CN104107301A - Medicinal composition for treating hysteromyoma and preparation method thereof - Google Patents
Medicinal composition for treating hysteromyoma and preparation method thereof Download PDFInfo
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- CN104107301A CN104107301A CN201410350626.5A CN201410350626A CN104107301A CN 104107301 A CN104107301 A CN 104107301A CN 201410350626 A CN201410350626 A CN 201410350626A CN 104107301 A CN104107301 A CN 104107301A
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Abstract
The invention relates to a medicinal composition for treating hysteromyoma and a preparation method thereof. The medicinal composition is prepared from salviae miltiorrhizae, radix paeoniae rubra, moutan bark, oldenlandia diffusa, rhizoma cyperi, ligusticum wallichii and rhizoma atractylodis; preparations of the medicinal composition comprise hard capsules, tablets and granules. The invention aims to provide the medicament for treating hysteromyoma with an exact curative effect.
Description
Technical field
The invention belongs to field of medicaments, be specifically related to a kind of pharmaceutical composition for the treatment of hysteromyoma and preparation method thereof.
Background technology
Hysteromyoma is the common benign tumors of female sex organs, and women at fertile age sickness rate is about 25%.Its modal clinical symptoms is: metrorrhagia, hypogastralgia, dysmenorrhea, pressure symptom, vaginal secretions increase, anemia, even cause infertile, have a strong impact on the healthy of women and daily life work, as treatment not in time, likely change malignant tumor into.
Summary of the invention
Goal of the invention of the present invention is to provide a kind of new Chinese medicine for the treatment of hysteromyoma and preparation method thereof, to remove patient's sufferings, creates good society and economic benefit.
Drug regimen raw material of the present invention is by weight ratio:
Radix Salviae Miltiorrhizae 170-190 part, Radix Paeoniae Rubra 150-170 part, Cortex Moutan 140-160 part, Herba Hedyotidis Diffusae 140-160 part, Rhizoma Cyperi 120-140 part, Rhizoma Chuanxiong 110-130 part, Rhizoma Atractylodis 110-130 part.
Preferably: 180 parts of Radix Salviae Miltiorrhizaes, 160 parts of Radix Paeoniae Rubra, 150 parts of Cortex Moutans, 150 parts of Herba Hedyotidis Diffusaes, 130 parts of Rhizoma Cyperis, 120 parts of Rhizoma Chuanxiongs, 120 parts of Rhizoma Atractylodis.
Above-mentioned raw materials is made hard capsule, tablet, granule etc. by the method for accepting on pharmaceutics, is wherein preferably granule.
The preparation method of above pharmaceutical composition is: get Rhizoma Cyperi, that Rhizoma Chuanxiong two tastes are ground into fine powder is standby; Get the remaining five tastes and decoct with water 3 times, decoct 2 hours at every turn, filter, merging filtrate, concentrating under reduced pressure becomes clear paste, adds ethanol and makes to reach 30%～60% containing alcohol amount; Cold preservation 24 hours, filters, decompression filtrate recycling ethanol, and continue to be condensed into thick paste, and mix thoroughly with above-mentioned fine powder, vacuum drying, dried cream powder is broken, adds proper auxiliary materials, makes corresponding dosage form.
Adjuvant in the present invention can be acceptable any excipient or carrier on pharmaceutics.
The present invention, on Chinese medical theory basis, can nourish blood through a large amount of clinical practices screening gained, blood circulation promoting and blood stasis dispelling, and antiinflammatory, antibacterial, inhibition tumor cell, the effects such as enhancing immunity, its formula is simple, onset is rapid, evident in efficacy, short treating period, be difficult for recurrence.
Radix Salviae Miltiorrhizae: Radix Salviae Miltiorrhizae nourishing blood to tranquillize the mind, blood circulation promoting and blood stasis dispelling.Modern pharmacy proves, Radix Salviae Miltiorrhizae contains TANSHINONES, salvianolic acid, and flavone, the materials such as triterpene, sterol, can strengthen myocardial contraction, improve cardiac function, do not increase myocardial oxygen consumption.
Radix Paeoniae Rubra: clearing away heat and cooling blood; Blood circulation promoting and blood stasis dispelling.Modern pharmacy proves, Radix Paeoniae Rubra can antithrombotic, antiplatelet aggregation, blood fat reducing, arteriosclerosis, removing oxygen-derived free radicals etc.
Cortex Moutan: clearing away heat and cooling blood; Promoting blood circulation to remove blood stasis.Modern pharmacy proves, Cortex Moutan has the effect of antiinflammatory, antibacterial, anticoagulant, inhibition tumor, enhancing immunity.
Herba Hedyotidis Diffusae: heat-clearing and toxic substances removing, medicinal powder for relieving pain knot, promoting urination to remove dampness.Modern pharmacy proves, Cortex Moutan have strengthen immunologic function, suppress tumor, antibacterial effect.
Rhizoma Cyperi: the resolving depression of regulating the flow of vital energy, menstruction regulating and pain relieving.Modern pharmacy proves, Rhizoma Cyperi volatile oil has slight estrogenic activity, in vitro tests, and Rhizoma Cyperi volatile oil has inhibitory action to staphylococcus aureus.The bacteriostasis of cyperene I and II is stronger than volatile oil, and also effective to sonne bacillus.Rhizoma Cyperi extract also has inhibitory action to some fungus.
Rhizoma Chuanxiong: blood-activating and qi-promoting, wind-expelling pain-stopping.Modern pharmacy proves, Rhizoma Chuanxiong has inhibitory action to large intestine, dysentery (Song Nei Shi), distortion, green pus, typhoid fever, Salmonella paratyphi and vibrio cholera etc.Rhizoma Chuanxiong water logging agent (1: 3) also has inhibitory action to some pathogenic dermatophytes in vitro.
Rhizoma Atractylodis: drying damp and strengthening spleen, expelling wind and cold.Modern pharmacy proves, Rhizoma Atractylodis extract can reduce the generation of bacterial drug resistance, and inhibition tumor cell.
In order to show that medicine of the present invention has therapeutic effect to hysteromyoma, the present invention has carried out following clinical experiment.
1. data and method
1.1 object of study
60 patients with uterin leiomyoma patients, all confirm through gynecologial examination and colorful ultrasonic inspection.Before this treatment, within least 3 months, do not use hormonal medicaments, parallel examining scraped proved by pathology ametria inner membrance malignant change, is not in the mood for, the important organ disease such as brain, liver, kidney.37～55 years old age, average 47 years old.60 routine patients have the clinical manifestations such as menorrhagia in various degree, menstrual cycle shortening, menostaxis, dysmenorrhea, wherein anemia person's 20 examples.
1.2 method
1.2.1 Therapeutic Method
Treatment group 30 examples, wherein anemia patient is 11 examples, hemoglobin is minimum is 58g/L, average out to 75g/L: the granule in Application Example 1, each 3 bags, every day three times, from menstruation, within 1st～3 days, start to take, serveing on 3 months is a course for the treatment of.Row pelvic cavity and gynecologial examination respectively before and after medication, colorful ultrasonic is measured the three-dimensional radial line of uterus and muscular tumor, volume calculated size.Blood drawing adopts measured by radioimmunoassay follicule-stimulating hormone (FSH) (FSH), lutropin (LH), estrogen (E
2), progesterone (P), lactotropin (PRL), androgen (T), each hormone determination batch in, batch between the equal < 10% of error.During medication, monthly check blood, routine urinalysis and liver function.
Matched group 30 examples, wherein anemia patient is 9 examples: application mifepristone 10mg, from menstruation, within 1st～3 days, start to take, clothes before sleeping every night, serveing on 3 months is a course for the treatment of.Row pelvic cavity and gynecologial examination respectively before and after medication, colorful ultrasonic is measured the three-dimensional radial line of uterus and muscular tumor, volume calculated size.Blood drawing adopts measured by radioimmunoassay follicule-stimulating hormone (FSH) (FSH), lutropin (LH), estrogen (E
2), progesterone (P), lactotropin (PRL), androgen (T), each hormone determination batch in, batch between the equal < 10% of error.During medication, monthly check blood, routine urinalysis and liver function.
1.2.2 computing formula hysteromyoma or uterus average external volume (cm
3)=0.523 * a * b * c (note: in formula, a, b, c represent respectively the three-dimensional radial line radius of uterus or hysteromyoma)
Uterus or hysteromyoma average external volume are dwindled percentage ratio (%)=[1-(a3 * b3 * c3)/(a0 * b0 * c0)] * 100% (note: in formula, a0, b0, c0 represent respectively the three-dimensional radial line radius of the front uterus for the treatment of or hysteromyoma; A3, b3, c3 represent respectively the three-dimensional radial line radius for the treatment of uterus or hysteromyoma after 3 months).
For multiple myomata person, calculate the volume of maximum muscular tumor as representative result.
1.3 statistical procedures
Adopt
represent the data of surveying, statistical procedures is carried out in row t check, and P < 0.05 is for there being significant difference.2 results
2.1 therapeutic effect
All there is amenorrhea 1 month time in the 30 routine patients that take medicine of the present invention, dysmenorrhea symptom fades away after taking medicine; 11 routine anemia anemias are all corrected, and Hemoglobin Value rises to 128g/L by average 75g/L.Before and after medication, uterus size and muscular tumor volume-diminished situation are in Table 1.
Uterus and muscular tumor change in volume situation before and after table 1 medication
As can be seen from Table 1, after taking medicine, the volume of uterus and muscular tumor obviously dwindles, and dwindles more obviously with hysteromyoma, and statistical procedures difference has significance (P < 0.05).
Before and after 2.2 medications, hormone serum level changes (in Table 2)
Hormone serum level situation of change before and after the medication of table 2 treatment group
As can be seen from Table 2, FSH, LH, E after medication
2, P average level decline before compared with medication, especially with E
2decline obviously with P, difference all has significance (P < 0.05), changes not obvious before and after PRL and T value medication.Period in a medicine routine urinalysis and liver function test are all normal.
Pharmaceutical composition of the present invention has the effect of blood circulation promoting and blood stasis dispelling, hard masses softening and resolving, promoting flow of QI and blood, can be used for treating hysteromyoma disease.
Specific embodiment
Embodiment 1
Radix Salviae Miltiorrhizae 180g, Radix Paeoniae Rubra 160g, Cortex Moutan 150g, Herba Hedyotidis Diffusae 150g, Rhizoma Cyperi 130g, Rhizoma Chuanxiong 120g, Rhizoma Atractylodis 120g
The preparation method of granule of the present invention: get Rhizoma Cyperi, that Rhizoma Chuanxiong two tastes are ground into fine powder is standby; Get the remaining five tastes and decoct with water 3 times, decoct 2 hours at every turn, filter, merging filtrate, concentrating under reduced pressure becomes clear paste, adds ethanol and makes to reach 30%～60% containing alcohol amount; Cold preservation 24 hours, filters decompression filtrate recycling ethanol, and continue to be condensed into thick paste, mix thoroughly with above-mentioned fine powder, vacuum drying, dried cream powder is broken, add amylum pregelatinisatum 1000g, sodium carboxymethyl cellulose 500g, mixed 80 mesh sieves, add suitable quantity of water and granulate, 60 ℃ of drying under reduced pressure, granulate, be distributed into 100 bags, obtain.
Embodiment 2
Radix Salviae Miltiorrhizae 170g, Radix Paeoniae Rubra 165g, Cortex Moutan 160g, Herba Hedyotidis Diffusae 140g, Rhizoma Cyperi 130g, Rhizoma Chuanxiong 110g, Rhizoma Atractylodis 130g
The preparation method of hard capsule of the present invention: get Rhizoma Cyperi, that Rhizoma Chuanxiong two tastes are ground into fine powder is standby; Get the remaining five tastes and decoct with water 3 times, decoct 2 hours at every turn, filter, merging filtrate, concentrating under reduced pressure becomes clear paste, adds ethanol and makes to reach 30%～60% containing alcohol amount; Cold preservation 24 hours, filters, decompression filtrate recycling ethanol, and continue to be condensed into thick paste, and mix thoroughly with above-mentioned fine powder, vacuum drying, dried cream powder is broken, incapsulates, and obtains.
Embodiment 3
Radix Salviae Miltiorrhizae 190g, Radix Paeoniae Rubra 150g, Cortex Moutan 140g, Herba Hedyotidis Diffusae 160g, Rhizoma Cyperi 135g, Rhizoma Chuanxiong 130g, Rhizoma Atractylodis 110g
The preparation method of tablet of the present invention: get Rhizoma Cyperi, that Rhizoma Chuanxiong two tastes are ground into fine powder is standby; Get the remaining five tastes and decoct with water 3 times, decoct 2 hours at every turn, filter, merging filtrate, concentrating under reduced pressure becomes clear paste, adds ethanol and makes to reach 30%～60% containing alcohol amount; Cold preservation 24 hours, filters, decompression filtrate recycling ethanol, and continue to be condensed into thick paste, and mix thoroughly with above-mentioned fine powder, vacuum drying, dried cream powder is broken, adds starch, Pulvis Talci and magnesium stearate appropriate, granulates, and in flakes, coating, obtains in compacting.
Claims (5)
1. a pharmaceutical composition for the treatment of hysteromyoma, it is characterized in that according to weight portion meter, the raw material of making this pharmaceutical composition active component is: Radix Salviae Miltiorrhizae 170-190 part, Radix Paeoniae Rubra 150-170 part, Cortex Moutan 140-160 part, Herba Hedyotidis Diffusae 140-160 part, Rhizoma Cyperi 120-140 part, Rhizoma Chuanxiong 110-130 part, Rhizoma Atractylodis 110-130 part.
2. a pharmaceutical composition for the treatment of hysteromyoma, it is characterized in that according to weight portion meter, the raw material of making this pharmaceutical composition active component is: 180 parts of Radix Salviae Miltiorrhizaes, 160 parts of Radix Paeoniae Rubra, 150 parts of Cortex Moutans, 150 parts of Herba Hedyotidis Diffusaes, 130 parts of Rhizoma Cyperis, 120 parts of Rhizoma Chuanxiongs, 120 parts of Rhizoma Atractylodis.
3. a kind of pharmaceutical composition for the treatment of hysteromyoma as claimed in claim 1 or 2, is characterized in that described pharmaceutical composition is hard capsule, tablet, granule.
4. a kind of preparation method for the treatment of the pharmaceutical composition of hysteromyoma as claimed in claim 1 or 2, is characterized in that the method is: get Rhizoma Cyperi, that Rhizoma Chuanxiong two tastes are ground into fine powder is standby; Get the remaining five tastes and decoct with water 3 times, decoct 2 hours at every turn, filter, merging filtrate, concentrating under reduced pressure becomes clear paste, adds ethanol and makes to reach 30%～60% containing alcohol amount; Cold preservation 24 hours, filters, decompression filtrate recycling ethanol, and continue to be condensed into thick paste, and mix thoroughly with above-mentioned fine powder, vacuum drying, dried cream powder is broken, adds proper auxiliary materials, makes corresponding dosage form.
5. a kind of preparation method for the treatment of the pharmaceutical composition of hysteromyoma as claimed in claim 4, is characterized in that the method is: get Rhizoma Cyperi, that Rhizoma Chuanxiong two tastes are ground into fine powder is standby; Get the remaining five tastes and decoct with water 3 times, decoct 2 hours at every turn, filter, merging filtrate, concentrating under reduced pressure becomes clear paste, adds ethanol and makes to reach 30%～60% containing alcohol amount; Cold preservation 24 hours, filters, decompression filtrate recycling ethanol, and continue to be condensed into thick paste, mix thoroughly with above-mentioned fine powder, vacuum drying, dried cream powder is broken, adds amylum pregelatinisatum 1000g, sodium carboxymethyl cellulose 500g, mixes 80 mesh sieves, add suitable quantity of water and granulate, 60 ℃ of drying under reduced pressure, granulate, is distributed into 100 bags.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410350626.5A CN104107301A (en) | 2014-07-16 | 2014-07-16 | Medicinal composition for treating hysteromyoma and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410350626.5A CN104107301A (en) | 2014-07-16 | 2014-07-16 | Medicinal composition for treating hysteromyoma and preparation method thereof |
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| CN104107301A true CN104107301A (en) | 2014-10-22 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201410350626.5A Pending CN104107301A (en) | 2014-07-16 | 2014-07-16 | Medicinal composition for treating hysteromyoma and preparation method thereof |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102247581A (en) * | 2011-08-18 | 2011-11-23 | 王思曾 | Medicament for treating myoma of uterus |
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2014
- 2014-07-16 CN CN201410350626.5A patent/CN104107301A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102247581A (en) * | 2011-08-18 | 2011-11-23 | 王思曾 | Medicament for treating myoma of uterus |
Non-Patent Citations (1)
| Title |
|---|
| 张寿国: "桂枝茯苓丸加味治疗子宫肌瘤18例", 《湖北中医杂志》 * |
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| PB01 | Publication | ||
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| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20141022 |