CN104116856A - Nose drop for quickly treating epistaxis and preparation method thereof - Google Patents
Nose drop for quickly treating epistaxis and preparation method thereof Download PDFInfo
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- CN104116856A CN104116856A CN201410394646.2A CN201410394646A CN104116856A CN 104116856 A CN104116856 A CN 104116856A CN 201410394646 A CN201410394646 A CN 201410394646A CN 104116856 A CN104116856 A CN 104116856A
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Abstract
The invention discloses a nose drop for quickly treating epistaxis. Each 100ml of nose drop comprises the following main components: 10-15g of folium callicarpae pedunculalae water extract, 3-6g of dandelion water extract, 2-6g of radix isatidis water extract and 4-8g of radix sophorae tonkinensis water extract. The nose drop has the efficacies of clearing away heat and toxic materials, cooling blood and stopping bleeding, invigorating the circulation of blood and reducing blood, discharging fire and eliminating dampness, calming liver wind and regulating yin and yang, vital energy and blood, high-concentration antibiotic medicine attack can be carried out on stubborn germs from a mucosa layer and vibrissa of a nasal cavity, and the nose drop is quick and thorough in epistaxis treatment, significant in curative effect, safe to take, significant in treatment effect, quick in hemostasis and worthy of popularization and application.
Description
Technical field
The present invention relates to Chinese medicine field, particularly relate to nasal drop of a kind of fast treating epistaxis and preparation method thereof.
Background technology
Epistaxis claims again epistaxis, is one of clinical common sympton, how because nasal cavity pathological changes causes, also can be caused by general disease, occasionally has because of the hemorrhage via intranasal application outflow of nasal cavity adjacent lesion.The hemorrhage any position that occurs in nasal cavity, but the most common with inferior segment before nasal septum, visible ejection or pulsation small artery are hemorrhage sometimes, the normal inflow rapidly of posterior epistaxis is pharyngeal, spues from mouth.At people's body part, there are a lot of places at the position that can not bleed voluntarily because of the attack of applied external force, as: cerebral hemorrhage, gastrorrhagia, dental hemorrhage, epistaxis etc., brain, stomach, tooth, nose, the blood vessel at these positions is abundanter, particularly blood capillary is comparatively flourishing, and the tube wall of blood vessel is more fragile, wherein common with epistaxis.Epistaxis is hemorrhage that under pathological conditions, human body is shown at most, is a kind of symptom of numerous disease, is also a kind of disease, is department of otorhinolaryngology commonly encountered diseases.The epistaxis that general local cause (as wound, nasal cavity pathological changes) causes often shows as a side epistaxis, and that the epistaxis that constitutional cause causes shows as bilateral more is simultaneously hemorrhage or alternately hemorrhage, epistaxis may be also the symptom that hypertensive crisis patient shows simultaneously.A small amount of epistaxis often, for being with blood or point-like to bleed in nasal mucus, can stop mostly voluntarily, recovery occurs without treatment.A large amount of epistaxiss is flowing water shape conventionally, continually, sometimes very wayward, must give emergent management.Amount of bleeding number each one is different, somebody only shows as nasal cavity has several bleeding flow out or be mixed with some bloods streak, clot in the nasal mucus of retraction.Some amounts of bleeding are more, break with tremendous force, and even can cause shock because of Massive Bleeding.Hemorrhagely many often make people panic-stricken, a small amount of epistaxis also can cause that people are anxious, weighed down with anxieties sometimes.
Also not definite boundary of the crowd's age that has an epistaxis symptom, has old man also to have child, but in the majority with older person.The pathology reason more complicated of epistaxis, has the reason of blood, also has the reason of liver, also has reason that outside antibacterial invades, also has a parasitic reason etc.For someone's epistaxis, can not just can draw nosogenetic conclusion for the moment.The reason of our first analyzing blood: vertebrate blood has automatic hemorrhage coagulation function, in the time of angiorrhexis, thrombin in blood plasma can be gathered in wound place and form blood clotting plate obstruction blood continuation outflow, these thrombins comprise Fibrinogen, platelet, many Cao body fibrin etc., if the shortage of these thrombins or suffer to destroy and all can cause the obstacle of hemostasis in blood plasma.People's the liver deficiency of YIN or liver-fire rise or the random function pathological changes that also can indirectly can cause hemostasis of liver function order.The invasion of outside antibacterial also can destroy the hemostatic function of blood, and some antibacterials can hinder the assembly of thrombin and can disassemble sludged blood and make wound place unblocked.Intranarial parasite also plays to epistaxis the effect that hinders hemostasis.It is one-sided that epistaxis mostly is, and also can be bilateral; Intermittently Repeated Hemorrhage, also sustainable hemorrhage; How many amounts of bleeding differs, and the lighter is only with blood in nasal mucus, and severe one can cause hemorrhagic shock; Repeated Hemorrhage can cause anemia, most hemorrhage can certainly stopping.
Child's epistaxis almost all occurs in nasal cavity front portion; Though adolescence is anterior hemorrhage common with nasal cavity, also has the hemorrhage nasal cavity rear portion that occurs in that minority is serious; The epistaxis of middle-aged and elderly people, normal relevant with hypertension and arteriosclerosis, bleeding part sees nasal cavity rear portion.It is one-sided that epistaxis mostly is, and under a few cases, can occur bilateral epistaxis; How many amounts of bleeding differs, and the lighter is only with blood in tears, and severe one can cause hemorrhagic shock, and epistaxis can cause anemia repeatedly.At present, adopt the treatment of physics way for epistaxis more, as patted patient's rear cervical region with cold water, though sometimes can play certain effect, do not effect a permanent cure.The traditional Chinese medical science thinks, epistaxis is by steaming on lung-heat, forces blood to drive in the wrong direction, or due to dryness attacks outward.
At present, have much about the Chinese medicine of epistaxis, for the problems referred to above, publication number 101983677A(application number 201010508616.1) patent a kind of medicine for the treatment of epistaxis is disclosed, concrete proportioning of the present invention is 10 grams of Crinis Carbonisatus, 10 grams of Sanguis Draxonis, 10 grams of Pulvis Fumi Carbonisatuss, 10 grams of Radix Rehmanniae, 10 grams of Semen Juglandis, 10 grams of Cacumen Platycladis, and the degree of accuracy of this medicine dose is positive and negative 10%.Publication number 102218132A(application number 201110157901.8) patent a kind of Chinese medicine composition for the treatment of epistaxis is disclosed, made by the medicine of following weight ratio example: Radix Angelicae Sinensis 7-12 gram, Rhizoma Chuanxiong 5-6 gram, Radix Glycyrrhizae 5-10 gram, Radix Rehmanniae Preparata 15-25 gram, Fructus Corni 10-20 gram, 15-25 gram of Radix Ophiopogonis, Herba Schizonepetae 3-5 gram, Herba Menthae 3-5 gram, Fructus Forsythiae 8-15 gram, Flos Lonicerae 20-120 gram, Cortex Magnoliae Officinalis 5-10 gram, Radix et Rhizoma Rhei (processed) 3-10 gram, Semen Persicae 3-7 gram, Rhizoma Cyperi (processed) 3-5 gram, Rhizoma Zingiberis Preparatum 6-10 gram, 8-15 gram of parching to brown Fructus Gardeniae, Cortex Cinnamomi 3-6 gram.Publication number 102512608A(application number 201110456060.0) patent Chinese drugs agentia and the preparation method of the epistaxis that a kind for the treatment of is interrupted repeatedly, amount of bleeding is few are disclosed, it is made up of the component of following weight portion: 70 parts, Gypsum Fibrosum, 10 parts of Rhizoma Anemarrhenae, 10 parts of Fructus Forsythiaes, 10 parts of Radix Angelicae Sinensis, 10 parts of charred Radix Scutellariaes, 15 parts of charred CORTEX MOUTANs, 10 parts of Cacumen Platycladis, 10 parts of Herba Agrimoniaes, 15 parts of charred Nodus Nelumbinis Rhizomatis, 3 parts, Radix Glycyrrhizae, 8 parts of Radix Et Rhizoma Rhei, 40 parts of Rhizoma Phragmitiss, 8 parts of mentha leavves.At present, medicine about treatment epistaxis is really many, but mostly be oral medicine, oral medicine can only arrive the hemorrhage wound of nasal cavity from blood with extremely low concentration, obstinate pathogenic bacteria to wound place does not constitute a threat to, some pathogenic bacterias are to stick on the vibrissa of nasal cavity or mucous layer, and the medicine in blood can not arrive at all eliminates them.
Summary of the invention
For the deficiencies in the prior art, the present invention further probes on the basis of existing technology, provides a kind of technique simple, with low cost, and medicament sources is extensive, and curative effect is the nasal drop of fast treating epistaxis rapidly.One of object of the present invention is to provide a kind of nasal drop of fast treating epistaxis, effect that this nasal drop has heat-clearing and toxic substances removing, stops blooding and fall blood, blood back removing heat from blood, regulate yang blood and qi, nourishing YIN and clearing away fire, can be from the antibiotic medicine attack of rete, vibrissa, obstinate pathogenic bacteria being carried out high concentration of being stained with of nasal cavity, its treatment epistaxis is evident in efficacy, reliable effect.Another object of the present invention is just to provide the preparation method of the nasal drop of above-mentioned fast treating epistaxis.
Above-mentioned purpose of the present invention is achieved through the following technical solutions:
The nasal drop of fast treating epistaxis, the main component of every 100ml nasal drop: Folium Callicarpae Formosanae water extract 10-15g, Herba Taraxaci water extract 3-6g, effects of Radix Isatidis water extract 2-6g, 4-8g(is preferred for Radix Sophorae Tonkinensis water extract, Radix Sophorae Tonkinensis water extract 4.5-7.0g; Be more preferably Radix Sophorae Tonkinensis water extract 6.0g).
The nasal drop of fast treating epistaxis, preferably scheme is, the main component of every 100ml nasal drop: Folium Callicarpae Formosanae water extract 11-14g, Herba Taraxaci water extract 4-5g, effects of Radix Isatidis water extract 3-5g, Radix Sophorae Tonkinensis water extract 5-7g.
The nasal drop of fast treating epistaxis, the scheme being more preferably is, the main component of every 100ml nasal drop: Folium Callicarpae Formosanae water extract 13g, Herba Taraxaci water extract 4.5g, effects of Radix Isatidis water extract 4g, Radix Sophorae Tonkinensis water extract 6g.
The preparation method of the nasal drop of above-mentioned fast treating epistaxis, step is as follows:
(1) get Folium Callicarpae Formosanae coarse powder, water extraction twice is boiled 1-2 hour at every turn, and twice filtrate merges, and is concentrated into thick paste shape, add ethanol, fully stir, washing, puts on cloth formula funnel and separates, discard ethanol mother solution, precipitation, 60 DEG C of following being dried, obtains Folium Callicarpae Formosanae water extract dry powder;
(2) Radix Isatidis and Radix Sophorae Tonkinensis are soaked respectively to 1-2 days, be placed in respectively marmite, decoct twice, 1-3 hour for the first time, 1-2 hour for the second time, twice filtrate merges, concentrated, dries, and obtains respectively effects of Radix Isatidis water extract and Radix Sophorae Tonkinensis water extract;
(3) Herba Taraxaci is placed in to marmite, intense fire is cut off, and turns slow fire boiling 40 minutes, filters, concentrated, dries, and obtains Herba Taraxaci water extract;
(4) get step (1) to step (3) gains, be placed in glass container, add distilled water dissolve, with charcoal treatment once, suction strainer, sterilizing 30 minutes, sterile packaged.
According to preparation method recited above: the preferred Callicarpa nudiflora of Folium Callicarpae Formosanae, Callicarpa lobo-apiculata Metc. or the Folium Callicarpae Macrophyllae described in step (1).
According to preparation method recited above: step (1) is concentrated into the thick paste that relative density is 1.2-1.4 (preferably, being concentrated into the thick paste that relative density is 1.2-1.4).
According to preparation method recited above: step (1) adds the ethanol (preferably, adding the ethanol with respect to 5 times of quality of Folium Callicarpae Formosanae coarse powder) with respect to 4-6 times of quality of Folium Callicarpae Formosanae coarse powder.
According to preparation method recited above: the charcoal treatment (preferably, by 0.2% charcoal treatment) of 0.1%-0.3% for step (4).
According to preparation method recited above: step (4) sterilizing at 80 DEG C-120 DEG C (preferably, sterilizing at 100 DEG C).
Using method: while dripping medicine, patient's layback, splashes into Ipsilateral or bilateral by medicinal liquid along the lateral border in nostril, and every side 3-5 drips, and has a rest to get up for 5 minutes again, can make like this medicinal liquid fully contact with bronchia mucosal.Infant, in the time using nasal drop, can drip medicinal liquid on swab, is then applied to nasal cavity, in order to avoid it is too much to splash into the medicament of nasal cavity, and the tender and lovely nasal mucosa of damage infant.
The pharmacological effect of each crude drug is respectively:
Folium Callicarpae Formosanae: acrid in the mouth, hardship, property is flat.Return liver, spleen, stomach warp.There is dissipating blood stasis hemostasis, effect of reducing swelling and alleviating pain.Leaves contains a kind of hemostatic compositions that is referred to as flavonoid condensed tannin, so have effect of hemostasis, dissipating blood stasis, antiinflammatory.Leaf is mainly used in spitting blood, spitting of blood, and epistaxis, has blood in stool; External curing traumatic hemorrhage.Root is mainly used in treating swelling and pain by traumatic injury, rheumatic ostalgia.Can astringing to arrest bleeding, again can cooling blood for hemostasis, be applicable to various interior traumatic hemorrhage, be especially used for lung gastrorrhagia.Folium Callicarpae Formosanae, except having anastalsis, still has good anti-anti-infectious function and astriction, tries out in burning, scald texts also better.
Herba Taraxaci: bitter in the mouth, sweet, cold in nature.Return liver, stomach warp.For feverfew Herba Taraxaci, alkali ground Herba Taraxaci or belong to the dry herbs of several plants together.There is heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, effect of inducing diuresis for treating stranguria syndrome.For furuncle swelling toxin, acute mastitis, scrofula, conjunctival congestion, pharyngalgia, lung abscess, enterodynia, jaundice due to damp-heat, the puckery pain of pyretic stranguria.
Radix Isatidis: bitter in the mouth, cold in nature.GUIXIN, stomach warp.For the dry root of cruciferae isatis, containing indigo glycoside, isatin, indigo, Isatan B, uridnine, uracil, hypoxanthine, salicylic acid, qingdainone, daucosterol, cupreol, Radix Isatidis second element, the third element and fourth element, also containing vegetable protein, resin-like thing, saccharide, sinigrin, several amino acids and trace element, still contain the antibacterial substance of anti-Grain-positive and negative bacteria.There is heat-clearing and toxic substances removing, effect of removing heat from blood sore-throat relieving.For maculae caused by violent heat pathogen, crimson tongue is purple dark, mumps, sore throat, scarlet fever, major part pestilence, erysipelas, carbuncle, high heat headache, skin ulcer is swollen, chickenpox, measles, hepatitis, influenza, epidemic encephalitis, encephalitis b, pneumonia, coma is told nosebleed, pharyngeal swelling, acute catarrhal conjunctivitis, skin ulcer rash, can prevent and treat epidemic encephalitis type B, acute, chronic hepatitis, mumps, osteomyelitis.
Radix Sophorae Tonkinensis: bitter in the mouth, cold in nature.Attach to the lung and stomach meridians.For the dry root and rhizome of leguminous plant Sophora tonkinensis Gagnep..There is heat-clearing and toxic substances removing, effect of reducing swelling and alleviating pain.Pent up laryngopharynx swelling and pain, gingivitis, throat gingival swelling and pain, cough due to lung-heat's excessive thirst, jaundice, constipation with heat retention for fire-toxin.
The nasal drop of fast treating epistaxis of the present invention is being summed up on the basis of forefathers' experience, adopts pure natural draft Chinese medicine unique formula and technique to refine and forms, and adopts comparatively common in the localities Chinese crude drug as raw material, and with low cost, medicine source is easy to get.This nasal drop has heat-clearing and toxic substances removing, and cooling blood for hemostasis is invigorated blood circulation and fallen blood, pathogenic fire purging dampness, and suppressing the hyperactive liver to relieve the wind syndrome, effect of adjusting yang blood and qi, can be from the antibiotic medicine attack of rete, vibrissa, obstinate pathogenic bacteria being carried out high concentration of being stained with of nasal cavity.Treatment epistaxis is thorough rapidly, and effect is remarkable, takes safety, and therapeutic effect is obvious, and hemostasis fast, is worth universal and uses.
Brief description of the drawings
Fig. 1 uses epistaxis remission situation after the nasal drop of embodiment 5 gained fast treating epistaxiss;
Fig. 2 is that after using the nasal drop of embodiment 5 gained fast treating epistaxiss, bleeding is alleviated required time.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not by this restriction.
embodiment 1the preparation process of the nasal drop of fast treating epistaxis is as follows:
(1) get Folium Callicarpae Formosanae coarse powder, water extraction twice is boiled 1 hour at every turn, and twice filtrate merges, and is concentrated into thick paste shape, add ethanol, fully stir, washing, puts on cloth formula funnel and separates, discard ethanol mother solution, precipitation, 60 DEG C of following being dried, obtains Folium Callicarpae Formosanae water extract dry powder;
(2) Radix Isatidis and Radix Sophorae Tonkinensis are soaked respectively to 1-2 days, be placed in respectively marmite, decoct twice, 1-3 hour for the first time, 1-2 hour for the second time, twice filtrate merges, concentrated, dries, and obtains respectively effects of Radix Isatidis water extract and Radix Sophorae Tonkinensis water extract;
(3) Herba Taraxaci is placed in to marmite, intense fire is cut off, and turns slow fire boiling 40 minutes, filters, concentrated, dries, and obtains Herba Taraxaci water extract;
(4) get step (1) to step (3) gains, be placed in glass container, add distilled water dissolve, with charcoal treatment once, suction strainer, control the main component of the every 100ml of nasal drop of gained fast treating epistaxis: Folium Callicarpae Formosanae water extract 10g, Herba Taraxaci water extract 3g, effects of Radix Isatidis water extract 2g, Radix Sophorae Tonkinensis water extract 4g, sterilizing 30 minutes, sterile packaged.
Using method: while dripping medicine, medicinal liquid is splashed into Ipsilateral or bilateral along the lateral border in nostril, every side 3-5 drips, and has a rest to get up for 5 minutes again, can make like this medicinal liquid fully contact with bronchia mucosal.
embodiment 2the preparation process of the nasal drop of fast treating epistaxis is as follows:
(1) get Folium Callicarpae Formosanae coarse powder, water extraction twice is boiled 1 hour at every turn, and twice filtrate merges, and is concentrated into thick paste shape, add ethanol, fully stir, washing, puts on cloth formula funnel and separates, discard ethanol mother solution, precipitation, 60 DEG C of following being dried, obtains Folium Callicarpae Formosanae water extract dry powder;
(2) Radix Isatidis and Radix Sophorae Tonkinensis are soaked respectively to 1-2 days, be placed in respectively marmite, decoct twice, 1-3 hour for the first time, 1-2 hour for the second time, twice filtrate merges, concentrated, dries, and obtains respectively effects of Radix Isatidis water extract and Radix Sophorae Tonkinensis water extract;
(3) Herba Taraxaci is placed in to marmite, intense fire is cut off, and turns slow fire boiling 40 minutes, filters, concentrated, dries, and obtains Herba Taraxaci water extract;
(4) get step (1) to step (3) gains, be placed in glass container, add distilled water dissolve, with charcoal treatment once, suction strainer,, the main component of the every 100ml of nasal drop of control gained fast treating epistaxis: Folium Callicarpae Formosanae water extract 15g, Herba Taraxaci water extract 6g, effects of Radix Isatidis water extract 6g, Radix Sophorae Tonkinensis water extract 8g, sterilizing 30 minutes, sterile packaged.
Using method: while using nasal drop, medicinal liquid can be dripped on swab, then be applied to nasal cavity, in order to avoid it is too much to splash into the medicinal liquid of nasal cavity, the tender and lovely nasal mucosa of damage infant.
model case one:lu XX, female, 4 years old, Yantai City Laiyang City people.Epistaxis just often since similar two years old, once epistaxis everyday almost for some time.Wake up morning, often sneeze, and the regular symptom that occurs epistaxis immediately, and also often understand epistaxis night sometimes, the head of a family is not easy timely discovery, many times all can epistaxis more, or even until stops voluntarily bleeding.Go to too much hospital of family, due to child also very little, can not diagnose with special diagnosis and treatment instrument, doctor does not provide clear and definite saying yet, all unanimously says that nothing hinders greatly, what have says what allergy caused, what have says what air too dry caused.Wherein continue to have an intravenous drip one week in a hospital, symptom obviously improves, and occurs seldom epistaxis again, but occurs again epistaxis more frequently after a wheat harvesting period, bad when fashion, intermittently continues so far.Dropping point Oleum sesami at ordinary times afterwards, but almost everyday hemorrhage is bled once two nostrils of crying and screaming sometimes simultaneously, bad stopping, its father and mother be worry very much, helpless.
Heard afterwards the nasal drop of fast treating epistaxis of the present invention, used the nasal drop of the fast treating epistaxis of embodiment 2 gained, medicinal liquid had been dripped on swab, then be applied to nasal cavity, when epistaxis is used for the first time, less than the time of two minutes, the situation of epistaxis was controlled.In ensuing two weeks, when each epistaxis, the haemostatic effect of the nasal drop of use embodiment 2 gained fast treating epistaxiss is all very good, generally within 1-2 minute, can stop blooding.
embodiment 3the preparation process of the nasal drop of fast treating epistaxis is as follows:
(1) get Folium Callicarpae Formosanae coarse powder, water extraction twice is boiled 1 hour at every turn, and twice filtrate merges, and is concentrated into thick paste shape, add ethanol, fully stir, washing, puts on cloth formula funnel and separates, discard ethanol mother solution, precipitation, 60 DEG C of following being dried, obtains Folium Callicarpae Formosanae water extract dry powder;
(2) Radix Isatidis and Radix Sophorae Tonkinensis are soaked respectively to 1-2 days, be placed in respectively marmite, decoct twice, 1-3 hour for the first time, 1-2 hour for the second time, twice filtrate merges, concentrated, dries, and obtains respectively effects of Radix Isatidis water extract and Radix Sophorae Tonkinensis water extract;
(3) Herba Taraxaci is placed in to marmite, intense fire is cut off, and turns slow fire boiling 40 minutes, filters, concentrated, dries, and obtains Herba Taraxaci water extract;
(4) get step (1) to step (3) gains, be placed in glass container, add distilled water dissolve, with charcoal treatment once, suction strainer, control the main component of the every 100ml of nasal drop of the fast treating epistaxis of gained: Folium Callicarpae Formosanae water extract 11g, Herba Taraxaci water extract 4g, effects of Radix Isatidis water extract 3g, Radix Sophorae Tonkinensis water extract 5g, sterilizing 30 minutes, sterile packaged.
Using method: while dripping medicine, medicinal liquid is splashed into Ipsilateral or bilateral along the lateral border in nostril, every side 3-5 drips, and has a rest to get up for 5 minutes again, can make like this medicinal liquid fully contact with bronchia mucosal.Infant, in the time using nasal drop, can drip medicinal liquid on swab, is then applied to nasal cavity.
embodiment 4the preparation process of the nasal drop of fast treating epistaxis is as follows:
(1) get Folium Callicarpae Formosanae coarse powder, water extraction twice is boiled 1 hour at every turn, and twice filtrate merges, and is concentrated into thick paste shape, add ethanol, fully stir, washing, puts on cloth formula funnel and separates, discard ethanol mother solution, precipitation, 60 DEG C of following being dried, obtains Folium Callicarpae Formosanae water extract dry powder;
(2) Radix Isatidis and Radix Sophorae Tonkinensis are soaked respectively to 1-2 days, be placed in respectively marmite, decoct twice, 1-3 hour for the first time, 1-2 hour for the second time, twice filtrate merges, concentrated, dries, and obtains respectively effects of Radix Isatidis water extract and Radix Sophorae Tonkinensis water extract;
(3) Herba Taraxaci is placed in to marmite, intense fire is cut off, and turns slow fire boiling 40 minutes, filters, concentrated, dries, and obtains Herba Taraxaci water extract;
(4) get step (1) to step (3) gains, be placed in glass container, add distilled water dissolve, with charcoal treatment once, suction strainer, control the main component of the every 100ml of nasal drop of the fast treating epistaxis of gained: Folium Callicarpae Formosanae water extract 14g, Herba Taraxaci water extract 5g, effects of Radix Isatidis water extract 5g, Radix Sophorae Tonkinensis water extract 7g, sterilizing 30 minutes, sterile packaged.
Using method: while dripping medicine, medicinal liquid is splashed into Ipsilateral or bilateral along the lateral border in nostril, every side 3-5 drips, and has a rest to get up for 5 minutes again.
model case two:feng XX, female, 58 years old, people from Huaiyin District, Jinan City, Shandong Province.Since nosebleed in 2008, amount of bleeding was more, and nose is dry, and starting is most a side nosebleed, causes nasal mucus band blood, does not take notice of, thinks that nosebleed there is no big harm, and is converted into both sides nosebleed through the time nosebleed of 2 years from a side.Discontinuity Repeated Hemorrhage, continuous bleeding.Because thereby the more patient of causing of amount of bleeding occurs anemia, even occurs hemorrhagic shock.Patient starts to pay attention to, and at many hospital admissions, therapeutic effect is not good enough.
The nasal drop that uses fast treating epistaxis of the present invention, while use for the first time, the symptom of epistaxis is eased soon, and the time epistaxis symptom of similar three minutes is just controlled completely.See this curative effect, Mrs Feng continues to use the nasal drop of embodiment 4 gained fast treating epistaxiss, when each epistaxis, all relatively good with the haemostatic effect of the nasal drop of the fast treating epistaxis of embodiment 4 gained, within 1-2 minute, can stop blooding, and Mrs Feng finds that the number of times of epistaxis has also reduced, amount of bleeding has also reduced.
embodiment 5the preparation process of the nasal drop of fast treating epistaxis is as follows:
(1) get Folium Callicarpae Formosanae coarse powder, water extraction twice is boiled 1 hour at every turn, and twice filtrate merges, and is concentrated into thick paste shape, add ethanol, fully stir, washing, puts on cloth formula funnel and separates, discard ethanol mother solution, precipitation, 60 DEG C of following being dried, obtains Folium Callicarpae Formosanae water extract dry powder;
(2) Radix Isatidis and Radix Sophorae Tonkinensis are soaked respectively to 1-2 days, be placed in respectively marmite, decoct twice, 1-3 hour for the first time, 1-2 hour for the second time, twice filtrate merges, concentrated, dries, and obtains respectively effects of Radix Isatidis water extract and Radix Sophorae Tonkinensis water extract;
(3) Herba Taraxaci is placed in to marmite, intense fire is cut off, and turns slow fire boiling 40 minutes, filters, concentrated, dries, and obtains Herba Taraxaci water extract;
(4) get step (1) to step (3) gains, be placed in glass container, add distilled water dissolve, with charcoal treatment once, suction strainer, control the main component of the every 100ml of nasal drop of the fast treating epistaxis of gained: Folium Callicarpae Formosanae water extract 13g, Herba Taraxaci water extract 4.5g, effects of Radix Isatidis water extract 4g, Radix Sophorae Tonkinensis water extract 6g, sterilizing 30 minutes, sterile packaged.
Using method: while dripping medicine, medicinal liquid is splashed into Ipsilateral or bilateral along the lateral border in nostril, every side 3-5 drips, and has a rest to get up for 5 minutes again.Infant, in the time using nasal drop, can drip medicinal liquid on swab, is then applied to nasal cavity, in order to avoid it is too much to splash into the medicinal liquid of nasal cavity, and the tender and lovely nasal mucosa of damage infant.
test example:in order to verify the nasal drop of embodiment 5 gained fast treating epistaxiss, we have carried out contrast experiment.Epistaxis Patients 200 people are selected in experiment, are divided into randomly matched group and experimental group, and every group number is identical, is respectively 100 people.With observation post administration and record patient's epistaxis situation.Experimental group: use the nasal drop of embodiment 5 gained fast treating epistaxiss, while dripping medicine, patient's layback, splashes into Ipsilateral or bilateral by medicinal liquid along the lateral border in nostril, and every side 3-5 drips, and has a rest to get up for 5 minutes again.Infant, in the time using nasal drop, can drip medicinal liquid on swab, is then applied to nasal cavity.Matched group: employing other treatment mode (such as the precious sheet of Orally taken hemostatic, a 2-4 grain, 2-3 time on the one, gradation warm water takes).Wherein criterion of therapeutical effect: cure: epistaxis symptom is inhibited completely; Effective: epistaxis symptom is obviously eased; Invalid: epistaxis symptom is without alleviation.Wherein effectively comprise healing and effective.
Observation period is limited to 20 days, and observed content is as follows:
1, within 5 days, be an observation cycle, record epistaxis situation, add up the amount of each average epistaxis of cycle, result is as accompanying drawing 1:
Analyze: from accompanying drawing 1, can find out, the haemostatic effect of the nasal drop of embodiment 5 gained fast treating epistaxiss is better, and epistaxis is had to better mitigation, more than adopting, the hemostatic healing efficacy of matched group of other treatment scheme is good.
2, within 5 days, be an observation cycle, record the controlled required time of epistaxis, add up average required bleeding stopping period of each cycle, result is as accompanying drawing 2:
Analyze: from accompanying drawing 2, can find out, the nasal drop of embodiment 5 gained fast treating epistaxiss, has curative effect more rapidly to hemostasis, stop blooding faster, more than the good effect of the matched group of employing other treatment scheme.
3, the Comparison of therapeutic that adopts the experimental group of the matched group of other treatment scheme and the nasal drop of use embodiment 5 gained fast treating epistaxiss, result is as shown in table 1:
Table 1
efficacy analysis:as can be seen from Table 1, use the experimental group of the nasal drop of the embodiment of the present invention 5 gained fast treating epistaxiss there is no invalid example, and adopt the matched group of other treatment scheme to have 3 people invalid.The cure rate of the experimental group of the nasal drop of use embodiment 5 gained fast treating epistaxiss is up to 91%, effective percentage has reached 100%, adopt the cure rate of the matched group of other treatment mode only to reach 68%, obviously can find out, the cure rate of the nasal drop of use the present embodiment 5 gained fast treating epistaxiss is higher, more reliable.Experiment shows the experimental group of the nasal drop that uses embodiment 5 gained fast treating epistaxiss and adopts compared with the matched group of other treatment scheme, and its curative effect increases substantially, and cure rate significantly promotes, and key is that inefficiency is reduced to zero.
Can find out from accompanying drawing 1-2, the matched group of the experimental group of the nasal drop of use embodiment 5 gained fast treating epistaxiss and employing other treatment scheme is in 20 days of the observation period, the amount of bleeding that uses nasal drop is obviously than matched group few who adopts other treatment scheme, and hemostasis is rapider, more remarkable treatment effect.Prove through clinical trial, this nasal drop has heat-clearing and toxic substances removing, and cooling blood for hemostasis, invigorate blood circulation and fall blood, pathogenic fire purging dampness, suppressing the hyperactive liver to relieve the wind syndrome, regulates effect of yang blood and qi, can attack from the antibiotic medicine that obstinate pathogenic bacteria is carried out to high concentration of being stained with rete, vibrissa of nasal cavity.Treatment epistaxis is thorough rapidly, and effect is remarkable, takes safely, has no side effect.Therapeutic effect is obvious, hemostasis is quick, is worth universal use.
Finally it should be noted that, embodiment is the detailed description of the invention of optimum of the present invention, be not limited to the present invention, although the present invention is had been described in detail with reference to previous embodiment, for a person skilled in the art, its technical scheme that still can record aforementioned each embodiment is modified, or part technical characterictic is wherein equal to replacement.Within the spirit and principles in the present invention all, any amendment of doing, be equal to replacement, improvement etc., within all should being included in protection scope of the present invention.
Claims (10)
1. the nasal drop of fast treating epistaxis, is characterized in that, the main component of every 100ml nasal drop: Folium Callicarpae Formosanae water extract 10-15g, Herba Taraxaci water extract 3-6g, effects of Radix Isatidis water extract 2-6g, Radix Sophorae Tonkinensis water extract 4-8g.
2. nasal drop according to claim 1, is characterized in that, the main component of every 100ml nasal drop: Folium Callicarpae Formosanae water extract 11-14g, Herba Taraxaci water extract 4-5g, effects of Radix Isatidis water extract 3-5g, Radix Sophorae Tonkinensis water extract 5-7g.
3. nasal drop according to claim 1, is characterized in that, the main component of every 100ml nasal drop: Folium Callicarpae Formosanae water extract 13g, Herba Taraxaci water extract 4.5g, effects of Radix Isatidis water extract 4g, Radix Sophorae Tonkinensis water extract 6g.
4. according to the preparation method of the arbitrary described nasal drop of claim 1-3, it is characterized in that, step is as follows:
(1) get Folium Callicarpae Formosanae coarse powder, water extraction twice is boiled 1-2 hour at every turn, and twice filtrate merges, and is concentrated into thick paste shape, add ethanol, fully stir, washing, puts on cloth formula funnel and separates, discard ethanol mother solution, precipitation, 60 DEG C of following being dried, obtains Folium Callicarpae Formosanae water extract dry powder;
(2) Radix Isatidis and Radix Sophorae Tonkinensis are soaked respectively to 1-2 days, be placed in respectively marmite, decoct twice, 1-3 hour for the first time, 1-2 hour for the second time, twice filtrate merges, concentrated, dries, and obtains respectively effects of Radix Isatidis water extract and Radix Sophorae Tonkinensis water extract;
(3) Herba Taraxaci is placed in to marmite, intense fire is cut off, and turns slow fire boiling 40 minutes, filters, concentrated, dries, and obtains Herba Taraxaci water extract;
(4) get step (1) to step (3) gains, be placed in glass container, add distilled water dissolve, with charcoal treatment once, suction strainer, sterilizing 30 minutes, sterile packaged.
5. the preparation method of nasal drop according to claim 4, is characterized in that: the preferred Callicarpa nudiflora of Folium Callicarpae Formosanae, Callicarpa lobo-apiculata Metc. or the Folium Callicarpae Macrophyllae described in step (1).
6. the preparation method of nasal drop according to claim 4, is characterized in that: step (1) is concentrated into the thick paste that relative density is 1.2-1.4 (preferably, being concentrated into the thick paste that relative density is 1.2-1.4).
7. the preparation method of nasal drop according to claim 4, is characterized in that: step (1) adds the ethanol (preferably, adding the ethanol with respect to 5 times of quality of Folium Callicarpae Formosanae coarse powder) with respect to 4-6 times of quality of Folium Callicarpae Formosanae coarse powder.
8. the preparation method of nasal drop according to claim 4, is characterized in that: the charcoal treatment (preferably, by 0.2% charcoal treatment) of 0.1%-0.3% for step (4).
9. the preparation method of nasal drop according to claim 4, is characterized in that: step (4) sterilizing at 80 DEG C-120 DEG C (preferably, sterilizing at 100 DEG C).
10. the application of the nasal drop as described in as arbitrary in claim 1-3 in the time of the medicine for fast treating epistaxis.
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Citations (2)
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| CN1660349A (en) * | 2005-01-17 | 2005-08-31 | 闫彬 | Combination of medication by using beartyberry and dragon's blood resin as combination of activities |
| CN101234159A (en) * | 2007-01-29 | 2008-08-06 | 陈晓坚 | Pharmaceutical combination with synergistic reaction |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1660349A (en) * | 2005-01-17 | 2005-08-31 | 闫彬 | Combination of medication by using beartyberry and dragon's blood resin as combination of activities |
| CN101234159A (en) * | 2007-01-29 | 2008-08-06 | 陈晓坚 | Pharmaceutical combination with synergistic reaction |
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