CN104107226A - Compound bone-joining tablet - Google Patents
Compound bone-joining tablet Download PDFInfo
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- CN104107226A CN104107226A CN201310137743.9A CN201310137743A CN104107226A CN 104107226 A CN104107226 A CN 104107226A CN 201310137743 A CN201310137743 A CN 201310137743A CN 104107226 A CN104107226 A CN 104107226A
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Abstract
The invention relates to a compound bone-joining tablet. The tablet is a medicine for treating fracture and injury of tendon and muscle, and contusion of muscles and bones, concretely is a Chinese patent medicine prepared by taking Chinese herbal medicines as raw materials, and is capable of treating fracture and soft tissue injury. The invention also relates to a preparation method of the medicine. The tablet is an oral tablet prepared by taking pyritum (calcined), ground beetle, pheretima, cortex mori, rhizoma drynariae (processed), radix dipsaci, herba taxilli, radix angelicae sinensis, frankincense (processed), radix angelicae dahuricae, flos carthami, myrrh (processed), radix et rhizoma rhei (processed) as bulk drugs and performing screening, drying and crushing on the raw materials through a provided table preparation technology. The provided formula is definite in therapeutic effect, and the tablet is an ideal medicine for rapidly treating fracture and soft tissue injury; and the tablet is simple in preparation method, easy to process and easy for large-scale production.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition for the treatment of fracture, soft tissue injury, relate in particular to a kind for the treatment of fracture injury of tendon and muscle that Chinese herbal medicine is crude drug of take, Chinese medicine composition that muscles and bones is dampened and preparation method thereof.
Background technology
Bone break the muscle wound due to external force, stagnation of QI and blood, its pathogenesis changes blood consumption gas at stake, impairment of QI resulting in pain, injury of configuration resulting in swelling, hinders outward to some extent, inside damage to some extent, stagnant blood is attributed to liver, and the stasis of blood goes new bone raw, therefore,, after fracture, there is partial gall in patient, limb function is limited, in compound connector sheet prescription, Pyritum energy promoting the circulation of bloodization is stagnant, has the merit of eliminating stasis to stop pain.After muscle and bone injury, needing QI and blood to support could regenerate, " regeneration vim and vigour, with synthetism ear ".In the Regeneration and Repair process of muscles and bones, not only need the QI and blood of whole body vigorous, local blood vessels also must be unobstructed, to guarantee that QI and blood can be moved, supports the part of damaging.Therefore, in treatment, must make local blood vessels smooth, to dispel congestion.So there is the opinion of " stasis of blood does not go bone not connect, and the stasis of blood is gone new bone life ".On muscle and bone physiology, rely on QI and blood to moisten foster, the change on pathology is the disorder of QI and blood often.Thereby the treatment to the wound disease of muscle and bone, all take and modulates QI and blood as core.In we with the Radix Angelicae Sinensis pain relieving of invigorating blood circulation, enrich blood, Pheretima, eupolyphage sece steleophaga promoting blood circulation to remove obstruction in the collateral, reunion of fractured tendons and bones, removing blood stasis analgesic therapy, Olibanum, Myrrha, blood stasis removing promoting blood circulation and stopping pain, helps the power of Pyritum monarch drug altogether.Herba Taxilli, Radix Dipsaci, the continuous folding of Rhizoma Drynariae synthetism, and energy invigorating liver and spleen, Radix et Rhizoma Rhei (processed) helps the effect of invigorating blood circulation of ministerial drug, all belongs to adjuvant drug.After fracture, venation is impaired, bone marrow periosteum and surrounding soft tissue's damage, and angiolysis is hemorrhage, blood circulating out of vessels, excessive skin, tissue edema, thus in treatment, answer promoting the circulation of QI to induce diuresis, Cortex Mori diuretic dehumidifying in prescription, with Pi Hangpi, Radix Angelicae Dahuricae detumescence, dampness.All medicines share common long memorial adhesion of tendon and muscle after injury bone, and the effect of the analgesic therapy of invigorating blood circulation, can promote growth of spur, accelerating union of bone fracture, shorten healing time, improve healing quality, promote healing mineralising, rising bone density, promoting bone growing, suppresses bone resorption, definitely alleviates bone pain, improve local blood circulation, promote angiogenesis, eliminate local swelling, disperse blood stasis, remove and prevent local adhesion, improve joint motion, prevent stiffly, prevent arthrogryposis and adhesion of tendon, alleviate local pain.
Summary of the invention
The present invention brings into play Chinese medicine in the advantage for the treatment of fracture, soft tissue injury, provides a kind of evident in efficacy, with low cost, treatment fracture injury of tendon and muscle that toxic and side effects is little, the pharmaceutical composition that muscles and bones is dampened.
technology realizes approach
The present invention is a kind of pharmaceutical composition for the treatment of fracture, soft tissue injury, and mainly the component by following weight portion forms:
Pyritum (forging) 100.6g Eupolyphaga Seu Steleophaga 40.2g Pheretima 40.2g Cortex Mori 40.2g
Rhizoma Drynariae (system) 20.1g Radix Dipsaci 20.1g Herba Taxilli 20.1g Radix Angelicae Sinensis 20.1g
Olibanum (system) 40.2g Radix Angelicae Dahuricae 40.2g Flos Carthami 20.1g Myrrha (processed) 40.2g
Radix Et Rhizoma Rhei (system) 12.1g
Pharmaceutical composition of the present invention is based on the Chinese medicine injury of tendon and muscle of fracturing, differential diagnosis of diseases and the dialectical principle that combines that muscles and bones is dampened, treating both the principal and secondary aspects of a disease, deficiency and excess is also controlled, reinforce insufficiency and reduce excessiveness, filter out the natural plant of reunion of fractured tendons and bones, blood circulation promoting and blood stasis dispelling, promoting diuresis to eliminate damp pathogen, promoting blood circulation and hemostasis, according to theory of Chinese medical science prescription, according to certain weight proportion, be prepared from.
Pharmaceutical composition of the present invention is through super-dry, pulverizing, and fine powder is crossed 100 mesh sieves, obtains medicated powder, with 50% ethanol, put into medicated powder, stir, cross 14 mesh sieve granulations, dry by 50～60 ℃, add 1% magnesium stearate, by 12 mesh sieves, granulate, uses tablet machine tabletting, coating, press mold, subpackage are made tablet.
The present invention herbal raw material Jun Kecong pharmaceuticals used buys, and it meets national medical standard.
usage and consumption
Per os hora somni every night, one time 6,1 time on the one; Child is cut down according to the circumstance or is followed the doctor's advice
The specific embodiment
Further describe by the following examples the present invention, should be noted that these embodiment, only for the object of illustration, never limit the scope of the invention.
The preparation of [embodiment 1] tablet, takes each raw material by following weight:
Pyritum (forging) 100.6g Eupolyphaga Seu Steleophaga 40.2g Pheretima 40.2g Cortex Mori 40.2g
Rhizoma Drynariae (system) 20.1g Radix Dipsaci 20.1g Herba Taxilli 20.1g Radix Angelicae Sinensis 20.1g
Olibanum (system) 40.2g Radix Angelicae Dahuricae 40.2g Flos Carthami 20.1g Myrrha (processed) 40.2g
Radix Et Rhizoma Rhei (system) 12.1g
By the pharmaceutical composition of above-mentioned weight, through super-dry, pulverizing, fine powder is crossed 100 mesh sieves, obtains medicated powder, with 50% ethanol, put into medicated powder, stir, cross 14 mesh sieve granulations, dry by 50～60 ℃, add 1% magnesium stearate, by 12 mesh sieves, granulate, uses tablet machine tabletting, coating, press mold, subpackage are made tablet.
The preparation of [embodiment 2] powder takes each raw material by following weight:
Pyritum (forging) 100.6g Eupolyphaga Seu Steleophaga 40.2g Pheretima 40.2g Cortex Mori 40.2g
Rhizoma Drynariae (system) 20.1g Radix Dipsaci 20.1g Herba Taxilli 20.1g Radix Angelicae Sinensis 20.1g
Olibanum (system) 40.2g Radix Angelicae Dahuricae 40.2g Flos Carthami 20.1g Myrrha (processed) 40.2g
Radix Et Rhizoma Rhei (system) 12.1g
Each raw material of above-mentioned weight is mixed, pulverize by after 200 mesh sieves, sieve, mix, play granule, granulate, subpackage, make powder
The preparation of [embodiment 3] small honey pill, takes each raw material by following weight:
Pyritum (forging) 100.6g Eupolyphaga Seu Steleophaga 40.2g Pheretima 40.2g Cortex Mori 40.2g
Rhizoma Drynariae (system) 20.1g Radix Dipsaci 20.1g Herba Taxilli 20.1g Radix Angelicae Sinensis 20.1g
Olibanum (system) 40.2g Radix Angelicae Dahuricae 40.2g Flos Carthami 20.1g Myrrha (processed) 40.2g
Radix Et Rhizoma Rhei (system) 12.1g
Each raw material of above-mentioned weight is mixed, pulverized after 120 mesh sieves, add the Mel of having refined by 1:0.8, close and stick together, pill, selects ball, and subpackage is made small honey pill.
[test example]
The medicine composite for curing fracture injury of tendon and muscle of the present invention, the joint stiffness person's that muscles and bones contusion is caused clinical observation on the therapeutic effect test.
One, the physical data of subjects: be inpatient, accept for medical treatment 500 routine patients are divided into treatment group and matched group at random, patient age 7～82 years old, 41.7 years old mean age, male 300 examples, female's 200 examples.Fracture of shaft of femur 101 examples wherein, hypomere 109 examples of fracturing in tibia, humeral shaft fracture 150 examples, forearm fracture 103 examples, radius far-end fracture 97 examples.Subjects age distribution as shown in Figure 1; Classification of fracture scattergram as shown in Figure 2.
Two, Therapeutic Method:
1 forms:
Pyritum (forging) 100.6g Eupolyphaga Seu Steleophaga 40.2g Pheretima 40.2g Cortex Mori 40.2g
Rhizoma Drynariae (system) 20.1g Radix Dipsaci 20.1g Herba Taxilli 20.1g Radix Angelicae Sinensis 20.1g
Olibanum (system) 40.2g Radix Angelicae Dahuricae 40.2g Flos Carthami 20.1g Myrrha (processed) 40.2g
Radix Et Rhizoma Rhei (system) 12.1g
2 usages: Trauma fracture, expectant treatment person, gives 6 of oral administered compound tablet for curing fracture after being admitted to hospital, before sleeping every night once, medication 3～4 weeks; Operative treatment person, both gave 6 of oral administered compound tablet for curing fracture the postoperative same day, every night per os hora somni once, medication 4～6 weeks, child patient is pressed the administration of 10kg/ sheet, medication 2～3 weeks.
Three, efficacy assessment standard:
Effective: the average healing time for the treatment of group is significantly less than the average healing time of matched group.
Effective: the average healing time for the treatment of group is less than the average healing time of matched group.
Invalid: the average healing time indifference of the average healing time for the treatment of group and matched group.
Four, model case:
1, people from Shenhe District of Xing XXNv60Sui Shenyang City.In 11 years Decembers, within 13rd, send granddaughter to go to school, fall down because of carelessness on foot, through the X-ray examination left hand Li Shi of section, fracture, carpal joint swelling and pain, doctor advised manual reduction oral compound connector sheet, took after one week, and symptom obviously alleviates, patient is emotionally stable, and takes medicine and by X-ray examination left hand, has started to have growth of spur in 3 weeks.After taking medicine 6 weeks, fracture site heals substantially.After leaving hospital, coordinate and take three courses for the treatment of of compound connector sheet, carpal joint recovers normal function substantially.
2, Lu XX man 40 people from Benxi.The Li Shi of right hand section fracture, the right hand swells and ache, and doctor advised manual reduction oral compound connector sheet are treated, and take after one week, and symptom obviously disappears, and patient is emotionally stable, and takes medicine and by the X-ray examination place of fracturing the right hands, has started to have growth of spur in 3 weeks.Fracture site all healed after taking medicine 6 weeks.
3, LiXXNan 45 people from Dadong District, Shenyang City.Sprain right crus of diaphragm downstairs, through the right distal tibial avulsion fracture of CT examination, internal malleolus splits folding, internal malleolus swells and ache, and doctor advised clamping plate fixation for treatment also coordinates compound connector sheet to treat, and takes after one week, symptom obviously alleviates, and patient is emotionally stable, and takes medicine and by X-ray examination, has started to have growth of spur in 3 weeks.After taking medicine 6 weeks, fracture site heals substantially.After leaving hospital, coordinate and take three courses for the treatment of of tablet for curing fracture, ankle joint recovers normal function substantially.
4, LiXXNv 48 people from Tiexi District, Shenyang City.Go window-shopping and fall down because of carelessness, through the left proximal ulna fracture of X-ray examination, forearm swells and ache, doctor advised clamping plate fixation for treatment oral compound connector sheet, took after one week, and symptom is obviously improved, red and swollen heat pain alleviates, and patient is emotionally stable, and takes medicine and by X-ray examination, has started to have growth of spur in 3 weeks.Fracture site all healed after taking medicine 6 weeks.After leaving hospital, coordinate and take a course for the treatment of of compound connector sheet, forearm recovers normal function substantially.
5, LiXXNan 38 people from Tiexi District, Shenyang City.Play basketball and fall down because of carelessness, through the left ulna fracture of distal of X-ray examination, forearm swells and ache, doctor advised clamping plate fixation for treatment is also joined oral administered compound tablet for curing fracture, takes after one week, and symptom is obviously improved, red and swollen heat pain alleviates, and takes medicine and by X-ray examination, has started to have growth of spur in 3 weeks.Fracture site all healed after taking medicine 6 weeks.
6, LiXXNv 68 people from Tiexi District, Shenyang City.Right radius far-end fracture, forearm swells and ache, and doctor advised clamping plate fixation for treatment oral compound connector sheet, took after one week, and symptom obviously disappears, and red and swollen heat pain disappears substantially, and patient is emotionally stable, and takes medicine and by X-ray examination, has started to have growth of spur in 4 weeks.Fracture site all healed after taking medicine 5 weeks.
7, people from Dadong District of Lee X Nan38 Shenyang City.The right distal tibial avulsion fracture of CT examination, internal malleolus splits folding, and internal malleolus swells and ache, and doctor advised clamping plate fixation for treatment oral administered compound tablet for curing fracture, took after 2 weeks, and symptom obviously disappears, and takes medicine and by X-ray examination, has started to have growth of spur in 3 weeks.Fracture site all healed after taking medicine 7 weeks.
8, WangXXNv 48 people from Yuhong District, Shenyang City.Upper bus is fallen down because of carelessness, through the right anklebone bone splits of X-ray examination, ankle joint swells and ache, doctor advised clamping plate fixation for treatment oral compound connector sheet, take after one week, symptom obviously alleviates, and red and swollen heat pain disappears substantially, patient is emotionally stable, and takes medicine within 3 weeks, by X-ray examination, to have started ankle joint and have growth of spur.After taking medicine 6 weeks, fracture site heals substantially.After leaving hospital, coordinate and take tablet for curing fracture 4 weeks, ankle joint recovers normal function substantially.
9, people from Shenhe District of grandson XXNan60Sui Shenyang City.Get off and fall down because of carelessness, through the X-ray examination left hand Li Shi of section fracture, carpal joint swelling and pain, doctor advised manual reduction also coordinates oral administered compound tablet for curing fracture, takes medicine and by X-ray examination left hand, has started to have growth of spur in 3 weeks.After taking medicine 6 weeks, fracture site heals substantially.After leaving hospital, coordinate and take three courses for the treatment of of tablet for curing fracture, carpal joint recovers normal function substantially.
10, the Meng people from peace zone of X Nv48 Shenyang City.Through the right anklebone bone splits of X-ray examination, ankle joint swells and ache, and doctor advised clamping plate fixation for treatment also coordinates oral administered compound tablet for curing fracture, takes after one week, and symptom obviously alleviates, and red and swollen heat pain disappears substantially, takes medicine within 4 weeks, by X-ray examination, to have started ankle joint and have growth of spur.After taking medicine 6 weeks, fracture site heals substantially.
Five, therapeutic outcome:
It is the longest 13 weeks, the shortest 3 weeks that this group case is accepted this law treatment time, average 9 weeks.The time of following up a case by regular visits to is the longest 24 months, the shortest 4 months, average 10 months.In 250 all routine subjects, remarkable result is 213 examples; Be effectively 29 examples; 7 invalid examples.Effective percentage 97%, good compliance rate 85%.
Test group and matched group fracture the average healing (week) contrast
Test group and matched group fracture the average healing (week) contrast are as shown in Figure 3.
Claims (6)
1. be used for the treatment of a fracture injury of tendon and muscle, the pharmaceutical composition that muscles and bones is dampened, is characterized in that being comprised of the crude drug of following weight portion:
8～12 parts of 8～12 parts of Cortex Mori of 8～12 parts of Pheretimas of 20～30 parts of Eupolyphaga Seu Steleophagas of Pyritum (forging)
2～4 parts of Rhizoma Drynariae (system) 4～6 parts of Radix Dipsacis, 4～6 parts of Herba Taxillis, 4～6 parts of Olibanums of 4～6 parts of Radix Angelicae Sinensis (system) 8～12 parts of Radixs Angelicae Dahuricae, 8～12 parts of Flos Carthamis, 8～12 parts of Radix Et Rhizoma Rhei of 4～6 parts of Myrrha (processed) (system).
2. according to pharmaceutical composition claimed in claim 1, it is characterized in that: the weight portion of each crude drug is:
9～11 parts of 9～11 parts of Cortex Mori of 9～11 parts of Pheretimas of 22～28 parts of Eupolyphaga Seu Steleophagas of Pyritum (forging)
2～3 parts of Rhizoma Drynariae (system) 3～5 parts of Radix Dipsacis, 3～5 parts of Herba Taxillis, 3～5 parts of Olibanums of 3～5 parts of Radix Angelicae Sinensis (system) 9～11 parts of Radixs Angelicae Dahuricae, 9～11 parts of Flos Carthamis, 9～11 parts of Radix Et Rhizoma Rhei of 3～5 parts of Myrrha (processed) (system).
3. according to pharmaceutical composition claimed in claim 3, wherein the weight portion of each component is:
40.2 parts of 40.2 parts of Cortex Mori of 40.2 parts of Pheretimas of 100.6 parts of Eupolyphaga Seu Steleophagas of Pyritum (forging)
40.2 parts of 20.1 parts of g Myrrha (processed) of 40.2 parts of Flos Carthamis of 40.2 parts of Radixs Angelicae Dahuricae of Rhizoma Drynariae (system) 20.1 parts of Radix Dipsacis, 20.1 parts of Herba Taxillis, 20.1 parts of Olibanums of 20.1 parts of Radix Angelicae Sinensis (system)
12.1 parts of Radix Et Rhizoma Rhei (system).
4. according to any one pharmaceutical composition described in claim 1,2,3, it is characterized in that: can method of Chinese medicinal routinely be prepared into any conventional oral formulations.
5. according to pharmaceutical composition claimed in claim 4, it is characterized in that: described oral formulations is pill, capsule, tablet, powder or granule.
6. the arbitrary pharmaceutical composition described in claim 1～5 is in the preparation treatment fracture injury of tendon and muscle, and muscles and bones is dampened the application in medicine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310137743.9A CN104107226A (en) | 2013-04-20 | 2013-04-20 | Compound bone-joining tablet |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310137743.9A CN104107226A (en) | 2013-04-20 | 2013-04-20 | Compound bone-joining tablet |
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| CN104107226A true CN104107226A (en) | 2014-10-22 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201310137743.9A Pending CN104107226A (en) | 2013-04-20 | 2013-04-20 | Compound bone-joining tablet |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107951970A (en) * | 2017-12-08 | 2018-04-24 | 蔡联英 | Treat the preparation method of acute injury of tendon and muscle external application Traditional Chinese ointments |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1144125A (en) * | 1996-03-07 | 1997-03-05 | 沈阳市骨科医院 | Xujinjiegu tablet for curing fracture |
| KR100731160B1 (en) * | 2006-05-26 | 2007-06-22 | 최영진 | Crude drugs composition for accelerating recovery of bone fracture |
-
2013
- 2013-04-20 CN CN201310137743.9A patent/CN104107226A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1144125A (en) * | 1996-03-07 | 1997-03-05 | 沈阳市骨科医院 | Xujinjiegu tablet for curing fracture |
| KR100731160B1 (en) * | 2006-05-26 | 2007-06-22 | 최영진 | Crude drugs composition for accelerating recovery of bone fracture |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107951970A (en) * | 2017-12-08 | 2018-04-24 | 蔡联英 | Treat the preparation method of acute injury of tendon and muscle external application Traditional Chinese ointments |
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Application publication date: 20141022 |