CA2636793C - Compounds and methods for the treatment of cancer - Google Patents
Compounds and methods for the treatment of cancer Download PDFInfo
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- CA2636793C CA2636793C CA2636793A CA2636793A CA2636793C CA 2636793 C CA2636793 C CA 2636793C CA 2636793 A CA2636793 A CA 2636793A CA 2636793 A CA2636793 A CA 2636793A CA 2636793 C CA2636793 C CA 2636793C
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- 229960004622 raloxifene Drugs 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
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- 238000007363 ring formation reaction Methods 0.000 description 1
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- 125000005630 sialyl group Chemical group 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
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- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
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- 239000003381 stabilizer Substances 0.000 description 1
- 238000011301 standard therapy Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 125000005420 sulfonamido group Chemical group S(=O)(=O)(N*)* 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 description 1
- 238000011477 surgical intervention Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 231100000057 systemic toxicity Toxicity 0.000 description 1
- 101150047061 tag-72 gene Proteins 0.000 description 1
- 229960001603 tamoxifen Drugs 0.000 description 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 description 1
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
- 229940033663 thimerosal Drugs 0.000 description 1
- 150000007970 thio esters Chemical class 0.000 description 1
- DUYAAUVXQSMXQP-UHFFFAOYSA-M thioacetate Chemical compound CC([S-])=O DUYAAUVXQSMXQP-UHFFFAOYSA-M 0.000 description 1
- 125000002813 thiocarbonyl group Chemical group *C(*)=S 0.000 description 1
- 125000003396 thiol group Chemical group [H]S* 0.000 description 1
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- 230000000699 topical effect Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000041 toxicology testing Toxicity 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
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- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
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- 230000001173 tumoral effect Effects 0.000 description 1
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- 238000001291 vacuum drying Methods 0.000 description 1
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- 239000008158 vegetable oil Substances 0.000 description 1
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- JXLYSJRDGCGARV-CFWMRBGOSA-N vinblastine Chemical compound C([C@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-CFWMRBGOSA-N 0.000 description 1
- 229960003048 vinblastine Drugs 0.000 description 1
- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 description 1
- 229960004528 vincristine Drugs 0.000 description 1
- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 description 1
- CILBMBUYJCWATM-PYGJLNRPSA-N vinorelbine ditartrate Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O.OC(=O)[C@H](O)[C@@H](O)C(O)=O.C1N(CC=2C3=CC=CC=C3NC=22)CC(CC)=C[C@H]1C[C@]2(C(=O)OC)C1=CC([C@]23[C@H]([C@@]([C@H](OC(C)=O)[C@]4(CC)C=CCN([C@H]34)CC2)(O)C(=O)OC)N2C)=C2C=C1OC CILBMBUYJCWATM-PYGJLNRPSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/285—Arsenic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/203—Retinoic acids ; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/66—Arsenic compounds
- C07F9/70—Organo-arsenic compounds
- C07F9/72—Aliphatic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/66—Arsenic compounds
- C07F9/70—Organo-arsenic compounds
- C07F9/80—Heterocyclic compounds
- C07F9/82—Arsenic compounds containing one or more pyridine rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75921806P | 2006-01-13 | 2006-01-13 | |
| US60/759,218 | 2006-01-13 | ||
| US76300806P | 2006-01-26 | 2006-01-26 | |
| US60/763,008 | 2006-01-26 | ||
| PCT/US2007/001127 WO2007082104A2 (en) | 2006-01-13 | 2007-01-16 | Compounds and methods for the treatment of cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2636793A1 CA2636793A1 (en) | 2007-07-19 |
| CA2636793C true CA2636793C (en) | 2014-07-08 |
Family
ID=38158019
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2636793A Active CA2636793C (en) | 2006-01-13 | 2007-01-16 | Compounds and methods for the treatment of cancer |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US8222440B2 (enExample) |
| EP (1) | EP1979368B1 (enExample) |
| JP (1) | JP5202332B2 (enExample) |
| KR (2) | KR20130129316A (enExample) |
| CN (2) | CN104109177A (enExample) |
| AU (1) | AU2007204831B2 (enExample) |
| CA (1) | CA2636793C (enExample) |
| HK (1) | HK1203512A1 (enExample) |
| IL (3) | IL192738A0 (enExample) |
| WO (1) | WO2007082104A2 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0821002A2 (pt) * | 2007-12-12 | 2015-06-16 | Ziopharm Oncology Inc | Compostos e métodos para o tratamento de câncer |
| PT2321012T (pt) | 2008-08-20 | 2019-01-11 | Solasia Pharma K K | Compostos organoarsénicos e métodos para o tratamento de cancro |
| TWI617305B (zh) * | 2013-12-05 | 2018-03-11 | 蘇愛康制藥有限公司 | 治療癌症的化合物及其應用程序 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL136051A0 (en) | 1997-11-10 | 2001-05-20 | Sloan Kettering Inst Cancer | Process for producing arsenic trioxide formulations and methods for treating cancer using arsenic trioxide or melarsoprol |
| EP1002537A1 (en) | 1998-10-30 | 2000-05-24 | Assistance Publique, Hopitaux De Paris | Use of melarsoprol for the manufacture of a medicament for treating B-cell lymphoproliferative diseases, such as multiple myeloma |
| WO2003057012A2 (en) * | 2002-01-07 | 2003-07-17 | Board Of Regents, The University Of Texas System | S-dimethylarsino-thiosuccinic acid s-dimethylarsino-2-thiobenzoic acid s-(dimethylarsino) glutathione as treatments for cancer |
| TW201440760A (zh) * | 2004-07-16 | 2014-11-01 | Texas A & M Univ Sys | 有機砷化合物、其用於治療癌症之用途及包含其之醫藥組成物 |
-
2007
- 2007-01-16 EP EP07717781.4A patent/EP1979368B1/en active Active
- 2007-01-16 CA CA2636793A patent/CA2636793C/en active Active
- 2007-01-16 CN CN201410253092.4A patent/CN104109177A/zh active Pending
- 2007-01-16 US US12/087,682 patent/US8222440B2/en not_active Expired - Fee Related
- 2007-01-16 AU AU2007204831A patent/AU2007204831B2/en not_active Ceased
- 2007-01-16 CN CN200780007370.6A patent/CN101395166B/zh not_active Expired - Fee Related
- 2007-01-16 WO PCT/US2007/001127 patent/WO2007082104A2/en not_active Ceased
- 2007-01-16 JP JP2008550463A patent/JP5202332B2/ja not_active Expired - Fee Related
- 2007-01-16 KR KR1020137029751A patent/KR20130129316A/ko not_active Ceased
-
2008
- 2008-07-09 IL IL192738A patent/IL192738A0/en unknown
- 2008-08-08 KR KR1020087019499A patent/KR101471498B1/ko active Active
-
2009
- 2009-09-25 HK HK15103803.4A patent/HK1203512A1/xx unknown
-
2012
- 2012-07-03 US US13/541,288 patent/US20130143950A1/en not_active Abandoned
-
2013
- 2013-05-16 IL IL226362A patent/IL226362A0/en unknown
- 2013-05-16 IL IL226363A patent/IL226363A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2636793A1 (en) | 2007-07-19 |
| WO2007082104A2 (en) | 2007-07-19 |
| IL226363A0 (en) | 2013-06-27 |
| US20090233894A1 (en) | 2009-09-17 |
| CN101395166B (zh) | 2014-07-09 |
| AU2007204831B2 (en) | 2013-10-03 |
| HK1130804A1 (en) | 2010-01-08 |
| WO2007082104A3 (en) | 2007-10-18 |
| US20130143950A1 (en) | 2013-06-06 |
| KR20080106897A (ko) | 2008-12-09 |
| KR20130129316A (ko) | 2013-11-27 |
| AU2007204831A1 (en) | 2007-07-19 |
| IL192738A0 (en) | 2009-02-11 |
| HK1203512A1 (en) | 2015-10-30 |
| US8222440B2 (en) | 2012-07-17 |
| IL226362A0 (en) | 2013-06-27 |
| KR101471498B1 (ko) | 2014-12-10 |
| CN104109177A (zh) | 2014-10-22 |
| JP5202332B2 (ja) | 2013-06-05 |
| JP2009527463A (ja) | 2009-07-30 |
| CN101395166A (zh) | 2009-03-25 |
| EP1979368A2 (en) | 2008-10-15 |
| EP1979368B1 (en) | 2014-12-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |