CN104116910A - Traditional Chinese medicine composition for treating mouth herpes and preparation method thereof - Google Patents

Abstract

The invention relates to the technical field of traditional Chinese medicine and particularly relates to a traditional Chinese medicine composition for treating mouth herpes. The components for oral administration are composed of 30 g of rheum officinale, 5 g of loofah sponge, 5 g of hypericum japonicum, 5 g of elsholtzia, 8 g of radices trichosanthis, 3 g of thyme, 7 g of honeysuckle, 6 g of blackend swallowwort root, 10 g of radix polygonati officinalis, 12 g of ampelopsis grossedentata, 15 g of Lysimachia barystachys Bunge, 10 g of oriental buckthorn root and 3 g of mustard; and the components for external application are composed of 5 g of calamine and 10 g of cactus. The treatment manner of combining oral administration with external application has quick curative effect of treating mouth herpes, becomes effective within one day and is good in curative effect, the effective rate is 100%, the cure rate is higher than 95%, and the traditional Chinese medicine composition can be used for effectively preventing breakage of the herpes to reduce the pain of children; and moreover, the oral liquid can be used for preventing the morbidity of the mouth herpes.

Description

A kind of Chinese medicine composition for the treatment of herpes of mouth and preparation method thereof

technical field

The present invention relates to technical field of Chinese medicines, particularly a kind of Chinese medicine composition for the treatment of herpes of mouth.

background technology

Children's's herpes of mouth is newfound a kind of exanthematous infectious disease eighties in last century, and the age, especially common with infant, summer and autumn were easy to popular on a large scale generally below 5 years old.This sick main clinical manifestation is that herpes or ulcer appear in hands, foot, oral mucosa.

Herpes of mouth is the infectious disease being caused by enterovirus, and the multiple infant of being born in, can cause the herpes at the positions such as hands, foot, oral cavity, and indivedual patients can cause the complication such as myocarditis, pulmonary edema, AME.The enterovirus that causes herpes of mouth has kind more than 20 (type), 16,4,5,9,10 types of CA group, 2,5 types of B group, and enterovirns type 71 is the more common pathogen of herpes of mouth, wherein common with coxsackie virus A 16-type (CoxA16) and enterovirns type 71 (EV71).Herpes of mouth just can cause the one in multiple infectious disease of being permitted of oral ulcer, and the reason of another kind of common oral ulcer is that HSV of Oral Swab in Healthy People infects, and it makes oral cavity and gingiva produce inflammation (sometimes claiming stomatitis).

Publication number is the Chinese invention patent application of CN102028736A, a kind of Chinese medicine patch for the treatment of herpes of mouth is disclosed, the sheet-like composition that this paster is made up of medicated layer and sealing coat, medicated layer contains Radix Isatidis, Herba Menthae and Borneolum Syntheticum fine powder, sealing coat is pharmaceutically acceptable water proof material, filler and lubricant, treatment oral cavity born of the same parents' rash effective percentage reaches 98%, and cure rate reaches 90%.But its sealing coat need to be prepared from by various auxiliary agents, prepares loaded down with trivial details.

Publication number is the Chinese invention patent application of CN102000191A, discloses a kind of the routed clear loose of oral cavity and throat ulcerate disease that be used for the treatment of, and it is by Radix Et Rhizoma Rhei 5 ~ 10; 5 ~ 10 parts of Rhizoma Coptidis, 5 ~ 10 parts of Cortex Phellodendris, 10 ~ 15 parts of Realgars; 8 ~ 15 parts, Cinnabaris; 10 ~ 15 parts of Boraxs, 1 ~ 5 part, Chalcanthitum, 11 ~ 16 parts of Indigo Naturaliss; 9 ~ 14 parts of dried Alumens; 1 ~ 7 part of Cornu rhinocerotis, 0.5 ~ 1.5 part of Calculus Bovis, 9 ~ 14 parts of Borneolum Syntheticums.Indication is oral ulcer, herpes of mouth, and oral erosion, angular cheilitis, gingivitis, throat festers, throat herpes, pharyngeal diphtheria, thrush, tonsillitis, pharyngitis, oral cavity and throat portion herpes and ulcer that Hand-Food-Mouth Disease causes; Adopt removing damp-heat, detoxicating, relieving inflammation, nourishing yin and promoting granulation, convergence pain relieving is to reach the object for the treatment of both the principal and secondary aspects of a disease; Within 1 ~ 2 day of its mild symptoms, just can fully recover, effective percentage is 100%.But its specific aim is not strong, and curative effect is also just well imagined.

summary of the invention

For the medicine specific aim that solves herpes of mouth in above prior art is strong, it is slow to take effect, prepare loaded down with trivial details defect, the invention provides a kind of specially for the Chinese medicine composition of herpes of mouth, instant effect, short treating period, without any side effects, the simple treatment of preparation herpes of mouth.

The present invention is achieved by the following measures:

Treat a Chinese medicine composition for herpes of mouth, crude drug weight proportion is as follows:

Component for oral administration:

Radix Et Rhizoma Rhei 30g, Retinervus Luffae Fructus 5g, Herba Hyperici Japonici 5g, Herba Moslae 5g, Radix Trichosanthis 8g, Herba thymi vulgaris 3g, Flos Lonicerae 7g, Radix Cynanchi Atrati 6g, Rhizoma Polygonati Odorati 10g, Herba Cayatiae Japonicae 12g, XUEJINGCAO 15g, Radix rhamni crenatae 10g, Semen Sinapis 3g;

External application component:

Calamina 5g, Radix et Caulis Opuntiae Dillenii 10g.

Described Chinese medicine composition, obtains by following steps:

Component for oral administration:

Radix Et Rhizoma Rhei, Retinervus Luffae Fructus, Herba Hyperici Japonici, Herba Moslae, Radix Trichosanthis, Herba thymi vulgaris, Flos Lonicerae, Radix Cynanchi Atrati, Rhizoma Polygonati Odorati, Herba Cayatiae Japonicae, XUEJINGCAO, Radix rhamni crenatae, Semen Sinapis mixed powder are broken into coarse powder, add in the boiled water of 10 times of weight and decoct 1 hour, filter, filtering residue adds in the boiled water of 5 times of weight and decocts 20 minutes, filter, merge filtrate twice, be concentrated into 25 DEG C of relative densities and be 1.25 and must take component medicinal liquid orally;

External application component:

By Radix et Caulis Opuntiae Dillenii peeling, thorn, mash, add Calamina, external application component mastic stirs to obtain.

Described Chinese medicine composition, medicinal liquid is taken 3 times every day, each 100mL, mastic spreads upon patient's lip for 1 time around and chin bottom every day, after doing, washes away.

Radix Et Rhizoma Rhei: attack stagnant; Clearing away damp-heat; Pathogenic fire purging; Removing heat from blood; Blood stasis dispelling; Removing toxic substances;

Retinervus Luffae Fructus: dredging collateral, invigorate blood circulation, dispel the wind;

Herba Hyperici Japonici: dampness removing jaundice eliminating, heat-clearing and toxic substances removing, promoting blood circulation and detumescence;

Herba Moslae: energy diaphoresis expelling summer-heat, row water wet dissipation, during stomach warming is adjusted;

Radix Trichosanthis: clearing away heat-fire class medicine, its concrete effect is clearing away heat-fire, promoting the production of body fluid to quench thirst, evacuation of pus detumescence;

Herba thymi vulgaris: expelling pathogenic wind from the body surface, promoting the circulation of QI to relieve pain, cough-relieving, blood pressure lowering;

Flos Lonicerae: dispelling wind-heat, removing summer-heat blood poison;

Radix Cynanchi Atrati: clearing away heat and cooling blood, inducing diuresis for treating stranguria syndrome, detoxification sore treatment;

Rhizoma Polygonati Odorati: nourishing YIN and moistening the lung; Nourishing the stomach to promote the production of body fluid;

Herba Cayatiae Japonicae: Herba Cayatiae Japonicae is the herb of vitaceae Herba Cayatiae Japonicae, has another name called Japanese Cayratia Herb, ipomoea cairica, Herba Ipomoeae Cairicae, Caulis et Folium cayratiae trifoliae.Be born in wilderness, mountain valley, sylvan life, roadside.It has heat-clearing and toxic substances removing, promoting blood circulation to remove blood stasis, and the function of diuresis,

XUEJINGCAO: promoting blood flow to regulate menstruation, dissipating blood stasis for subsidence of swelling, diuresis.

Radix rhamni crenatae: clearing away heat-damp and promoting diuresis, parasite killing, removing toxic substances;

Semen Sinapis: warming the lung eliminating phlegm promoting the circulation of QI, resolving mass and removing the obstruction of the collateral pain relieving.

Beneficial effect of the present invention: Chinese medicine composition of the present invention adopts treatment skill for oral administration and that external application combines, treatment herpes of mouth, curative effect is fast, in one day, take effect, therapeutic effect is good, effective percentage 100%, cure rate reaches 100%, and can effectively prevent herpes ulceration, reduces children's's misery; And medicinal liquid for oral administration can prevent the morbidity of herpes of mouth.

Detailed description of the invention

For a better understanding of the present invention, further illustrate below in conjunction with specific embodiment.

embodiment 1:

Treat a Chinese medicine composition for herpes of mouth, crude drug weight proportion is as follows:

Component for oral administration:

Radix Et Rhizoma Rhei 30g, Retinervus Luffae Fructus 5g, Herba Hyperici Japonici 5g, Herba Moslae 5g, Radix Trichosanthis 8g, Herba thymi vulgaris 3g, Flos Lonicerae 7g, Radix Cynanchi Atrati 6g, Rhizoma Polygonati Odorati 10g, Herba Cayatiae Japonicae 12g, XUEJINGCAO 15g, Radix rhamni crenatae 10g, Semen Sinapis 3g;

External application component:

Calamina 5g, Radix et Caulis Opuntiae Dillenii 10g.

Preparation method is as follows:

Component for oral administration:

Radix Et Rhizoma Rhei, Retinervus Luffae Fructus, Herba Hyperici Japonici, Herba Moslae, Radix Trichosanthis, Herba thymi vulgaris, Flos Lonicerae, Radix Cynanchi Atrati, Rhizoma Polygonati Odorati, Herba Cayatiae Japonicae, XUEJINGCAO, Radix rhamni crenatae, Semen Sinapis mixed powder are broken into coarse powder, add in the boiled water of 10 times of weight and decoct 1 hour, filter, filtering residue adds in the boiled water of 5 times of weight and decocts 20 minutes, filter, merge filtrate twice, be concentrated into 25 DEG C of relative densities and be 1.25 and must take component medicinal liquid orally;

External application component:

By Radix et Caulis Opuntiae Dillenii peeling, thorn, mash, add Calamina, external application component mastic stirs to obtain.

Using method: medicinal liquid is taken 3 times every day, each 100mL, mastic spreads upon patient's lip for 1 time around and chin bottom every day, after doing, washes away.

clinical effectiveness experiment:

One, therapeutic effect

1, case selection

50 of the children's of herpes of mouth suffer from certain children's hospital, between age 2-6 year, and wherein 35 of boys, 15 of girls, are equally divided into two groups by infant, 25 of every group of infants, no difference of science of statistics between two groups.

2, Therapeutic Method

Wherein agree to through infants ' parents for one group, use Chinese medicine composition of the present invention to treat, called after treatment group, takes medicinal liquid every day 5 times, each 100mL, and mastic spreads upon patient's lip for 1 time around and chin bottom every day, after doing, washes away; One group uses hospital's conventional treatments to treat, called after matched group.Sooner or later observe therapeutic outcome twice every day.

3, therapeutic outcome

Treatment first day evening, treatment group had been smeared external application mastic, liquor taking 3 times, while having 4 infants to feel to swallow food, do not have ached the morning, there is shrivelled sign in the herpes of 4 infant handss, foot position, matched group is with respect to before treatment, without significant change.

Treat second day evening, ached, and have the herpes of 19 infant handss, foot position to occur shrivelled sign when treatment group has 22 infants to feel to swallow food before not treating, all infant temperature recovery is normal.Before not treating when matched group has 8 infants to feel to swallow food, ached, 14 infants occur generating heat and disappear, but shrivelled sign does not appear in herpes.

Treat the 3rd day evening, treatment group infant is without herpes ulceration phenomenon, and 20 infants return to one's perfect health, and the herpes of 5 infant handss, foot, port part still exists, and does not disappear completely.Matched group has 3 infant herpes ulcerations, 6 basic rehabilitations of infant, and 18 infant temperature recoveries are normal, but the herpes of hands, foot, port part still exists, and do not disappear completely.

Treat after five days, treatment group infant returns to one's perfect health substantially, and matched group has 10 basic rehabilitations of infant, and the herpes of 15 infant handss, foot, port part still exists, and does not disappear completely.

Treat after one week, matched group still has 6 not rehabilitations of infant, has 1 infant to develop complications, the whole rehabilitations for the treatment of group infant.

Two, preventive effect

, there is herpes of mouth infant in certain kindergarten, the classmate of the same class with infant has infected possibility.Obtaining under the prerequisite of head of a family's agreement, classmate is divided into two groups, no difference of science of statistics between two groups, one group of classmate does not carry out any preventive measure, as a control group, another group classmate takes the present invention medicinal liquid 100mL for oral administration sooner or later for twice, as prevention group, after 10 days, matched group classmate herpes of mouth sickness rate is 61%, and prevention group classmate hand-foot-mouth disease sickness rate is only 7%, visible, the traditional Chinese medical science of the present invention medicinal liquid for oral administration, having good effect aspect the morbidity of prevention herpes of mouth, is worth promoting in herpes of mouth prone areas.

Above-described embodiment is preferably embodiment of the present invention; but embodiments of the present invention are not subject to the restriction of embodiment; other is any does not deviate from change, modification, the combination made under spirit of the present invention and principle, substitute, simplify and all should be equivalent substitute mode, within being included in protection scope of the present invention.

Claims (3)

1. treat a Chinese medicine composition for herpes of mouth, it is characterized in that crude drug weight proportion is as follows:

Component for oral administration:

Radix Et Rhizoma Rhei 30g, Retinervus Luffae Fructus 5g, Herba Hyperici Japonici 5g, Herba Moslae 5g, Radix Trichosanthis 8g, Herba thymi vulgaris 3g, Flos Lonicerae 7g, Radix Cynanchi Atrati 6g, Rhizoma Polygonati Odorati 10g, Herba Cayatiae Japonicae 12g, XUEJINGCAO 15g, Radix rhamni crenatae 10g, Semen Sinapis 3g;

External application component:

Calamina 5g, Radix et Caulis Opuntiae Dillenii 10g.

2. Chinese medicine composition according to claim 1, it is characterized in that obtaining by following steps:

Component for oral administration:

Radix Et Rhizoma Rhei, Retinervus Luffae Fructus, Herba Hyperici Japonici, Herba Moslae, Radix Trichosanthis, Herba thymi vulgaris, Flos Lonicerae, Radix Cynanchi Atrati, Rhizoma Polygonati Odorati, Herba Cayatiae Japonicae, XUEJINGCAO, Radix rhamni crenatae, Semen Sinapis mixed powder are broken into coarse powder, add in the boiled water of 10 times of weight and decoct 1 hour, filter, filtering residue adds in the boiled water of 5 times of weight and decocts 20 minutes, filter, merge filtrate twice, be concentrated into 25 DEG C of relative densities and be 1.25 and must take component medicinal liquid orally;

External application component:

By Radix et Caulis Opuntiae Dillenii peeling, thorn, mash, add Calamina, external application component mastic stirs to obtain.

3. Chinese medicine composition according to claim 2, is characterized in that medicinal liquid takes 3 times every day, each 100mL, and mastic spreads upon patient's lip for 1 time around and chin bottom every day, washes away after dry.