CN104096209A - Preparation method of traditional Chinese medicine composition for dispelling cold and relieving cough and application thereof - Google Patents
Preparation method of traditional Chinese medicine composition for dispelling cold and relieving cough and application thereof Download PDFInfo
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Abstract
The invention discloses a preparation method of a traditional Chinese medicine composition for dispelling cold and relieving cough and an application thereof. The active ingredients of the composition are prepared from the following raw materials in parts by weight: 9 to 15 parts of dried ginger, 5 to 11 parts of perilla fruit, 2 to 8 parts of pepperweed seeds, 1 to 7 parts of perilla leaves, 1 to 7 parts of folium artemisiae argyi, 5 to 11 parts of cassia twig, 5 to 11 parts of raphanus satlvus linne and 5 to 11 parts of houttuynia cordata. The traditional Chinese medicine composition for dispelling cold and relieving cough provided by the invention is prepared through adopting the theory and compatibility of Chinese traditional medicine of adjuvants and messengers, so that the composition has the effects of dispersing body surface and dispelling cold, warming the meridians, depressing qi and reducing phlegm and relieving cough and asthma, and meanwhile, clinical verifications have proven that the effective rate of the composition for relieving cough and asthma reaches 87.9%; besides, the composition is mild, non-irritant to skin, has no toxic and side effects, and meanwhile, the adopted raw materials are pure traditional Chinese medicines containing no antibiotics and hormone, so that the composition will not result in drug dependence.
Description
Technical field
The present invention relates to Chinese medicine composition field, particularly relate to a kind of Chinese medicine composition of cough-relieving effect and its preparation method and application of dispeling cold that has.
Background technology
Cough is a kind of protectiveness respiratory reflex action of human body, can effectively be removed the secretions in respiratory tract or be entered the foreign body of air flue by coughre flex.But cough also has disadvantageous one side, trachea pathological changes can be diffused into contiguous bronchia, aggravates disease, violent cough can cause respiratory tract hemorrhage etc.In addition, lasting violent cough can affect rest, goes back easy consumption muscle power, and can cause the destruction of alveolar wall Elastic tissue, brings out emphysema.
At present, cough, in diagnosis and treatment process, exists many treatments mistaken ideas, especially aspect clinical application, exist that abuse of antibiotics, a medicine hundred are controlled, medication not in time, ignore the mistaken ideas such as addiction, cure the symptoms, not the disease, side effect is larger, causes chronic cough difficult, and delay repeatedly.
Chinese medicine is often divided into cough: exogenous cough's (cough due to wind and cold, cough due to pathogenic wind-heat, wind-dryness cough etc.) and endogenous cough (phlegm dampness in lungs, expectorant heat stagnation lung, liver-fire invading the lung, syndrome of deficiency of lung yin etc.).Cold coughing, i.e. cough due to wind and cold's disease name.Cough due to affection of exogenous wind-cold, mainly violates lung by wind and cold, and impaired depurative descending of lung QI is shown in cough work frequently, thin white phlegm, and nasal obstruction, snivel, itching throat is low voice speaking.The traditional Chinese medical science is coughed treatment to be mainly expelling wind and cold lung qi dispersing is main cold, is particular about diagnosis and prescription in treatment, determined curative effect, and treating both the principal and secondary aspects of a disease, has no drug resistance, and side effect is little, can life-time service.
Summary of the invention
Based on this, the object of the present invention is to provide a kind of Chinese medicine composition with the cough-relieving effect of dispeling cold.
For achieving the above object, the present invention takes following technical scheme:
The one cough relief traditional Chinese medicine compositions of dispeling cold, its effective ingredient is mainly prepared from by the raw material of following weight portion: 9～15 parts of Rhizoma Zingiberiss, 5～11 parts of Fructus Perillaes, 2～8 parts of Semen Lepidii (Semen Descurainiae)s, 1～7 part of Folium Perillae, 1～7 part of Folium Artemisiae Argyi, 5～11 parts of Ramulus Cinnamomi, 5～11 parts of Semen Raphanis, 5～11 parts of Herba Houttuyniae.
In an embodiment, its effective ingredient is mainly prepared from by the raw material of following weight portion therein: 10～15 parts of Rhizoma Zingiberiss, 6～11 parts of Fructus Perillaes, 2～8 parts of Semen Lepidii (Semen Descurainiae)s, 3～5 parts of Folium Perillaes, 3～7 parts of Folium Artemisiae Argyis, 6～10 parts of Ramulus Cinnamomi, 6～10 parts of Semen Raphanis, 6～10 parts of Herba Houttuyniae.
In an embodiment, its effective ingredient is mainly prepared from by the raw material of following weight portion therein: 11～13 parts of Rhizoma Zingiberiss, 7～9 parts of Fructus Perillaes, 4～6 parts of Semen Lepidii (Semen Descurainiae)s, 3～5 parts of Folium Perillaes, 3～5 parts of Folium Artemisiae Argyis, 7～9 parts of Ramulus Cinnamomi, 7～9 parts of Semen Raphanis, 7～9 parts of Herba Houttuyniae.
The present invention also provides the preparation method of the above-mentioned cough relief traditional Chinese medicine compositions of dispeling cold, and comprises the steps:
The Rhizoma Zingiberis of described weight portion, Fructus Perillae, Semen Lepidii (Semen Descurainiae), Folium Perillae, Folium Artemisiae Argyi are mixed and be placed in extraction pot, decoct with water extraction, collect traditional medicine volatile oil and extracting solution, extracting liquid filtering, subsequent filtrate precipitate with ethanol, filters, and concentrates to obtain concentrated solution; Again the Ramulus Cinnamomi of described weight portion, Semen Raphani, Herba Houttuyniae are mixed and be placed in supersound extraction device, add ethanol extraction, after extracting liquid filtering, merge to obtain Chinese medicine extraction liquid with concentrated solution; Merge traditional medicine volatile oil and the Chinese medicine extraction liquid cough relief traditional Chinese medicine compositions of dispeling cold described in obtaining; Or,
The Rhizoma Zingiberis of described weight portion, Fructus Perillae, Semen Lepidii (Semen Descurainiae), Folium Perillae, Folium Artemisiae Argyi, Ramulus Cinnamomi, Semen Raphani, Herba Houttuyniae are fully mixed, decoct with water extraction or add ethanol extraction, collect traditional medicine volatile oil and extracting solution, extracting solution filters, the concentrated Chinese medicine extraction liquid that to obtain, merges Chinese medicine extraction liquid or the nonjoinder traditional medicine volatile oil cough relief traditional Chinese medicine compositions of dispeling cold described in obtaining.
In an embodiment, will after described traditional medicine volatile oil and Chinese medicine extraction liquid merging, add pharmaceutically acceptable carrier to make conventional formulation, the cough relief traditional Chinese medicine of dispeling cold described in obtaining compositions therein.
Therein in an embodiment, the method for described water boiling and extraction is the water boiling and extraction 2～3 times that adds 6～9 times of crude drug weight; The method of described ethanol extraction is the ethanol ultrasonic extraction that adds the mass fraction 30～50% of 5～7 times of crude drug weight.
In an embodiment, described concentrated method is 1.05～1.25 for described extracting solution is concentrated into relative density in 55 DEG C～65 DEG C therein.
The present invention also provides the above-mentioned cough relief traditional Chinese medicine compositions of dispeling cold to have the application in the medicine of the cough-relieving effect of dispeling cold in preparation.
In an embodiment, the dosage form of described medicine is externally used paste therein.
Therein in an embodiment, described externally used paste, in weight portion, comprise following component: 20～46 parts of cough relief traditional Chinese medicine compositionss that what above-mentioned preparation method prepared dispel cold, 5～12 parts of wetting agents, 5～10 parts of isostearyl glyceryl pentaerythrityl ether, 0.1～0.3 part of thickening agent, 0.4～1.0 part of emulsifying agent, 30.0～60.0 parts, water, 0.10～0.25 part of chelating agen, 0.08～0.12 part of antiseptic.
Principle and advantage of the present invention is as follows:
The pharmacology of the Chinese crude drug that the cough relief traditional Chinese medicine compositions of dispeling cold of the present invention adopts is as follows:
Rhizoma Zingiberis: pungent, heat.Warming spleen and stomach for dispelling cold, recuperating depleted YANG is promoted blood circulation, warming the lung to resolve fluid-retention.For coldness and pain in the epigastrium, cold extremities faint pulse, cold fluid-retention is breathed with cough.
Fructus Perillae: pungent, temperature.Lowering the adverse-rising QI to resolve phlegm, relieving cough and asthma.Stop up QI rising in reverse order, cough and asthma for expectorant.
Semen Lepidii (Semen Descurainiae): pungent, bitter, Great Cold.Eliminating pathogen from the lung for relieving asthma, line water detumescence.Stop up lung for sputum, dyspnea and cough with excessive sputum, distending pain in the chest and hypochondrium, must not put down sleeping.
Folium Perillae: pungent, temperature.The cold expelling that induces sweat, relieving QI stagnancy in the stomach.For anemofrigid cold, cough vomiting and nausea.
Folium Artemisiae Argyi: pungent, bitter, temperature.Warming the meridian, dispersing cold for relieving pain; External removing dampness to relieve itching.
Ramulus Cinnamomi: pungent, sweet, warm.Diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, the flat gas that spins.For anemofrigid cold, phlegm retention.
Semen Raphani: pungent, sweet, flat.Lowering the adverse-rising QI to resolve phlegm.Stop up and breath with cough for expectorant.
Herba Houttuyniae: pungent, be slightly cold.Heat-clearing and toxic substances removing, eliminating carbuncle evacuation of pus.Spit for lung abscess, expectorant dyspnea of heat type is coughed, too fat to move sore.
The cough relief traditional Chinese medicine compositions of dispeling cold of the present invention is selected Rhizoma Zingiberis, Fructus Perillae, Semen Lepidii (Semen Descurainiae), Folium Perillae, Folium Artemisiae Argyi, Ramulus Cinnamomi, Semen Raphani, the Chinese crude drugs such as Herba Houttuyniae, compatibility, overcomes the deficiency that single medicinal material effect is single mutually, strengthen drug effect, suppress or eliminate toxic and side effects, many-sided regulation and control, to reach effect of the cough-relieving of dispeling cold.Above-mentioned Chinese crude drug, according to the theory of Chinese medicine " monarch ", taking Rhizoma Zingiberis, Folium Perillae, Ramulus Cinnamomi as monarch drug, is had to the cold expelling of delivering, promoting the flow of QI-blood by warming the meridian, warming the lung to resolve fluid-retention, effect of supporing yang activating QI; Semen Raphani, Fructus Perillae are ministerial drug, have lowering the adverse-rising QI to resolve phlegm, effect of relieving cough and asthma; Herba Houttuyniae, Semen Lepidii (Semen Descurainiae) are adjuvant drug, have eliminating pathogen from the lung for relieving asthma, effect of line water detumescence; Folium Artemisiae Argyi, for making medicine, has effect of dispersing cold for relieving pain.All medicines share, and complement each other, and play altogether and deliver cold expelling, promoting the flow of QI-blood by warming the meridian, lowering the adverse-rising QI to resolve phlegm, the effect of relieving cough and asthma.
In addition, although a lot of for cold Chinese patent medicine and the health product of coughing on the market at present, but be mostly granule, syrup, mixture, pill etc., as cough due to wind and cold's granule, cough due to wind and cold's ball, Tongxuanlifei electuary, imperial KECHUANNING JIAONANG etc., this series products all needs to take orally, is not suitable for the patient that difficulty is taken medicine.
Based on this, the present invention also passes through to add wetting agent, emulsifying agent, and water, chelating agen, isostearyl glyceryl pentaerythrityl ether, thickening agent, the pharmaceutically acceptable carrier such as antiseptic, is prepared into externally used paste by described Chinese medicine composition, is convenient to patient's use that difficulty is taken medicine.
Wherein, described wetting agent can be butanediol and allantoin; Described emulsifying agent can be stearyl alcohol polyethers-2, stearyl alcohol polyethers-21 and stearyl sodium glutamate; Described chelating agen can be EDETATE SODIUM; Described isostearyl glyceryl pentaerythrityl ether can be cetearyl alcohol, isopropyl myristate and bisabolol; Described thickening agent can be xanthan gum; Described antiseptic can be Sensiva SC50.
Compared with prior art, the present invention has following beneficial effect:
(1) the cough relief traditional Chinese medicine compositions of dispeling cold of the present invention, raw material adopts Rhizoma Zingiberis, Fructus Perillae, Semen Lepidii (Semen Descurainiae), Folium Perillae, Folium Artemisiae Argyi, Ramulus Cinnamomi, Semen Raphani, the Chinese crude drugs such as Herba Houttuyniae, form according to the tcm theory compatibility of monarch, there is the good cold expelling of delivering, promoting the flow of QI-blood by warming the meridian, lowering the adverse-rising QI to resolve phlegm, effect of relieving cough and asthma.Through clinical verification, the cough relief traditional Chinese medicine compositions of dispeling cold of the present invention has reached 87.9% to disease effective percentage such as cough, asthma, and non-stimulated to skin gentleness, have no side effect.Meanwhile, because the raw material adopting is pure Chinese medicine,, containing antibiotic and hormone, can not produce drug dependence.
(2) preparation method of the cough relief traditional Chinese medicine compositions of dispeling cold of the present invention, simple to operation.
(3) the present invention also passes through to add wetting agent, emulsifying agent, and water, chelating agen, isostearyl glyceryl pentaerythrityl ether, thickening agent, the pharmaceutically acceptable carrier such as antiseptic, is applied to externally used paste by described Chinese medicine composition, is convenient to patient's use that difficulty is taken medicine.The experiment proved that simultaneously, described externally used paste safety, stable, non-stimulated to skin.
Detailed description of the invention
Below in conjunction with specific embodiment, dispel cold cough relief traditional Chinese medicine composition and method of making the same and application of the present invention are described further.
Embodiment 1
The present embodiment one cough relief traditional Chinese medicine compositions of dispeling cold, its effective ingredient is prepared from by the raw material of following weight portion:
12 parts of Rhizoma Zingiberiss, 8 parts of Fructus Perillaes, 5 parts of Semen Lepidii (Semen Descurainiae)s, 4 parts of Folium Perillaes, 4 parts of Folium Artemisiae Argyis, 8 parts of Ramulus Cinnamomi, 8 parts of Semen Raphanis, 8 parts of Herba Houttuyniae.
The preparation method of the described cough relief traditional Chinese medicine compositions of dispeling cold, comprises the steps:
The Rhizoma Zingiberis of described weight portion, Fructus Perillae, Semen Lepidii (Semen Descurainiae), Folium Perillae, Folium Artemisiae Argyi are fully mixed, be placed in extraction pot, add the water boiling and extraction 2 times of 8 times of crude drug weight, collect traditional medicine volatile oil and extracting solution, extracting liquid filtering, subsequent filtrate precipitate with ethanol, filters, it is 1.05～1.25 that filtrate is concentrated into relative density in 55 DEG C～65 DEG C, obtains concentrated solution;
After the Ramulus Cinnamomi of described weight portion, Semen Raphani, Herba Houttuyniae pulverizing are sieved, fully mix, be placed in supersound extraction device, add the ethanol ultrasonic extraction of the mass fraction 50% of 5 times of crude drug weight, after extracting liquid filtering, merge with described concentrated solution, obtain Chinese medicine extraction liquid;
Merge described traditional medicine volatile oil and the Chinese medicine extraction liquid cough relief traditional Chinese medicine compositions of dispeling cold described in obtaining.
Embodiment 2
The present embodiment one cough relief traditional Chinese medicine compositions of dispeling cold, its effective ingredient is prepared from by the raw material of following weight portion:
9 parts of Rhizoma Zingiberiss, 5 parts of Fructus Perillaes, 2 parts of Semen Lepidii (Semen Descurainiae)s, 1 part of Folium Perillae, 1 part of Folium Artemisiae Argyi, 5 parts of Ramulus Cinnamomi, 5 parts of Semen Raphanis, 5 parts of Herba Houttuyniae.
The preparation method of the described cough relief traditional Chinese medicine compositions of dispeling cold, comprises the steps:
The Rhizoma Zingiberis of described weight portion, Fructus Perillae, Semen Lepidii (Semen Descurainiae), Folium Perillae, Folium Artemisiae Argyi are fully mixed, be placed in extraction pot, add the water boiling and extraction 2 times of 7 times of crude drug weight, collect traditional medicine volatile oil and extracting solution, extracting liquid filtering, subsequent filtrate precipitate with ethanol, filters, it is 1.05～1.25 that filtrate is concentrated into relative density in 55 DEG C～65 DEG C, obtains concentrated solution;
After the Ramulus Cinnamomi of described weight portion, Semen Raphani, Herba Houttuyniae pulverizing are sieved, fully mix, be placed in supersound extraction device, add the ethanol ultrasonic extraction of the mass fraction 40% of 6 times of crude drug weight, after extracting liquid filtering, merge with described concentrated solution, obtain Chinese medicine extraction liquid;
Merge described traditional medicine volatile oil and the Chinese medicine extraction liquid cough relief traditional Chinese medicine compositions of dispeling cold described in obtaining; Or, can also add pharmaceutically acceptable carrier to make regular dosage form, the cough relief traditional Chinese medicine of dispeling cold described in obtaining compositions.
Embodiment 3
The present embodiment one cough relief traditional Chinese medicine compositions of dispeling cold, its effective ingredient is prepared from by the raw material of following weight portion:
15 parts of Rhizoma Zingiberiss, 11 parts of Fructus Perillaes, 8 parts of Semen Lepidii (Semen Descurainiae)s, 7 parts of Folium Perillaes, 7 parts of Folium Artemisiae Argyis, 11 parts of Ramulus Cinnamomi, 11 parts of Semen Raphanis, 11 parts of Herba Houttuyniae.
The preparation method of the described cough relief traditional Chinese medicine compositions of dispeling cold, comprises the steps:
The Rhizoma Zingiberis of described weight portion, Fructus Perillae, Semen Lepidii (Semen Descurainiae), Folium Perillae, Folium Artemisiae Argyi are fully mixed, be placed in extraction pot, add the water boiling and extraction 3 times of 9 times of crude drug weight, collect traditional medicine volatile oil and extracting solution, extracting liquid filtering, subsequent filtrate precipitate with ethanol, filters, it is 1.05～1.25 that filtrate is concentrated into relative density in 55 DEG C～65 DEG C, obtains concentrated solution;
After the Ramulus Cinnamomi of described weight portion, Semen Raphani, Herba Houttuyniae pulverizing are sieved, fully mix, be placed in supersound extraction device, add the ethanol ultrasonic extraction of the mass fraction 50% of 7 times of crude drug weight, after extracting liquid filtering, merge with described concentrated solution, obtain Chinese medicine extraction liquid;
Merge described traditional medicine volatile oil and the Chinese medicine extraction liquid cough relief traditional Chinese medicine compositions of dispeling cold described in obtaining; Or, can also add pharmaceutically acceptable carrier to make regular dosage form, the cough relief traditional Chinese medicine of dispeling cold described in obtaining compositions.
Embodiment 4
The present embodiment one cough relief traditional Chinese medicine compositions of dispeling cold, its effective ingredient is prepared from by the raw material of following weight portion:
12 parts of Rhizoma Zingiberiss, 8 parts of Fructus Perillaes, 5 parts of Semen Lepidii (Semen Descurainiae)s, 4 parts of Folium Perillaes, 4 parts of Folium Artemisiae Argyis, 8 parts of Ramulus Cinnamomi, 8 parts of Semen Raphanis, 8 parts of Herba Houttuyniae.
The preparation method of the described cough relief traditional Chinese medicine compositions of dispeling cold, comprises the steps:
By the Rhizoma Zingiberis of described weight portion, Fructus Perillae, Semen Lepidii (Semen Descurainiae), Folium Perillae, Folium Artemisiae Argyi, Ramulus Cinnamomi, Semen Raphani, Herba Houttuyniae shatters into coarse powder after fully mixing, and adds the water boiling and extraction 2 times of 8 times of crude drug weight, collect traditional medicine volatile oil and extracting solution, described extracting solution filters, and being concentrated into relative density in 55 DEG C～65 DEG C is 1.05～1.25, obtains Chinese medicine extraction liquid, described Chinese medicine extraction liquid is merged to described traditional medicine volatile oil, the cough relief traditional Chinese medicine of dispeling cold described in obtaining compositions; Or, can also add pharmaceutically acceptable carrier, make regular dosage form, the cough relief traditional Chinese medicine of dispeling cold described in obtaining compositions.
Embodiment 5
The present embodiment one cough relief traditional Chinese medicine compositions of dispeling cold, its effective ingredient is prepared from by the raw material of following weight portion:
12 parts of Rhizoma Zingiberiss, 8 parts of Fructus Perillaes, 5 parts of Semen Lepidii (Semen Descurainiae)s, 4 parts of Folium Perillaes, 4 parts of Folium Artemisiae Argyis, 8 parts of Ramulus Cinnamomi, 8 parts of Semen Raphanis, 8 parts of Herba Houttuyniae.
The preparation method of the described cough relief traditional Chinese medicine compositions of dispeling cold, comprises the steps:
By the Rhizoma Zingiberis of described weight portion, Fructus Perillae, Semen Lepidii (Semen Descurainiae), Folium Perillae, Folium Artemisiae Argyi, Ramulus Cinnamomi, Semen Raphani, after Herba Houttuyniae fully mixes, be placed in supersound extraction device, add the water supersound extraction of 6 times of crude drug weight, extracting solution filters, and being concentrated into relative density in 55 DEG C～65 DEG C is 1.05～1.25, obtain Chinese medicine extraction liquid, the cough relief traditional Chinese medicine of dispeling cold described in being compositions; Or, can also add pharmaceutically acceptable carrier, make regular dosage form, the cough relief traditional Chinese medicine of dispeling cold described in obtaining compositions.
Embodiment 6
The present embodiment one cough relief traditional Chinese medicine compositions of dispeling cold, its effective ingredient is prepared from by the raw material of following weight portion:
12 parts of Rhizoma Zingiberiss, 8 parts of Fructus Perillaes, 5 parts of Semen Lepidii (Semen Descurainiae)s, 4 parts of Folium Perillaes, 4 parts of Folium Artemisiae Argyis, 8 parts of Ramulus Cinnamomi, 8 parts of Semen Raphanis, 8 parts of Herba Houttuyniae.
The preparation method of the described cough relief traditional Chinese medicine compositions of dispeling cold, comprises the steps:
By the Rhizoma Zingiberis of described weight portion, Fructus Perillae, Semen Lepidii (Semen Descurainiae), Folium Perillae, Folium Artemisiae Argyi, Ramulus Cinnamomi, Semen Raphani, after Herba Houttuyniae fully mixes, be placed in supersound extraction device, add mass fraction 35% ethanol ultrasonic extraction of 6 times of crude drug weight, extracting solution filters, and being concentrated into relative density in 55 DEG C～65 DEG C is 1.05～1.25, obtain Chinese medicine extraction liquid, the cough relief traditional Chinese medicine of dispeling cold described in being compositions; Or, can also add pharmaceutically acceptable carrier, make regular dosage form, the cough relief traditional Chinese medicine of dispeling cold described in obtaining compositions.
Embodiment 7
The present embodiment cough relief traditional Chinese medicine compositions of dispeling cold described in being has the application in the medicine of the cough-relieving effect of dispeling cold in preparation.The dosage form of described medicine is externally used paste, in weight portion, comprises following component (table 1):
Table 1
The preparation method of above-mentioned externally used paste, comprises the following steps:
(1) accurately take the mutually each component of A in oil phase pot, be heated with stirring to 75～85 DEG C, be incubated to all components and dissolve completely, obtain component A for subsequent use;
(2) the each component that accurately weighs B phase is in emulsifying pot, and heated and stirred to 75～85 DEG C are stirred to completely evenly without granule, obtain B component for subsequent use;
(3) accurately weigh C phase component, heating in water bath to 75～85 DEG C, be stirred to complete dispersing and dissolving, under the mixing speed of 30r/min, after 200 object filter-cloth filterings, filtrate is evacuated in the described emulsifying pot of step (2), mix with described B component for subsequent use, insulated and stirred, and middling speed homogenizing 2 minutes (evacuation-0.02～0.05Mpa), gained material body is complete even agranular fluid;
(4) under the mixing speed of 50r/min, described step (1) component A for subsequent use is crossed to 200 order filter clothes, in the described fluid of filtrate suction step (3), evacuation, high speed homogenization 1～5 minute, stirs cooling;
(5) be cooled to after 40～50 DEG C, add one by one D phase component, fully stirring, and evacuation homogenizing 3～5 minutes, makes product complete and homogeneous, stirs cooling.
(6) continue to be cooled to 35～45 DEG C of sampling censorships, qualified discharging, obtains described externally used paste.
Embodiment 8
Dispel cold described in the being skin irritation test of cough relief traditional Chinese medicine compositions of the present embodiment.
(1) cough relief traditional Chinese medicine of dispeling cold described in Experimental agents: embodiment 1 compositions (wherein said Chinese medicine extraction liquid and traditional medicine volatile oil are tested respectively).
(2) laboratory animal: healthy white is 8 of rabbits, body weight 2.0～3.0kg, animal credit number: SCXK (Guangdong) 2012-0015 for experiment.
(3) experimental technique: laboratory animal is divided into 2 groups at random, A group and B group.
A group laboratory animal one side is smeared Chinese medicine extraction liquid described in embodiment 1, is experimental side A, and opposite side is not smeared any sample, in contrast side A; B group laboratory animal one side is smeared traditional medicine volatile oil described in embodiment 1, is experimental side B; Opposite side is not smeared any sample, in contrast side B.
A group is carried out to repeatedly skin irritation test, B group is carried out to acute skin irritation experiment.Acute skin irritation experiment and repeatedly skin irritation test method and step are all carried out according to skin irritation test method and step in " cosmetics health specification 2007 editions ".
(4) stimulus intensity evaluation criterion (table 2):
Table 2
(5) experimental result
A organizes repeatedly skin irritation test result, as shown in table 3.
Table 3
As can be seen from Table 3, Chinese medicine extraction liquid is to laboratory animal repeatedly in irritation test described in embodiment 1, and every day, the integral mean value of every laboratory animal was 0.36, stimulus intensity evaluation is less than 0.5, for non-stimulated, Chinese medicine extraction liquid nonirritant described in embodiment 1 is described thus, safe.
B group acute skin irritation experimental result, as shown in table 4.
Table 4
As can be seen from Table 4, described in embodiment 1, traditional medicine volatile oil is to laboratory animal acute skin irritation test reaction, integral mean value at 24h, 48h and 72h is up to 0.25, stimulus intensity evaluation is less than 0.5, for non-stimulated, traditional medicine volatile oil nonirritant described in embodiment 1 is described thus, safe.
Embodiment 9
The present embodiment is externally used paste stability described in embodiment 7, safety and clinical effectiveness experiment.
(1) stability experiment
Externally used paste described in embodiment 7 is deposited after 30 days 40 DEG C (heat-resisting) and-10 DEG C (resisting cold) respectively, observed, without lamination, illustrate that the cough relief traditional Chinese medicine composition stable of dispeling cold described in embodiment 7 is good.
(2) safety
Heavy metal detects: entrust China Guangzhou Analysis &. Test Center, the content of the heavy metal in externally used paste described in embodiment 7 is detected, testing result is as shown in table 5:
Table 5
| Analysis project | Check result | Measurement unit |
| Hydrargyrum | < 1 (qualified) | mg/kg |
| Plumbous | < 10 (qualified) | mg/kg |
| Arsenic | < 1 (qualified) | mg/kg |
| Cadmium | < 2 (qualified) | mg/kg |
Can be learnt by table 5, externally used paste heavy metal testing result is qualified described in embodiment 7.
(3) clinical effectiveness experiment
3.1 subject enrollment standards:
1. men and women does not limit, and coordinates product beta test requirement; 2. there is the significantly cold symptom of coughing; 3. well compatibility test, can keep good daily life system time and dietary habit in the trial employment period.
Externally used paste described in 3.2 laboratory samples: embodiment 7, specification is every 3mL.
3.3 experimental techniques: the back DAZHUI acupoint, FEIYU acupoint and near the position that laboratory sample are applied to experimenter, every day 1 time (time on probation: afternoon 5:03-6:30), continuous 7 days, divide and observe for four times, be respectively the 1st day, the 2nd day, the 3rd day and the 7th day for the treatment of.
3.4 evaluation of clinical curative effect standards
Disappear or good to some extent transferring to effectively with cough, asthma; Cough, asthma, without improvement, even increase the weight of as invalid.
3.5 interpretation of result
Experimenter must not be lower than 50 people.
Have 58 people and participate in the experiment of this clinical effectiveness as experimenter.
In process on probation, all there is not the symptoms such as skin pruritus, twinge, redness in experimenter.
Experimental result is as shown in table 6:
Table 6
| The course for the treatment of | The 1st day | The 2nd day | The 3rd day | The 7th day |
| Effectively | 38 | 44 | 47 | 51 |
| Invalid | 20 | 14 | 11 | 7 |
| Effective percentage | 65.5％ | 75.8％ | 81.0％ | 87.9％ |
As can be seen from Table 6, externally used paste described in embodiment 7, in the 1st day on probation, has just reached 65.5% effective percentage, and on probation after 7 days, effective percentage rises to 87.9%.As can be seen here, the cough-relieving compositions of dispeling cold of the present invention has good cough and asthma relieving efficacy.
The above embodiment has only expressed several embodiment of the present invention, and it describes comparatively concrete and detailed, but can not therefore be interpreted as the restriction to the scope of the claims of the present invention.It should be pointed out that for the person of ordinary skill of the art, without departing from the inventive concept of the premise, can also make some distortion and improvement, these all belong to protection scope of the present invention.Therefore, the protection domain of patent of the present invention should be as the criterion with claims.
Claims (10)
1. the cough relief traditional Chinese medicine compositions of dispeling cold, it is characterized in that, its effective ingredient is mainly prepared from by the raw material of following weight portion: 9～15 parts of Rhizoma Zingiberiss, 5～11 parts of Fructus Perillaes, 2～8 parts of Semen Lepidii (Semen Descurainiae)s, 1～7 part of Folium Perillae, 1～7 part of Folium Artemisiae Argyi, 5～11 parts of Ramulus Cinnamomi, 5～11 parts of Semen Raphanis, 5～11 parts of Herba Houttuyniae.
2. the cough relief traditional Chinese medicine compositions of dispeling cold according to claim 1, it is characterized in that, its effective ingredient is mainly prepared from by the raw material of following weight portion: 10～15 parts of Rhizoma Zingiberiss, 6～11 parts of Fructus Perillaes, 2～8 parts of Semen Lepidii (Semen Descurainiae)s, 3～5 parts of Folium Perillaes, 3～7 parts of Folium Artemisiae Argyis, 6～10 parts of Ramulus Cinnamomi, 6～10 parts of Semen Raphanis, 6～10 parts of Herba Houttuyniae.
3. the cough relief traditional Chinese medicine compositions of dispeling cold according to claim 2, it is characterized in that, its effective ingredient is mainly prepared from by the raw material of following weight portion: 11～13 parts of Rhizoma Zingiberiss, 7～9 parts of Fructus Perillaes, 4～6 parts of Semen Lepidii (Semen Descurainiae)s, 3～5 parts of Folium Perillaes, 3～5 parts of Folium Artemisiae Argyis, 7～9 parts of Ramulus Cinnamomi, 7～9 parts of Semen Raphanis, 7～9 parts of Herba Houttuyniae.
4. the preparation method of the cough relief traditional Chinese medicine compositions of dispeling cold described in claim 1-3 any one, is characterized in that, comprises the steps:
The Rhizoma Zingiberis of described weight portion, Fructus Perillae, Semen Lepidii (Semen Descurainiae), Folium Perillae, Folium Artemisiae Argyi are mixed and be placed in extraction pot, decoct with water extraction, collect traditional medicine volatile oil and extracting solution, extracting liquid filtering, subsequent filtrate precipitate with ethanol, filters, and concentrates to obtain concentrated solution; Again the Ramulus Cinnamomi of described weight portion, Semen Raphani, Herba Houttuyniae are mixed and be placed in supersound extraction device, add ethanol extraction, after extracting liquid filtering, merge to obtain Chinese medicine extraction liquid with concentrated solution; Merge traditional medicine volatile oil and the Chinese medicine extraction liquid cough relief traditional Chinese medicine compositions of dispeling cold described in obtaining; Or,
The Rhizoma Zingiberis of described weight portion, Fructus Perillae, Semen Lepidii (Semen Descurainiae), Folium Perillae, Folium Artemisiae Argyi, Ramulus Cinnamomi, Semen Raphani, Herba Houttuyniae are fully mixed, decoct with water extraction or add ethanol extraction, collect traditional medicine volatile oil and extracting solution, extracting solution filters, the concentrated Chinese medicine extraction liquid that to obtain, merges Chinese medicine extraction liquid or the nonjoinder traditional medicine volatile oil cough relief traditional Chinese medicine compositions of dispeling cold described in obtaining.
5. the preparation method of the cough relief traditional Chinese medicine compositions of dispeling cold according to claim 4, is characterized in that, will after described traditional medicine volatile oil and Chinese medicine extraction liquid merging, add pharmaceutically acceptable carrier to make conventional formulation, the cough relief traditional Chinese medicine of dispeling cold described in obtaining compositions.
6. the preparation method of the cough relief traditional Chinese medicine compositions of dispeling cold according to claim 4, is characterized in that, the method for described water boiling and extraction is the water boiling and extraction 2～3 times that adds 6～9 times of crude drug weight; The method of described ethanol extraction is the ethanol ultrasonic extraction that adds the mass fraction 30～50% of 5～7 times of crude drug weight.
7. the preparation method of the cough relief traditional Chinese medicine compositions of dispeling cold according to claim 4, is characterized in that, described concentrated method is 1.05～1.25 for described extracting solution is concentrated into relative density in 55 DEG C～65 DEG C.
8. the cough relief traditional Chinese medicine compositions of dispeling cold described in claim 1-3 any one has the application in the medicine of the cough-relieving effect of dispeling cold in preparation.
9. application according to claim 8, is characterized in that, the dosage form of described medicine is externally used paste.
10. application according to claim 9, it is characterized in that, described externally used paste, in weight portion, comprise following component: 20～46 parts of cough relief traditional Chinese medicine compositionss that what described in claim 4, preparation method prepared dispel cold, 5～12 parts of wetting agents, 5～10 parts of isostearyl glyceryl pentaerythrityl ether, 0.1～0.3 part of thickening agent, 0.4～1.0 part of emulsifying agent, 30.0～60.0 parts, water, 0.10～0.25 part of chelating agen, 0.08～0.12 part of antiseptic.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104922464A (en) * | 2015-07-16 | 2015-09-23 | 王乾林 | Traditional Chinese medicine for treating chronic cough |
| CN110711243A (en) * | 2019-10-30 | 2020-01-21 | 从江神瑶保健品有限公司 | Traditional Chinese medicine bath powder for children cough rehabilitation and preparation method thereof |
| CN113058024A (en) * | 2021-05-13 | 2021-07-02 | 北京梅尔森医药技术开发有限公司 | Traditional Chinese medicine composition and preparation method and application thereof |
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| CN1116101A (en) * | 1994-08-01 | 1996-02-07 | 程春桂 | Healthful preparation for therapy of cough and making method thereof |
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| CN1116101A (en) * | 1994-08-01 | 1996-02-07 | 程春桂 | Healthful preparation for therapy of cough and making method thereof |
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| 沈企华: "中西医结合治疗慢性肺心病124例分析", 《实用中医内科杂志》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104922464A (en) * | 2015-07-16 | 2015-09-23 | 王乾林 | Traditional Chinese medicine for treating chronic cough |
| CN110711243A (en) * | 2019-10-30 | 2020-01-21 | 从江神瑶保健品有限公司 | Traditional Chinese medicine bath powder for children cough rehabilitation and preparation method thereof |
| CN113058024A (en) * | 2021-05-13 | 2021-07-02 | 北京梅尔森医药技术开发有限公司 | Traditional Chinese medicine composition and preparation method and application thereof |
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