CN104127667B - It is a kind of to treat pharmaceutical composition of chronic pharyngitis and preparation method thereof - Google Patents
It is a kind of to treat pharmaceutical composition of chronic pharyngitis and preparation method thereof Download PDFInfo
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- CN104127667B CN104127667B CN201410339173.6A CN201410339173A CN104127667B CN 104127667 B CN104127667 B CN 104127667B CN 201410339173 A CN201410339173 A CN 201410339173A CN 104127667 B CN104127667 B CN 104127667B
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Abstract
It is an object of the invention to disclose a kind of pharmaceutical composition for treating chronic pharyngitis, the present invention also aims to the preparation method of open said composition.The bulk drug proportion of composing of pharmaceutical composition of the present invention is：30 120 parts of the tuber of dwarf lilyturf, 20 100 parts of corydlis bungeana, 10 80 parts of the tuber of pinellia, 10 80 parts of Radix Codonopsis, 10 80 parts of Chinese yam, 10 80 parts of the bighead atractylodes rhizome, 10 80 parts of Poria cocos, 10 60 parts of balloonflower root, 10 60 parts of hawthorn, 10 50 parts of cultivated land, 5 30 parts of the fruit of Chinese magnoliavine, 5 30 parts of the fruit of glossy privet, 5 30 parts of the root of herbaceous peony, 3 30 parts of radix glycyrrhizae.Medicine of the present invention can add customary adjuvant, according to common process, and clinically-acceptable tablet, granule, pill, capsule, sustained release agent, oral liquid etc. is made.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition and preparation method thereof, specifically, it is related to a kind of chronic pharyngitis for the treatment of
Pharmaceutical composition and preparation method thereof.
Background technology
The general common and adult of chronic pharyngitis, is particularly what those were often smoked, amount of dust is than work under larger environment
The crowd of work, is frequently accompanied by other upper respiratory diseases with pharyngeal discomfort, dry, foreign body sensation or slight during disease hair
Pain, dry cough, nausea, congestion of throat are in kermesinus, and the visible grade of pharynx rear wall is main clinical manifestation.
Chronic pharyngitis refers to the lesion caused by pharyngeal chronic infection, and the traditional Chinese medical science claims " globus hysteriocus ".Chronic pharyngitis has to be pharyngeal
Do, itch, secret anguish, foreign body sensation are the disease of primary symptom, are also a part for inflammation of upper respiratory tract.
If pharyngo-laryngitis chronica is crept up, ear, nose can be thus fed through to, it is more likely that can cause acute rhinitis, nasal sinus
Inflammation, otitis media acuta；If development downwards, the lower respiratory tracts such as larynx, tracheae can be invaded, cause acute laryngitis, tracheitis, branch
Tracheitis and pneumonia；Both are the most common development trends of pharyngo-laryngitis chronica.
The treatment method that doctor trained in Western medicine is not adapted to for treatment of chronic pharyngitis, it is impossible to effect a radical cure.Being used existing Chinese medicine compound prescription more
Containing honeysuckle, effect is not good, and what is had is also toxic.
The content of the invention
It is an object of the invention to disclose a kind of pharmaceutical composition for treating chronic pharyngitis, the present invention also aims to public affairs
Open the preparation method of said composition.
A kind of pharmaceutical composition for treating chronic pharyngitis involved in the present invention, it is mainly by the bulk drug tuber of dwarf lilyturf, bitter ground
Fourth, the tuber of pinellia, Radix Codonopsis, Chinese yam, the bighead atractylodes rhizome, Poria cocos, balloonflower root, hawthorn, cultivated land, the fruit of Chinese magnoliavine, the fruit of glossy privet, the root of herbaceous peony, radix glycyrrhizae is made.
The card of the present invention that cure mainly that is formulated is monarch drug in a prescription tuber of dwarf lilyturf nourishing Yin and promoting production of body fluid, moistening lung clears away heart-fire, ministerial drug caused by fire excess from yin deficiency
Corydlis bungeana is clearing heat and detoxicating, subduing inflammation wheat；Pinellia drop is inverse, the beneficial stomach of Radix Codonopsis, Chinese yam, the bighead atractylodes rhizome and Poria cocos tonifying spleen, balloonflower root facilitaing lung relieving sore-throat,
Hawthorn digesting stomach invigorating, activate blood circulation and disperse blood clots as adjutant, cultivated land life essence-filling, marrow-benefitting, enriching yin, checking exuberance of yang, kidney tonifying, the fruit of Chinese magnoliavine, the fruit of glossy privet, the root of herbaceous peony are mended
Liver kidney yin, altogether to make medicine, all formulas are matched for radix glycyrrhizae coordinating the drug actions of a prescription, and the effect of clearing removes heat, reinforcing both QI and YIN, invigorating the spleen facilitaing lung is played altogether.
Clearing of the present invention, for clinical common type of hyperactivity of fire caused by deficiency of YIN, is controlled except heat, reinforcing both QI and YIN, invigorating the spleen facilitaing lung because chronic cough loses,
Lung heat impairment of yin, or after pyreticosis, stomach-Yin consumption is lost, deficiency-fire produced in the interior, upper bright pharynx key and cause.Symptoms include dry throat shoot, there is foreign body sensation, itch dry
Cough, the glutinous amount of phlegm is few, afternoon dysphoria with smothery sensation, gastral cavity burns dry.Red tongue body, yellow tongue fur and do, pulse condition is counted accurately.
The Chinese medicine composition of the present invention and its consumption of drug component are also to carry out largely groping to summarize by inventor
Go out
The composition and parts by weight of a kind of described pharmaceutical composition for treating chronic pharyngitis for the treatment of be：Tuber of dwarf lilyturf 30-120 part,
20-100 parts of corydlis bungeana, 10-80 parts of the tuber of pinellia, 10-80 parts of Radix Codonopsis, 10-80 parts of Chinese yam, 10-80 parts of the bighead atractylodes rhizome, 10-80 parts of Poria cocos, tangerine
10-60 parts of stalk, 10-60 parts of hawthorn, 10-50 parts of cultivated land, 5-30 parts of the fruit of Chinese magnoliavine, 5-30 parts of the fruit of glossy privet, 5-30 parts of the root of herbaceous peony, radix glycyrrhizae 3-
30 parts.
The further composition and parts by weight of a kind of described pharmaceutical composition for treating chronic pharyngitis for the treatment of be：The tuber of dwarf lilyturf
20-100 parts, 10-80 parts of corydlis bungeana, 12-60 parts of the tuber of pinellia, 15-75 parts of Radix Codonopsis, 15-75 parts of Chinese yam, 20-60 parts of the bighead atractylodes rhizome, Poria cocos
20-50 parts, 20-50 parts of balloonflower root, 20-50 parts of hawthorn, 20-40 parts of cultivated land, 10-20 parts of the fruit of Chinese magnoliavine, 10-20 parts of the fruit of glossy privet, the root of herbaceous peony
10-20 parts, 9-20 parts of radix glycyrrhizae.
The preferred composition and parts by weight of a kind of described pharmaceutical composition for treating chronic pharyngitis for the treatment of be：The tuber of dwarf lilyturf 100
Part, 80 parts of corydlis bungeana, 60 parts of the tuber of pinellia, 75 parts of Radix Codonopsis, 60 parts of Chinese yam, 60 parts of the bighead atractylodes rhizome, 45 parts of Poria cocos, 40 parts of balloonflower root, 30 parts of hawthorn,
30 parts of cultivated land, 10 parts of the fruit of Chinese magnoliavine, 10 parts of the fruit of glossy privet, 20 parts of the root of herbaceous peony, 10 parts of radix glycyrrhizae.
The preferred composition and parts by weight of a kind of described pharmaceutical composition for treating chronic pharyngitis for the treatment of be：The tuber of dwarf lilyturf 80
Part, 30 parts of corydlis bungeana, 40 parts of the tuber of pinellia, 50 parts of Radix Codonopsis, 50 parts of Chinese yam, 40 parts of the bighead atractylodes rhizome, 40 parts of Poria cocos, 20 parts of balloonflower root, hawthorn 200
Part, 200 parts of cultivated land, 100 parts of the fruit of Chinese magnoliavine, 12 parts of the fruit of glossy privet, 12 parts of the root of herbaceous peony, 12 parts of radix glycyrrhizae.
The preferred composition and parts by weight of a kind of described pharmaceutical composition for treating chronic pharyngitis for the treatment of be：The tuber of dwarf lilyturf 50
Part, 20 parts of corydlis bungeana, 30 parts of the tuber of pinellia, 50 parts of Radix Codonopsis, 50 parts of Chinese yam, 26 parts of the bighead atractylodes rhizome, 20 parts of Poria cocos, 25 parts of balloonflower root, 25 parts of hawthorn,
25 parts of cultivated land, 12 parts of the fruit of Chinese magnoliavine, 12 parts of the fruit of glossy privet, 18 parts of the root of herbaceous peony, 15 parts of radix glycyrrhizae.
In a word, the present invention composition monarch, minister, help, make various, compatibility is rigorous, complements each other, and clearing is played altogether except heat, gas is cloudy double
Mend, the work(of invigorating the spleen facilitaing lung.
Medicine of the present invention can add customary adjuvant, according to common process, be made clinically-acceptable tablet, granule,
Pill, capsule, sustained release agent, oral liquid etc..
The preparation method of medicine of the present invention comprises the following steps：
More than Radix Codonopsis, Chinese yam, Poria cocos three tastes are ground into fine powder, sieving.Remaining nine taste decocting, is concentrated, and is dried.Mix, system
Particle, is dried, and is mixed, and is made pellet, and is dried, encapsulated.
The preparation method of the tablet of medicine of the present invention comprises the following steps：It is more than Radix Codonopsis, Chinese yam, Poria cocos that three tastes are ground into carefully
Powder, sieving.Remaining nine taste decocting, is concentrated, and is dried.Mix, make pellet, dry, tablet is made.
The preparation method of the oral liquid of medicine of the present invention comprises the following steps：After the taste decocting of the above 14, concentrate, filtering,
Oral liquid is made.
The preparation method of medicine of the present invention preferably includes following steps：It is more than Radix Codonopsis, Chinese yam, Poria cocos that three tastes are ground into carefully
Powder, sieving.Remaining nine taste decocting 2 times, 30 minutes every time, is concentrated, spray drying.Mix, make pellet, dry, tablet is made.
Embodiment
Following examples are used to illustrate the present invention, but are not limited to the scope of the present invention.
Embodiment 1
1st, prescription：
Tuber of dwarf lilyturf 100g, corydlis bungeana 80g, tuber of pinellia 60g, Radix Codonopsis 75g, Chinese yam 60g, bighead atractylodes rhizome 60g, Poria cocos 45g, balloonflower root 40g, mountain
Short, bristly hair or beard 30g, cultivated land 30g, fruit of Chinese magnoliavine 10g, fruit of glossy privet 10g, root of herbaceous peony 20g, radix glycyrrhizae 10g..
2. preparation method：
More than Radix Codonopsis, Chinese yam, Poria cocos three tastes are ground into fine powder, sieving.Remaining nine taste decocting 2 times, it is 30 minutes every time, dense
Contracting, spray drying.Mix, make pellet, dry, tablet is made, is made 500, produces.
Embodiment 2
1st, prescription：
Tuber of dwarf lilyturf 80g, corydlis bungeana 30g, tuber of pinellia 40g, Radix Codonopsis 50g, Chinese yam 50g, bighead atractylodes rhizome 40g, Poria cocos 40g, balloonflower root 20g, mountain
Short, bristly hair or beard 200g, cultivated land 200g, fruit of Chinese magnoliavine 100g, fruit of glossy privet 12g, root of herbaceous peony 12g, radix glycyrrhizae 12g..
2. preparation method：
After the taste decocting of the above 14, concentrate, filtering is made oral liquid 500ml, produced.
Embodiment 3
1st, prescription：
Tuber of dwarf lilyturf 50g, corydlis bungeana 20g, tuber of pinellia 30g, Radix Codonopsis 50g, Chinese yam 50g, bighead atractylodes rhizome 26g, Poria cocos 20g, balloonflower root 25g, mountain
Short, bristly hair or beard 25g, cultivated land 25g, fruit of Chinese magnoliavine 12g, fruit of glossy privet 12g, root of herbaceous peony 18g, radix glycyrrhizae 15g.
2nd, technique：
More than Radix Codonopsis, Chinese yam, Poria cocos three tastes are ground into fine powder, sieving.Remaining nine taste decocting 2 times, it is 30 minutes every time, dense
Contracting, spray drying.Mix, make pellet, dry, capsule is made, is made 500, produces.
Embodiment 4
1st, prescription：
Tuber of dwarf lilyturf 120g, corydlis bungeana 80g, tuber of pinellia 50g, Radix Codonopsis 70g, Chinese yam 60g, bighead atractylodes rhizome 80g, Poria cocos 80g, balloonflower root 60g, mountain
Short, bristly hair or beard 60g, cultivated land 50g, fruit of Chinese magnoliavine 30g, fruit of glossy privet 30g, root of herbaceous peony 30g, radix glycyrrhizae 30g.
2. preparation method：
More than Radix Codonopsis, Chinese yam, Poria cocos three tastes are ground into fine powder, sieving.Remaining nine taste decocting 2 times, it is 30 minutes every time, dense
Contracting, spray drying.Mix, make pellet, dry, capsule 800 is made, produces.
Embodiment 5
1st, prescription：
Tuber of dwarf lilyturf 30g, corydlis bungeana 20g, tuber of pinellia 60g, Radix Codonopsis 20g, Chinese yam 50g, bighead atractylodes rhizome 40g, Poria cocos 3g, balloonflower root 20g, hawthorn
10g, cultivated land 20g, fruit of Chinese magnoliavine 30g, fruit of glossy privet 10g, root of herbaceous peony 10g, radix glycyrrhizae 9g.
2. preparation method：
After the taste decocting of the above 14, concentrate, filtering is made oral liquid 300ml, produced.
The test of pesticide effectiveness of embodiment 6：Mouse auricle swelling test
【Test material】
Test medicine：Swallow capsule for curing：Chocolate brown powder, is made by embodiment 3 by 0.3g/, and institute is made into distilled water with preceding
The suspension of the concentration needed.
Acetylsalicylic acid tablet, lot number：20101207, Shandong pharmaceutical Co. Ltd of Xinhua.
【Test method and result】
Kunming mouse 40, male is randomly divided into model control group, swallows capsule for curing high and low dose group, aspirin sun
Property control group.Medicine is substantially soluble in distilled water, pharynx capsule for curing high and low dose is respectively 18,9gkg-1 (crude drug amount)；Ah
This woods dosage is 0.20gkg-1；Model control group gives distilled water.Ig is administered once/d, continuous 7d.1h after last dose,
Mouse is put to death in dislocation of cervical vertebra method after each melted paraxylene 0.05mL of each mouse right ear auricle positive and negative, 1h, in left and right two ears auricle
Same area is removed auricle with 4.5mm card punch and weighed, and the difference of left and right ear quality is swelling, is as a result examined and is united with t
Count processing.
It the results are shown in Table 1.
The pharynx capsule for curing paraxylene of table 1 causes the influence (x ± s) of mice auricle swelling
Note：Compared with model group, Δ Δ p ＜ 0.01.
As shown in Table 1, pharynx capsule for curing high and low dose group can subtract clear mice caused by dimethylbenzene xylene auricle edema, statistical result tool
There is notable statistical significance.
Embodiment 7
【Test material】
Test medicine：Swallow capsule for curing：Chocolate brown powder, is made by embodiment 3 by 0.3g/, and institute is made into distilled water with preceding
The suspension of the concentration needed.
Yin huang pian, lot number 20090202, Tonghua Golden-Horse Pharmaceutical Industry Co., Ltd..
【Test method and result】
Japan large ear rabbit 30, regular grade, male and female half and half, 2.0~2.5Kg of body weight is divided into blank using random device
Control group, model group, yin huang pian group and pharynx capsule for curing high and low dose group, every group 6.In addition to blank control group, remaining each group man
Each 2.5% ammoniacal liquor of upper and lower noon sprays its pharyngeal 1 time rabbit daily, is pressed every time with sprayer spray 3；Physiology salt is pressed in blank control group spray 3
Water, each group is continuously sprayed 13 days.Modeling the 8th day, in addition to blank control group, remaining each group is noted turpentine oil with tonsil needle
Penetrate under the pharyngeal mucous membrane of rabbit, every animal injects 0.5ml.Modeling the 14th day, rabbit pharyngeal is in chronic congestion state, dark red
Color, mucus sexual secretion increase, hence it is evident that swelling is modeling success.
Modeling the 14th day, pharynx capsule for curing high and low dose group gives pharynx capsule for curing 20,10gkg-1；Yin huang pian group is given
0.026g/ml yin huang pian suspension 10ml/kg gavages；Blank control group and model group give isometric physiological saline.Each group
Equal daily gavages 1 time, continuous 8 days.
In 1h after perfusion in the 8th day, pharyngeal mucous membrane is visually observed and grading evaluation, according to pharyngeal color, have unglazed
Damp, secretion is how many, redness degree, swelling degree are divided into level Four："-" level, pharyngeal pale red, moistening, surface is smooth, not
See the pathological phenomenons such as hyperemia, swelling；"+" level, animal pharyngeal has Some Animals visible slight substantially close to "-" level
Chronic congestion, mucous membrane glossiness is not good enough, pharyngeal to have a small amount of secretion；" ++ " level, animal pharyngeal is in chronic congestion, dark red
Color, there is mild swelling, there is a small amount of secretion；" +++ " level, pharyngeal is in chronic congestion state, kermesinus, mucus sexual secretion
Increase, hence it is evident that swelling.
It the results are shown in Table 2：
The pharyngeal mucous membrane naked eyes classification of each group rabbit of table 2 is compared (only)
Compared with blank control group, the pharyngeal mucous membrane naked eyes changed in stages of model group significantly (P ＜ 0.01；Compared with model group,
High dose group, low dose group and pharyngeal statistically significant (the P ＜ of mucous membrane naked eyes changed in stages difference of yin huang pian group rabbit are cured in pharynx
0.01)。
The toxicity test of embodiment 8
【Test material】
Test medicine：Swallow capsule for curing：Chocolate brown powder, is made by embodiment 3 by 0.3g/, and institute is made into distilled water with preceding
The concentration needed.
【Test method and result】
18 ± 2g of Kunming mouse used in acute toxicity test, male and female half and half.Selection buys this laboratory and adapts to shape after 3d
State is good, and behavior, activity animal without exception are tested.Fasting 14~16h, fasting 4h after administration before each animal administration, no
Prohibit water.Single oral gavage is administered during experiment, and 40mL/kg, wherein blank control group such as give at the distilled water of capacity.It is dynamic to observation post administration
The response situation of thing, and continuous observation 4h, Continuous Observation 7d. acute toxicity test observation index：Observe animal body quality, drink
Food, outward appearance, behavior, secretion, excreta and poisoning symptom, the initial time of toxic reaction, the order of severity, duration, note
The death condition of animal is recorded, and distinguishes the 3rd day (D3), the 7th day (D7) after (D0), administration before administration and claims the animal scale of construction.
It is administered in 4h and in 1 week, blank control group shows no obvious abnormalities reaction, all animals have no dead.Each group animal
The scale of construction normally increases, and administration group is compared with blank group, no significant difference.Illustrate the Chinese medicine composition safety non-toxic
Property.
Claims (4)
1. a kind of pharmaceutical composition for treating chronic pharyngitis, it is characterised in that the composition and parts by weight of the bulk drug of the medicine is made
For：100 parts of the tuber of dwarf lilyturf, 80 parts of corydlis bungeana, 60 parts of the tuber of pinellia, 75 parts of Radix Codonopsis, 60 parts of Chinese yam, 60 parts of the bighead atractylodes rhizome, 45 parts of Poria cocos, balloonflower root 40
Part, 30 parts of hawthorn, 30 parts of cultivated land, 10 parts of the fruit of Chinese magnoliavine, 10 parts of the fruit of glossy privet, 20 parts of the root of herbaceous peony, 10 parts of radix glycyrrhizae.
2. a kind of pharmaceutical composition for treating chronic pharyngitis, it is characterised in that the composition and parts by weight of the bulk drug of the medicine is made
For：50 parts of the tuber of dwarf lilyturf, 20 parts of corydlis bungeana, 30 parts of the tuber of pinellia, 50 parts of Radix Codonopsis, 50 parts of Chinese yam, 26 parts of the bighead atractylodes rhizome, 20 parts of Poria cocos, 25 parts of balloonflower root,
25 parts of hawthorn, 25 parts of cultivated land, 12 parts of the fruit of Chinese magnoliavine, 12 parts of the fruit of glossy privet, 18 parts of the root of herbaceous peony, 15 parts of radix glycyrrhizae.
3. pharmaceutical composition as claimed in claim 1 or 2, it is characterised in that take bulk drug, adds customary adjuvant, according to routine
Technique, is made clinically-acceptable tablet, granule, pill, capsule, sustained release agent, oral liquid.
4. the preparation method of pharmaceutical composition as claimed in claim 1 or 2, comprises the following steps：After the taste decocting of the above 14,
Concentration, filtering, is made oral liquid.
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Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105412559A (en) * | 2015-12-02 | 2016-03-23 | 济南舜祥医药科技有限公司 | Traditional Chinese medicine for treating pharyngitis caused by lung and kidney yin deficiency and accompanied by insomnia |
| CN105288137A (en) * | 2015-12-02 | 2016-02-03 | 济南舜祥医药科技有限公司 | Traditional Chinese medicine for treating pharyngitis caused by lung-kidney Yin deficiency |
| CN105327111A (en) * | 2015-12-02 | 2016-02-17 | 济南舜祥医药科技有限公司 | Traditional Chinese medicine for treating pharyngitis accompanied by cough and caused by yin deficiency of lung and kidney |
| CN105327231A (en) * | 2015-12-02 | 2016-02-17 | 济南舜祥医药科技有限公司 | Traditional Chinese medicine for treating pharyngitis accompanied by coughs caused by spleen-kidney-yang deficiency |
| CN105343504A (en) * | 2015-12-02 | 2016-02-24 | 济南舜祥医药科技有限公司 | Traditional Chinese medicine for treating pharyngitis caused by spleen-kidney-yang deficiency |
| CN108543013A (en) * | 2018-06-26 | 2018-09-18 | 桐城市泰安中药材种植专业合作社 | A kind of Chinese medicine for treating chronic pharyngitis |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2208500A1 (en) * | 2009-01-16 | 2010-07-21 | Bionap S.r.L. | Compositions for the treatment of gerd (gastroesophageal reflux disease) |
| CN102228624A (en) * | 2011-06-18 | 2011-11-02 | 长治市郊区黄碾镇中心卫生院 | Medicament for treating pharyngitis and preparation method thereof |
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2014
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2208500A1 (en) * | 2009-01-16 | 2010-07-21 | Bionap S.r.L. | Compositions for the treatment of gerd (gastroesophageal reflux disease) |
| CN102228624A (en) * | 2011-06-18 | 2011-11-02 | 长治市郊区黄碾镇中心卫生院 | Medicament for treating pharyngitis and preparation method thereof |
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| Title |
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| 经方临证偶拾;水文霞等;《辽宁中医杂志》;20000618;第27卷(第06期);268-269 * |
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