CN104043147B - Anesthesia Department sucks blood by the preparation method of sponge - Google Patents
Anesthesia Department sucks blood by the preparation method of sponge Download PDFInfo
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Abstract
The present invention relates to a kind of Anesthesia Department and suck blood by sponge and preparation method, mainly take off the raw material stating weight proportion to be prepared from: Myrrha 3-8 part, Ilex purpurea Hassk.[I.chinensis Sims 10-18 part, Radix Notoginseng 16-22 part, Herba Artemisiae Anomalae 7-13 part, Herba Scutellariae Barbatae 12-19 part, Endoconcha Sepiae 10-14 part, Herba Acalyphae 6-10 part, Olibanum 7-15 part, Herba Schizonepetae 12-20 part, Herba Euphorbiae Humifusae 13-21 part, Rhizoma Paridis tetraphyllae's 7-14 part.The present invention has scientific formula, with low cost, and the feature such as have no side effect, and adds sponge by having the Chinese medicine composition of hemostasis effectiveness, makes sponge to physical exertion anastalsis while absorbing blood, it may be achieved the efficiently effect of quick-acting haemostatic powder.
Description
Technical field
The present invention relates to a kind of Anesthesia Department to suck blood by sponge and preparation method, belonged to traditional Chinese medicine field, be mainly used in containment otch and wound hemorrhage.
Background technology
It is hemorrhage that operation technique inevitably causes from tremulous pulse, vein and blood capillary, and hemorrhage in operation can affect visual area, upsets surgical operation technique, severe patient threat to life.Hemostatic technique is one of core of operation basic fundamental, and along with the development of modern science and technology, hemostatic technique has developed into the mature technology system including medicine, equipment, anesthesia etc..In recent years, the research that Chinese medicine plays anastalsis is increasing, is too many levels, by all kinds of means with Western medicine hemostasis the difference is that, Chinese medicine plays the mechanism of anastalsis.Absorbable gelatin sponge is a kind of local hemostatic, belongs to hemostasis quasi drugs, and the light weight for white or micro-Huang is soft and the sponge of porous, has water absorption；Though rubbing through heavier, will not collapse broken.Absorbable gelatin sponge has large area water sucting surface, and whole sponge, up to more than 30 times of this product volume, is pasted on wound surface by water absorption, it is possible to sucks the blood of the blood flow of several times bigger than weight own, and makes blood within it solidify as a mold.This product itself then can by Absorption of antibody in 4～6 weeks, therefore can in indwelling body cavity or wound intracavity.Undue scar tissue and bad fiberization is not produced with contact tissue.
Suck blood with in the pertinent literature of sponge existing, application publication number CN102753203A(application number 201080061630.X) Chinese patent literature disclose a kind of hemostasis composite sponge, it comprises biomaterial porous matrix and for strengthening described sponge for being applied the adhering material of tissue, and when using, at least one surface of described sponge is connected with the described tissue that is applied securely；Additionally provide a kind of method producing these sponges and their purposes in hemostasis.Application publication number CN103224645A(application number 201310170559.4) Chinese patent literature disclose a kind of sthptic sponge and application thereof, this sthptic sponge is by modified starch of the prior art degeneration again and is finally prepared from through microwave treatment.Application publication number CN102475900A(application number 201010553421.9) Chinese patent literature disclose hemostatic material that a kind of Pseudobulbus Bletillae (Rhizoma Bletillae) makes and preparation method thereof, it is dissolved in water with Pseudobulbus Bletillae polysaccharose, make concentration 1-3% aqueous solution, make under low temperature and vacuum drying.
At present, the prior art including above-mentioned patent documentation remains deficiency in solving wound bleeding, and such as uncertain therapeutic efficacy is cut, with high costs etc..A kind of Anesthesia Department of clinical practice urgent need sucks blood and uses sponge.
Summary of the invention
For the present situation of the various bleeding of Anesthesia Department and patient, it is an object of the invention to provide a kind of Anesthesia Department can effectively sucked blood and stop blooding and suck blood by sponge and preparation method.
The above-mentioned purpose of the present invention is achieved through the following technical solutions:
Anesthesia Department sucks blood with sponge, take off the primary raw material stating weight proportion to be prepared from: Myrrha 3-8 part, Ilex purpurea Hassk.[I.chinensis Sims 10-18 part, Radix Notoginseng 16-22 part, Herba Artemisiae Anomalae 7-13 part, Herba Scutellariae Barbatae 12-19 part, Endoconcha Sepiae 10-14 part, Herba Acalyphae 6-10 part, Olibanum 7-15 part, Herba Schizonepetae 12-20 part, Herba Euphorbiae Humifusae 13-21 part, Rhizoma Paridis tetraphyllae's 7-14 part.
Above-mentioned Anesthesia Department sucks blood with sponge, it is preferred that scheme, takes off the primary raw material stating weight proportion and is prepared from: Myrrha 5-6 part, Ilex purpurea Hassk.[I.chinensis Sims 13-15 part, Radix Notoginseng 18-20 part, Herba Artemisiae Anomalae 9-11 part, Herba Scutellariae Barbatae 15-16 part, Endoconcha Sepiae 11-13 part, Herba Acalyphae 7-9 part, Olibanum 9-13 part, Herba Schizonepetae 14-18 part, Herba Euphorbiae Humifusae 16-18 part, Rhizoma Paridis tetraphyllae's 9-12 part.
The above Anesthesia Department sucks blood and uses sponge, and more preferably preferred scheme, takes off the primary raw material stating weight proportion and be prepared from: Myrrha 6 parts, Ilex purpurea Hassk.[I.chinensis Sims 14 parts, Radix Notoginseng 19 parts, Herba Artemisiae Anomalae 10 parts, Herba Scutellariae Barbatae 16 parts, Endoconcha Sepiae 12 parts, Herba Acalyphae 8 parts, Olibanum 11 parts, Herba Schizonepetae 16 parts, Herba Euphorbiae Humifusae 17 parts, Rhizoma Paridis tetraphyllae 10 parts.
Sucking blood according to any of the above described Anesthesia Department and use sponge, its preparation methods steps is as follows:
(1) yellow wine that weight ratio is 2-4:1 is mixed to get adjuvant with vinegar, take Myrrha and the Olibanum of cleaning, add the adjuvant of 0.1-0.3 times that weight is Myrrha and Olibanum weight, slightly moistening, after liquid is sucked, is placed in marmite, heat with slow fire, frying to surface and show glossy gloss, taking-up is dried in the air cool, standby；
(2) Endoconcha Sepiae taking cleaning is placed in and forges in tank, upper cover one pannikin, and commissure, with yellow mud sealing, pannikin is put several rice, with slow fire grilling, waits a meter zoom Huang, takes out, must forge Endoconcha Sepiae, cool standby after truce；
(3) Ilex purpurea Hassk.[I.chinensis Sims, Herba Scutellariae Barbatae, Herba Acalyphae, Herba Euphorbiae Humifusae, Rhizoma Paridis tetraphyllae and step (2) gained are forged Endoconcha Sepiae, pulverize, cross 100-160 mesh sieve, standby；
(4) Radix Notoginseng, Herba Artemisiae Anomalae and Herba Schizonepetae vinegar is soaked 3-6 hour, taking-up drains, mix with step (3) gained medicated powder, boiling 2 times, adds 2-5 times amount water every time, each pan-fried 1-3 hour (preferably 2 hours), it is then combined with medicinal liquid, centrifugation, taking supernatant concentration to relative density is the concentrated solution of 0.6-0.8, stand-by；
(5) chitosan is configured to, with the glacial acetic acid solution of 1%, the chitosan solution that mass concentration is 3%, mixes with the ratio of 1:1 with step (4) gained filtrate；
(6) step (5) gained solution, fish gelatin solution and glycerol are pressed the volume ratio mixing of 5:2:3, and evacuation is degassed；
(7) step (6) gained mixed liquor is placed in silica gel mould (6cm × 3cm × 1.5cm), freezing 18-24 hour in-50 DEG C, put in freezer dryer-70 DEG C of lyophilisation 36 hours, Ji get Anesthesia Department medicated sponge.
According to preparation method recited above, it is preferred that scheme is, the consumption of step (1) adjuvant is 0.2 times of Myrrha and Olibanum weight.
According to preparation method recited above, it is preferred that scheme is, step (3) crosses 120-140 mesh sieve (preferably 130 mesh sieve).
According to preparation method recited above, it is preferred that scheme is, the soak time of step (4) vinegar is 4-5 hour (preferably 4.5 hours).
According to preparation method recited above, it is preferred that scheme is, step (4) amount of water is 3-4 times (preferred amount of water is 3.5 times).
According to preparation method recited above, it is preferred that scheme is, step (4) is concentrated into the concentrated solution that relative density is 0.7.
According to preparation method recited above, it is preferred that scheme is, step (7) cooling time is 20-22 hour (preferably 21 hours).
Anesthesia Department sucks blood and uses sponge, and the pharmacological effect of each raw material of contained Chinese medicine is respectively as follows:
Myrrha: for the gum resin of olive subject plant myrrh or Alan fort myrrh.Dissipate blood blood stasis removing, subduing swelling and relieving pain.Control and fall damage, incised wound, muscles and bones, all pains of trusted subordinate, abdominal mass, amenorrhea, ulcer sore pain, anal fistula, diseases of the eye.
Ilex purpurea Hassk.[I.chinensis Sims: bitter, puckery is cool.Heat-clearing and toxic substances removing；Promoting tissue regeneration and ulcer healing；Promoting blood circulation and hemostasis.Cure mainly cough due to lung-heat；Laryngopharynx swelling and pain；Dysentery；Diarrhoea；Biliary tract infection；Urinary tract infection；Angina pectoris；Burn and scald；Pyretic toxicity carbuncle；Ulcer of the lower limb；Leprelcosis；Eczema；Chilblain；Chap；Thromboangiitis obliterans；Traumatic hemorrhage.
Radix Notoginseng: hardship sweet, micro-, temperature.Return liver, lung, the heart, large intestine channel.Effect: hemostasis dissipating blood stasis, subduing swelling and relieving pain.Cure mainly haematemesis, hemoptysis, hematuria, have blood in stool, dysentery, metrorrhagia, postpartum hemorrhage, traumatic hemorrhage, injury from falling down, obstruction of qi in the chest and cardialgia, the gastral cavity side of body for a long time pain, abdominal mass amasss block, blood stasis amenorrhea, dysmenorrhea, puerperal the stagnant stomachache of the stasis of blood, sore, carbuncle and painful swelling.
Herba Artemisiae Anomalae: for the wounded in the battle herb of Compositae sagebruss artemisia anomalas.The property of medicine: bitter, pungent, temperature.GUIXIN, liver, spleen channel.Effect: removing blood stasis dysmenorrhea, removing food stagnancy, hemostasia and detumescence.Cure mainly amenorrhea due to stagnation of blood, dysmenorrhea, puerperal the stagnant stomachache of the stasis of blood, abdominal mass, abdominal pain due to retention of food, traumatic injury, incised wound is hemorrhage, hematuria, carbuncle poison, scalds.
Herba Scutellariae Barbatae: for the herb of Labiatae Scutellaria plant Herba Scutellariae Barbatae.Pungent, bitter, cold.Return lung, liver, kidney channel.Heat-clearing and toxic substances removing, hemostasis, detumescence.Cure mainly pyretic toxicity carbuncle, have sore throat, lung abscess acute appendicitis, scrofula, traumatic injury, various hemorrhage, edema, ascites and cancer.
Endoconcha Sepiae: for the inner shell of the multiple sepiellae seu sepiaes such as Sepiidae sepiella maindroni de Rochebrune, Sepia animal golden cuttlefish.The property of medicine: salty, puckery, temperature.Return liver, kidney channel.Effect: astringing to arrest bleeding, treating spontaneous emission and leukorrhagia, relieving gastric hyperacidity to alleviate stomachache, removing dampness sore.Cure mainly haematemesis, hematemesis, metrorrhagia, have blood in stool, epistaxis, wound hemorrhage, emission due to deficiency of the kidney spermatorrhea, leucorrhea with red and white discharge, have a stomachache noisy, belch pantothenic acid, eczema ulcer.
Herba Acalyphae: the herb of Euphorbiaceae Acalypha plant iron Amaranthus mangostanus L. and Acalypha brachystachya Hornem.Bitter, puckery, cool.GUIXIN, lung, large intestine, small intestine meridian.Clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body, removing food stagnancy.Cure mainly dysentery, have loose bowels, spit blood, epistaxis, hematuria, have blood in stool, metrorrhagia, infantile malnutrition, carbuncle furuncle infections, skin eczema.
Olibanum: the oleo-gum-resin oozed out for skin zones such as Burseraceae Boswellia Boswellia carterii, Bao Da Boswellia carterii, wild Boswellia carteriis.The property of medicine: pungent, bitter, temperature.GUIXIN, liver, spleen channel.Effect: invigorate blood circulation, circulation of qi promoting, pain relieving.Cure mainly trusted subordinate's pain, amenorrhea, dysmenorrhea, puerperal the stagnant stomachache of the stasis of blood, traumatic injury stasis of blood pain, swollen ulcer drug, the sore being festered and unhealed.
Herba Schizonepetae: for the herb of Labiatae Schizonepeta tenuifolia platymiscium Herba Schizonepetae and many lobed leaf Herba Schizonepetae.The property of medicine: hardship pungent, micro-, tepor.Return lung, Liver Channel.Effect: dispel the wind, induces sweat, rash, hemostasis.Cure mainly cold, fever, headache, eye itching, cough, laryngopharynx swelling and pain, measles, rubella, carbuncle, skin ulcer scabies, epistaxis, spit blood, have blood in stool, metrorrhagia, puerperal blood faints.
Herba Euphorbiae Humifusae: for the herb of euphorbia plant Radix seu Caulis Parthenocissi tricuspidatae or Herba Euphorbiae supinae.Pungent, flat.Return liver, large intestine channel.Heat clearing away, dampness removing, jaundice eliminating, hemostasis.Cure mainly dysentery, have loose bowels, jaundice, hemoptysis, spit blood, hematuria, have blood in stool, metrorrhagia, agalactia, treating swelling and pain by traumatic injury and pathopyretic ulcer, the rotten skin ulcer of ecthyma.
Rhizoma Paridis tetraphyllae: for the rhizome of Liliaceae paris plant Paris bashanensis Wang et Tang.The property of medicine: bitter, pungent, temperature.Effect: expelling cold and dampness, removing obstruction in the collateral to relieve pain, hemostasia and promoting granulation.Cure mainly chronic arthralgia caused by cold-damp, chills and pain of the waist and kness, traumatic hemorrhage.
The invention has the beneficial effects as follows:
1, the Anesthesia Department of the present invention sucks blood and uses sponge, and the prescription of contained Chinese medicine is according to modern Chinese medicine pharmacology, have passed through again clinical trial for many years, constantly gropes formation；Wherein Ilex purpurea Hassk.[I.chinensis Sims, Radix Notoginseng, Endoconcha Sepiae and Rhizoma Paridis tetraphyllae are hemostasis principal agent, Herba Artemisiae Anomalae, Herba Scutellariae Barbatae, Herba Acalyphae, Herba Schizonepetae and Herba Euphorbiae Humifusae are accessory drugs, the premium properties feature of crude drug and the complementary superposition of they performances are given full play to, there is promoting blood circulation to remove blood stasis, the several functions such as astringing to arrest bleeding, Myrrha and Olibanum then serve and well balance the property of medicine, eliminate this Chinese medicine function to the infringement of health；Owing to medicine source is easy to get, so the present invention is cheap compared with other hemorrhage；
2, the Chinese medicine composition with hemostasis effectiveness is added in sponge, make sponge to physical exertion anastalsis while absorbing blood, the effect of efficient quick-acting haemostatic powder can be played.
Detailed description of the invention
Describe technical scheme in detail below in conjunction with embodiment and experimental example, but protection domain is not by this restriction.
Embodiment 1 Anesthesia Department sucks blood with sponge, takes off the primary raw material stating weight proportion and is prepared from (every part takes 25g): Myrrha 3 parts, Ilex purpurea Hassk.[I.chinensis Sims 10 parts, Radix Notoginseng 16 parts, Herba Artemisiae Anomalae 7 parts, Herba Scutellariae Barbatae 12 parts, Endoconcha Sepiae 10 parts, Herba Acalyphae 6 parts, Olibanum 7 parts, Herba Schizonepetae 12 parts, Herba Euphorbiae Humifusae 13 parts, Rhizoma Paridis tetraphyllae 7 parts.
Above-mentioned Anesthesia Department sucks blood by the preparation method of sponge, and step is as follows:
(1) yellow wine that weight ratio is 2:1 and vinegar are mixed to get adjuvant, take Myrrha and the Olibanum of cleaning, add the adjuvant of 0.1 times that weight is Myrrha and Olibanum weight, slightly moistening, after liquid is sucked, it is placed in marmite, heats with slow fire, frying to surface and show glossy gloss, taking-up is dried in the air cool, standby；
(2) Endoconcha Sepiae taking cleaning is placed in and forges in tank, upper cover one pannikin, and commissure, with yellow mud sealing, pannikin is put several rice, with slow fire grilling, waits a meter zoom Huang, takes out, must forge Endoconcha Sepiae, cool standby after truce；
(3) Ilex purpurea Hassk.[I.chinensis Sims, Herba Scutellariae Barbatae, Herba Acalyphae, Herba Euphorbiae Humifusae, Rhizoma Paridis tetraphyllae and step (2) gained are forged Endoconcha Sepiae, pulverize, cross 100 mesh sieves, standby；
(4) being soaked 3 hours by Radix Notoginseng, Herba Artemisiae Anomalae and Herba Schizonepetae vinegar, taking-up drains, and mixes with step (3) gained medicated powder, boiling 2 times, add 2 times amount water every time, each pan-fried 1 hour, be then combined with medicinal liquid, centrifugation, taking supernatant concentration to relative density is the concentrated solution of 0.6, stand-by；
(5) chitosan is configured to, with the glacial acetic acid solution of 1%, the chitosan solution that mass concentration is 3%, mixes with the ratio of 1:1 with step (4) gained filtrate；
(6) step (5) gained solution, fish gelatin solution and glycerol are pressed the volume ratio mixing of 5:2:3, and evacuation is degassed；
(7) step (6) gained mixed liquor is placed in silica gel mould (6cm × 3cm × 1.5cm), in-50 DEG C of freezings 18 hours, puts in freezer dryer-70 DEG C of lyophilisation 36 hours, Ji get Anesthesia Department medicated sponge.
Typical case one pair certain, 36 years old, man.In JIUYUE, 2013 has carried out intracavity urological surgery because suffering from renal calculus, Post operation is because of aggravating activities, operation and incision are burst apart, a large amount of oozing of blood occurs, oozing of blood is wiped only by nurse immediately, it is pasted on wound surface with the embodiment of the present invention 1 gained sponge immediately, then is oppressed with dry gauze, patient's no longer oozing of blood after 4 minutes.
Embodiment 2 Anesthesia Department sucks blood with sponge, takes off the primary raw material stating weight proportion and is prepared from (every part takes 5g): Myrrha 8 parts, Ilex purpurea Hassk.[I.chinensis Sims 18 parts, Radix Notoginseng 22 parts, Herba Artemisiae Anomalae 13 parts, Herba Scutellariae Barbatae 19 parts, Endoconcha Sepiae 14 parts, Herba Acalyphae 10 parts, Olibanum 15 parts, Herba Schizonepetae 20 parts, Herba Euphorbiae Humifusae 21 parts, Rhizoma Paridis tetraphyllae 14 parts.
Above-mentioned Anesthesia Department sucks blood by the preparation method of sponge, and step is as follows:
(1) yellow wine that weight ratio is 4:1 and vinegar are mixed to get adjuvant, take Myrrha and the Olibanum of cleaning, add the adjuvant of 0.3 times that weight is Myrrha and Olibanum weight, slightly moistening, after liquid is sucked, it is placed in marmite, heats with slow fire, frying to surface and show glossy gloss, taking-up is dried in the air cool, standby；
(2) Endoconcha Sepiae taking cleaning is placed in and forges in tank, upper cover one pannikin, and commissure, with yellow mud sealing, pannikin is put several rice, with slow fire grilling, waits a meter zoom Huang, takes out, must forge Endoconcha Sepiae, cool standby after truce；
(3) Ilex purpurea Hassk.[I.chinensis Sims, Herba Scutellariae Barbatae, Herba Acalyphae, Herba Euphorbiae Humifusae, Rhizoma Paridis tetraphyllae and step (2) gained are forged Endoconcha Sepiae, pulverize, cross 160 mesh sieves, standby；
(4) being soaked 6 hours by Radix Notoginseng, Herba Artemisiae Anomalae and Herba Schizonepetae vinegar, taking-up drains, and mixes with step (3) gained medicated powder, boiling 2 times, add 5 times amount water every time, each pan-fried 3 hours, be then combined with medicinal liquid, centrifugation, taking supernatant concentration to relative density is the concentrated solution of 0.8, stand-by；
(5) chitosan is configured to, with the glacial acetic acid solution of 1%, the chitosan solution that mass concentration is 3%, mixes with the ratio of 1:1 with step (4) gained filtrate；
(6) step (5) gained solution, fish gelatin solution and glycerol are pressed the volume ratio mixing of 5:2:3, and evacuation is degassed；
(7) step (6) gained mixed liquor is placed in silica gel mould (6cm × 3cm × 1.5cm), in-50 DEG C of freezings 24 hours, puts in freezer dryer-70 DEG C of lyophilisation 36 hours, Ji get Anesthesia Department medicated sponge.
Typical case two Lee, man, 58 years old, married, Han nationality, people from Baoding, workman.Zest is choked and is coughed more than March, increases the weight of gradually, and the heat that occurs together over nearly 1 month and apoplexy due to phlegm are with the scarlet blood streak, and after with antibiotic therapy, body temperature is down to normally, but cough, cough up phlegm, sputum mixed with blood is without alleviating.Patient has more than 30 years of smoking history.It is that bronchus lobaris superior dexter pulmonary carcinoma causes obstructive atelectasis, doctor advised excision disease lung through hospital diagnosis.Post-surgical incisions oozing of blood, oozing of blood is wiped only by nurse immediately, is pasted on wound surface with the embodiment of the present invention 1 gained sponge immediately, then is oppressed with dry gauze, patient's no longer oozing of blood after 6 minutes.
Embodiment 3 Anesthesia Department sucks blood with sponge, takes off the primary raw material stating weight proportion and is prepared from (every part takes 18g): Myrrha 5 parts, Ilex purpurea Hassk.[I.chinensis Sims 13 parts, Radix Notoginseng 18 parts, Herba Artemisiae Anomalae 9 parts, Herba Scutellariae Barbatae 15 parts, Endoconcha Sepiae 11 parts, Herba Acalyphae 7 parts, Olibanum 9 parts, Herba Schizonepetae 14 parts, Herba Euphorbiae Humifusae 16 parts, Rhizoma Paridis tetraphyllae 9 parts.
Above-mentioned Anesthesia Department sucks blood by the preparation method of sponge, and step is as follows:
(1) yellow wine that weight ratio is 2:1 and vinegar are mixed to get adjuvant, take Myrrha and the Olibanum of cleaning, add the adjuvant of 0.1 times that weight is Myrrha and Olibanum weight, slightly moistening, after liquid is sucked, it is placed in marmite, heats with slow fire, frying to surface and show glossy gloss, taking-up is dried in the air cool, standby；
(2) Endoconcha Sepiae taking cleaning is placed in and forges in tank, upper cover one pannikin, and commissure, with yellow mud sealing, pannikin is put several rice, with slow fire grilling, waits a meter zoom Huang, takes out, must forge Endoconcha Sepiae, cool standby after truce；
(3) Ilex purpurea Hassk.[I.chinensis Sims, Herba Scutellariae Barbatae, Herba Acalyphae, Herba Euphorbiae Humifusae, Rhizoma Paridis tetraphyllae and step (2) gained are forged Endoconcha Sepiae, pulverize, cross 120 mesh sieves, standby；
(4) being soaked 4 hours by Radix Notoginseng, Herba Artemisiae Anomalae and Herba Schizonepetae vinegar, taking-up drains, and mixes with step (3) gained medicated powder, boiling 2 times, add 3 times amount water every time, each pan-fried 1 hour, be then combined with medicinal liquid, centrifugation, taking supernatant concentration to relative density is the concentrated solution of 0.6, stand-by；
(5) chitosan is configured to, with the glacial acetic acid solution of 1%, the chitosan solution that mass concentration is 3%, mixes with the ratio of 1:1 with step (4) gained filtrate；
(6) step (5) gained solution, fish gelatin solution and glycerol are pressed the volume ratio mixing of 5:2:3, and evacuation is degassed；
(7) step (6) gained mixed liquor is placed in silica gel mould (6cm × 3cm × 1.5cm), in-50 DEG C of freezings 20 hours, puts in freezer dryer-70 DEG C of lyophilisation 36 hours, Ji get Anesthesia Department medicated sponge.
Embodiment 4 Anesthesia Department sucks blood with sponge, takes off the primary raw material stating weight proportion and is prepared from (every part takes 12g): Myrrha 6 parts, Ilex purpurea Hassk.[I.chinensis Sims 15 parts, Radix Notoginseng 20 parts, Herba Artemisiae Anomalae 11 parts, Herba Scutellariae Barbatae 16 parts, Endoconcha Sepiae 13 parts, Herba Acalyphae 9 parts, Olibanum 13 parts, Herba Schizonepetae 18 parts, Herba Euphorbiae Humifusae 18 parts, Rhizoma Paridis tetraphyllae 12 parts.
Above-mentioned Anesthesia Department sucks blood by the preparation method of sponge, and step is as follows:
(1) yellow wine that weight ratio is 4:1 and vinegar are mixed to get adjuvant, take Myrrha and the Olibanum of cleaning, add the adjuvant of 0.3 times that weight is Myrrha and Olibanum weight, slightly moistening, after liquid is sucked, it is placed in marmite, heats with slow fire, frying to surface and show glossy gloss, taking-up is dried in the air cool, standby；
(2) Endoconcha Sepiae taking cleaning is placed in and forges in tank, upper cover one pannikin, and commissure, with yellow mud sealing, pannikin is put several rice, with slow fire grilling, waits a meter zoom Huang, takes out, must forge Endoconcha Sepiae, cool standby after truce；
(3) Ilex purpurea Hassk.[I.chinensis Sims, Herba Scutellariae Barbatae, Herba Acalyphae, Herba Euphorbiae Humifusae, Rhizoma Paridis tetraphyllae and step (2) gained are forged Endoconcha Sepiae, pulverize, cross 140 mesh sieves, standby；
(4) being soaked 5 hours by Radix Notoginseng, Herba Artemisiae Anomalae and Herba Schizonepetae vinegar, taking-up drains, and mixes with step (3) gained medicated powder, boiling 2 times, add 4 times amount water every time, each pan-fried 3 hours, be then combined with medicinal liquid, centrifugation, taking supernatant concentration to relative density is the concentrated solution of 0.8, stand-by；
(5) chitosan is configured to, with the glacial acetic acid solution of 1%, the chitosan solution that mass concentration is 3%, mixes with the ratio of 1:1 with step (4) gained filtrate；
(6) step (5) gained solution, fish gelatin solution and glycerol are pressed the volume ratio mixing of 5:2:3, and evacuation is degassed；
(7) step (6) gained mixed liquor is placed in silica gel mould (6cm × 3cm × 1.5cm), in-50 DEG C of freezings 22 hours, puts in freezer dryer-70 DEG C of lyophilisation 36 hours, Ji get Anesthesia Department medicated sponge.
Typical case three Zhang, female, 50 years old.In April, 2012, having carried out hysterectomy because suffering from cervical cancer, there is oozing of blood in postoperative patients's incision, after oozing of blood is dried by nurse, is pasted on hemorrhage place with the embodiment of the present invention 4 gained sponge at once, and stopped bleeding after 5 minutes, operation proceeds.
Embodiment 5 Anesthesia Department sucks blood with sponge, takes off the primary raw material stating weight proportion and is prepared from (every part takes 15g): Myrrha 6 parts, Ilex purpurea Hassk.[I.chinensis Sims 14 parts, Radix Notoginseng 19 parts, Herba Artemisiae Anomalae 10 parts, Herba Scutellariae Barbatae 16 parts, Endoconcha Sepiae 12 parts, Herba Acalyphae 8 parts, Olibanum 11 parts, Herba Schizonepetae 16 parts, Herba Euphorbiae Humifusae 17 parts, Rhizoma Paridis tetraphyllae 10 parts.
Above-mentioned Anesthesia Department sucks blood by the preparation method of sponge, and step is as follows:
(1) yellow wine that weight ratio is 3:1 and vinegar are mixed to get adjuvant, take Myrrha and the Olibanum of cleaning, add the adjuvant of 0.2 times that weight is Myrrha and Olibanum weight, slightly moistening, after liquid is sucked, it is placed in marmite, heats with slow fire, frying to surface and show glossy gloss, taking-up is dried in the air cool, standby；
(2) Endoconcha Sepiae taking cleaning is placed in and forges in tank, upper cover one pannikin, and commissure, with yellow mud sealing, pannikin is put several rice, with slow fire grilling, waits a meter zoom Huang, takes out, must forge Endoconcha Sepiae, cool standby after truce；
(3) Ilex purpurea Hassk.[I.chinensis Sims, Herba Scutellariae Barbatae, Herba Acalyphae, Herba Euphorbiae Humifusae, Rhizoma Paridis tetraphyllae and step (2) gained are forged Endoconcha Sepiae, pulverize, cross 130 mesh sieves, standby；
(4) being soaked 4.5 hours by Radix Notoginseng, Herba Artemisiae Anomalae and Herba Schizonepetae vinegar, taking-up drains, and mixes with step (3) gained medicated powder, boiling 2 times, add 3.5 times amount water every time, each pan-fried 1.5 hours, be then combined with medicinal liquid, centrifugation, taking supernatant concentration to relative density is the concentrated solution of 0.7, stand-by；
(5) chitosan is configured to, with the glacial acetic acid solution of 1%, the chitosan solution that mass concentration is 3%, mixes with the ratio of 1:1 with step (4) gained filtrate；
(6) step (5) gained solution, fish gelatin solution and glycerol are pressed the volume ratio mixing of 5:2:3, and evacuation is degassed；
(7) step (6) gained mixed liquor is placed in silica gel mould (6cm × 3cm × 1.5cm), in-50 DEG C of freezings 21 hours, puts in freezer dryer-70 DEG C of lyophilisation 36 hours, Ji get Anesthesia Department medicated sponge.
Experimental example, in order to verify sucking blood and haemostatic effect of the present invention, carries out Anesthesia Department and sucks blood with the animal model experiment of sponge.
1, method for building animal model: white mice, after the procaine anesthesia of 1%, removes back hair, and conventional transdermal is sterilized, both sides, back cut the stringer otch of a 1.5cm length respectively, cut muscle, as deep as abdominal cavity simultaneously, then layer-by-layer suture muscle and skin, whole process simulation clinical operation process.
2, laboratory animal packet: taking 120 body weight is the white mice of 200-300g, it is randomly divided into 6 groups, often group 20, respectively use the matched group of regular absorbent gelfoam and use the experimental group of embodiment 1-5 gained sponge, when operative hemorrhage, sponge is applied in bleeding part, record every white mice hemostasis time used.
3, haemostatic effect is shown in following table:
Table 1
Analyze: from observed result it can be seen that Anesthesia Department of the present invention suck blood with sponge suck blood and haemostatic effect is substantially better than regular absorbent gelfoam, sponge of the present invention is sucked blood rapidly, stops blooding rapid-action, and without any side effects.
Claims (1)
1. Anesthesia Department sucks blood by the preparation method of sponge, it is characterized in that, takes off and state raw material, and every part takes 15g: Myrrha 6 parts, Ilex purpurea Hassk.[I.chinensis Sims 14 parts, Radix Notoginseng 19 parts, Herba Artemisiae Anomalae 10 parts, Herba Scutellariae Barbatae 16 parts, Endoconcha Sepiae 12 parts, Herba Acalyphae 8 parts, Olibanum 11 parts, Herba Schizonepetae 16 parts, Herba Euphorbiae Humifusae 17 parts, Rhizoma Paridis tetraphyllae 10 parts；Step is as follows:
(1) yellow wine that weight ratio is 3:1 and vinegar are mixed to get adjuvant, take Myrrha and the Olibanum of cleaning, add the adjuvant of 0.2 times that weight is Myrrha and Olibanum weight, slightly moistening, after liquid is sucked, it is placed in marmite, heats with slow fire, frying to surface and show glossy gloss, taking-up is dried in the air cool, standby；
(2) Endoconcha Sepiae taking cleaning is placed in and forges in tank, upper cover one pannikin, and commissure, with yellow mud sealing, pannikin is put several rice, with slow fire grilling, waits a meter zoom Huang, takes out, must forge Endoconcha Sepiae, cool standby after truce；
(3) Ilex purpurea Hassk.[I.chinensis Sims, Herba Scutellariae Barbatae, Herba Acalyphae, Herba Euphorbiae Humifusae, Rhizoma Paridis tetraphyllae and step (2) gained are forged Endoconcha Sepiae, pulverize, cross 130 mesh sieves, standby；
(4) being soaked 4.5 hours by Radix Notoginseng, Herba Artemisiae Anomalae and Herba Schizonepetae vinegar, taking-up drains, and mixes with step (3) gained medicated powder, boiling 2 times, add 3.5 times amount water every time, each pan-fried 1.5 hours, be then combined with medicinal liquid, centrifugation, taking supernatant concentration to relative density is the concentrated solution of 0.7, stand-by；
(5) chitosan is configured to, with the glacial acetic acid solution of 1%, the chitosan solution that mass concentration is 3%, mixes with the ratio of 1:1 with step (4) gained filtrate；
(6) step (5) gained solution, fish gelatin solution and glycerol are pressed the volume ratio mixing of 5:2:3, and evacuation is degassed；
(7) being placed in the silica gel mould of 6cm × 3cm × 1.5cm by step (6) gained mixed liquor, in-50 DEG C of freezings 21 hours, put in freezer dryer-70 DEG C of lyophilisation 36 hours, Ji get Anesthesia Department sucks blood and uses sponge.
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| CN101695581A (en) * | 2009-10-26 | 2010-04-21 | 西北大学 | Method for preparing human-like collagen haemostatic sponge in scale |
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