dried module 100
Compare, air-dry module 200 in addition to without runner, other structures can be same or analogous with air-dried module 100.
Film groove 202 is directly sealingly engaged with fan 208, to receive the crossing current wind with uniform flow field for coming from fan 208.With Fig. 1
Shown situation is similar, and the top of film groove 202 can also be provided with the transparent dividing plate 206 with film groove upper end distance such as d, and in wind
Set and support accordingly with supporting clapboard 206 in dry module 200, so as to constitute sealing air together with film groove 202 and dividing plate 206
Road.
Fig. 7 (a), which is shown in biological detection and analytical equipment according to the application one embodiment, air-dries bowing for module 100
Depending on schematic diagram.Fig. 7 (b) show the air-dried module 100 in the equipment shown in Fig. 7 (a) and the top view of scanner 110.Scanning
Instrument 110 is located at the top for air-drying film groove 102 in module, and the face-up film bar in film groove 102 is entered through lamina of septum pellucidum 106
Row scanning.Air enters fan 108 from air inlet 112, and module 100 is air-dried from the outflow of air outlet 114.
According to one embodiment, biological detection and analytical equipment in the application can also include timer, for wind
The air dry operation of dry module carries out timing, so as to be controlled to the operation.
Because the air-dried module in the application employs the wind with uniform plane flow field parallel to film bar surface, this is big
The physical space occupied by air-dried module is reduced greatly.Further, since film groove and the distance between lamina of septum pellucidum are very narrow and small, example
Such as 5-20mm, so air quantity is up to such as 0.04m in the reachable such as 8m/s of wind speed, film groove3/ min, such wind speed and air quantity phase
For size only has such as 2mm × 100mm film bar, it can significantly improve and the speed carried out is air-dried to film bar, save wind
The dry time.For example, the air-dry time of 50 film bars can be as using foreshortening to 25 minutes needed for the air-dried technology of tradition for 2 hours.
Because wind speed is very fast, so even to multiple, such as 50 film bars are air-dried, the single strip of film different piece obtained simultaneously
Air-dried degree, and air-dried degree between multiple film bars is all uniform.
Fig. 8 is shown carries out method flow that is air-dried and reading to biological test film bar according to the application one embodiment
Figure.This method can have the biological detection and analytical equipment that air-dry module 100 or 200 to implement in the application, or by appointing
Where implement without departing from the similar devices constructed on the basis of the application thought.In module 802, film bar is face-up placed in
In the film groove for air-drying module, produced by air-drying the cross flow fan in module or the non-cross flow fan with rectification leaf grating parallel to film
Bar is positive, wind with uniform flow field, and blow air over film bar just carries out air dry operation in face of film bar.According to one embodiment,
For it is that film bar is air-dried, parallel to film bar is positive, wind with uniform flow field by air quantity be about 2-5m3/ min wind
Source is produced.In module 804, film bar after air-drying is scanned and read through dividing plate above film groove, transparent.By
It is face-up to be air-dried in film bar, without being overturn again as existing air-dry method to film bar, but can be with
Directly the film bar after air-drying is scanned and read by scanner, the automation of detection and analysis is realized.In addition, using this
The described method and apparatus of application, it is not required that exchange the dry temperature of the rectification campaign and air-dried area, therefore simplify what film bar was air-dried
Flow, and the reaction result that will not be embodied on film bar produces influence.
Above-described embodiment is only used for explanation the application, and is not the limitation to the application, about the general of technical field
Logical technical staff, in the case where not departing from the application scope, can also make a variety of changes and modification, therefore, all equivalent
Technical scheme should also belong to category disclosed in the present application.
Claims (10)
1. a kind of biological detection analytical equipment, including：
Module is air-dried, it includes
Film groove, is configured as bearing test film bar, wherein the film bar is face-up placed among the film groove；
Wind regime, be configured as produce parallel to the film bar it is positive, with uniform flow field, for entering sector-style to the film bar
Dry wind；
Lamina of septum pellucidum, above the film groove, is formed from the wind regime to the narrow and small close of the film groove together with the film groove
Seal air channel；And
Scanner, for being scanned through the lamina of septum pellucidum to the film bar.
2. equipment as claimed in claim 1, wherein the air-dried module also includes being sealably engaged on the wind regime and the film
Runner between groove, the runner is sealingly engaged to form the sealing air flue with the lamina of septum pellucidum and film groove.
3. equipment as claimed in claim 1 or 2, wherein the distance between the lamina of septum pellucidum and upper edge of the film groove are
5mm-20mm。
4. equipment as claimed in claim 1 or 2, wherein the wind regime includes cross flow fan, the fan is configured to produce wind
Measure as 2-5m3/ min the wind with uniform flow field.
5. equipment as claimed in claim 1 or 2, wherein the wind regime includes non-cross flow fan and rectification leaf grating, to produce
Air quantity is 2-5m3/ min the wind with uniform flow field.
6. equipment as claimed in claim 2, wherein the length of the runner is not more than 15cm.
7. the equipment as described in any in claim 1 to 6, in addition to timer, are configured as the wind to the air-dried module
Dry run carries out timing.
8. a kind of be used in equipment according to claim 1 carry out biological test film bar method that is air-dried and reading,
Including make parallel to film bar it is positive, blow air over film bar front with uniform flow field to be air-dried；Wherein described film
Bar is face-up placed in the film groove of the air-dried module.
9. method as claimed in claim 8, also passes through dividing plate be located above the film groove, transparent using scanner
The film bar after air-drying is scanned and read.
10. method as claimed in claim 9, wherein the wind with uniform flow field is 2-5m by air quantity3/ min wind regimes are produced
It is raw.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410398764.0A CN104155461B (en) | 2014-08-14 | 2014-08-14 | A kind of biological detection analytical equipment and its application method with air-dried module |
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| CN201410398764.0A CN104155461B (en) | 2014-08-14 | 2014-08-14 | A kind of biological detection analytical equipment and its application method with air-dried module |
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| CN104155461B true CN104155461B (en) | 2017-09-01 |
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| CN110702931A (en) * | 2019-09-19 | 2020-01-17 | 广州欧蒙未一医学检验实验室有限公司 | Biological detection and analysis equipment with air drying system and use method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| FI92882C (en) * | 1992-12-29 | 1995-01-10 | Medix Biochemica Ab Oy | Disposable test strip and process for its manufacture |
| EP1023600A4 (en) * | 1998-07-29 | 2002-05-08 | Syntron Biores Inc | Immunoassay device |
| US6998251B2 (en) * | 2001-01-12 | 2006-02-14 | Syngenta Participations Ag | Nanoporous membrane reactor for miniaturized reactions and enhanced reaction kinetics |
| GB2436616A (en) * | 2006-03-29 | 2007-10-03 | Inverness Medical Switzerland | Assay device and method |
| CN102375054A (en) * | 2010-08-06 | 2012-03-14 | 艾博生物医药(杭州)有限公司 | Detection device comprising immune test strips and production method of detection device |
| CN102507929B (en) * | 2011-10-28 | 2014-03-26 | 合肥工业大学 | Preparation method of signal-enhancement type immunochromatographic gold-labeled test strip |
| CN103616526B (en) * | 2013-12-16 | 2015-10-28 | 深圳市亚辉龙生物科技股份有限公司 | A kind of full-automatic immunoblotting assay instrument and using method thereof and application |
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