CN104055802A - Medicine for reducing side effects of chemoradiotherapy for tumour - Google Patents
Medicine for reducing side effects of chemoradiotherapy for tumour Download PDFInfo
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Abstract
The invention discloses a medicine for reducing side effects of chemoradiotherapy for tumour. The medicine for reducing side effects of chemoradiotherapy for tumour is prepared from whole egg powder rich in zinc and selenium, lentinan, cordyceps militaris and vitamin E which are taken as active ingredients according to certain parts by weight. The medicine is scientific in formula, safe and free of toxic and side effect; the zinc and the selenium in the whole egg powder rich in zinc and selenium are biological natural active zinc proteinate and selenium proteinate, good in absorption, high in activity and free of toxic and side effect; the biological natural active zinc proteinate and selenium proteinate, lentinan and the cordyceps militaris are combined for achieving synergy effect, so that the medicine is remarkable in effect and capable of improving the immunity of the organism, reducing the toxic effects of the chemoradiotherapy on the human body, improving the problems of appetite reduction, emesis, nausea, epilation and leucopenia caused due to the chemoradiotherapy treatment and further improving the treatment effect of the chemoradiotherapy. The medicine is used for treating 1000 patients totally, and the total effective rate reaches 96%.
Description
(1) technical field
The present invention relates to a kind of medicine that reduces tumor chemoradiotherapy side effect.
(2) background technology
Chemicotherapy is a kind of common mode for the treatment of malignant tumor, normally with high energy lonizing radiation or to the method for injected chemical medicine in patient body, kill cancerous cell, but chemicotherapy also can damage human normal cell when killing cancerous cell, there is sizable side effect, be embodied in: 1. the situations such as the whole body fatigue and weak, lethargy, cold perspiration, drowsiness, alopecia can appear in patient; 2. chemotherapeutics can damage patient's immune system, causes immunodeficiency or decline; 3. most of chemotherapeutics all can cause bone marrow depression, show as leukocyte and platelet and decline, and even cause erythrocyte, hematochrome to decline; 4. a lot of chemotherapeutics can stimulating gastrointestinal mucous membranes, thereby cause that appetite declines, dietary amount reduces, feel sick, vomiting, abdominal distention, stomachache, diarrhoea or constipation etc.; 5. radiotherapy is to kill cancerous cell with high energy lonizing radiation, during radiotherapy, inevitably can damage human normal cell, causes patient's resistance to decline, and has had a strong impact on patient's rehabilitation process.At present, tackle chemicotherapy side effect and do not have effective medicine, although some drugs can play certain mitigation, it,, when reducing side effect, has also suppressed the killing action of chemicotherapy to tumor cell.
(3) summary of the invention
The present invention is in order to make up the deficiencies in the prior art, a kind of medicine that reduces tumor chemoradiotherapy side effect is provided, not only can improve immunity of organisms, reduce the toxic action of chemicotherapy to human body, also can improve appetite depression, vomiting that chemicotherapy treatment brings, feel sick, the problem such as alopecia and leukopenia, can also strengthen in addition the therapeutic effect of chemicotherapy.
The present invention is achieved through the following technical solutions:
Reduce a medicine for tumor chemoradiotherapy side effect, its active component is made by the raw material of following parts by weight: Zinc-enriched selenium-enriched dried whole-egg 10-90 part, lentinan 1-50 part, Cordyceps militaris (L.) Link. 1-50 part and vitamin E 0.001-0.5 part.
The preparation method of described Zinc-enriched selenium-enriched dried whole-egg, comprises the steps:
(1) in common egg feedstuff per ton, add the zinc source additive of 500-3000g, the selenium source additive of 5-30g, after stirring, with it, feed laying hen, feed and collect the egg that laying hen produces after 7 days, be i.e. Zinc-enriched selenium-enriched egg;
(2) Zinc-enriched selenium-enriched Ovum Gallus domesticus album is washed, washed away surperficial dust and impurity;
(3) after egg is shelled, egg liquid is stirred, filters to remove impurity, and then sieve with 20 order dusting covers;
(4) at temperature 64-65 ℃, the egg liquid after filtering is carried out to pasteurize, the time is 5-8min;
(5) use high-pressure pump under the pressure of 15-25MPa the egg liquid through pasteurize, the droplet that is atomization shape through nozzle ejection, droplet enters drying tower with the hot blast through air air filter and heater heating, carries out heat exchange in drying tower, and egg liquid is dried to powdered egg powder.
(6) dry again after powdered egg moisture regain that will be dry, dry in the air that cool rear ground floor is 40 mesh sieves respectively through three layers of sieve, the second layer is 60 mesh sieves, the 3rd layer is 60 mesh sieves, obtains Zinc-enriched selenium-enriched dried whole-egg after sieving.
Described zinc source additive is zinc sulfate, zinc oxide or zinc gluconate.
Described selenium source additive is selenocarrageenan, sodium selenite or selenomethionine.
Content >=the 45mg/kg of zinc in described Zinc-enriched selenium-enriched dried whole-egg is, the content >=1.5mg/kg of selenium.
The dosage form of the medicine of described reduction tumor chemoradiotherapy side effect is tablet or electuary.
Usage and dosage:
Reduce the medicinal tablet 1g/ sheet of tumor chemoradiotherapy side effect, every day 3 times, each 4;
Reduce the medicine instant 6g/ bag of tumor chemoradiotherapy side effect, every day 2 times, each 1 bag.
The pharmaceutical characteristic of each active component of the present invention is as follows:
Zinc-enriched selenium-enriched dried whole-egg: zinc is Promote immunity allelotaxis's key factor, sufficient zinc can impel thymosin secretion, promotes the ability that T lymphocyte is attacked, annihilated pathogenic microorganism, improves immunity of organisms; Current research is found, if the intake of long-term nutrition zinc is not enough, can damage anti-oxidative defense function and the cytothesis mechanism of body, cause DNA to destroy and gene mutation, make the imbalance of immune surveillance network, can not reverse canceration bio signal, become the key factor that inspires cancer; Epidemiological study data shows, cancer patient's ubiquity zinc deficiency phenomenon, and zinc deficiency is the precipitating factor of the humans and animals esophageal carcinoma, and closely related with nitrosamine carcinogenesis, so zinc intake wretched insufficiency can increase the sickness rate of humans and animals digestive tract tumor; Selenium can directly affect by inhibition of cell proliferation, protein synthesis and copying of DNA the growth of tumor cell, under normal circumstances, in the organs such as the lymph node of human body, liver and spleen, Se content is higher, and these organize just immunocyte intensively, tumor patient blood selenium level is very low, selenium supplement can effectively improve patient's immunity, makes it complete smoothly chemicotherapy; Selenium, by being combined with heavy metal, forms metallic selenium albumen composition, and performance is detoxified, functions of expelling toxin; At chemotherapy, take larger dose selenium, can reduce leucocytes reduction, feel sick, the side effect such as vomiting, loss of appetite, serious alopecia, nephrotoxicity; Selenium supplement contributes to rationally to strengthen the dosage of chemotherapeutics, to obtain better curative effect; Long-term chemotherapy, malignant cell easily produces drug resistance, supplements high dose selenium when using chemotherapeutics, can significantly reduce the drug resistance of malignant cell to chemotherapeutics, makes it all the time chemotherapeutics to be kept to responsive, is easy to treatment; Selenium is powerful antioxidant, and human body is heavy dose of selenium supplement when radiotherapy, can improve rapidly antioxidant ability of organism, removes harmful free radical, the side effect while reducing radiotherapy; The mode that tradition is supplemented zinc, selenium is mostly to adopt the preparations such as zinc sulfate, zinc gluconate, sodium selenite, this zinc supplement, selenium mode zinc, selenium absorption rate are lower, some patients were also there will be digestive tract reaction (feel sick, vomit), take in a large number the absorption that also can affect other element, cause that in-vivo element is unbalance; Zinc glycyrrhetate has the edema of causing and hypokalemic danger, current also less employing; And make a living states of matter type protein-zinc and albumen selenium of contained zinc, selenium in the Zinc-enriched selenium-enriched dried whole-egg of the present invention, its version is consistent with zinc, the selenium form in human body, so good absorbing, active high, and protein and zinc, selenium are in conjunction with relative firm, can not separate out zinc, plasma selenium under one's belt, can toxic side effect, can long-term safety take;
Lentinan: lentinan has antitumor action, and there is no a toxic and side effects of chemotherapeutics, lentinan can induce body to produce a kind of immunocompetent cytokine that has after entering antibody, under the comprehensive function of these cytokines, body's immunity strengthens, and can play better defence and lethal effect to tumor cell; Lentinan can pass through activating macrophage, strengthens the cell toxicant (ADDC) of antibody dependent cellular induction, performance anti-tumor activity; In addition, lentinan can also make the vasodilation of tumor locus and hemorrhage, causes tumor hemorrhagic necrosis and degenerates completely;
Cordyceps militaris (L.) Link.: sweet in the mouth, property are flat, enter lung, kidney two warps, has the effect of " lung benefiting kidney, mends marrow, enriches blood and reduces phlegm "; Modern medicine study shows, Cordyceps militaris (L.) Link. contains the multiple active substance relevant to antitumor action, and as Cordyceps polysaccharide, cordycepin, nucleosides material, obviously inhibition tumor cell growth, has good anti-tumor activity; The ability that Cordyceps militaris (L.) Link. is engulfed tumor cell is 4 times of selenium, the contained cordycepin of Cordyceps militaris (L.) Link. can obviously strengthen the ability of red blood cell adhesion tumor cell, suppress growth and metastasis of tumours, can alleviate the inhibition of chemotherapeutics to bone marrow, obviously promote leukocyte and platelet counts, improve rapidly the symptoms such as vomiting after chemicotherapy is felt sick, poor appetite, alopecia, insomnia; Cordyceps militaris (L.) Link. and chemotherapeutics have synergism, can improve chemotherapeutic efficacy, and inducing apoptosis of tumour cell suppresses tumor growth; Cordyceps militaris (L.) Link. can be protected chemicotherapy patient's immunologic function, improves patient body state, makes patient complete smoothly chemicotherapy, improves quality of life of patients, extends life cycle;
Vitamin E: can effectively suppress tumor growth, prevent that chemical carcinogen from destroying intracellular gene; The shortage of vitamin E all has impact to the immunologic function of the mankind or animal, not only makes humoral immunization reduce, and cellular immunization is also had a significant impact; The antioxidation of vitamin E can also protect body cell to avoid the murder by poisoning of free radical.
Pharmaceutical formulation science of the present invention, have no side effect safely,, make a living states of matter type natural activity protein-zinc, albumen selenium of contained zinc selenium in Zinc-enriched selenium-enriched dried whole-egg, its version is consistent with the form of zinc selenium in human body, therefore good absorbing, active high and can toxic side effect, can long-term safety take; Biological state type natural activity protein-zinc, albumen selenium, lentinan, Cordyceps militaris (L.) Link., combination and cooperation onset, effect is remarkable, can improve immunity of organisms, reduce the toxic action of chemicotherapy to human body, can improve appetite depression, vomiting that chemicotherapy treatment brings, feel sick, the problem such as alopecia and leukopenia, can also strengthen in addition and regulate patient body immunity, strengthen the function of liver and kidney, promote sleep, stabilizing blood pressure, improves patient's whole quality of life, can effectively improve cancer patient's therapeutic effect.Treat altogether 1000 examples, total effective rate reaches 96%.
(4) specific embodiment
Below in conjunction with embodiment, the invention will be further described, but the present invention is not limited thereto, and the preparation method in embodiment is conventional preparation method, no longer describes in detail.
Embodiment 1:
This reduces the medicine of tumor chemoradiotherapy side effect, and its active component is made by the raw material of following weight: 50 kilograms of Zinc-enriched selenium-enriched dried whole-eggs, 25 kilograms of lentinan, 25 kilograms of Cordyceps militaris (L.) Link., 0.25 kilogram of vitamin E;
The preparation method of this Zinc-enriched selenium-enriched dried whole-egg, adopts following steps:
(1) in common egg feedstuff per ton, add zinc sulfate, zinc oxide or the zinc gluconate of 1500g, the sodium selenite of 20g, after stirring, with it, feed laying hen, feed and collect the egg that laying hen produces after 7 days, be Zinc-enriched selenium-enriched egg, now the zinc Se content in Zinc-enriched selenium-enriched egg be common egg 2-10 doubly;
(2) Zinc-enriched selenium-enriched egg cleans through egg automatic rinser, washes away surperficial dust and impurity;
(3) after egg is shelled, egg liquid is stirred, filters to remove the impurity such as scrambled egg shell, faciola, membrane of yolk, egg shell membrane, make egg liquid structural state even, for more effective, filter out impurities, except with mechanical filter, with 20 order dusting covers, sieve again, so that technique carries out and improve end product quality smoothly;
(4) at temperature 64-65 ℃, the egg liquid after filtering is carried out to pasteurize, the time is 5-8min, to kill escherichia coli and other miscellaneous bacterias, as large in egg liquid viscosity, can add a small amount of sterilized water, stirs, then carries out pasteurize;
(5) use high-pressure pump under the pressure of 15-25MPa the egg liquid through pasteurize, the droplet that is atomization shape through nozzle ejection, droplet enters drying tower with the hot blast through air air filter and heater heating, carries out heat exchange in drying tower, and egg liquid is dried to powdered egg powder; During spraying is dry, the control of temperature is: before general spraying, the temperature of drying tower, at 120-140 ℃, drops to 60-70 ℃ after injection, in spray process, hot blast temperature is controlled at 150-200 ℃, and powdered egg temperature is at 60-80 ℃. and the color of powdered egg, taste are normal like this, and water content could conformance with standard;
(6) in order to make dried powdered egg instant, need to be by dry again after dry powdered egg moisture regain, dry in the air cool rear respectively through three layers of sieve, ground floor is 40 mesh sieves, the second layer is 60 mesh sieves, the 3rd layer is 60 mesh sieves, obtains Zinc-enriched selenium-enriched dried whole-egg after sieving, and the content >=45mg/kg of zinc in Zinc-enriched selenium-enriched dried whole-egg is, the content >=1.5mg/kg of selenium;
The preparation method of the medicine of this reduction tumor chemoradiotherapy side effect is: by above-mentioned weight, take raw material, make the tablet of 1g/ sheet with the conventional preparation method of Chinese medicine.
Usage and consumption: oral, every day 3 times, each 4.
Embodiment 2:
This reduces the medicine of tumor chemoradiotherapy side effect, and its active component is made by the raw material of following weight: 10 kilograms of Zinc-enriched selenium-enriched dried whole-eggs, 1 kilogram of lentinan, 1 kilogram of Cordyceps militaris (L.) Link., 0.001 kilogram of vitamin E.
Preparation method and usage and dosage are with embodiment 1.
Embodiment 3:
This reduces the medicine of tumor chemoradiotherapy side effect, and its active component is made by the raw material of following weight: 90 kilograms of Zinc-enriched selenium-enriched dried whole-eggs, 50 kilograms of lentinan, 50 kilograms of Cordyceps militaris (L.) Link., 0.5 kilogram of vitamin E.
Preparation method and usage and dosage are with embodiment 1.
Embodiment 4:
This reduces the medicine of tumor chemoradiotherapy side effect, and its active component is made by the raw material of following weight: 30 kilograms of Zinc-enriched selenium-enriched dried whole-eggs, 12 kilograms of lentinan, 13 kilograms of Cordyceps militaris (L.) Link., 0.12 kilogram of vitamin E.
Preparation method and usage and dosage are with embodiment 1.
Embodiment 5:
This reduces the medicine of tumor chemoradiotherapy side effect, and its active component is made by the raw material of following weight: 70 kilograms of Zinc-enriched selenium-enriched dried whole-eggs, 35 kilograms of lentinan, 40 kilograms of Cordyceps militaris (L.) Link., 0.37 kilogram of vitamin E;
The preparation method of this Zinc-enriched selenium-enriched dried whole-egg, adopts following steps:
(1) in common egg feedstuff per ton, add zinc sulfate, zinc oxide or the zinc gluconate of 1500g, the sodium selenite of 20g, after stirring, with it, feed laying hen, feed and collect the egg that laying hen produces after 7 days, be Zinc-enriched selenium-enriched egg, now the zinc Se content in Zinc-enriched selenium-enriched egg be common egg 2-10 doubly;
(2) Zinc-enriched selenium-enriched egg cleans through egg automatic rinser, washes away surperficial dust and impurity;
(3) after egg is shelled, egg liquid is stirred, filters to remove the impurity such as scrambled egg shell, faciola, membrane of yolk, egg shell membrane, make egg liquid structural state even, for more effective, filter out impurities, except with mechanical filter, with 20 order dusting covers, sieve again, so that technique carries out and improve end product quality smoothly;
(4) at temperature 64-65 ℃, the egg liquid after filtering is carried out to pasteurize, the time is 5-8min, to kill escherichia coli and other miscellaneous bacterias, as large in egg liquid viscosity, can add a small amount of sterilized water, stirs, then carries out pasteurize;
(5) use high-pressure pump under the pressure of 15-25MPa the egg liquid through pasteurize, the droplet that is atomization shape through nozzle ejection, droplet enters drying tower with the hot blast through air air filter and heater heating, carries out heat exchange in drying tower, and egg liquid is dried to powdered egg powder; During spraying is dry, the control of temperature is: before general spraying, the temperature of drying tower, at 120-140 ℃, drops to 60-70 ℃ after injection, in spray process, hot blast temperature is controlled at 150-200 ℃, and powdered egg temperature is at 60-80 ℃. and the color of powdered egg, taste are normal like this, and water content could conformance with standard;
(6) in order to make dried powdered egg instant, need to be by dry again after dry powdered egg moisture regain, dry in the air cool rear respectively through three layers of sieve, ground floor is 40 mesh sieves, the second layer is 60 mesh sieves, the 3rd layer is 60 mesh sieves, obtains Zinc-enriched selenium-enriched dried whole-egg after sieving, and the content >=45mg/kg of zinc in Zinc-enriched selenium-enriched dried whole-egg is, the content >=1.5mg/kg of selenium;
The preparation method of the medicine of this reduction tumor chemoradiotherapy side effect is: by above-mentioned weight, take raw material, make the electuary of 6g/ bag with the conventional preparation method of Chinese medicine.
Usage and consumption: with mixing in water for oral taking, every day 2 times, each 1 bag.
Embodiment 6:
This reduces the medicine of tumor chemoradiotherapy side effect, and its active component is made by the raw material of following weight: 20 kilograms of Zinc-enriched selenium-enriched dried whole-eggs, 7 kilograms of lentinan, 8 kilograms of Cordyceps militaris (L.) Link., 0.06 kilogram of vitamin E.
Preparation method and usage and dosage are with embodiment 5.
Embodiment 7:
This reduces the medicine of tumor chemoradiotherapy side effect, and its active component is made by the raw material of following weight: 60 kilograms of Zinc-enriched selenium-enriched dried whole-eggs, 30 kilograms of lentinan, 30 kilograms of Cordyceps militaris (L.) Link., 0.31 kilogram of vitamin E.
Preparation method and usage and dosage are with embodiment 5.
Embodiment 8:
This reduces the medicine of tumor chemoradiotherapy side effect, and its active component is made by the raw material of following weight: 80 kilograms of Zinc-enriched selenium-enriched dried whole-eggs, 40 kilograms of lentinan, 46 kilograms of Cordyceps militaris (L.) Link., 0.43 kilogram of vitamin E.
Preparation method and usage and dosage are with embodiment 5.
Clinical observation:
(1) clinical data
In order to verify the curative effect of this medicine, the inventor from 2008 so far, observes altogether treatment 1000 examples and through pathology, is diagnosed as the chemicotherapy patient of malignant tumor, male 610 examples wherein, female's 390 examples, age 29-68 year, average 45.8 years old; Wherein adenocarcinoma of lung 270 examples, bronchovesicular cancer 140 examples, esophageal carcinoma 170 examples, nasopharyngeal carcinoma 80 examples, mammary cancer 1 00 example, uterus carcinoma 130 examples, ovarian germ cell tumors 10 examples, lymphatic cancer 60 examples, intestinal cancer 40 examples.
(2) Therapeutic Method
The present invention reduces the medicinal tablet 1g/ sheet of tumor chemoradiotherapy side effect, oral, every day 3 times, each 4; The present invention reduces the medicine instant 6g/ bag of tumor chemoradiotherapy side effect, with mixing in water for oral taking, every day 2 times, and each 1 bag.
(3) curative effect determinate standard
" effective ": chemicotherapy side effect obviously alleviates.
" effectively ": chemicotherapy side effect is slightly improved.
Engineering noise: chemicotherapy side effect is without improvement.
(4) therapeutic effect:
Clinical observation treatment 1000 examples, effective 770 examples, account for 77%; Effective 190 examples, account for 19%; Invalid 40 examples, total effective rate 96%.
Good absorbing effect of the present invention, evident in efficacy, have no side effect, safe, be conducive to patient and alleviate in time condition of illness.In to the process of various concurrent chemoradiotherapy of malignant tumor treatment, can play the effect of auxiliary treatment, alleviate the untoward reaction during Chemotherapy in Patients.
Model case:
Case 1: Lin, female, 39 years old.Suffer from breast carcinoma, when chemotherapeutic treatment is after 2 courses for the treatment of, occur serious nausea and vomiting, alopecia, inappetence symptom.Take the made medicinal tablet of the embodiment of the present invention 1,1g/ sheet, oral, every day 3 times, each 4, after three weeks, various malaise symptoms obviously alleviate, and appetite strengthens.
Case 2: Lee, man, 50 years old.Suffer from esophageal carcinoma, after 1 course for the treatment of of radiotherapy, occur that whole body fatigue and weak, lethargy, leukocyte and platelet decline.Take the made medicinal tablet of the embodiment of the present invention 2,1g/ sheet, oral, every day 3 times, each 4, after two weeks, the mental status is improved, and therapeutic effect is good.
Case 3: Korea Spro, man, 60 years old.Suffer from nasopharyngeal carcinoma, radiotherapy is main, and chemotherapy is auxiliary, after treating 2 courses for the treatment of, occurs that obstinate headache is dizzy, abdominal distention diarrhoea.Take the made medicinal tablet of the embodiment of the present invention 4,1g/ sheet, oral, every day 3 times, each 4, after surrounding, headache and dizzy is alleviated, and abdominal distention diarrhoea alleviates, and therapeutic effect is good.
Case 4: permitted certain, female 61 years old.Suffer from right lung adenocarcinoma, within after excision 4 months, carry out chemotherapy, spiritlessness and weakness, deficiency of QI with disinclination to talk, pale complexion, loss of appetite, soreness of waist and knee joint, dizziness and tinnitus after end of chemotherapy, check that routine blood test shows: leukocyte: 2.9 * 10
9l, erythrocyte 3.12 * 10
12/ L, takes the made medicine instant of the present embodiment 5,6g/ bag, and with mixing in water for oral taking, every day 2 times, each 1 bag, after six weeks, patient's muscle power increases, dizziness and tinnitus, soreness of waist and knee joint transference cure, check routine blood test, indices all rises to normal range.
Case 5: Zhang, man, 50 years old.Suffer from right lung adenocarcinoma pulmonary carcinoma, alopecia after chemotherapy 3 times, people is partially thin, and face is without color, listless.Take the made medicine instant of the embodiment of the present invention 8,6g/ bag, with mixing in water for oral taking, every day 2 times, each 1 bag, after five weeks, patient's spirit is clearly better, and body weight increases by 3 jin.
Claims (6)
1. a medicine that reduces tumor chemoradiotherapy side effect, is characterized in that: its active component is made by the raw material of following parts by weight: Zinc-enriched selenium-enriched dried whole-egg 10-90 part, lentinan 1-50 part, Cordyceps militaris (L.) Link. 1-50 part and vitamin E 0.001-0.5 part.
2. a kind of medicine that reduces tumor chemoradiotherapy side effect according to claim 1, is characterized in that: the preparation method of described Zinc-enriched selenium-enriched dried whole-egg, comprises the steps:
(1) in common egg feedstuff per ton, add the zinc source additive of 500-3000g, the selenium source additive of 5-30g, after stirring, with it, feed laying hen, feed and collect the egg that laying hen produces after 7 days, be i.e. Zinc-enriched selenium-enriched egg;
(2) Zinc-enriched selenium-enriched Ovum Gallus domesticus album is washed, washed away surperficial dust and impurity;
(3) after egg is shelled, egg liquid is stirred, filters to remove impurity, and then sieve with 20 order dusting covers;
(4) at temperature 64-65 ℃, the egg liquid after filtering is carried out to pasteurize, the time is 5-8min;
(5) use high-pressure pump under the pressure of 15-25MPa the egg liquid through pasteurize, the droplet that is atomization shape through nozzle ejection, droplet enters drying tower with the hot blast through air air filter and heater heating, carries out heat exchange in drying tower, and egg liquid is dried to powdered egg powder.
(6) dry again after powdered egg moisture regain that will be dry, dry in the air that cool rear ground floor is 40 mesh sieves respectively through three layers of sieve, the second layer is 60 mesh sieves, the 3rd layer is 60 mesh sieves, obtains Zinc-enriched selenium-enriched dried whole-egg after sieving.
3. a kind of medicine that reduces tumor chemoradiotherapy side effect according to claim 2, is characterized in that: described zinc source additive is zinc sulfate, zinc oxide or zinc gluconate.
4. a kind of medicine that reduces tumor chemoradiotherapy side effect according to claim 2, is characterized in that: described selenium source additive is selenocarrageenan, sodium selenite or selenomethionine.
5. a kind of medicine that reduces tumor chemoradiotherapy side effect according to claim 1 and 2, is characterized in that: the content >=45mg/kg of zinc in described Zinc-enriched selenium-enriched dried whole-egg is, the content >=1.5mg/kg of selenium.
6. a kind of medicine that reduces tumor chemoradiotherapy side effect according to claim 1, is characterized in that: the dosage form of the medicine of described reduction tumor chemoradiotherapy side effect is tablet or electuary.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105901559A (en) * | 2016-04-21 | 2016-08-31 | 窦观 | Adjustable-type quantitatively-accurate selenium-supplement egg powder |
| CN106692178A (en) * | 2017-02-22 | 2017-05-24 | 泗洪雅苏中草药种植有限公司 | Pure traditional Chinese medicine preparation and application thereof |
| CN109123648A (en) * | 2018-10-19 | 2019-01-04 | 陈玉祥 | For mitigating the composition and preparation method thereof of carcinosis radiotherapy and chemotherapy toxic side effect |
| CN115989872A (en) * | 2022-12-07 | 2023-04-21 | 山东欣希安药业股份有限公司 | Composition for improving nutritional status of tumor patient and preparation method thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1185908A (en) * | 1996-12-27 | 1998-07-01 | 李江 | Functional cordyceps sinensis milk, products made from cordyceps sinensis milk and preparation thereof |
| CN1304663A (en) * | 2000-12-12 | 2001-07-25 | 李江 | Canned Se-enriched cordyceps militaris and its preparing process |
| CN101248869A (en) * | 2008-04-09 | 2008-08-27 | 李勇 | Method for preparing health care food by edible fungus mycelium or seed |
| CN101313760A (en) * | 2007-05-28 | 2008-12-03 | 河南商都生物技术股份有限公司 | Egg with strengthened micro-element nutrition, preparation and uses thereof |
| CN102266036A (en) * | 2011-05-17 | 2011-12-07 | 湖北省农业科学院农产品加工与核农技术研究所 | Mushroom and cordyceps militaris extract flavoring and preparation method thereof |
-
2014
- 2014-05-31 CN CN201410243030.5A patent/CN104055802A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1185908A (en) * | 1996-12-27 | 1998-07-01 | 李江 | Functional cordyceps sinensis milk, products made from cordyceps sinensis milk and preparation thereof |
| CN1304663A (en) * | 2000-12-12 | 2001-07-25 | 李江 | Canned Se-enriched cordyceps militaris and its preparing process |
| CN101313760A (en) * | 2007-05-28 | 2008-12-03 | 河南商都生物技术股份有限公司 | Egg with strengthened micro-element nutrition, preparation and uses thereof |
| CN101248869A (en) * | 2008-04-09 | 2008-08-27 | 李勇 | Method for preparing health care food by edible fungus mycelium or seed |
| CN102266036A (en) * | 2011-05-17 | 2011-12-07 | 湖北省农业科学院农产品加工与核农技术研究所 | Mushroom and cordyceps militaris extract flavoring and preparation method thereof |
Non-Patent Citations (3)
| Title |
|---|
| 中华中医药学刊: "蘑菇和鸡蛋等食物降低胰腺癌风险", 《中华中医药学刊》 * |
| 关惠连: "在大白鼠低蛋白食料中添加全鸡蛋粉和胆碱对二甲基黄诱发肝癌癌变及肝脏中核酸和磷脂的影响", 《中山医学院学报》 * |
| 邱小文、肖桂珍 等: "高效免疫蛋粉i26肠内免疫营养对胃癌患者术后化疗免疫及营养支持效果的影响", 《安徽医药 》 * |
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| CN105901559A (en) * | 2016-04-21 | 2016-08-31 | 窦观 | Adjustable-type quantitatively-accurate selenium-supplement egg powder |
| CN106692178A (en) * | 2017-02-22 | 2017-05-24 | 泗洪雅苏中草药种植有限公司 | Pure traditional Chinese medicine preparation and application thereof |
| CN109123648A (en) * | 2018-10-19 | 2019-01-04 | 陈玉祥 | For mitigating the composition and preparation method thereof of carcinosis radiotherapy and chemotherapy toxic side effect |
| CN115989872A (en) * | 2022-12-07 | 2023-04-21 | 山东欣希安药业股份有限公司 | Composition for improving nutritional status of tumor patient and preparation method thereof |
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