CN104109177A - 用于治疗癌症的化合物和方法 - Google Patents

用于治疗癌症的化合物和方法 Download PDF

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Publication number
CN104109177A
CN104109177A CN201410253092.4A CN201410253092A CN104109177A CN 104109177 A CN104109177 A CN 104109177A CN 201410253092 A CN201410253092 A CN 201410253092A CN 104109177 A CN104109177 A CN 104109177A
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CN
China
Prior art keywords
cancer
compound
alkyl
amine
aralkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201410253092.4A
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English (en)
Chinese (zh)
Inventor
R·A·辛加洛
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Texas A&M University System
Original Assignee
Texas A&M University System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Texas A&M University System filed Critical Texas A&M University System
Publication of CN104109177A publication Critical patent/CN104109177A/zh
Pending legal-status Critical Current

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/28Compounds containing heavy metals
    • A61K31/285Arsenic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/20Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/203Retinoic acids ; Salts thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/555Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/66Arsenic compounds
    • C07F9/70Organo-arsenic compounds
    • C07F9/72Aliphatic compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/66Arsenic compounds
    • C07F9/70Organo-arsenic compounds
    • C07F9/80Heterocyclic compounds
    • C07F9/82Arsenic compounds containing one or more pyridine rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201410253092.4A 2006-01-13 2007-01-16 用于治疗癌症的化合物和方法 Pending CN104109177A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US75921806P 2006-01-13 2006-01-13
US60/759,218 2006-01-13
US76300806P 2006-01-26 2006-01-26
US60/763,008 2006-01-26

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN200780007370.6A Division CN101395166B (zh) 2006-01-13 2007-01-16 用于治疗癌症的化合物和方法

Publications (1)

Publication Number Publication Date
CN104109177A true CN104109177A (zh) 2014-10-22

Family

ID=38158019

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201410253092.4A Pending CN104109177A (zh) 2006-01-13 2007-01-16 用于治疗癌症的化合物和方法
CN200780007370.6A Expired - Fee Related CN101395166B (zh) 2006-01-13 2007-01-16 用于治疗癌症的化合物和方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN200780007370.6A Expired - Fee Related CN101395166B (zh) 2006-01-13 2007-01-16 用于治疗癌症的化合物和方法

Country Status (10)

Country Link
US (2) US8222440B2 (enExample)
EP (1) EP1979368B1 (enExample)
JP (1) JP5202332B2 (enExample)
KR (2) KR20130129316A (enExample)
CN (2) CN104109177A (enExample)
AU (1) AU2007204831B2 (enExample)
CA (1) CA2636793C (enExample)
HK (1) HK1203512A1 (enExample)
IL (3) IL192738A0 (enExample)
WO (1) WO2007082104A2 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0821002A2 (pt) * 2007-12-12 2015-06-16 Ziopharm Oncology Inc Compostos e métodos para o tratamento de câncer
PT2321012T (pt) 2008-08-20 2019-01-11 Solasia Pharma K K Compostos organoarsénicos e métodos para o tratamento de cancro
TWI617305B (zh) * 2013-12-05 2018-03-11 蘇愛康制藥有限公司 治療癌症的化合物及其應用程序

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050131062A1 (en) * 2002-01-07 2005-06-16 The Texas A&M University System S-dimethylarsino-thiosuccinic acid s-dimethylarsino-2-thiobenzoic acid s-(dimethylarsino) glutathione as treatments for cancer

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL136051A0 (en) 1997-11-10 2001-05-20 Sloan Kettering Inst Cancer Process for producing arsenic trioxide formulations and methods for treating cancer using arsenic trioxide or melarsoprol
EP1002537A1 (en) 1998-10-30 2000-05-24 Assistance Publique, Hopitaux De Paris Use of melarsoprol for the manufacture of a medicament for treating B-cell lymphoproliferative diseases, such as multiple myeloma
TW201440760A (zh) * 2004-07-16 2014-11-01 Texas A & M Univ Sys 有機砷化合物、其用於治療癌症之用途及包含其之醫藥組成物

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050131062A1 (en) * 2002-01-07 2005-06-16 The Texas A&M University System S-dimethylarsino-thiosuccinic acid s-dimethylarsino-2-thiobenzoic acid s-(dimethylarsino) glutathione as treatments for cancer

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JAMES R. DANIEL等: "6-THIO-AND-SELENO-D-GALACTOSE ESTERS OF DIMETHYLARSINOUS ACID", 《CARBOHYDRATE RESEARCH》 *
W.R.CULLEN等: "The reaction of methylarsenicals with thiols: some biological implications", 《JOURNAL OF INORGANIC BIOCHEMISTRY》 *

Also Published As

Publication number Publication date
CA2636793A1 (en) 2007-07-19
WO2007082104A2 (en) 2007-07-19
CA2636793C (en) 2014-07-08
IL226363A0 (en) 2013-06-27
US20090233894A1 (en) 2009-09-17
CN101395166B (zh) 2014-07-09
AU2007204831B2 (en) 2013-10-03
HK1130804A1 (en) 2010-01-08
WO2007082104A3 (en) 2007-10-18
US20130143950A1 (en) 2013-06-06
KR20080106897A (ko) 2008-12-09
KR20130129316A (ko) 2013-11-27
AU2007204831A1 (en) 2007-07-19
IL192738A0 (en) 2009-02-11
HK1203512A1 (en) 2015-10-30
US8222440B2 (en) 2012-07-17
IL226362A0 (en) 2013-06-27
KR101471498B1 (ko) 2014-12-10
JP5202332B2 (ja) 2013-06-05
JP2009527463A (ja) 2009-07-30
CN101395166A (zh) 2009-03-25
EP1979368A2 (en) 2008-10-15
EP1979368B1 (en) 2014-12-24

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