CN104045615B - (1s)-1-[4-氯-3-(4-乙氧基苄基)苯基]-1,6-二脱氧-d-葡萄糖的晶型a及其制备方法和应用 - Google Patents

(1s)-1-[4-氯-3-(4-乙氧基苄基)苯基]-1,6-二脱氧-d-葡萄糖的晶型a及其制备方法和应用 Download PDF

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Publication number
CN104045615B
CN104045615B CN201310239524.1A CN201310239524A CN104045615B CN 104045615 B CN104045615 B CN 104045615B CN 201310239524 A CN201310239524 A CN 201310239524A CN 104045615 B CN104045615 B CN 104045615B
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crystal form
glucose
dideoxy
phenyl
chloro
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Chinese (zh)
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CN104045615A (zh
Inventor
赵桂龙
刘冰妮
魏群超
王玉丽
刘鹏
李川
张海枝
徐为人
汤立达
邹美香
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Guangzhou Lixin Pharmaceuticals Co ltd
Tianjin Institute of Pharmaceutical Research Co Ltd
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Tianjin Institute of Pharmaceutical Research Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A61K31/708—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid having oxo groups directly attached to the purine ring system, e.g. guanosine, guanylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
CN201310239524.1A 2013-03-15 2013-06-17 (1s)-1-[4-氯-3-(4-乙氧基苄基)苯基]-1,6-二脱氧-d-葡萄糖的晶型a及其制备方法和应用 Active CN104045615B (zh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN201310239524.1A CN104045615B (zh) 2013-03-15 2013-06-17 (1s)-1-[4-氯-3-(4-乙氧基苄基)苯基]-1,6-二脱氧-d-葡萄糖的晶型a及其制备方法和应用
PCT/CN2014/073365 WO2014139447A1 (fr) 2013-03-15 2014-03-13 Forme cristalline a de (1s)-1-[4-chloro-3-(4-éthoxybenzyl)phényl]-1,6-didésoxy-d-glucose et procédé de préparation et utilisation de celle-ci

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201310084842.5 2013-03-15
CN201310084842 2013-03-15
CN201310239524.1A CN104045615B (zh) 2013-03-15 2013-06-17 (1s)-1-[4-氯-3-(4-乙氧基苄基)苯基]-1,6-二脱氧-d-葡萄糖的晶型a及其制备方法和应用

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CN104045615A CN104045615A (zh) 2014-09-17
CN104045615B true CN104045615B (zh) 2015-11-18

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WO (1) WO2014139447A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016155578A1 (fr) * 2015-03-27 2016-10-06 苏州晶云药物科技有限公司 Nouvelle forme cristalline de dapagliflozine et son procédé de préparation
CN108675976B (zh) * 2018-05-14 2020-07-14 浙江宏元药业股份有限公司 一种6-卤代葡萄糖碳苷及其制备方法和应用
CN111559997A (zh) * 2019-02-13 2020-08-21 罗欣药业(上海)有限公司 一种达格列净新晶型及其制备方法
WO2021176096A1 (fr) 2020-03-05 2021-09-10 Krka, D.D., Novo Mesto Composition pharmaceutique comprenant un inhibiteur du sglt2

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101065391A (zh) * 2004-09-23 2007-10-31 布里斯托尔-迈尔斯斯奎布公司 C－芳基葡糖苷sglt2抑制剂和方法
CN102408459A (zh) * 2011-09-29 2012-04-11 天津药物研究院 一类含异头位烷基的苯基c-葡萄糖苷衍生物、其制备方法和用途

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101065391A (zh) * 2004-09-23 2007-10-31 布里斯托尔-迈尔斯斯奎布公司 C－芳基葡糖苷sglt2抑制剂和方法
CN102408459A (zh) * 2011-09-29 2012-04-11 天津药物研究院 一类含异头位烷基的苯基c-葡萄糖苷衍生物、其制备方法和用途

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WO2014139447A1 (fr) 2014-09-18

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Address after: 300193 Tianjin City, Nankai District Anshan West Road No. 308

Patentee after: Tianjin Institute of Pharmaceutical Research Co.,Ltd.

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Address after: Guangzhou hi tech Development Zone 510663 Guangdong Science City skim Springs Road No. 3, Guangzhou international business incubator A A1206

Patentee after: GUANGZHOU LIXIN PHARMACEUTICALS CO.,LTD.

Address before: 300193 Tianjin City, Nankai District Anshan West Road No. 308

Patentee before: Tianjin Institute of Pharmaceutical Research Co.,Ltd.