CN101395166B - 用于治疗癌症的化合物和方法 - Google Patents

用于治疗癌症的化合物和方法 Download PDF

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Publication number
CN101395166B
CN101395166B CN200780007370.6A CN200780007370A CN101395166B CN 101395166 B CN101395166 B CN 101395166B CN 200780007370 A CN200780007370 A CN 200780007370A CN 101395166 B CN101395166 B CN 101395166B
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CN
China
Prior art keywords
cancer
purposes
compound
carcinoma
therapy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN200780007370.6A
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English (en)
Chinese (zh)
Other versions
CN101395166A (zh
Inventor
R·A·辛加洛
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Texas A&M University
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Texas A&M University
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Publication date
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Publication of CN101395166A publication Critical patent/CN101395166A/zh
Application granted granted Critical
Publication of CN101395166B publication Critical patent/CN101395166B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/285—Arsenic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/203—Retinoic acids ; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/66—Arsenic compounds
    • C07F9/70—Organo-arsenic compounds
    • C07F9/72—Aliphatic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/66—Arsenic compounds
    • C07F9/70—Organo-arsenic compounds
    • C07F9/80—Heterocyclic compounds
    • C07F9/82—Arsenic compounds containing one or more pyridine rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN200780007370.6A 2006-01-13 2007-01-16 用于治疗癌症的化合物和方法 Expired - Fee Related CN101395166B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US75921806P 2006-01-13 2006-01-13
US60/759,218 2006-01-13
US76300806P 2006-01-26 2006-01-26
US60/763,008 2006-01-26
PCT/US2007/001127 WO2007082104A2 (en) 2006-01-13 2007-01-16 Compounds and methods for the treatment of cancer

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201410253092.4A Division CN104109177A (zh) 2006-01-13 2007-01-16 用于治疗癌症的化合物和方法

Publications (2)

Publication Number Publication Date
CN101395166A CN101395166A (zh) 2009-03-25
CN101395166B true CN101395166B (zh) 2014-07-09

Family

ID=38158019

Family Applications (2)

Application Number Title Priority Date Filing Date
CN200780007370.6A Expired - Fee Related CN101395166B (zh) 2006-01-13 2007-01-16 用于治疗癌症的化合物和方法
CN201410253092.4A Pending CN104109177A (zh) 2006-01-13 2007-01-16 用于治疗癌症的化合物和方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201410253092.4A Pending CN104109177A (zh) 2006-01-13 2007-01-16 用于治疗癌症的化合物和方法

Country Status (10)

Country Link
US (2) US8222440B2 (enExample)
EP (1) EP1979368B1 (enExample)
JP (1) JP5202332B2 (enExample)
KR (2) KR20130129316A (enExample)
CN (2) CN101395166B (enExample)
AU (1) AU2007204831B2 (enExample)
CA (1) CA2636793C (enExample)
HK (1) HK1203512A1 (enExample)
IL (3) IL192738A0 (enExample)
WO (1) WO2007082104A2 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100331403A1 (en) * 2007-12-12 2010-12-30 Amedio Jr John C Compounds and methods for the treatment of cancer
CA2734650A1 (en) 2008-08-20 2010-02-25 Ziopharm Oncology, Inc. Organoarsenic compounds and methods for the treatment of cancer
JP2016540775A (ja) * 2013-12-05 2016-12-28 ソレイジア・ファーマ株式会社 癌の処置のための化合物および方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001522799A (ja) 1997-11-10 2001-11-20 メモリアル スローン−ケタリング キャンサー センター 三酸化ヒ素製剤の製造方法および三酸化ヒ素またはメラルソプロールを使用する癌の治療方法
EP1002537A1 (en) 1998-10-30 2000-05-24 Assistance Publique, Hopitaux De Paris Use of melarsoprol for the manufacture of a medicament for treating B-cell lymphoproliferative diseases, such as multiple myeloma
EP2420229A1 (en) * 2002-01-07 2012-02-22 Board Of Regents, University Of Texas System S-dimethylarsino-thiosuccinic acid s-dimethylarsino-2-thiobenzoic acid s-(dimethylarsino) glutathione as treatments for cancer
TW201440760A (zh) * 2004-07-16 2014-11-01 Texas A & M Univ Sys 有機砷化合物、其用於治療癌症之用途及包含其之醫藥組成物

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JAMES R. DANIEL et al..6-THIO-AND-SELENO-D-GALACTOSE ESTERS OF DIMETHYLARSINOUS ACID.《Carbohydrate Research》.1978,第64卷第69-79页. *

Also Published As

Publication number Publication date
JP2009527463A (ja) 2009-07-30
AU2007204831A1 (en) 2007-07-19
EP1979368A2 (en) 2008-10-15
IL226362A0 (en) 2013-06-27
US8222440B2 (en) 2012-07-17
KR101471498B1 (ko) 2014-12-10
US20130143950A1 (en) 2013-06-06
CN104109177A (zh) 2014-10-22
CN101395166A (zh) 2009-03-25
EP1979368B1 (en) 2014-12-24
WO2007082104A2 (en) 2007-07-19
KR20080106897A (ko) 2008-12-09
IL226363A0 (en) 2013-06-27
AU2007204831B2 (en) 2013-10-03
HK1203512A1 (en) 2015-10-30
IL192738A0 (en) 2009-02-11
JP5202332B2 (ja) 2013-06-05
US20090233894A1 (en) 2009-09-17
CA2636793C (en) 2014-07-08
KR20130129316A (ko) 2013-11-27
WO2007082104A3 (en) 2007-10-18
CA2636793A1 (en) 2007-07-19
HK1130804A1 (en) 2010-01-08

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