CN104127918A - Medical indwelling catheter care agent and usage thereof - Google Patents
Medical indwelling catheter care agent and usage thereof Download PDFInfo
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- CN104127918A CN104127918A CN201410399996.8A CN201410399996A CN104127918A CN 104127918 A CN104127918 A CN 104127918A CN 201410399996 A CN201410399996 A CN 201410399996A CN 104127918 A CN104127918 A CN 104127918A
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- nursing agent
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Abstract
The invention relates to a medical indwelling catheter care agent containing a microorganism killing or inhibiting component as well as a usage and an application of the medical indwelling catheter care agent. The invention also provides several preparation schemes of the medical indwelling catheter care agent. The medical indwelling catheter care agent is prepared by combining the component with the function of killing or inhibiting microorganisms and a corresponding carrier. The medical indwelling catheter care agent is used after being punctured, so that the problem of microorganism residues before indwelling needle puncturing until sealing by material paving is solved, the infection rate of the indwelling catheter can be greatly lowered, and the indwelling time of the indwelling catheter is prolonged.
Description
Technical field
The invention belongs to field of medical article technology, be specifically related to a kind of containing killing or suppress medical retention conduit (containing inlying catheter, indwelling needle catheter) nursing agent of microbe composition and its preparation method and application.
Background technology
Along with the development of medical science, inlying catheter in blood vessel (containing indwelling needle catheter) is not only for critical patient's rescue and treatment, and is widely used in medical practice, as aspects such as venous transfusion, Drug therapy, total intravenous nutrition, hemodynamic monitorings.And, infusion be medical personnel patient is carried out have wound one for the treatment of means, after nineteen fifty-seven invention scalp acupuncture, venous transfusion has had develop rapidly, and venous detaining needle is as the substitute products of scalp acupuncture, comes out in 1962 years.Up to the present produced the 6th generation venous detaining needle.Remaining needle is made up of advanced biomaterial, can be retained in blood vessel, thereby reduce puncture time, alleviates patient's misery, reduces nurse job amount, has been widely used in clinical.But remaining needle communicates with the external world as endovascular foreign body, increase equally the infection chance of human body.In the U.S., hospital will buy millions of catheter in blood vessel every year, and prediction has every year and exceedes 200000 routine conduit dependency hematogenous infections (CRBSI) occurs.In a year assessment, the mortality rate of CRBSI is increased to 25% by 12%, and economic costs is increased to 4.6 hundred million by 6,000 ten thousand.U.S. Center for Disease Control (CDC) (CDC) are about the report demonstration of catheter in blood vessel infection rate, and peripheral vein infection rate is 0～0.6/1000 catheter retaining day, and central vein infection rate is 1～4.25/1000 catheter retaining day.In international hospital, the research report of monitoring of infection system (Nationl Nosocomil Ifections SurveillnceSystem) shows, the pathogenic microorganism of 1992-1999 years Nosocomial hematogenous infections is respectively coagulase negative staphylococcus (37%), enterococcus (13.5%), staphylococcus aureus (12.5%), Candida (8%), gram negative bacteria (14%).And research shows how hematogenous infection is caused by central vein catheter, the infection of peripheral vein is main relevant with skin flore.The resident bacterium of human body skin has staphylococcus and gram negative bacteria (acinetobacter calcoaceticus, micrococcus luteus, yeast etc.), and field planting is at skin surface, hair follicle and sebaceous gland duct; Stay temporarily bacterium and have candidiasis, escherichia coli and staphylococcus aureus.The pathogen that remaining needle infects is taking gram positive bacteria and gram negative bacteria as main, and as staphylococcus epidermidis, class corynebacterium diphtheriae etc., and great majority are the common bacteria of human body surface.
Conventionally the use procedure of inlying catheter is as follows: first point of puncture is carried out disinfection by corresponding specification by disinfectant, after to be sterilized dose of evaporation, carry out the puncture of inlying catheter, use dressing to cover after puncture.
From above process analysis, before puncture, the load of microorganisms amount of point of puncture near zone can be reduced to reasonable level by the sterilizing operation of specification, after puncture, also can make paracentesis area and external environment fully isolate by the covering of aseptic dressing.
But it should be noted that, the inlying catheter especially puncture procedure overwhelming majority of indwelling needle catheter is in the conventional environment of ward or injection room, along with sufferer number and health, turnover family members' number and Personal hygiene situation, whether the working clothing that comprises medical personnel is clean etc. on request, all can cause existing in environment variable concentrations, different types of microorganism floating in air.Therefore during waiting for disinfectant solution evaporation time, puncture procedure until in this process before aseptic dressing covering, the meeting of having an opportunity or even be difficult to avoid is touched point of puncture even point of puncture of skin around by microorganism in environment, and the air that causes a part to be loaded with microorganism along with the covering of aseptic dressing is sealed up for safekeeping in the closed environment around point of puncture by aseptic dressing.Before nursing next time, this part microorganism, by possessing suitable, the ventilative good culture environment of temperature, will increase and infect probability.This is a uncontrollable weak link still in current inlying catheter use procedure.
Therefore; if being provided, a kind of product can kill or suppress the microorganism of the confined space at point of puncture place; be applied to point of puncture after inlying catheter uses around, protect; realize the aseptic of the space that contacts with point of puncture or at least suppress the breeding of microorganism, this will greatly reduce the infection chance of inlying catheter.
Summary of the invention
The object of this invention is to provide a kind of nursing agent containing killing or suppress the medical retention conduit of microbe composition, can further reduce inlying catheter infection rate, extend inlying catheter service time, reduce patient's misery and medical expense, alleviate medical personnel's burden, thus the deficiency of the prior art of making up, product.
The nursing agent of medical retention conduit of the present invention, includes the composition of killing or suppressing microorganism.
Above-mentioned can killing microorganisms composition be one or more in the liquid with killing microorganisms function that makes by electrolysis, ethanol, povidone iodine, iodine tincture, hydrogen peroxide.
Above-mentioned can the interpolation mass percent of killing microorganisms composition in the component of inlying catheter nursing agent be 0.5 ~ 100%.
Above-mentioned nursing agent, also can include auxiliary material.Described auxiliary material are one or more medical materials made in chitosan, carboxymethyl chitosan, hydroxyethyl chitosan, hydroxypropyl chitosan, carboxymethyl cellulose, hydroxyethyl-cellulose, polyvinyl alcohol, polyurethane, polyurethane, politef.
Above-mentioned auxiliary material can also comprise acetic acid.
Above-mentioned nursing agent state can be powder, fiber, fabric, non-woven, colloid, liquid etc.
A wherein liquid nursing agent, for including neutral oxidization electrolysis aqueous solution.
Another kind of liquid nursing agent, for including the acidic oxidized electric potential water solution of chitosan or derivatives thereof.
Another aspect of the present invention also provides the purposes that adopts above-mentioned inlying catheter nursing agent to be applied to the clinical infection rate with reduction inlying catheter.
The microorganism of the confined space at point of puncture place can be killed or suppress to nursing agent of the present invention; be applied to point of puncture after inlying catheter uses around, protect; realize the aseptic condition in the space that contacts with point of puncture or at least suppress the breeding of microorganism, this will greatly reduce the infection chance of inlying catheter.Add the nursing agent of chitosan or derivatives thereof, also there is hemostasis, promote healing, suppress the effects such as cicatrix, analgesia.
Detailed description of the invention
The invention will be further described by the following examples.
Embodiment 1
The preparation of inlying catheter nursing agent: under clean environment, take 50 grams, Neutral Electrolysis water (claiming again neutral ion water, subacidity brine electrolysis etc.), be placed in 100ml conical flask, add 50 grams of thinned waters, stir, detect qualified rear packaging, make inlying catheter nursing agent.Wherein Neutral Electrolysis water be mode by barrier film or diaphragm-free electrolysis by NaCl electrolysis, a kind of liquid that possesses pH neutral, high redox potential and higher available chlorine content preparing.
The use of inlying catheter nursing agent: routine disinfection also carries out after inlying catheter puncture, and above nursing agent is applied on puncture orifice surrounding skin, then carries out routinely dressing covering.Each replacing also operates before applying ointment or plaster equally.
In the present embodiment, the main component of inlying catheter nursing agent is water, hypochlorous acid, sodium hypochlorite and sodium chloride etc., and pH value is subacidity or neutrality.Use result shows, after this product is used, the methicillin-resistant staphylococcus aureus to clinical separation, Acinetobacter baumannii, lung streptococcus effect 0.5min killing rate are 99.99%, and effect 1min sterilizing rate can reach 100.00%.Bacillus subtilis black mutation spore effect 10min killing rate is also reached to 100.00%.Not only sterilization is rapid, and antibacterial, virus are difficult for developing immunity to drugs, and directly contacts skin mucosa without sensitization and untoward reaction, and is reduced into water after effect, pollution-free residual.
Embodiment 2
The preparation of inlying catheter nursing agent: under aseptic condition, take 60 grams of electrolyzed-oxidizing waters (being also called as electrolyzed oxidizing water, acidic water with high redox potential, high potential peroxide deionized water, strong peroxide deionized water, acidify electrode water etc.), be placed in 100ml conical flask, add 40 grams of thinned waters, stir, detect qualified rear filling and package, make inlying catheter nursing agent.Wherein electrolyzed-oxidizing water be mode by diaphragm electrolysis by sodium chloride solution or dilute hydrochloric acid solution electrolysis, a kind of high redox potential preparing and the liquid of higher available chlorine content.
The use of inlying catheter nursing agent: routine disinfection also carries out after inlying catheter puncture, and above nursing agent is applied on puncture orifice surrounding skin, then carries out routinely dressing covering.Each replacing also operates before applying ointment or plaster equally.
In the present embodiment, the main component of inlying catheter nursing agent is that water and sodium chloride (or hydrochloric acid) are prepared into through electrochemical reaction, has the liquid of high redox potential (ORP), low pH value and certain oxidability and strong sterilizing ability.
Use result shows, the time of killing of the strains such as staphylococcus aureus, staphylococcus epidermidis, enterococcus faecalis, bacillus pyocyaneus is all less than to 10s; Same Candida albicans, native aspergillosis and trichosporon bacteria effect 30s, killing rate is all greater than 99.90%, and point of puncture is had to significant protective effect, greatly reduces the infection rate of point of puncture.
Embodiment 3
The preparation of inlying catheter nursing agent: under aseptic condition, take 50 grams, Neutral Electrolysis water (claiming again neutral ion water, subacidity brine electrolysis etc.), 49 grams of pure water, be placed in 100ml beaker, add 1 gram of carboxymethyl chitosan (or hydroxyethyl chitosan, hydroxypropyl chitosan, carboxymethyl cellulose, hydroxyethyl-cellulose, polyvinyl alcohol), after stirring and dissolving, make inlying catheter nursing agent.
The use of inlying catheter nursing agent: routine disinfection also carries out after inlying catheter puncture, and above nursing agent is applied on puncture orifice surrounding skin, then carries out routinely dressing covering.Each replacing also operates before applying ointment or plaster equally.
In the present embodiment, the main component of inlying catheter nursing agent is water, carboxymethyl chitosan (or other thickening agents), hypochlorous acid, sodium hypochlorite and sodium chloride etc., and pH value is subacidity or neutrality.This product uses latter 24 hours, does not detect the bacterial strains such as staphylococcus aureus, staphylococcus epidermidis, enterococcus faecalis, bacillus pyocyaneus.And directly contact skin mucosa without sensitization and untoward reaction, obviously reduce infection rate, and for gel dosage form be not easy trickling.
Embodiment 4
The preparation of inlying catheter nursing agent: under clean environment, take 60 grams of electrolyzed-oxidizing waters (being also called as electrolyzed oxidizing water, acidic water with high redox potential, high potential peroxide deionized water, strong peroxide deionized water, acidify electrode water etc.), 40 grams of pure water, be placed in 100ml beaker, add 1 gram of chitosan (or hydroxyethyl chitosan, hydroxypropyl chitosan, carboxymethyl cellulose, hydroxyethyl-cellulose, polyvinyl alcohol), after stirring and dissolving, make inlying catheter nursing agent.
The use of inlying catheter nursing agent: routine disinfection also carries out after inlying catheter puncture, and above nursing agent is applied on puncture orifice surrounding skin, then carries out routinely dressing covering.Each replacing also operates before applying ointment or plaster equally.
In the present embodiment, the main component of inlying catheter nursing agent is water, chitosan (or other thickening agents), hypochlorous acid, sodium hypochlorite and sodium chloride etc., and pH value is subacidity or neutrality.This product uses latter 24 hours, does not detect the bacterial strains such as staphylococcus aureus, staphylococcus epidermidis, enterococcus faecalis, bacillus pyocyaneus.And directly contact skin mucosa without sensitization and untoward reaction, and chitosan have long-acting bacteriostatic, hemostasis, promotion healing, analgesia and suppress the effects such as scar hyperplasia.
Embodiment 5
The preparation of inlying catheter nursing agent: under clean environment, take 50 grams, Neutral Electrolysis water (claiming again neutral ion water, subacidity brine electrolysis etc.), 50 grams of pure water, be placed in 100ml beaker, adding diameter is the chitosan non-woven fabrics (or sterile gauze, alginic acid non-woven fabrics or other solid carriers) of 10mm, after enclosed package, make inlying catheter nursing agent.
The use of inlying catheter nursing agent: routine disinfection also carries out after inlying catheter puncture, sticks above nursing agent in puncture orifice above around, then carries out routinely dressing covering.Each replacing also operates before applying ointment or plaster equally.
In the present embodiment, the main component of inlying catheter nursing agent is water, chitosan (or other solid carriers), hypochlorous acid, sodium hypochlorite and sodium chloride etc., and pH value is subacidity or neutrality.This product uses 24 hours, do not detect the bacterial strains such as staphylococcus aureus, staphylococcus epidermidis, enterococcus faecalis, bacillus pyocyaneus, directly contact skin mucosa without sensitization and untoward reaction, and chitosan have long-acting bacteriostatic, hemostasis, promotion healing, analgesia and suppress the effects such as scar hyperplasia.
Embodiment 6
The preparation of inlying catheter nursing agent: under clean environment, take 98.5 grams of purified water, be placed in 100ml beaker, add 1 gram of chitosan, 0.5 milliliter of acetic acid, after enclosed package, makes inlying catheter nursing agent after dissolving.
The use of inlying catheter nursing agent: routine disinfection also carries out after inlying catheter puncture, is coated on puncture orifice by above nursing agent upper around, then carries out routinely dressing covering.Each replacing also operates before applying ointment or plaster equally.
In the present embodiment, the main component of inlying catheter nursing agent is chitosan solution.This product has very strong bacteriostasis; and chitosan has hemostasis, promotion is healed, eases pain and suppresses the effects such as scar hyperplasia, the pH value of nursing agent approaches the pH value of skin, non-stimulated to skin; and along with the evaporation of moisture can form membranaceous covering, play better protective effect.
Claims (10)
1. a nursing agent for medical retention conduit, is characterized in that, described nursing agent includes the composition of killing or suppressing microorganism.
2. nursing agent as claimed in claim 1, is characterized in that, the interpolation mass percent of the described composition of killing or suppress microorganism in the component of inlying catheter nursing agent is 0.5 ~ 100%.
3. nursing agent as claimed in claim 1 or 2, the described composition of killing or suppress microorganism is one or more in the liquid with killing microorganisms function that makes by electrolysis, ethanol, povidone iodine, iodine tincture, hydrogen peroxide.
4. nursing agent as claimed in claim 1, is characterized in that, also includes medical auxiliary material; Auxiliary material are one or more medical materials made in chitosan, carboxymethyl chitosan, hydroxyethyl chitosan, hydroxypropyl chitosan, carboxymethyl cellulose, hydroxyethyl-cellulose, polyvinyl alcohol, polyurethane, polyurethane, politef.
5. nursing agent as claimed in claim 4, it is characterized in that, described auxiliary material are one or more medical materials made in chitosan, carboxymethyl chitosan, hydroxyethyl chitosan, hydroxypropyl chitosan, carboxymethyl cellulose, hydroxyethyl-cellulose, polyvinyl alcohol, polyurethane, polyurethane, politef.
6. nursing agent as claimed in claim 4, is characterized in that, described auxiliary material are acetic acid.
7. nursing agent as claimed in claim 1, is characterized in that, described nursing agent is liquid nursing agent, includes neutral oxidization electrolysis aqueous solution.
8. nursing agent as claimed in claim 1, is characterized in that, described nursing agent is liquid nursing agent, includes chitosan or derivatives thereof.
9. nursing agent as claimed in claim 1, is characterized in that, described nursing agent is liquid nursing agent, includes acidic oxidized electric potential water solution.
10. the application of nursing agent claimed in claim 1 in the infected by microbes rate that reduces inlying catheter puncture orifice.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410399996.8A CN104127918A (en) | 2014-08-15 | 2014-08-15 | Medical indwelling catheter care agent and usage thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410399996.8A CN104127918A (en) | 2014-08-15 | 2014-08-15 | Medical indwelling catheter care agent and usage thereof |
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| CN104127918A true CN104127918A (en) | 2014-11-05 |
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| CN201410399996.8A Pending CN104127918A (en) | 2014-08-15 | 2014-08-15 | Medical indwelling catheter care agent and usage thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105802192A (en) * | 2016-04-29 | 2016-07-27 | 苏州林华医疗器械股份有限公司 | Novel material applied to indwelling needle catheter and preparation method thereof |
-
2014
- 2014-08-15 CN CN201410399996.8A patent/CN104127918A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105802192A (en) * | 2016-04-29 | 2016-07-27 | 苏州林华医疗器械股份有限公司 | Novel material applied to indwelling needle catheter and preparation method thereof |
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Application publication date: 20141105 |
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| WD01 | Invention patent application deemed withdrawn after publication |