CN104119385A - 核苷类似物的磷酸酯前药及其应用 - Google Patents
核苷类似物的磷酸酯前药及其应用 Download PDFInfo
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Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2015081133A3 (en) * | 2013-11-27 | 2015-12-17 | Idenix Pharmaceuticals, Inc. | Nucleotides for the treatment of liver cancer |
WO2016078160A1 (zh) * | 2014-11-17 | 2016-05-26 | 常州方圆制药有限公司 | 胞苷衍生物及其应用 |
WO2017124896A1 (zh) * | 2016-01-19 | 2017-07-27 | 四川海思科制药有限公司 | 一种核苷类似物的磷酰胺酯前药及其应用 |
CN108137630A (zh) * | 2016-09-23 | 2018-06-08 | 鲁汶天主教大学 | 氟化无环核苷膦酸酯的前药 |
CN108276444A (zh) * | 2017-01-06 | 2018-07-13 | 米文君 | 一类新的化合物及其用途 |
CN112409431A (zh) * | 2020-12-07 | 2021-02-26 | 武汉伯瑞恒医药科技有限公司 | 阿糖胞苷结构类似物及其制备方法和用途 |
CN114349816A (zh) * | 2021-11-30 | 2022-04-15 | 青岛博创生物科学研究院 | 一种基于氨肽酶n/cd13的小分子偶联分子及其制备方法和应用 |
WO2024103979A1 (zh) * | 2022-11-17 | 2024-05-23 | 北京凯因科技股份有限公司 | 一种抑制疱疹病毒的化合物 |
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2014
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Non-Patent Citations (5)
Title |
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AKITSUGU TAKADA 等: ""PK-PD modeling of 1-(3-C-ethynyl-β-D-ribo-pentofuranosyl)cytosine and the enhanced antitumor effect of its phospholid derivatives in long-circulating liposomes"", 《INTERNATIONAL JOURNAL OF PHARMACEUTICS》 * |
C.YING 等: ""Novel Acyclic Nucleoside Phosphonate Analogues with Potent Anti-Hepatitis B Virus Activities"", 《ANTIMICROBIAL AGENTSAND CHEMOTHERAPY》 * |
LISA A 等: ""Phase I and pharmacokinetic study of 3’-C-ethynylcytidine (TAS-106), an inhibitor of RNA polymerase I, II and III, in patients with advanced solid malignancies"", 《INVEST NEW DRUGS》 * |
PETR JANSA等: ""A novel and efficient one-pot synthesis of symmetrical diamide (bis-amidate) prodrugs of acyclic nucleoside phosphonates and evaluation of their biological activities"", 《EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY》 * |
杨康辉 等: ""开环膦酸核苷类药物前药的研究进展"", 《食品与药品》 * |
Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2015081133A3 (en) * | 2013-11-27 | 2015-12-17 | Idenix Pharmaceuticals, Inc. | Nucleotides for the treatment of liver cancer |
US10030044B2 (en) | 2013-11-27 | 2018-07-24 | Idenix Pharmaceuticals Llc | Nucleotides for the treatment of liver cancer |
CN106146583B (zh) * | 2014-11-17 | 2019-11-08 | 常州方圆制药有限公司 | 新型胞苷衍生物及其应用 |
WO2016078160A1 (zh) * | 2014-11-17 | 2016-05-26 | 常州方圆制药有限公司 | 胞苷衍生物及其应用 |
CN106146583A (zh) * | 2014-11-17 | 2016-11-23 | 常州方圆制药有限公司 | 新型胞苷衍生物及其应用 |
WO2017124896A1 (zh) * | 2016-01-19 | 2017-07-27 | 四川海思科制药有限公司 | 一种核苷类似物的磷酰胺酯前药及其应用 |
CN107849075A (zh) * | 2016-01-19 | 2018-03-27 | 四川海思科制药有限公司 | 一种核苷类似物的磷酰胺酯前药及其应用 |
CN108137630A (zh) * | 2016-09-23 | 2018-06-08 | 鲁汶天主教大学 | 氟化无环核苷膦酸酯的前药 |
CN108276444A (zh) * | 2017-01-06 | 2018-07-13 | 米文君 | 一类新的化合物及其用途 |
CN112409431A (zh) * | 2020-12-07 | 2021-02-26 | 武汉伯瑞恒医药科技有限公司 | 阿糖胞苷结构类似物及其制备方法和用途 |
CN112409431B (zh) * | 2020-12-07 | 2023-04-21 | 武汉伯瑞恒医药科技有限公司 | 阿糖胞苷结构类似物及其制备方法和用途 |
CN114349816A (zh) * | 2021-11-30 | 2022-04-15 | 青岛博创生物科学研究院 | 一种基于氨肽酶n/cd13的小分子偶联分子及其制备方法和应用 |
WO2024103979A1 (zh) * | 2022-11-17 | 2024-05-23 | 北京凯因科技股份有限公司 | 一种抑制疱疹病毒的化合物 |
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