CN104127482A - Introducible joint nutrient solution - Google Patents
Introducible joint nutrient solution Download PDFInfo
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- CN104127482A CN104127482A CN201410308138.8A CN201410308138A CN104127482A CN 104127482 A CN104127482 A CN 104127482A CN 201410308138 A CN201410308138 A CN 201410308138A CN 104127482 A CN104127482 A CN 104127482A
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Abstract
The invention relates to the field of medicines, and especially relates to an introducible joint nutrient solution. The introducible joint nutrient solution comprises the following substances in parts by weight: 30-60 parts of deionized water, 10-30 parts of amino sugar, 8-20 parts of chondroitin sulfate, 2-10 parts of fructus sophorae extractive, 5-10 parts of II type collagen, 5-15 parts of lysozyme, 5-8 parts of an amino acid humectant, and 0.1-1 part of sodium hyaluronate. The beneficial effects comprise that the active compositions can be uniformly comprehensively quantitatively directly conveyed to a joint badly in need of treatment in a multiple-point positioned determined-layer manner through an instrument, and the multiple active compositions and nutrients are rapidly absorbed by the joint and peripheral tissue, and thus joint metabolism is promoted, and glucosamine and other nutrients give play to maximum effectiveness.
Description
Technical field
The present invention relates to field of medicaments, relate in particular to a kind of joint nutritional solution that can be used for importing.
Background technology
Osteoarthritis just has from ancient times and spreads all over the world, and all finds that there is osteoarthritis and exist in the dinosaur of paleontologist from 200,000,000 years and the human osseous remains before 500,000 years.People is to after 60 years old, and almost nil when when D-glucosamine only has youth in body 3%, 70 years old, osteoarthritis is almost inevitable, so supplementing D-glucosamine is as early as possible the most important thing of preventing and treating osteoarthritis.
At present, in worldwide, D-glucosamine, as the most directly nutrient of articular cartilage, is known as the specific drug of unique fundamentally rehabilitation osteoarthrosis by World Health Organization (WHO).On market, be mainly traditional oral D-glucosamine now, although oral D-glucosamine has certain effect to treatment joint disease, also produce very large side effect simultaneously, it will pass through peptic digestion and intestinal absorption, increase to some extent the intestines and stomach burden and Liver and kidney burden, especially very big to the damage of kidney; Secondly,, although oral D-glucosamine has played certain mitigation to aseptic inflammation, can not tackle the problem at its root.
Summary of the invention
The object of invention: for a kind of joint nutritional solution that does not damage Liver and kidney of better effects if is provided, specific purposes are shown in multiple essence technique effects of concrete implementation section.
In order to reach as above object, the present invention takes following technical scheme:
Can be used for the joint nutrient solution prescription importing, it is characterized in that, the material that comprises following parts by weight, 30 parts of deionized waters---60 parts; D-glucosamine, 10 parts---30 parts; Chondroitin sulfate, 8 parts---20 parts; Fructus Sophorae extract, 2 parts---10 parts; TypeⅡ Collagen, 5 parts---10 parts; Lysozyme, 5 parts---15 parts; Amino acid humectant, 5 parts---8 parts; Hyaluronate sodium, 0.1 part---1 part.
Can be used for the joint nutritional solution importing, it is characterized in that, the material of following parts by weight is proceeded as follows, the material that comprises following parts by weight, 30 parts of deionized waters---60 parts; D-glucosamine, 10 parts---30 parts; Chondroitin sulfate, 8 parts---20 parts; Fructus Sophorae extract, 2 parts---10 parts; TypeⅡ Collagen, 5 parts---10 parts; Lysozyme, 5 parts---15 parts; Amino acid humectant, 5 parts---8 parts; Hyaluronate sodium, 0.1 part---1 part;
Above various materials except Fructus Sophorae extract and deionized water are removed to impurity; Each raw material is carried out to innoxious extraction with supercritical fluid CO2 respectively, extraction conditions for for first by raw material pulverizing to 20-60 order; Pressure 50MPa-60MPa; Entrainer: ethyl acetate parts by weight are 30% of raw material gross weight; Deionized water is added to reactor, be heated to 85 DEG C of insulations 30 minutes, be cooled to 5 DEG C, add formula needed raw material, stir constant temperature 72 hours, 500 order filtrations, roguing, for subsequent use 30 minutes.
The further technical scheme of the present invention is, also comprises the step of sneaking into active substance, and described active substance is sneaked in liquid for subsequent use, adds vacuum stirring in the aqueous solution of Fructus Sophorae extract after 1.5 hours, to leave standstill 48 hours, discharging; Semi-finished product detect; Sterile filling; Packaging.
The further technical scheme of the present invention is, described active substance is biological active ammonia sugar.
Adopt as above the present invention of technical scheme, there is following beneficial effect with respect to prior art: our company has researched and developed a kind of liquid of effective treatment joint disease, this liquid by instrument can multiple spot, evenly, comprehensively, location, given layer, quantitatively active ingredient is delivered directly in the osteoarthrosis of being badly in need for the treatment of, allow various active composition and nutrient substance be absorbed by osteoarthrosis and surrounding tissue rapidly, and then promote osteoarthrosis metabolism, the function of the nutrient substance such as D-glucosamine is performed to maximum utility; Secondly, this liquid has fundamentally solved the problem of aseptic inflammation, drives away inflammation, effectively treats osteoarthrosis; Again, this liquid, without oral, makes gastrointestinal zero burden, Liver and kidney not damaged, and therapeutic process without any side effect, fast and effeciently solves pain to human body.
Detailed description of the invention
Below embodiments of the invention are described, embodiment is not construed as limiting the invention:
Embodiment mono-:
The material of following parts by weight is proceeded as follows to the material that comprises following parts by weight, 30 parts of deionized waters; D-glucosamine, 10 parts; Chondroitin sulfate, 8 parts; Fructus Sophorae extract, 2 parts; TypeⅡ Collagen, 5 parts; Lysozyme, 5 parts; Amino acid humectant, 5 parts; Hyaluronate sodium, 0.1 part;
Above various materials except Fructus Sophorae extract and deionized water are removed to impurity; Each raw material is carried out to innoxious extraction with supercritical fluid CO2 respectively, extraction conditions for for first by raw material pulverizing to 20-60 order; Pressure 50MPa-60MPa; Entrainer: ethyl acetate parts by weight are 30% of raw material gross weight; Deionized water is added to reactor, be heated to 85 DEG C of insulations 30 minutes, be cooled to 5 DEG C, add formula needed raw material, stir constant temperature 72 hours, 500 order filtrations, roguing, for subsequent use 30 minutes.
The further technical scheme of the present invention is, also comprises the step of sneaking into active substance, and described active D-glucosamine is sneaked in liquid for subsequent use, adds vacuum stirring in the aqueous solution of Fructus Sophorae extract after 1.5 hours, to leave standstill 48 hours, discharging; Semi-finished product detect; Sterile filling; Packaging.
Embodiment bis-:
Can be used for the joint nutritional solution importing, it is characterized in that, the material of following parts by weight is proceeded as follows to the material that comprises following parts by weight, 60 parts of deionized waters; D-glucosamine, 30 parts; Chondroitin sulfate, 20 parts; Fructus Sophorae extract, 10 parts; TypeⅡ Collagen, 10 parts; Lysozyme, 15 parts; Amino acid humectant, 8 parts; Hyaluronate sodium, 1 part;
Above various materials except Fructus Sophorae extract and deionized water are removed to impurity; Each raw material is carried out to innoxious extraction with supercritical fluid CO2 respectively, extraction conditions for for first by raw material pulverizing to 20-60 order; Pressure 50MPa-60MPa; Entrainer: ethyl acetate parts by weight are 30% of raw material gross weight; Deionized water is added to reactor, be heated to 85 DEG C of insulations 30 minutes, be cooled to 5 DEG C, add formula needed raw material, stir constant temperature 72 hours, 500 order filtrations, roguing, for subsequent use 30 minutes.
The further technical scheme of the present invention is, also comprises the step of sneaking into active substance, and described active substance is sneaked in liquid for subsequent use, adds vacuum stirring in the aqueous solution of Fructus Sophorae extract after 1.5 hours, to leave standstill 48 hours, discharging; Semi-finished product detect; Sterile filling; Packaging.
It should be noted that, the biological activity D-glucosamine that the present invention only treats osteoarthritis is example, but not as restriction, similarly as long as the mixing of water-soluble material can both.
The various appellations that occur in literary composition are prior art, but its combination is not;
Below noun being done to some explains substantially:
The material of hyaluronate sodium (SODIUM HYALURONATE) for extracting from cockscomb;
Amino acid humectant chemical name: trimethyl glycine; English name: trimethyl glycine;
Chondroitin sulfate (CS) be covalently bound
proteinone class glycosaminoglycans of upper formation Dan Baiduotang proteoglycan PG.Chondroitin sulfate is distributed widely in extracellular matrix and the cell surface of animal tissue, sugar chain is made up of the glucuronic acid replacing and N-acetylgalactosamine (claiming again N-acetylamino galactosamine) disaccharide unit, is connected to core protein by one like sugar chain block
serineon residue.
The full name D-glucosamine of D-glucosamine, belongs to
monosaccharidecomposition, can be from Eriocheir sinensis Crusta Penaeus seu Panulirus and in red utmost point ginseng
extraction, be the important component part of the extremely strong proteoglycan of hydrophilic.
Fructus Sophorae extract is also Fructus Sophorae extract, Latin formal name used at school:
Fructus sophorae.
Enclose clinical experiment report:
| Name | Sex | Age | Address | Sick time | Control front symptom | With this medicine treatment time | Clinical cure |
| Grandson | Female | 76 years old | Xi'an | 2000.5 | Prolapse of lumbar intervertebral disc | 3 months (embodiment mono-) | Clinical Pain disappears |
| Lee | Man | 82 years old | Wugong County | 1986.3 | Sciatic neuritis | 3 months (embodiment mono-) | Clinical Pain disappears |
| Side certain | Man | 70 years old | Nanning City | 1997.11 | Shank degeneration | 12 months (embodiment mono-) | Clinical Pain disappears |
| Liu | Man | 65 years old | Yuanmou of Yunnan Province | 2009.11 | Both feet bony spur | 6 months (embodiment mono-) | Clinical Pain disappears |
| Wang | Female | 65 years old | Yibin, Sichuan | 2003.4 | Rheumatoid arthritis | 12 months (embodiment mono-) | Clinical Pain disappears |
| Shen | Female | 69 years old | Guangxi Yulin | 2009.5 | Hyperosteogeny | 9 months (embodiment mono-) | Clinical Pain disappears |
| Cui | Man | 57 years old | Chengde | 1994.1 | Knee joint degeneration | 5 months (embodiment mono-) | Clinical Pain disappears |
| Wang | Man | 52 years old | Tieling | 2011.5 | Lumbar intervertebral disc prolapse | 4 months (embodiment mono-) | Clinical Pain disappears |
| High mountain | Man | 45 years old | Heze City, Shandong Province | 2012.3 | Prolapse of lumbar intervertebral disc | 3 months (embodiment mono-) | Clinical Pain disappears |
| Pungent certain | Female | 49 years old | Distributions in Liaocheng of Shandong Province | ?2011.9 | Cervical spondylosis bone mill sassafras sound | 8 months (embodiment mono-) | Clinical Pain disappears |
| Money | Man | 57 years old | Yinchuan of Ningxia Province | ?2004.8 | Prolapse of lumbar intervertebral disc | 6 months (embodiment bis-) | Clinical Pain disappears |
| Dragon certain | Female | 68 years old | Chengde | 1988.4 | Synovitis | 1 month (embodiment bis-) | Clinical Pain disappears |
| Ma | Man | 52 years old | Huludao City | 2001.9 | Knee joint rheumatic arthritis | 6 months (embodiment bis-) | Clinical Pain disappears |
| Cao | Female | 53 years old | Xi'an | 2013.5 | Cervical spondylosis | 2 months (embodiment bis-) | Clinical Pain disappears |
| Lu | Man | 55 years old | Tieling | 2012.8 | Lumbar intervertebral disc prolapse | 6 months (embodiment bis-) | Clinical Pain disappears |
| Wang | Female | 66 years old | Yingkou City | 1999.3 | Knee joint degeneration | 5 months (embodiment bis-) | Clinical Pain disappears |
| Ma | Man | 56 years old | Baotou | 1989.5 | Prolapse of lumbar intervertebral disc | 3 months (embodiment bis-) | Clinical Pain disappears |
| Wang | Man | 73 years old | Heze City | 2012.4 | Rheumatoid arthritis | 12 months (embodiment bis-) | Clinical Pain disappears |
| Money | Man | 60 years old | Urumchi | 2009.8 | Cervical spondylosis | 7 months (embodiment bis-) | Clinical Pain disappears |
| Poplar | Man | 77 years old | Changsha | 1982.1 | Rheumatic arthritis | 12 months (embodiment bis-) | Clinical Pain disappears |
| Lee | Female | 59 years old | Luoyang City | 2012.3 | Prolapse of lumbar intervertebral disc | 4 months (embodiment bis-) | Clinical Pain disappears |
| Liu | Female | 67 years old | Xinjiang Urumqi | 2009.5 | Knee joint degeneration | 6 months (embodiment bis-) | Clinical Pain disappears |
| History | Female | 55 years old | Anyang | 2011.6 | Cervical spondylosis | 1 month (embodiment bis-) | Clinical Pain disappears |
| Cui | Female | 56 years old | Yichang City | 1985.2 | Rheumatic gonarthritis | 3 months (embodiment bis-) | Clinical Pain disappears |
| Guo | Man | 55 years old | Wuhan City | 2011.6 | Knee joint endoprosthesis inflammation | 3 months (embodiment bis-) | Clinical Pain disappears |
| Normal certain | Man | 48 years old | Jingmen | 2014.1 | Bursitis | 7 months (embodiment bis-) | Clinical Pain disappears |
| Zhao | Man | 66 years old | Hangzhou | 2011.7 | Prolapse of lumbar intervertebral disc | 3 months (embodiment bis-) | Clinical Pain disappears |
| Wang | Female | 49 years old | Yingkou City | 2013.9 | Cervical spondylosis | 3 months (embodiment bis-) | Clinical Pain disappears |
| Week certain | Female | 46 years old | Chiping County | 2014.3 | Articulations digitorum manus tenosynovitis | 2 months (embodiment bis-) | Clinical Pain disappears |
| Fourth | Man | 42 years old | Yinchuan | 2012.3 | Prolapse of lumbar intervertebral disc | 7 months (embodiment bis-) | Clinical Pain disappears |
| Stone | Man | 56 years old | Xinjiang Urumqi | 2009.12 | Tennis elbow | 2 months (embodiment bis-) | Clinical Pain disappears |
| Gold certain | Female | 73 years old | Weinan City | 2000.5 | Shank degeneration | 4 months (embodiment bis-) | Clinical Pain disappears |
| Still certain | Man | 49 years old | Tieling | 2011.3 | Prolapse of lumbar intervertebral disc | 8 months (embodiment bis-) | Clinical Pain disappears |
more than show and described ultimate principle of the present invention, principal character and advantage of the present invention.Those skilled in the art should understand the present invention and not be restricted to the described embodiments; that in above-described embodiment and description, describes just illustrates principle of the present invention; without departing from the spirit and scope of the present invention; the present invention also has various changes and modifications, and these changes and improvements all fall in claimed scope.
Claims (3)
1. can be used for the joint nutrient solution prescription importing, it is characterized in that, the material that comprises following parts by weight, 30 parts of deionized waters---60 parts; D-glucosamine, 10 parts---30 parts; Chondroitin sulfate, 8 parts---20 parts; Fructus Sophorae extract, 2 parts---10 parts; TypeⅡ Collagen, 5 parts---10 parts; Lysozyme, 5 parts---15 parts; Amino acid humectant, 5 parts---8 parts; Hyaluronate sodium, 0.1 part---1 part.
2. can be used for the joint nutritional solution importing, it is characterized in that, the material of following parts by weight is proceeded as follows, the material that comprises following parts by weight, 30 parts of deionized waters---60 parts; D-glucosamine, 10 parts---30 parts; Chondroitin sulfate, 8 parts---20 parts; Fructus Sophorae extract, 2 parts---10 parts; TypeⅡ Collagen, 5 parts---10 parts; Lysozyme, 5 parts---15 parts; Amino acid humectant, 5 parts---8 parts; Hyaluronate sodium, 0.1 part---1 part;
Above various materials except Fructus Sophorae extract and deionized water are removed to impurity; Each raw material is used respectively to supercritical fluid CO
2carry out innoxious extraction, extraction conditions for for first by raw material pulverizing to 20-60 order; Pressure 50MPa-60MPa; Entrainer: ethyl acetate parts by weight are 30% of raw material gross weight; Deionized water is added to reactor, be heated to 85 DEG C of insulations 30 minutes, be cooled to 5 DEG C, add formula needed raw material, stir constant temperature 72 hours, 500 order filtrations, roguing, for subsequent use 30 minutes.
3. a kind of joint nutritional solution that can be used for importing as claimed in claim 2, is characterized in that, also comprises the step of sneaking into active substance, described active substance is sneaked in liquid for subsequent use, add vacuum stirring in the aqueous solution of Fructus Sophorae extract after 1.5 hours, to leave standstill 48 hours, discharging; Semi-finished product detect; Sterile filling; Packaging.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410308138.8A CN104127482B (en) | 2014-07-01 | 2014-07-01 | A kind of joint nutrient solution that can be used to import |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410308138.8A CN104127482B (en) | 2014-07-01 | 2014-07-01 | A kind of joint nutrient solution that can be used to import |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104127482A true CN104127482A (en) | 2014-11-05 |
| CN104127482B CN104127482B (en) | 2019-01-29 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201410308138.8A Expired - Fee Related CN104127482B (en) | 2014-07-01 | 2014-07-01 | A kind of joint nutrient solution that can be used to import |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105030900A (en) * | 2015-07-08 | 2015-11-11 | 吴秉民 | Externally used paste for treating rheumatic and rheumatoid arthritis and its preparation method and use |
| EP3117834A1 (en) * | 2015-07-14 | 2017-01-18 | Infinitus (China) Company Ltd. | A bone and joint protection composition and use thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004032980A1 (en) * | 2002-10-04 | 2004-04-22 | Elan Pharma International Limited | Gamma irradiation of solid nanoparticulate active agents |
| CN101810855A (en) * | 2010-05-20 | 2010-08-25 | 佟刚 | II-type collagen joint cartilage fluid and preparation method thereof |
-
2014
- 2014-07-01 CN CN201410308138.8A patent/CN104127482B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004032980A1 (en) * | 2002-10-04 | 2004-04-22 | Elan Pharma International Limited | Gamma irradiation of solid nanoparticulate active agents |
| CN101810855A (en) * | 2010-05-20 | 2010-08-25 | 佟刚 | II-type collagen joint cartilage fluid and preparation method thereof |
Non-Patent Citations (3)
| Title |
|---|
| 刘永新: "《国家药典中药实用手册中》", 30 April 2011 * |
| 王求淦: "《新编实用临床药物手册》", 30 September 2010 * |
| 赛安生物: "红极参高活性生物氨糖", 《HTTP://WWW/SAIANSW.COM/PRODUCT/GGJIL/2012072449.HTML》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105030900A (en) * | 2015-07-08 | 2015-11-11 | 吴秉民 | Externally used paste for treating rheumatic and rheumatoid arthritis and its preparation method and use |
| EP3117834A1 (en) * | 2015-07-14 | 2017-01-18 | Infinitus (China) Company Ltd. | A bone and joint protection composition and use thereof |
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| Publication number | Publication date |
|---|---|
| CN104127482B (en) | 2019-01-29 |
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Granted publication date: 20190129 Termination date: 20200701 |