CN104138418B - A kind of drying means of mulberry leaf - Google Patents
A kind of drying means of mulberry leaf Download PDFInfo
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- CN104138418B CN104138418B CN201410418566.6A CN201410418566A CN104138418B CN 104138418 B CN104138418 B CN 104138418B CN 201410418566 A CN201410418566 A CN 201410418566A CN 104138418 B CN104138418 B CN 104138418B
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Abstract
The present invention relates to a kind of drying means of mulberry leaf, get fresh mulberry leaf, when freeze-drying is extremely half-dried, pile vexed rear dry. Main active components of mulberry leaf general flavone content prepared by the present invention is high, and active ingredient dissolution rate is high, and then known biologically active is high.
Description
Invention field
The present invention relates to medicine method for making, particularly a kind of drying means of mulberry leaf, belongs to medical technical field.
Background technology
Mulberry leaf are the dry leaf of moraceae plants mulberry MorusalbaL.. Function dispelling wind and heat from the body, clearing away the lungheat and moisturizing, clears liver and improve vision. Be mainly used in anemopyretic cold, lung-heat type cough, dizziness headache, hot eyes is dim-sighted. Cultivation or wild, all there is product national most areas. The composition that mulberry leaf contain is more, and flavonoids is its main active ingredient, and taking rutin as main; Chlorogenic acid is one of active ingredient in mulberry leaf, has anti-inflammatory, the effect such as antibacterial. The production cycle of mulberry leaf is relatively long, starts annual April to germinate, and May, leaf was newly grown up, 7, August blade the most luxuriant, about late October, start through first frost, after frost, about 1 month, just start fallen leaves, and content sharply declines, should not be used as medicine.
Summary of the invention
The object of this invention is to provide a kind of drying means of mulberry leaf, mulberry leaf prepared by the party, main active ingredient Flavone content is high, and dissolution rate is high, and clinical efficacy is better.
The object of the present invention is achieved like this:
A drying means for mulberry leaf, gets fresh mulberry leaf, when freeze-drying is extremely half-dried, piles vexed rear dry.
The drying means of a kind of mulberry leaf of the present invention, gets fresh mulberry leaf, and freeze-drying finishes distillation when extremely half-dried, piles vexed rear dry.
The drying means of a kind of mulberry leaf of the present invention, gets fresh mulberry leaf, puts in freeze dryer, and solidification point is controlled between-28～-32 DEG C; Reach and control after temperature, open immediately vavuum pump and be evacuated to below drying chamber pressure 50Pa, then start heater switch, promote distillation; The temperature of distillation is controlled at below 40 DEG C, finishes distillation when extremely half-dried, takes out, and piles after vexed 1-5 days, dry.
Material of the present invention is extremely half-dried is a fuzzy concept, and the explication of non-mathematics is to determine according to the half the time of distillation overall process. The time of distillation overall process is determined, is after distillation starts, and when state state before condenser temperature drops to distillation, distillation finishes, and counts the time of distillation overall process. Time and the solidification point of distillation overall process, how much relevant be dried constant pressure, sublimation temperature, material. When concrete enforcement, can determine according to test.
So far completed the present invention, main active components of mulberry leaf general flavone content prepared by the present invention is high, and active ingredient dissolution rate is high, and then known biologically active is high.
Test example is intended to further illustrate usefulness of the present invention below, but not restriction of the present invention.
One, the dry total flavonoids from mulberry tree leaf assay of distinct methods
1, instrument 3010 uv-spectrophotometric instrument (HIT); AR2140 electronic analytical balance (Shanghai Ao Haosi company).
2, mulberry leaf: pick up from ancient same of mulberry field, Wudi County, Accessories during Binzhou, Shandong Province mulberry tree, on August 15th, 2011 gathers. Sample is divided into 4 parts, dry by following method.
Dry mulberry leaf: get fresh mulberry leaf, dry;
Freeze-drying is the vexed mulberry leaf that dry of half-dried heap extremely: get fresh mulberry leaf, put in freeze dryer, solidification point is controlled at-32 DEG C; Reach and control after temperature, open immediately vavuum pump and be evacuated to below drying chamber pressure 50Pa, then start heater switch, promote distillation; The temperature of distillation is controlled at below 40 DEG C; Distil and finish for 5 o'clock, take out, pile after vexed 1 day and dry.
3, method and result
Measure according to determination of total flavonoids method under Chinese pharmacopoeia mulberry leaf item, the results are shown in Table 1.
Table 1 different dry drying method total flavonoids from mulberry tree leaf assay result (%)
| Drying means | Dry | Freeze-drying is dried to half-dried heap is vexed | Fresh mulberry leaf |
| Content | 5.63 | 7.62 | 4.23 |
Table 1 finds out, dry total flavonoids from mulberry tree leaf content is higher than mulberry leaf, and freeze-drying finishes when half-dried, takes out, and piles that to dry content after vexed obviously high.
Detailed description of the invention
Embodiment 1
Get fresh mulberry leaf, put in freeze dryer, solidification point is controlled at-28 DEG C; Reach and control after temperature, be evacuated to drying chamber pressure 40Pa; Heating sublimation, the temperature of distillation is controlled at 40 DEG C; When state state before condenser temperature drops to distillation, distillation finishes, 13 hours used times of distillation, take out, and measure moisture, content amount is 9.7%.
According to the distillation overall process used time, be decided to be in order to below legal system for mulberry leaf: get fresh mulberry leaf, put in freeze dryer, solidification point is controlled at-28 DEG C; Reach and control after temperature, be evacuated to drying chamber pressure 40Pa; Heating sublimation, the temperature of distillation is controlled at 40 DEG C, and the end in 6.5 hours that distils is taken out, and piles after vexed 2 days and dries.
Embodiment 2
Get fresh mulberry leaf, put in freeze dryer, solidification point is controlled at-32 DEG C; Reach and control after temperature, be evacuated to drying chamber pressure 50Pa; Heating sublimation, the temperature of distillation is controlled at 45 DEG C; When state state before condenser temperature drops to distillation, distillation finishes, 10 hours used times of distillation.
According to the distillation overall process used time, be decided to be in order to below legal system for mulberry leaf: get fresh mulberry leaf, put in freeze dryer, solidification point is controlled at-32 DEG C; Reach and control after temperature, be evacuated to drying chamber pressure 50Pa; Heating sublimation, the temperature of distillation is controlled at 45 DEG C, and the end in 5 hours that distils is taken out, and piles after vexed 3 days 60 DEG C of oven dry.
Embodiment 3
Get fresh mulberry leaf, put in freeze dryer, solidification point is controlled at-15 DEG C; Reach and control after temperature, be evacuated to drying chamber pressure 60Pa; Heating sublimation, the temperature of distillation is controlled at 50 DEG C; When state state before condenser temperature drops to distillation, distillation finishes, 8 hours used times of distillation.
According to the distillation overall process used time, be decided to be in order to below legal system for mulberry leaf: get fresh mulberry leaf, put in freeze dryer, solidification point is controlled at-15 DEG C; Reach and control after temperature, be evacuated to drying chamber pressure 60Pa; Heating sublimation, the temperature of distillation is controlled at 50 DEG C, and the end in 4 hours that distils is taken out, and piles after vexed 5 days and dries.
Embodiment 4
Get fresh mulberry leaf, put in freeze dryer, solidification point is controlled at-15 DEG C; Reach and control after temperature, be evacuated to drying chamber pressure 60Pa; Heating sublimation, the temperature of distillation is controlled at 50 DEG C; When state state before condenser temperature drops to distillation, distillation finishes, 8 hours used times of distillation.
According to the distillation overall process used time, be decided to be in order to below legal system for mulberry leaf: get fresh mulberry leaf, put in freeze dryer, solidification point is controlled at-15 DEG C; Reach and control after temperature, be evacuated to drying chamber pressure 60Pa; Heating sublimation, the temperature of distillation is controlled at 50 DEG C, and the end in 3 hours that distils is taken out, and piles after vexed 4 days 60 DEG C of oven dry.
Embodiment 5
Get fresh mulberry leaf, put in freeze dryer, solidification point is controlled at-15 DEG C; Reach and control after temperature, be evacuated to drying chamber pressure 60Pa; Heating sublimation, the temperature of distillation is controlled at 50 DEG C; When state state before condenser temperature drops to distillation, distillation finishes, 8 hours used times of distillation.
According to the distillation overall process used time, be decided to be in order to below legal system for mulberry leaf: get fresh mulberry leaf, put in freeze dryer, solidification point is controlled at-15 DEG C; Reach and control after temperature, be evacuated to drying chamber pressure 60Pa; Heating sublimation, the temperature of distillation is controlled at 50 DEG C, and the end in 5 hours that distils is taken out, and piles after vexed 3 days, spreads out, dries.
Claims (1)
1. the drying means of mulberry leaf, it is characterized in that: get fresh mulberry leaf, put in freeze dryer, solidification point is controlled at-32 DEG C, reach and control after temperature, open immediately vavuum pump and be evacuated to below drying chamber pressure 50Pa, then start heater switch, promote distillation, the temperature of distillation is controlled at below 40 DEG C, distil and finish for 5 o'clock, take out, pile after vexed 1 day and dry; And the mulberry leaf that make are measured according to determination of total flavonoids method under Chinese pharmacopoeia mulberry leaf item, and general flavone content is 4.62%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201410418566.6A CN104138418B (en) | 2014-08-25 | 2014-08-25 | A kind of drying means of mulberry leaf |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410418566.6A CN104138418B (en) | 2014-08-25 | 2014-08-25 | A kind of drying means of mulberry leaf |
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| CN104138418A CN104138418A (en) | 2014-11-12 |
| CN104138418B true CN104138418B (en) | 2016-05-18 |
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| CN110063393A (en) * | 2019-05-16 | 2019-07-30 | 山东黑尚莓生物技术发展有限公司 | A kind of compound small berries fermented type fruit tea beverage and preparation method thereof |
| CN110226697A (en) * | 2019-07-03 | 2019-09-13 | 高剑文 | The preparation method and its product of mulberry leaf is lyophilized |
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| WO2012098358A1 (en) * | 2011-01-20 | 2012-07-26 | Biopharma Technology Ltd | Freeze drying method |
| CN103610752A (en) * | 2013-11-21 | 2014-03-05 | 华侨大学 | Functional food with hypoglycemic effect and preparation method thereof |
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Address after: 250014 81 thousand Buddha Shandong Road, Lixia District, Ji'nan, Shandong Patentee after: Shandong Zhonghong Kang Pharmaceutical Technology Development Co Ltd Address before: 250014 No. 4, West building, Shandong Academy of Sciences, 19 Shandong Road, Lixia Road, Lixia District, Shandong Patentee before: Jinan Kangzhong Medicin Science & Technology Co., Ltd. |