CN104042881A - Compositions used for regulating functions of ovary - Google Patents
Compositions used for regulating functions of ovary Download PDFInfo
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- CN104042881A CN104042881A CN201410328211.8A CN201410328211A CN104042881A CN 104042881 A CN104042881 A CN 104042881A CN 201410328211 A CN201410328211 A CN 201410328211A CN 104042881 A CN104042881 A CN 104042881A
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Abstract
The invention relates to compositions used for regulating functions of ovary. The compositions used for regulating the functions of the ovary take tortoiseshell as a monarch drug and sea horse and lily as ministerial drugs; then characteristics of female patients in different ages are combined, according to the condition of the female patients, ovary hypofunction is classified into three stages, namely kidney qi deficiency, kidney yin deficiency and internal thermal, deficiency of liver-yin and kidney-yin as well as heart-kidney imbalance; medicinal materials are selected and applied according to the ages of the patients and the condition of the patients in clinic. The compositions provided by the invention start from a viewpoint of 'life network regulation', according to physiological and pathological characteristics of women in different ages, a principle of syndrome differentiation is adopted, a conditioning formula applicable to 'women of 30 years old', 'women of 40 years old' and 'women of 50 years old' is summarized, and ovary functions of the women in the three age groups are adjusted, so that ovary functions of the patient are improved, and life quality is improved.
Description
Technical field
The present invention relates to a kind of for regulating the compositions of woman organ function, relate in particular to a kind of its by several kinds of Chinese medicinal materials by monarch, minister, help, make compatible compositions, be applicable to ovarian function to regulate, thereby improve patient's ovarian function, improve fertility and quality of life.
Background technology
Ovarian hypofunction is diminished ovarian reserve function, refers to that the ability of folliculus ovarii growth weakens, and ovum quality declines, thereby causes the decline of fertility.By in the traditional Chinese medical science, through theory, " seven years old kidney qi of woman contained, and dental transition is sent out long: two or seven menarches, conception vessel is logical, and taichong channel is contained, and regular menstrual cycle, therefore there is son; Radix Notoginseng kidney qi is all flat, therefore growth of wisdom tooth and mature development of the body; Four or seven strong muscle and bones, the long utmost point of tooth, sturdy body; Five or seven yangming meridians decline, and the face becoming withered is sent out and begun to fall; 673 YANG pulse decline in upper, and wrinkly face is sent out and begun in vain; Seventy-seven conception vessels are empty, and taichong channel declines few, exhaustion of kidney-essence with promoting reproductive function, and menopause, therefore senile appearance and loss of fecundity are also." 14 years old menstrual onset of this section of literature record prompting woman, within 35 years old, start to have facial pigmentation, the hair old and feeble sign such as easily come off, left and right menopause in 49 years old.
Chinese invention patent ZL02110299.6 discloses a kind of health-care nutrient capsule and method for making and application, belong to pharmaceutical composition, it is by 1～5 part of succinum, 1～5 part of Margarita, 0～5 part of Os Draconis or Concha Ostreae, 2～4 parts of Semen Ziziphi Spinosaes, 0～5 part of Semen Platycladi, 2～4 portions of Ganodermas or Caulis Polygoni Multiflori, 0～4 part of Fructus Lycii, 0～5 part of Radix Astragali, 0～4 part of Radix Codonopsis, 1～5 part of Carapax Trionycis or Carapax et Plastrum Testudinis, 2～4 parts of Radix Salviae Miltiorrhizaes, 0～4 part of Rhizoma Chuanxiong, 0～5 part of Semen Persicae or Flos Carthami, 0～5 part of Rhizoma Curcumae, 0～5 portion of Radix Curcumae, 1～5 portion of Eupolyphaga Seu Steleophaga, 0～5 portion of Hirudo or Tabanus, 0～5 part of Radix Rehmanniae Preparata, 0～5 part of Radix Angelicae Sinensis, 1～5 part of Radix Polygoni Multiflori or Fructus Mori, 1～5 part of Semen Cassiae, 0～5 part of Semen Celosiae, 1～5 part of Concha Haliotidis or Flos Chrysanthemi, 0～5 portion of Hippocampus, 1～5 part of Herba Cistanches, the capsule that 0～5 part of Semen Juglandis or Semen Cuscutae etc. are made for raw material, there is calcium-tonifying bone-strengthening, health invigorating, balanced nutrients, anti-ageing Fructus Alpiniae Oxyphyllae, the auxiliary therapeutic action such as toxin expelling and skin care.
Modern study also shows under physiological conditions, and women is after 35 years old, and follicle and ovum quality there will be sharply and decline, and cause reduce fertility.But along with social development, the change of living environment and rhythm of life, also there is variation in this rule.According to clinical observation, the original aging course of women shifted to an earlier date about 5 years, within 30 years old, had seen tired outly, and face tarnishes, and even has pigmentation, the corresponding decline of hormonal readiness of ovary, existing infrequent menstruation or more menopause syndrome about 40 years old.Ovarian hypofunction occurs infrequent menstruation, amenorrhea in advance except causing, also with infertile and miscarry relevant.And women is now except facing hard work pressure, due to the postponement of general childbearing age, more to face the immense pressure that fertility is difficult.How solving this and do sth. in advance aging phenomenon, improve the quality of living and fertility, is the difficult point of current reproductive medicine research.Doctor trained in Western medicine adopts the Therapeutic Method of complementing estrogen more clinically, but prolonged application has again carcinogenic misgivings.For infertile patient, still can adopt Assisted Reproductive Technology ART as the method for test-tube baby (IVF-ET), but after super induced ovulation, the ovum quality obtaining is poor, obtain ovum rate and transplantation embryo number obviously declines, there is 9%～26% start-up period even to cancel the cycle because failing to obtain transplantable embryo without the follicular development of sufficient amount, become the one of the main reasons of the method failures such as test-tube baby.
In order to improve the growth promoter of follicle, improve patient's ovulation rate and pregnancy rate, carry out much exploration, and formed all multirows and effective treatment technology scheme.As: Chinese invention patent ZL201110226280.4 discloses a kind of Chinese medicine composition for insufficiency of kidney-YANG phlegm retention polycystic ovarian syndrome, it take the Herba Epimedii of weight portion 12-21 and the Bulbus Fritillariae Uninbracteatae of weight portion 9-24 is monarch drug, weight portion is that the Hippocampus that the Fructus Psoraleae of 12-21, Cornu Cervi tablet that weight portion is 6-15 and weight portion are 0.3-15 is ministerial drug, and the Rhizoma Acori Graminei that the Spina Gleditsiae that the Carapax et Plastrum Testudinis that weight portion is 9-21, weight portion are 9-21 and weight portion are 9-21 is that adjuvant drug makes.Said composition reduces PCOS patient's androgen and Androgen Receptor Level, improves sex hormone binding globulin levels, reduces free testosterone level, further improves body inner estrogen level, improves the growth promoter of follicle, improves patient's ovulation rate and pregnancy rate.
For another example: Chinese invention patent ZL201110270264.5 discloses a kind of Chinese medicine composition for deficiency of the kidney yin intermingled phlegm and blood stasis type polycystic ovarian syndrome, it take the Rhizoma Anemarrhenae of weight portion 9-21, the Bulbus Fritillariae Uninbracteatae of weight portion 9-24 is monarch drug, weight portion is that the Carapax et Plastrum Testudinis of 9-21, the Radix Polygoni Multiflori Preparata that weight portion is 12-24, the Radix Angelicae Sinensis that weight portion is 9-21, the Radix Ophiopogonis that weight portion is 9-24 are ministerial drug, weight portion is that the Hippocampus of 0.3-15 is adjuvant drug, and Spina Gleditsiae and Rhizoma Acori Graminei.Said composition can reduce PCOS patient's androgen and Androgen Receptor Level, improves sex hormone binding protein level, reduces free testosterone level, further improves body inner estrogen level, improves the growth promoter of follicle, improves patient's ovulation rate and pregnancy rate.
In addition, improving aspect female dimacteric syndrome, as: Chinese invention patent application 200510031012.1 discloses a kind of Chinese medicine composition for the treatment of women's fatigue in climacteric period, adopting Chinese crude drug Carapax et Plastrum Testudinis and Herba Epimedii is principal agent, be equipped with other Chinese medicine Hippocampus, Fructus Lycii, the Radix Polygoni Multiflori and Semen Ziziphi Spinosae, by taking the method for " being decocted first " and " under rear " to make by medical material quality difference.This Chinese medicine composition has kidney-tonifying health-care, the function that skin care adjusts punching to appoint, be used for the treatment of the vexed xerostomia that occurs after menopausal women or artificial menopause, warm sweating, fatiguability and emotion cannot automatic control etc. climacteric syndrome there is good result.
And for example: Chinese invention patent ZL200510079323 discloses a kind of Chinese medicine composition for the treatment of climacteric syndrome, adopting Chinese medicine Carapax et Plastrum Testudinis and Herba Epimedii is principal agent, be equipped with Anemarrhena asphodeloides Bge, Fructus Lycii, Hippocampus, Radix Polygoni Multiflori, Rhizoma Polygonati, Radix Scutellariae, Rhizoma Coptidis, Gypsum Fibrosum, Radix Et Rhizoma Rhei, Semen Ziziphi Spinosae and Semen Persicae, make capsule, the powder of the climacteric syndrome occurring after treatment menopausal women or artificial menopause or be pressed into tablet medicine.This pharmaceutical composition by being there is to vexed xerostomia in 547 examples, warm sweating, emotion rises and falls cannot automatic control, the female patient of the climacteric syndrome of forgetful, dizzy, insomnia, melancholy or halitosis, toothache constipation symptom is tried out, result show determined curative effect, lasting, without any untoward reaction, safe and effective.
But these achievements in research stay in climacteric women more concern, and not for all ages and classes women (as: " woman 30 ", " woman 40 " and " woman 50 " etc.) physiological and pathological feature, all can blanket ovarian function regulation scheme, thus the aspects such as menstruation, General Symptoms and energy of improving women are improved effect.
Summary of the invention
One object of the present invention is to provide a kind of and is applicable to ovarian function to regulate for regulating the compositions of ovarian function, thereby improves patient's ovarian function, improves the quality of living.
It is a kind of for regulating the composite preparation of ovarian function that another object of the present invention is to provide, be applicable to adjust " 30 ", " 40 " and " 50 " these three all ages and classes section women simultaneously, improve patient's ovarian function, thereby improve their aspects such as menstruation, General Symptoms and energy, improve fertility and quality of life.
The traditional Chinese medical science is thought, " kidney governing reproduction " has substantial connection with the adjusting of female reproduction physiological function.On kidney, lead in brain (" the kidney generating marrow and dominating bone " " the brain being the reservoir of the marrow "), lower Lian Chongren, uterus (" kidney is appointed originally for rushing " " the collaterals of the uterus connecting with the kidney "), thereby formed the such axis that regulates female reproduction physiological function of appoint-uterus of brain-kidney-punching, it regulates punching to appoint the function of uterus by " menses ", and this has forgiven hypothalamic-pituitary-ovarian axis in modern medicine from macroscopic view and by various hormones, cytokine etc., has regulated the understanding of female reproductive function.In to the clinical and laboratory observation of kidney-nourishing tcm drug treatment ovarian hypofunction, find for many years, in premature ovarian failure patient therapy of combining Chinese and Western medicine, at gonadotropin releasing hormone (FSH), do not reduce to the normal pregnancy of can becoming pregnant to obtain when normal.The kidney tonifying Chinese medicine that relieves inflammation or internal heat can make the Estrogen Receptor of the women that enters into the climacteric period and old rats rise, and the FSH and lutropin (LH) level that have increased are declined, and immunologic function improves, and the climacteric women having in treatment obtains normal pregnancy.This type of clinical picture shows that kidney-nourishing tcm drug can improve estrogen receptor amount and function old and feeble in body, has the effect of adjusting neuroendocrine-metabolism-immunological network, from improving whole body organ, as: the organ dysfunctions such as brain, the heart, spleen, ovary and skin.On the basis of above clinical practice and animal experiment study, viewpoint from " life network regulation and control ", physiological and pathological feature for all ages and classes women, principle with determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, sum up " woman 30 ", " woman 40 ", the conditioning prescription that " woman 50 " are applicable, to adjust these three all ages and classes section women's life network function.
Alleged " patient " of the present invention refers to suffer from people, wild animal and the domestic animal (Livestock) of disease.Wild animal is without domestication's animal under naturalness.Domestic animal is the animal of the artificial breeding for food source is provided, as: monkey, ape, Canis familiaris L., Mus, hamster, pig, rabbit, milch cow, Babalus bubalis L., bull, sheep and goat etc." experimenter " that diagnose preferentially selects mammal, especially people.
Carapax et Plastrum Testudinis, salty sweet being slightly cold into Liver and kidney heart channel, is the in love product of flesh and blood, nourishing YIN for benefiting the kidney, take it as monarch drug in the present invention.
Hippocampus, Gan Wen returns Liver and kidney warp, is also the in love product of flesh and blood, the kidney warming tonify deficiency, with the Carapax et Plastrum Testudinis monoyin and monoyang that matches, treating YIN within YANG, the merit of playing altogether liver and kidney tonifying, take it as ministerial drug in the present invention.
Bulbus Lilii, sweet trembling with fear into cardiopulmonary warp, has the merit of yin nourishing clearing away heart-fire for tranquillization, and asthenic fire, treats restlessness of asrhenia type and insomnia clearly, take it as ministerial drug in the present invention.
Provided by the invention a kind of for regulating the compositions of ovarian function, take Carapax et Plastrum Testudinis as monarch drug, Hippocampus and Bulbus Lilii be ministerial drug, its consumption is the Carapax et Plastrum Testudinis of weight portion 5-21, the Hippocampus of weight portion 0.3-9, and the Bulbus Lilii of weight portion 3-21.
Theory of Chinese medical science is thought, the hepatic and renal YIN deficiency easily causes hyperactivity of the ministerial fire, and mutually fiery disturbance heart-fire is everlasting and is caused clinically the clinical symptoms of disarmony between the heart and kidney, as: insomnia and agitation etc.Therefore, we think that women's ovarian hypofunction belongs to the hepatic and renal YIN deficiency, the diseases of disarmony between the heart and kidney clinical more.Clinical treatment is with enriching yin and nourishing kidney, and double clearing away heart-fire is main.In conjunction with the feature in female patient all ages and classes stage, according to the weight of the state of an illness, ovarian hypofunction is divided into deficiency of kidney-QI, deficiency of the kidney yin interior-heat again, and the hepatic and renal YIN deficiency, the three phases such as disarmony between the heart and kidney.Clinical can according to the weight of patient's age or the state of an illness to above-mentioned three kinds of medicines, selected application.In addition,, also according to the physiological characteristics of all ages and classes section, also needing increases one or more medicines in conjunction with the actual state of an illness.
Fructus Lycii, sweet putting down into Liver and kidney spleen lung meridian, has the kidney invigorating nourishing the liver, improving eyesight is calmed the nerves, and can separate face poison, easily color, the effect such as bleach.
Herba Epimedii, sweet micro-pungent temperature enters Liver and kidney warp, has the effect of the strong muscle of the kidney invigorating, can control the exhausted cloudy loss of fecundity of woman, the middle aged forgetful disease of waiting.
The Radix Polygoni Multiflori, bitter sweet tepor enters Liver and kidney warp, has kidney tonifying tonifying liver, can the happy face of hair color.
The Rhizoma Anemarrhenae, bitter cold enters lung, harmonization of the stomach kidney channel, has nourishing kidney-yin clearind deficient heat, the effect that relieving restlessness is allayed excitement.
Rhizoma Polygonati, sweet putting down into lung, spleen stomach function regulating warp, has the effect of spleen reinforcing lung moistening and the skin care of promoting the production of body fluid.
Cortex Moutan, arduous being slightly cold into the heart, liver, kidney and pericardium channel, has and blood removing heat from blood, controls the blood fire second of the three ten-day periods of the hot season, the effect of heat clearing away and restlessness relieving.
Gypsum Fibrosum, though enter lung stomach tri-jiao channel pungent sweet Great Cold, a small amount of and yin-nourishing drug shares to harness the river and loses fire Sheng.
Semen Ziziphi Spinosae, sweet acidity is put down into liver heart channel, nourishing the liver mind tranquilizing and the heart calming.
Semen Persicae, bitter sweet putting down into cardiopulmonary warp, blood activating and moisten intestine, at blood system and not dry.
For take syndrome of deficiency of kidney-QI as main person, it is also the more common situation of women of " 30 " age bracket.The present invention also adds Fructus Lycii, Herba Epimedii fleece-flower root in the above-mentioned basic side who is comprised of Carapax et Plastrum Testudinis, Hippocampus and Bulbus Lilii.Full side's invigorating kidney qi, is applicable to women's kidney qi and just declines, and ovarian function declines, and sees facial pigmentation, deficient in energy, weak, the diseases such as hypomnesis.
Another kind provided by the invention is for regulating the compositions of ovarian function, take Carapax et Plastrum Testudinis as monarch drug, Hippocampus and Bulbus Lilii be ministerial drug, its consumption is the Carapax et Plastrum Testudinis of weight portion 5-21, the Hippocampus of weight portion 0.3-9, and the Bulbus Lilii of weight portion 3-21, also add Fructus Lycii gram, the Herba Epimedii of weight portion 3-21 and the Radix Polygoni Multiflori of weight portion 3-24 of weight portion 3-30.
For heat syndrome in deficiency of the kidney yin, being main person, is also the more common situation of women of " 40 " age bracket.The present invention also adds Fructus Lycii, Herba Epimedii, the Radix Polygoni Multiflori, the Rhizoma Anemarrhenae, Rhizoma Polygonati and Cortex Moutan in the above-mentioned basic side who is comprised of Carapax et Plastrum Testudinis, Hippocampus and Bulbus Lilii.The prescription of full side more above-mentioned " take syndrome of deficiency of kidney-QI as main person ", Cortex Moutan and Bulbus Lilii two taste medical materials are used simultaneously, and in side, the strength of clearing away heart-fire is stronger, and its nourishing YIN and clearing away fire strength is heavier.Be applicable to deficiency of the kidney yin, ovarian hypofunction, is shown in xerostomia, vexed and the hepatic and renal YIN deficiency such as warm, and the upper scorching all diseases of the fire of conscience.
Another kind provided by the invention is for regulating the compositions of ovarian function, take Carapax et Plastrum Testudinis as monarch drug, Hippocampus and Bulbus Lilii be ministerial drug, its consumption is the Carapax et Plastrum Testudinis of weight portion 5-21, the Hippocampus of weight portion 0.3-9, and the Bulbus Lilii of weight portion 3-21, also add the Fructus Lycii of weight portion 3-30, the Radix Polygoni Multiflori of the Herba Epimedii of weight portion 3-21, weight portion 3-24, the Herba Epimedii of the Fructus Lycii of weight portion 3-30, weight portion 3-21, the Rhizoma Polygonati of the Rhizoma Anemarrhenae of the Radix Polygoni Multiflori of weight portion 3-24, weight portion 3-21, weight portion 3-24 gram and the Cortex Moutan of weight portion 3-15.
For the hepatic and renal YIN deficiency, syndrome of disharmony between heart and kidney person, is also the more common situation of women of " 50 " age bracket.The present invention also adds Fructus Lycii, Herba Epimedii, the Radix Polygoni Multiflori, the Rhizoma Anemarrhenae, Rhizoma Polygonati, Cortex Moutan, Gypsum Fibrosum, Semen Persicae and Semen Ziziphi Spinosae in the above-mentioned basic side who is comprised of Carapax et Plastrum Testudinis, Hippocampus and Bulbus Lilii.
In prescription, Gypsum Fibrosum and the Rhizoma Anemarrhenae share not specially Zhi Yangming qifen fever, to deficiency of YIN fire Sheng person, help the effect of Rhizoma Anemarrhenae heat clearing away.Semen Ziziphi Spinosae add the moon with principal drug assistance nourishing the liver and kidney, and have the merit of nourishing YIN for suppressing the hyperactive YANG arresting sweating.Semen Persicae, in this prescription, has the merit that priming enters blood.The heart is monarch fire, and Liver and kidney is for fiery mutually, and monarch fire is recklessly acted, and fire also can move thereupon mutually, more easily consumes the moon of impairing the liver kidney, aggravates disease, and therefore adds the medicine of Cortex Moutan and Bulbus Lilii clearing away heart-fire, can stop this vicious cycle, increases clinical efficacy.Full side, on the basis of the moon of nourishing the liver and kidney, has strengthened the strength of clearing away heart-fire for tranquillization, and with nourishing kidney easing the affected liver, clearing away heart-fire for tranquillization is main.Be applicable to the hepatic and renal YIN deficiency, the upper scorching ovarian hypofunction patient of the fire of conscience, sees vexed xerostomia, warms sweating, the inclined to one side severe one of abnormal emotion-thought such as emotion rises and falls cannot automatic control, forgetful, dizzy, insomnia and melancholy.
Another kind provided by the invention is for regulating the compositions of ovarian function, take Carapax et Plastrum Testudinis as monarch drug, Hippocampus and Bulbus Lilii are ministerial drug, its consumption is the Carapax et Plastrum Testudinis of weight portion 5-21, the Hippocampus of weight portion 0.3-9, and the Bulbus Lilii of weight portion 3-21, the Fructus Lycii that also adds weight portion 3-30, the Herba Epimedii of weight portion 3-21, the Radix Polygoni Multiflori of weight portion 3-24, the Fructus Lycii of weight portion 3-30, the Herba Epimedii of weight portion 3-21, the Radix Polygoni Multiflori of weight portion 3-24, the Rhizoma Anemarrhenae of weight portion 3-21, the Rhizoma Polygonati of weight portion 3-24 gram, the Cortex Moutan of weight portion 3-15, the Gypsum Fibrosum of weight portion 3-30, the Semen Ziziphi Spinosae of the Semen Persicae of weight portion 3-15 and weight portion 3-20.
Provided by the inventionly variously for regulating the compositions of ovarian function, by decocting method, make decoction, or make unguentum, pill, powder and patch by traditional Chinese medical science traditional method.
The beneficial effect that technical solution of the present invention realizes:
Provided by the invention for regulating the compositions of ovarian function, take Carapax et Plastrum Testudinis as monarch drug, Hippocampus and Bulbus Lilii be ministerial drug, the viewpoint from " life network regulation and control ", for all ages and classes women's physiological and pathological feature, with the principle of determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, sum up " woman 30 ", " woman 40 ", the conditioning prescription that " woman 50 " are applicable, to adjust these three all ages and classes section women's ovarian function, thereby improve patient's ovarian function, improve the quality of living.
These compositionss are divided into groups patient and imposed respectively the preparation that the present composition is made according to different Western medicine diagnose standards and Standards of Chinese Medical Syndrome Differentiation, after treatment in 3-6 month, patient's menstruation obviously improves, and General Symptoms (as: xerostomia, vexed, leucorrhea reduce and the soreness of waist etc.) is also obviously good.After treatment, patient's blood FSH, FSH/LH obviously reduce, and blood estradiol (E
2) and LH etc. without significant change (not statistically significant), ovarian functional status improves, estrogen usefulness increases.
The specific embodiment
Below describe technical scheme of the present invention in detail.The embodiment of the present invention is only unrestricted in order to technical scheme of the present invention to be described, although the present invention is had been described in detail with reference to preferred embodiment, those of ordinary skill in the art is to be understood that, can modify or be equal to replacement the technical scheme of invention, and not departing from the spirit and scope of technical solution of the present invention, it all should be encompassed in claim scope of the present invention.
Embodiment of the present invention medical material used, except as otherwise indicating, all can obtain from Chinese crude drug sales company.The medical material obtaining, except as otherwise indicating, is tcm and herbal slice.Decoction pieces both can obtain from sales company, can be also to obtain by processing.
The preparation of embodiment 1 decoction
According to patient's situation, get as required the Carapax et Plastrum Testudinis of weight portion 5-21, the Hippocampus of weight portion 0.3-9, the Bulbus Lilii of weight portion 3-21, the Fructus Lycii of weight portion 3-30, the Herba Epimedii of weight portion 3-21, the Radix Polygoni Multiflori of weight portion 3-24, the Fructus Lycii of weight portion 3-30, the Herba Epimedii of weight portion 3-21, the Radix Polygoni Multiflori of weight portion 3-24, the Rhizoma Anemarrhenae of weight portion 3-21, the Rhizoma Polygonati of weight portion 3-24 gram, the Cortex Moutan of weight portion 3-15, the Gypsum Fibrosum of weight portion 3-30, the Semen Ziziphi Spinosae of the Semen Persicae of weight portion 3-15 and weight portion 3-20 etc. is suited the remedy to the case, water soaks more than 2 hours after rinsing in container, then adopt be decocted first and rear under the fried technique of tradition, normal pressure decocts and within 20 minutes, leaches medicinal liquid.
The preparation of embodiment 2 unguentum
According to patient's situation, get as required the Carapax et Plastrum Testudinis of weight portion 5-21, the Hippocampus of weight portion 0.3-9, the Bulbus Lilii of weight portion 3-21, the Fructus Lycii of weight portion 3-30, the Herba Epimedii of weight portion 3-21, the Radix Polygoni Multiflori of weight portion 3-24, the Fructus Lycii of weight portion 3-30, the Herba Epimedii of weight portion 3-21, the Radix Polygoni Multiflori of weight portion 3-24, the Rhizoma Anemarrhenae of weight portion 3-21, the Rhizoma Polygonati of weight portion 3-24 gram, the Cortex Moutan of weight portion 3-15, the Gypsum Fibrosum of weight portion 3-30, the Semen Ziziphi Spinosae of the Semen Persicae of weight portion 3-15 and weight portion 3-20 etc. is suited the remedy to the case, water soaks more than 2 hours after rinsing in container, then adopt be decocted first and rear under the fried technique of tradition, normal pressure leaches medicinal liquid concentrating under reduced pressure medicinal liquid after decocting, in medicinal liquid concentration process, add crystal sugar, the saccharide that maltose and yellow wine etc. are required and necessary adjuvant, stir and receive cream.
3 pairs of follicular developments of embodiment improve the observation of situation
Get the Bulbus Lilii of the Carapax et Plastrum Testudinis of weight portion 5-21, the Hippocampus of weight portion 0.3-9 and weight portion 3-21, make decoction, twice-daily is oral, not drug withdrawal in menstrual period.
Before and after treatment, carry out Monitor Follicles, method: in menstrual cycle, within the 9th day, start to monitor, row both transvaginal ultrasonography checks every other day, and when follicular diameter is greater than 15mm, monitor once every day, when follicular diameter is greater than 18mm, instructs patient, and continue monitoring until follicle is discharged.
Treat altogether 106 routine patients, before treatment, B ultrasonic monitoring is without follicular development person's 34 examples, and follicular development abnormal (comprise follicle atrophy, follicle do not discharge) person's 55 examples, have ovulation (comprising the ovulation of ovule bubble) person's 17 examples; After treatment, B ultrasonic monitoring is without follicular development (comprise follicle atrophy, follicle do not discharge) person's 8 examples, and abnormal person's 6 examples of follicular development, have ovulation (comprising the ovulation of ovule bubble) person's 92 examples (referring to table 1).
Before and after table 1 treatment two groups of patients ovulate situation comparison (
)
Note: before and after treatment, relatively, " * " represents P≤0.01.
From table 1, after treatment, patient's follicle maximum gauge obviously increases, and maximum gauge and minimum diameter difference obviously reduce (P≤0.05), illustrates that follicular development quality improves.
4 pairs of every hormonal readinesses of embodiment improve the observation of situation
Enter to organize patient by following Western medicine diagnose standard:
1) amenorrhea or delayed menstrual cycle amount are few;
2) anovular menstruation, luteal phase defect or relevant infertile, Early recurrent spontaneous abortion history;
3) endocrine detection (the 3rd day cycle) blood FSH>=8IU/L or FSH/LH>=2, E
2level is low.Age below 40 years old as FSH > 40IU/L (repeatedly checking more than 3 times), both transvaginal ultrasonography shows ovary diameter < 2cm, has no the follicle person of existence, is diagnosed as premature ovarian failure.
Get the Bulbus Lilii of the Carapax et Plastrum Testudinis of weight portion 5-21, the Hippocampus of weight portion 0.3-9 and weight portion 3-21, make decoction, twice-daily is oral, not drug withdrawal in menstrual period.After lab testing is found treatment, patient's blood FSH, FSH/LH obviously reduce (P < 0.01), and blood estradiol (E
2) without significant change (in Table 2).
Table 2
In table 2, " * * " represents and the front relatively P < 0.01 for the treatment of.。
After treatment, patient's blood FSH and FSH/LH obviously decline (P < 0.01), and blood estradiol rises to some extent, but not statistically significant (P > 0.05).Explanation is in patient body inner estrogen level without significant change in the situation that, and patient's ovarian functional status improves, and estrogen usefulness increases.
Embodiment 5 clinical observations
Ovarian hypofunction case load 40 examples, enter to organize patient as follows by Western medicine diagnose standard:
1) amenorrhea or delayed menstrual cycle amount are few;
2) anovular menstruation, luteal phase defect or relevant infertile, Early recurrent spontaneous abortion history;
3) endocrine detects (the 3rd day cycle) blood FSH>=10IU/L, E
2level is low.Age below 40 years old as FSH > 40IU/L (repeatedly checking more than 3 times), both transvaginal ultrasonography shows ovary diameter < 2cm, has no the follicle person of existence, is diagnosed as premature ovarian failure.
Enter to organize patient by Standards of Chinese Medical Syndrome Differentiation---the hepatic and renal YIN deficiency, syndrome of disharmony between heart and kidney:
Few or the amenorrhea of delayed menstrual cycle amount, hectic fever sweating, susceptible to lose temper due to restlessness, feverish sensation in the palms and soles, insomnia and dreamful sleep, xerostomia, the soreness of waist, constipation, leucorrhea reduces, or order is dry, dry and astringent in the moon, infertile, hypomnesis, the dark red tongue of tongue is few, thready and rapid pulse.
Prescription: Rhizoma Polygonati, the Cortex Moutan of weight portion 3-15, the Semen Persicae of the Gypsum Fibrosum of weight portion 3-30, weight portion 3-15 and the Semen Ziziphi Spinosae of weight portion 3-20 of the Hippocampus of the Carapax et Plastrum Testudinis of weight portion 13-45, weight portion 0.3-9, the Bulbus Lilii of weight portion 3-21, the Fructus Lycii of weight portion 3-30, the Radix Polygoni Multiflori of the Herba Epimedii of weight portion 3-21, weight portion 3-24, the Herba Epimedii of the Fructus Lycii of weight portion 3-30, weight portion 3-21, the Rhizoma Anemarrhenae of the Radix Polygoni Multiflori of weight portion 3-24, weight portion 3-21, weight portion 3-24 gram.
Above-mentioned prescription is made to decoction, and twice-daily is oral, not drug withdrawal in menstrual period.After treatment in 3-6 month, patient's menstruation obviously improves, and General Symptoms (as: xerostomia, vexed, leucorrhea reduces and the soreness of waist etc.) is obviously good (in Table 4) also.The ovulation rate of being controlled patient has 9 examples before treatment to be increased to 36 examples (in Table 3).
Table 3
In table 3, " recovery from illness " refers to that menstruation monthly rises, and occurs continuously that 3 ovulations or blood FSH return to below 8IU/L in half a year; The General Symptomies such as simultaneously xerostomia, vexed, leucorrhea minimizing obviously improve; " effective " refers to that menstruation rises once for 30～45 days, has 2 ovulations in half a year, and General Symptoms obviously improves; " effectively " refers to that menstruation rises once for 1～February, has 1 ovulation in half a year, and General Symptoms improves; Engineering noise refers to that menstruation can rise, anovulation phenomenon, and General Symptoms improves.
Table 4
Table 5
In table 5, " * " represents and the front relatively P < 0.05 for the treatment of; " * * " represents and the front relatively P < 0.01 for the treatment of.
After treatment, patient's blood FSH and FSH/LH obviously decline (P < 0.01 or P < 0.05), and blood estradiol rises to some extent, but not statistically significant (P > 0.05).Explanation is in patient body inner estrogen level without significant change in the situation that, and patient's ovarian functional status improves, and estrogen usefulness increases.
Embodiment 6 clinical observations
Ovarian hypofunction case load 36 examples, enter to organize patient as follows by Western medicine diagnose standard:
1) amenorrhea or delayed menstrual cycle amount are few;
2) anovular menstruation, luteal phase defect or relevant infertile, Early recurrent spontaneous abortion history;
3) endocrine detects (the 3rd day cycle) blood FSH >=8IU/L, and E2 level is low.
Enter to organize patient by Standards of Chinese Medical Syndrome Differentiation---heat syndrome in deficiency of the kidney yin:
Few or the amenorrhea of delayed menstrual cycle amount, feverish sensation in the palms and soles, flushing in zygomatic region red lip, xerostomia, vexed, soreness of waist tinnitus, leucorrhea reduces, or order is dry, the few tongue thready and rapid pulse of red tongue.
Prescription: the Rhizoma Polygonati of the Hippocampus of the Carapax et Plastrum Testudinis of weight portion 5-21, weight portion 0.3-9, the Bulbus Lilii of weight portion 3-21, the Fructus Lycii of weight portion 3-30, the Radix Polygoni Multiflori of the Herba Epimedii of weight portion 3-21, weight portion 3-24, the Herba Epimedii of the Fructus Lycii of weight portion 3-30, weight portion 3-21, the Rhizoma Anemarrhenae of the Radix Polygoni Multiflori of weight portion 3-24, weight portion 3-21, weight portion 3-24 gram and the Cortex Moutan of weight portion 3-15.
Above-mentioned prescription is made to decoction, and twice-daily is oral, not drug withdrawal in menstrual period.After treatment in 3-6 month, patient's menstruation obviously improves, and General Symptoms (as: xerostomia, vexed, leucorrhea reduces and the soreness of waist etc.) is obviously good (in Table 7) also.The ovulation rate of being controlled patient has 8 examples before treatment to be increased to 31 examples (in Table 6).
Table 6
In table 7, " recovery from illness " refers to that menstruation monthly rises, and occurs continuously that 3 ovulations or blood FSH return to below 8IU/L in half a year, and meanwhile, the General Symptomies such as xerostomia, vexed, leucorrhea minimizing obviously improve; " effective " refers to that menstruation rises once for 30～45 days, has 2 ovulations in half a year, and General Symptoms obviously improves; " effectively " refers to that menstruation rises once for 1～February, has 1 ovulation in half a year, and General Symptoms improves; Engineering noise refers to that menstruation can rise, anovulation phenomenon, and General Symptoms improves.
Table 7
Table 8
In table 8, " * " represents and the front relatively P < 0.05 for the treatment of; " * * " represents and the front relatively P < 0.01 for the treatment of.
After treatment, patient's blood FSH and FSH/LH obviously decline (P < 0.01 or P < 0.05), and blood estradiol is without significant change (P > 0.05).Explanation is in patient body inner estrogen level without significant change in the situation that, and patient's ovarian functional status improves, and estrogen usefulness increases.
Embodiment 7 clinical observations
Ovarian hypofunction case load 30 examples, enter group person by Standards of Chinese Medical Syndrome Differentiation---syndrome of deficiency of kidney-QI:
Few or the amenorrhea of delayed menstrual cycle amount, weak, the soreness of waist, tinnitus, leukorrhagia reduces, or have infertile, pale tongue with white fur deep-thready pulse.
Prescription: the Fructus Lycii of the Hippocampus of the Carapax et Plastrum Testudinis of weight portion 5-21, weight portion 0.3-9, the Bulbus Lilii of weight portion 3-21, weight portion 3-30 gram, the Herba Epimedii of weight portion 3-21 and the Radix Polygoni Multiflori of weight portion 3-24.
Above-mentioned prescription is made to decoction, and twice-daily is oral, not drug withdrawal in menstrual period.After treatment in 3-6 month, patient's menstruation obviously improves, and General Symptoms (as: weak, leucorrhea reduce and the soreness of waist etc.) is obviously good (in Table 10) also.The ovulation rate of being controlled patient has 10 examples before treatment to be increased to 25 examples (in Table 9).
Table 9
In table 9, " recovery from illness " refers to that menstruation monthly rises, and occurs continuously that 3 ovulations or blood FSH/LH return to below 2 in half a year, and meanwhile, the General Symptomies such as xerostomia, vexed, leucorrhea minimizing obviously improve; " effective " refers to that menstruation rises once for 30～45 days, has 2 ovulations in half a year, and General Symptoms obviously improves; " effectively " refers to that menstruation rises once for 1～February, has 1 ovulation in half a year, and General Symptoms improves; Engineering noise refers to that menstruation can rise, anovulation phenomenon, and General Symptoms improves.
Table 10
Table 11
In table 9, " * " represents and the front relatively P < 0.05 for the treatment of.
After treatment, patient's blood FSH and FSH/LH obviously decline (P < 0.05), blood estradiol (E
2though) and LH have rising, not statistically significant (P > 0.05).Explanation is in patient body inner estrogen level without significant change in the situation that, and patient's ovarian functional status improves, and estrogen usefulness increases.
Claims (9)
1. for regulating a compositions for ovarian function, it is characterized in that comprising
Monarch drug: the Carapax et Plastrum Testudinis of weight portion 5-21; With
Ministerial drug: the Hippocampus of weight portion 0.3-9, and the Bulbus Lilii of weight portion 3-21.
2. according to claim 1 for regulating the compositions of ovarian function, it is characterized in that described compositions also adds one or more of Fructus Lycii, Herba Epimedii, the Radix Polygoni Multiflori, the Rhizoma Anemarrhenae, Rhizoma Polygonati, Cortex Moutan, Gypsum Fibrosum, Semen Ziziphi Spinosae and Semen Persicae.
3. for regulating a compositions for ovarian function, it is characterized in that comprising
Monarch drug: the Carapax et Plastrum Testudinis of weight portion 5-21;
Ministerial drug: the Hippocampus of weight portion 0.3-9, and the Bulbus Lilii of weight portion 3-21; And
The Radix Polygoni Multiflori of the Herba Epimedii of the Fructus Lycii of weight portion 3-30, weight portion 3-21 and weight portion 3-24.
4. according to claim 3 for regulating the compositions of ovarian function, it is characterized in that described compositions also adds one or more of the Rhizoma Anemarrhenae, Rhizoma Polygonati, Cortex Moutan, Gypsum Fibrosum, Semen Ziziphi Spinosae and Semen Persicae.
5. for regulating a compositions for ovarian function, it is characterized in that comprising
Monarch drug: the Carapax et Plastrum Testudinis of weight portion 5-21;
Ministerial drug: the Hippocampus of weight portion 0.3-9, and the Bulbus Lilii of weight portion 3-21; And
The Rhizoma Polygonati of the Fructus Lycii of weight portion 3-30 gram, the Herba Epimedii of weight portion 3-21, the Rhizoma Anemarrhenae of the Radix Polygoni Multiflori of weight portion 3-24, weight portion 3-21, weight portion 3-24 gram and the Cortex Moutan of weight portion 3-15.
6. according to claim 5 for regulating the compositions of ovarian function, it is characterized in that described compositions also adds one or more of Gypsum Fibrosum, Semen Ziziphi Spinosae and Semen Persicae.
7. for regulating a compositions for ovarian function, it is characterized in that comprising
Monarch drug: the Carapax et Plastrum Testudinis of weight portion 5-21;
Ministerial drug: the Hippocampus of weight portion 0.3-9, and the Bulbus Lilii of weight portion 3-21; And
Rhizoma Polygonati, the Cortex Moutan of weight portion 3-15, the Semen Persicae of the Gypsum Fibrosum of weight portion 3-30, weight portion 3-15 and the Semen Ziziphi Spinosae of weight portion 3-20 of the Fructus Lycii of weight portion 3-30 gram, the Herba Epimedii of weight portion 3-21, the Rhizoma Anemarrhenae of the Radix Polygoni Multiflori of weight portion 3-24, weight portion 3-21, weight portion 3-24 gram.
8. for regulating a preparation for ovarian function, it is characterized in that comprising one of claim 1-7 described for regulating the compositions of ovarian function.
9. according to claim 8 for regulating the preparation of ovarian function, it is characterized in that described preparation is selected from one or more of decoction, unguentum, pill, powder and patch.
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