CN104013654A - Preparing method of isatis root injection - Google Patents
Preparing method of isatis root injection Download PDFInfo
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- CN104013654A CN104013654A CN201410242008.9A CN201410242008A CN104013654A CN 104013654 A CN104013654 A CN 104013654A CN 201410242008 A CN201410242008 A CN 201410242008A CN 104013654 A CN104013654 A CN 104013654A
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Abstract
A preparing method of an isatis root injection is disclosed. The method includes steps of: 1) steaming with vapour; 2) performing vacuum concentration; 3) blending liquid and filtering; 4) filling and 5) sterilizing and performing leakage detection. The method is simpler than traditional preparing methods. The process is simple and easy to operate. The preparation cost is reduced and the production efficiency is increased. Medicinal components of the liquid are protected from being damaged in the preparation process so that the medicinal effects of the isatis root injection are guaranteed. Sediments are not liable to generate in storing processes so that the isatis root injection meets the requirements of visible foreign matter detection of products and medicinal safety is guaranteed.
Description
Technical field
The present invention relates to pharmaceutical technology field, relate in particular to a kind of preparation method of Radix Isatidis injection.
Background technology
Radix Isatidis is the dry root of cruciferae isatis, Radix Isatidis injection be by Radix Isatidis through extracting, after purification, the Chinese medicine injection of being processed into.There is heat-clearing and toxic substances removing, removing heat from blood sore-throat relieving, the effect of detumescence.Can be used for treating domestic animal influenza, piglet pujos blancos, pneumonia and some heat generation illness.
At present, the preparation method of Radix Isatidis injection is comparatively complicated, and technological process is comparatively numerous and diverse, and cost is high, and preparation process easily destroys the property of medicine composition of medicinal liquid, and the Radix Isatidis injection effect preparing is undesirable.In storage process, easily produce micro-deposit, cause the check of product visible foreign matters against regulation, not only to manufacturing enterprise, caused certain economic loss, also administrable has brought safely hidden danger.
Summary of the invention
For solving existing problem in above-mentioned prior art, the invention provides a kind of preparation method of Radix Isatidis injection.
The present invention adopts following technical scheme to realize: a kind of preparation method of Radix Isatidis injection, comprises the steps:
1) steam steaming and decocting: the Radix Isatidis of 400～600 weight portions is put in steaming plant, add octuple in the water of described Radix Isatidis weight, at 40～60 ℃, warm macerating is 4.5～7.5 hours, pass into Steam Heating and boil 1～2 hour, cooling after, again pass into steam and boil 0.5～1.5 hour, again after filtration, clarification, removes slag, and obtains medicinal liquid;
2) concentrating under reduced pressure: the described medicinal liquid obtaining in step 1 is evaporated to 520～840 weight portions below at 70 ℃, then is cooled to below 60 ℃, under agitation slowly add ethanol,, staticly settle containing alcohol amount >=60% to solution, filter; The filtrate decompression obtaining is after filtration concentrated into 240～420 weight portions, and cold preservation staticly settles, and again filters; In again filtering the filtrate obtaining, adding strong aqua ammonia to regulate pH value to 7.8～8.2 again, cold preservation staticly settles, and filters for the third time; To heat deammoniation to pH value to 5.5～6.0 through filtering the filtrate obtaining for the third time again, cold preservation staticly settles; Adding water to solution total amount is 400～600 parts by volume again, and the corresponding relation of described weight portion and described parts by volume is equal to gram the relation with milliliter;
3) compounded Liquid medicine-filtering: the solution finally obtaining in step 2 is joined in reaction vessel, under constantly stirring, slowly add the Tween-80 of 8～12 weight portions and the benzoic acid of 8～12 weight portions, the charcoal that adds 2～4 weight portions after stirring and dissolving, stir 10～20 minutes, adsorption bleaching filtered by filter after 15～30 minutes again, adding water for injection to solution total amount is 760～1140 parts by volume again, detect pH value, if pH value is between 5.0～6.5, adding water for injection to solution total amount is 800～1200 parts by volume, if pH value is outside 5.0～6.5, first regulate between pH value to 5.0～6.5, adding water for injection to solution total amount is 800～1200 parts by volume again,
4) embedding: the solution finally obtaining in step 3 is adopted to aseptic filling technology fill, sealing, be filled in clean ampoule;
5) sterilizing leak detection: the medicine after filling and sealing in step 4 was moved in 4 hours to sterilizing leak detection in leak detection sterilizing cabinet, sterilising temp is 95～110 ℃, and sterilization time is 25～40 minutes.
Preferably, the preparation method of described Radix Isatidis injection, comprises the steps:
1) steam steaming and decocting: the Radix Isatidis of 500 weight portions is put in steaming plant, add octuple in the water of described Radix Isatidis weight, at 50 ℃, warm macerating is 6 hours, pass into Steam Heating and boil 1.5 hours, cooling after, again pass into steam and boil 1 hour, again after filtration, clarification, removes slag, and obtains medicinal liquid;
2) concentrating under reduced pressure: the described medicinal liquid obtaining in step 1 is evaporated to 650～700 weight portions below at 70 ℃, be cooled to below 60 ℃, under agitation slowly adding volume fraction is 95% ethanol again, reaches 60% to solution containing alcohol amount, staticly settle, filter; The filtrate decompression obtaining is after filtration concentrated into 300～350 weight portions, and cold preservation staticly settles, and again filters; In again filtering the filtrate obtaining, adding strong aqua ammonia to regulate pH value to 8.0 again, cold preservation staticly settles, and filters for the third time; To heat deammoniation to pH value to 5.5～6.0 through filtering the filtrate obtaining for the third time again, cold preservation staticly settles; Adding water to solution total amount is 500 parts by volume again, and the corresponding relation of described weight portion and described parts by volume is equal to gram the relation with milliliter;
3) compounded Liquid medicine-filtering: the solution finally obtaining in step 2 is joined in reaction vessel, under constantly stirring, slowly add the Tween-80 of 10 weight portions and the benzoic acid of 10 weight portions, the charcoal that adds 3 weight portions after stirring and dissolving, stir 15 minutes, adsorption bleaching filtered by filter after 20 minutes again, adding water for injection to solution total amount is 950 parts by volume again, detect pH value, if pH value is between 5.0～6.5, adding water for injection to solution total amount is 1000 parts by volume, if pH value is outside 5.0～6.5, first regulate between pH value to 5.0～6.5, adding water for injection to solution total amount is 1000 parts by volume again,
4) embedding: the solution finally obtaining in step 3 is adopted to aseptic filling technology fill, sealing, be filled in clean ampoule;
5) sterilizing leak detection: the medicine after filling and sealing in step 4 was moved in 4 hours to sterilizing leak detection in leak detection sterilizing cabinet, sterilising temp is 100 ℃, and sterilization time is 30 minutes.
Preferably, described distilling apparatus is multi-function extractor.
Preferably, described charcoal is at least one in active carbon or medicinal charcoal.
Further, described charcoal is medicinal charcoal.
Preferably, described filter is nuclepore membrane filter, its bubble point pressure >=0.34Mpa.
Preferably, described ampoule is processed through following: ampoule is put into ampoule washing machine and by purified water, slightly wash, again the ampoule after slightly washing is carried out to above in triplicate water filling water dumping fine purifiation, again the ampoule after fine purifiation is put into heated-air circulation oven and dried bottle, drying bottle temperature is 180 ℃, drying the bottle time is 120 minutes, dries after bottle finishes and treats that ampoule is cooled to 40～50 ℃.
Compared with prior art, the present invention has following beneficial effect: the present invention is more simpler than traditional preparation method, and technological process is simple to operation, has reduced preparation cost, has improved production efficiency; And in preparation process, protect the property of medicine composition of medicinal liquid not damaged, guaranteed the property of medicine effect of the Radix Isatidis injection for preparing; In storage process, be difficult for producing deposit, meet the regulation of product to visible foreign matters check, ensured medicinal safety.
Accompanying drawing explanation
Fig. 1 is process chart of the present invention.
The specific embodiment
Below in conjunction with specific embodiment, the preparation method of a kind of Radix Isatidis injection of the present invention is described in further detail.
Embodiment 1
A preparation method for Radix Isatidis injection, comprises the steps:
1) steam steaming and decocting: 500g Radix Isatidis is put in multi-function extractor, added octuple in the water of described Radix Isatidis weight, warm macerating is 6 hours at 50 ℃, passes into Steam Heating and boils 1.5 hours, after cooling, again pass into steam and boil 1 hour, more after filtration, clarification, removes slag, and obtains medicinal liquid;
2) concentrating under reduced pressure: the described medicinal liquid obtaining in step 1 is evaporated to 650～700g below at 70 ℃, then is cooled to below 60 ℃, under agitation slowly adding volume fraction is 95% ethanol, reaches 60% containing alcohol amount to solution, staticly settles, and filters; The filtrate decompression obtaining is after filtration concentrated into 300～350g, and cold preservation staticly settles, and again filters; In again filtering the filtrate obtaining, adding strong aqua ammonia to regulate pH value to 8.0 again, cold preservation staticly settles, and filters for the third time; To heat deammoniation to pH value to 5.5～6.0 through filtering the filtrate obtaining for the third time again, cold preservation staticly settles; Adding water to solution total amount is 500ml again;
3) compounded Liquid medicine-filtering: the solution finally obtaining in step 2 is joined in reaction vessel, under constantly stirring, slowly add 10g Tween-80 and 10g benzoic acid, after stirring and dissolving, add 3g medicinal charcoal, stir 15 minutes, adsorption bleaching filtered by nuclepore membrane filter after 20 minutes again, described nuclepore membrane filter bubble point pressure >=0.34Mpa; Adding water for injection to solution total amount is 950ml again, the filtrate that takes a morsel is detected pH value, if pH value is between 5.0～6.5, adding water for injection to solution total amount is 1000ml, if pH value is outside 5.0～6.5, first regulate between pH value to 5.0～6.5, then to add water for injection to solution total amount be 1000ml;
4) embedding: the solution finally obtaining in step 3 is adopted to aseptic filling technology fill, sealing, be filled in clean ampoule, every fill 10.5～11ml, fill should complete in 6 hours after dosing finishes, described ampoule need be processed through following: ampoule is put into ampoule washing machine and by purified water, slightly wash, again the ampoule after slightly washing is carried out to above in triplicate water filling water dumping fine purifiation, again the ampoule after fine purifiation is put into heated-air circulation oven and dried bottle, drying bottle temperature is 180 ℃, drying the bottle time is 120 minutes, dry after bottle finishes and treat that ampoule is cooled to 40～50 ℃,
5) sterilizing leak detection: the medicine after filling and sealing in step 4 was moved in 4 hours to sterilizing leak detection in leak detection sterilizing cabinet, sterilising temp is 100 ℃, and sterilization time is 30 minutes; Leak detection comprises negative pressure leak detection and positive pressure leak detection, should the be less than-0.09Mpa of pressure of negative pressure leak detection, and the pressure of positive pressure leak detection is 0.4～0.8Mpa.
Embodiment 2
A preparation method for Radix Isatidis injection, comprises the steps:
1) steam steaming and decocting: 100kg Radix Isatidis is put in multi-function extractor, added octuple in the water of described Radix Isatidis weight, warm macerating is 6 hours at 50 ℃, passes into Steam Heating and boils 1.5 hours, after cooling, again pass into steam and boil 1 hour, more after filtration, clarification, removes slag, and obtains medicinal liquid;
2) concentrating under reduced pressure: the described medicinal liquid obtaining in step 1 is evaporated to 130～140kg below at 70 ℃, then is cooled to below 60 ℃, under agitation slowly adding volume fraction is 95% ethanol, reaches 60% containing alcohol amount to solution, staticly settles, and filters; The filtrate decompression obtaining is after filtration concentrated into 60～70kg, and cold preservation staticly settles, and again filters; In again filtering the filtrate obtaining, adding strong aqua ammonia to regulate pH value to 8.0 again, cold preservation staticly settles, and filters for the third time; To heat deammoniation to pH value to 5.5～6.0 through filtering the filtrate obtaining for the third time again, cold preservation staticly settles; Adding water to solution total amount is 100L again;
3) compounded Liquid medicine-filtering: the solution finally obtaining in step 2 is joined in reaction vessel, under constantly stirring, slowly add 2000g Tween-80 and 2000g benzoic acid, after stirring and dissolving, add 600g medicinal charcoal, stir 15 minutes, adsorption bleaching filtered by nuclepore membrane filter after 20 minutes again, described nuclepore membrane filter bubble point pressure >=0.34Mpa; Adding water for injection to solution total amount is 190L again, the filtrate that takes a morsel is detected pH value, if pH value is between 5.0～6.5, adding water for injection to solution total amount is 200L, if pH value is outside 5.0～6.5, first regulate between pH value to 5.0～6.5, then to add water for injection to solution total amount be 200L;
4) embedding: the solution finally obtaining in step 3 is adopted to aseptic filling technology fill, sealing, be filled in clean ampoule, every fill 10.5～11ml, fill should complete in 6 hours after dosing finishes, described ampoule need be processed through following: ampoule is put into ampoule washing machine and by purified water, slightly wash, again the ampoule after slightly washing is carried out to above in triplicate water filling water dumping fine purifiation, again the ampoule after fine purifiation is put into heated-air circulation oven and dried bottle, drying bottle temperature is 180 ℃, drying the bottle time is 120 minutes, dry after bottle finishes and treat that ampoule is cooled to 40～50 ℃,
5) sterilizing leak detection: the medicine after filling and sealing in step 4 was moved in 4 hours to sterilizing leak detection in leak detection sterilizing cabinet, sterilising temp is 100 ℃, and sterilization time is 30 minutes; Leak detection comprises negative pressure leak detection and positive pressure leak detection, should the be less than-0.09Mpa of pressure of negative pressure leak detection, and the pressure of positive pressure leak detection is 0.4～0.8Mpa.
Embodiment 3
A preparation method for Radix Isatidis injection, comprises the steps:
1) steam steaming and decocting: 400g Radix Isatidis is put in multi-function extractor, add octuple in the water of described Radix Isatidis weight, at 40 ℃, warm macerating is 4.5 hours, pass into Steam Heating and boil 1 hour, cooling after, again pass into steam and boil 0.5 hour, again after filtration, clarification, removes slag, and obtains medicinal liquid;
2) concentrating under reduced pressure: the described medicinal liquid obtaining in step 1 is evaporated to 520～560g below at 70 ℃, then is cooled to below 60 ℃, under agitation slowly adding volume fraction is 95% ethanol, reaches 60% containing alcohol amount to solution, staticly settles, and filters; The filtrate decompression obtaining is after filtration concentrated into 240～280g, and cold preservation staticly settles, and again filters; In again filtering the filtrate obtaining, adding strong aqua ammonia to regulate pH value to 8.0 again, cold preservation staticly settles, and filters for the third time; To heat deammoniation to pH value to 5.5～6.0 through filtering the filtrate obtaining for the third time again, cold preservation staticly settles; Adding water to solution total amount is 400ml again;
3) compounded Liquid medicine-filtering: the solution finally obtaining in step 2 is joined in reaction vessel, under constantly stirring, slowly add 8g Tween-80 and 8g benzoic acid, after stirring and dissolving, add 2g medicinal charcoal, stir 10 minutes, adsorption bleaching filtered by nuclepore membrane filter after 15 minutes again, described nuclepore membrane filter bubble point pressure >=0.34Mpa; Adding water for injection to solution total amount is 760ml again, the filtrate that takes a morsel is detected pH value, if pH value is between 5.0～6.5, adding water for injection to solution total amount is 800ml, if pH value is outside 5.0～6.5, first regulate between pH value to 5.0～6.5, then to add water for injection to solution total amount be 800ml;
4) embedding: the solution finally obtaining in step 3 is adopted to aseptic filling technology fill, sealing, be filled in clean ampoule, every fill 10.5～11ml, fill should complete in 6 hours after dosing finishes, described ampoule need be processed through following: ampoule is put into ampoule washing machine and by purified water, slightly wash, again the ampoule after slightly washing is carried out to above in triplicate water filling water dumping fine purifiation, again the ampoule after fine purifiation is put into heated-air circulation oven and dried bottle, drying bottle temperature is 180 ℃, drying the bottle time is 120 minutes, dry after bottle finishes and treat that ampoule is cooled to 40～50 ℃,
5) sterilizing leak detection: the medicine after filling and sealing in step 4 was moved in 4 hours to sterilizing leak detection in leak detection sterilizing cabinet, sterilising temp is 95 ℃, and sterilization time is 25 minutes; Leak detection comprises negative pressure leak detection and positive pressure leak detection, should the be less than-0.09Mpa of pressure of negative pressure leak detection, and the pressure of positive pressure leak detection is 0.4～0.8Mpa.
Embodiment 4
A preparation method for Radix Isatidis injection, comprises the steps:
1) steam steaming and decocting: 600g Radix Isatidis is put in multi-function extractor, add octuple in the water of described Radix Isatidis weight, at 60 ℃, warm macerating is 7.5 hours, pass into Steam Heating and boil 2 hours, cooling after, again pass into steam and boil 1.5 hours, again after filtration, clarification, removes slag, and obtains medicinal liquid;
2) concentrating under reduced pressure: the described medicinal liquid obtaining in step 1 is evaporated to 780～840g below at 70 ℃, then is cooled to below 60 ℃, under agitation slowly adding volume fraction is 95% ethanol, reaches 60% containing alcohol amount to solution, staticly settles, and filters; The filtrate decompression obtaining is after filtration concentrated into 360～420g, and cold preservation staticly settles, and again filters; In again filtering the filtrate obtaining, adding strong aqua ammonia to regulate pH value to 8.0 again, cold preservation staticly settles, and filters for the third time; To heat deammoniation to pH value to 5.5～6.0 through filtering the filtrate obtaining for the third time again, cold preservation staticly settles; Adding water to solution total amount is 600ml again;
3) compounded Liquid medicine-filtering: the solution finally obtaining in step 2 is joined in reaction vessel, under constantly stirring, slowly add 12g Tween-80 and 12g benzoic acid, after stirring and dissolving, add 4g medicinal charcoal, stir 20 minutes, adsorption bleaching filtered by nuclepore membrane filter after 30 minutes again, described nuclepore membrane filter bubble point pressure >=0.34Mpa; Adding water for injection to solution total amount is 1140ml again, the filtrate that takes a morsel is detected pH value, if pH value is between 5.0～6.5, adding water for injection to solution total amount is 1200ml, if pH value is outside 5.0～6.5, first regulate between pH value to 5.0～6.5, then to add water for injection to solution total amount be 1200ml;
4) embedding: the solution finally obtaining in step 3 is adopted to aseptic filling technology fill, sealing, be filled in clean ampoule, every fill 10.5～11ml, fill should complete in 6 hours after dosing finishes, described ampoule need be processed through following: ampoule is put into ampoule washing machine and by purified water, slightly wash, again the ampoule after slightly washing is carried out to above in triplicate water filling water dumping fine purifiation, again the ampoule after fine purifiation is put into heated-air circulation oven and dried bottle, drying bottle temperature is 180 ℃, drying the bottle time is 120 minutes, dry after bottle finishes and treat that ampoule is cooled to 40～50 ℃,
5) sterilizing leak detection: the medicine after filling and sealing in step 4 was moved in 4 hours to sterilizing leak detection in leak detection sterilizing cabinet, sterilising temp is 110 ℃, and sterilization time is 40 minutes; Leak detection comprises negative pressure leak detection and positive pressure leak detection, should the be less than-0.09Mpa of pressure of negative pressure leak detection, and the pressure of positive pressure leak detection is 0.4～0.8Mpa.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, all any modifications of doing within the spirit and principles in the present invention, be equal to and replace and improvement etc., within all should being included in protection scope of the present invention.
Claims (7)
1. a preparation method for Radix Isatidis injection, is characterized in that, comprises the steps:
1) steam steaming and decocting: the Radix Isatidis of 400～600 weight portions is put in steaming plant, add octuple in the water of described Radix Isatidis weight, at 40～60 ℃, warm macerating is 4.5～7.5 hours, pass into Steam Heating and boil 1～2 hour, cooling after, again pass into steam and boil 0.5～1.5 hour, again after filtration, clarification, removes slag, and obtains medicinal liquid;
2) concentrating under reduced pressure: the described medicinal liquid obtaining in step 1 is evaporated to 520～840 weight portions below at 70 ℃, then is cooled to below 60 ℃, under agitation slowly add ethanol,, staticly settle containing alcohol amount >=60% to solution, filter; The filtrate decompression obtaining is after filtration concentrated into 240～420 weight portions, and cold preservation staticly settles, and again filters; In again filtering the filtrate obtaining, adding strong aqua ammonia to regulate pH value to 7.8～8.2 again, cold preservation staticly settles, and filters for the third time; To heat deammoniation to pH value to 5.5～6.0 through filtering the filtrate obtaining for the third time again, cold preservation staticly settles; Adding water to solution total amount is 400～600 parts by volume again, and the corresponding relation of described weight portion and described parts by volume is equal to gram the relation with milliliter;
3) compounded Liquid medicine-filtering: the solution finally obtaining in step 2 is joined in reaction vessel, under constantly stirring, slowly add the Tween-80 of 8～12 weight portions and the benzoic acid of 8～12 weight portions, the charcoal that adds 2～4 weight portions after stirring and dissolving, stir 10～20 minutes, adsorption bleaching filtered by filter after 15～30 minutes again, adding water for injection to solution total amount is 760～1140 parts by volume again, detect pH value, if pH value is between 5.0～6.5, adding water for injection to solution total amount is 800～1200 parts by volume, if pH value is outside 5.0～6.5, first regulate between pH value to 5.0～6.5, adding water for injection to solution total amount is 800～1200 parts by volume again,
4) embedding: the solution finally obtaining in step 3 is adopted to aseptic filling technology fill, sealing, be filled in clean ampoule;
5) sterilizing leak detection: the medicine after filling and sealing in step 4 was moved in 4 hours to sterilizing leak detection in leak detection sterilizing cabinet, sterilising temp is 95～110 ℃, and sterilization time is 25～40 minutes.
2. the preparation method of Radix Isatidis injection according to claim 1, is characterized in that, comprises the steps:
1) steam steaming and decocting: the Radix Isatidis of 500 weight portions is put in steaming plant, add octuple in the water of described Radix Isatidis weight, at 50 ℃, warm macerating is 6 hours, pass into Steam Heating and boil 1.5 hours, cooling after, again pass into steam and boil 1 hour, again after filtration, clarification, removes slag, and obtains medicinal liquid;
2) concentrating under reduced pressure: the described medicinal liquid obtaining in step 1 is evaporated to 650～700 weight portions below at 70 ℃, be cooled to below 60 ℃, under agitation slowly adding volume fraction is 95% ethanol again, reaches 60% to solution containing alcohol amount, staticly settle, filter; The filtrate decompression obtaining is after filtration concentrated into 300～350 weight portions, and cold preservation staticly settles, and again filters; In again filtering the filtrate obtaining, adding strong aqua ammonia to regulate pH value to 8.0 again, cold preservation staticly settles, and filters for the third time; To heat deammoniation to pH value to 5.5～6.0 through filtering the filtrate obtaining for the third time again, cold preservation staticly settles; Adding water to solution total amount is 500 parts by volume again, and the corresponding relation of described weight portion and described parts by volume is equal to gram the relation with milliliter;
3) compounded Liquid medicine-filtering: the solution finally obtaining in step 2 is joined in reaction vessel, under constantly stirring, slowly add the Tween-80 of 10 weight portions and the benzoic acid of 10 weight portions, the charcoal that adds 3 weight portions after stirring and dissolving, stir 15 minutes, adsorption bleaching filtered by filter after 20 minutes again, adding water for injection to solution total amount is 950 parts by volume again, detect pH value, if pH value is between 5.0～6.5, adding water for injection to solution total amount is 1000 parts by volume, if pH value is outside 5.0～6.5, first regulate between pH value to 5.0～6.5, adding water for injection to solution total amount is 1000 parts by volume again,
4) embedding: the solution finally obtaining in step 3 is adopted to aseptic filling technology fill, sealing, be filled in clean ampoule;
5) sterilizing leak detection: the medicine after filling and sealing in step 4 was moved in 4 hours to sterilizing leak detection in leak detection sterilizing cabinet, sterilising temp is 100 ℃, and sterilization time is 30 minutes.
3. the preparation method of Radix Isatidis injection according to claim 1 and 2, is characterized in that, described distilling apparatus is multi-function extractor.
4. the preparation method of Radix Isatidis injection according to claim 1 and 2, is characterized in that, described charcoal is at least one in active carbon or medicinal charcoal.
5. the preparation method of Radix Isatidis injection according to claim 4, is characterized in that, described charcoal is medicinal charcoal.
6. the preparation method of Radix Isatidis injection according to claim 1 and 2, is characterized in that, described filter is nuclepore membrane filter, its bubble point pressure >=0.34Mpa.
7. the preparation method of Radix Isatidis injection according to claim 1 and 2, it is characterized in that, described ampoule is processed through following: ampoule is put into ampoule washing machine and by purified water, slightly wash, again the ampoule after slightly washing is carried out to above in triplicate water filling water dumping fine purifiation, again the ampoule after fine purifiation is put into heated-air circulation oven and dried bottle, drying bottle temperature is 180 ℃, and drying the bottle time is 120 minutes, dries after bottle finishes and treats that ampoule is cooled to 40～50 ℃.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107233397A (en) * | 2017-07-01 | 2017-10-10 | 山东中牧兽药有限公司 | A kind of compound isatis-root injection and preparation method thereof |
| CN109364275A (en) * | 2018-10-19 | 2019-02-22 | 江苏浦金药业有限公司 | A kind of sterilizing methods in Venenum Bufonis Injection preparation process |
| CN111450135A (en) * | 2020-05-18 | 2020-07-28 | 山西省芮城县红宝兽药有限责任公司 | High-purity radix isatidis and preparation method of injection thereof |
| CN114452339A (en) * | 2022-01-12 | 2022-05-10 | 河南百草元兽药有限公司 | Isatis root injection and preparation method thereof |
-
2014
- 2014-06-03 CN CN201410242008.9A patent/CN104013654B/en active Active
Non-Patent Citations (2)
| Title |
|---|
| 赵新先主编: "《中药注射剂学》", 30 November 2000, 广东科技出版社 * |
| 高鸿慈等: "用微孔滤膜除去输液中的微粒", 《医院药学杂志》 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107233397A (en) * | 2017-07-01 | 2017-10-10 | 山东中牧兽药有限公司 | A kind of compound isatis-root injection and preparation method thereof |
| CN109364275A (en) * | 2018-10-19 | 2019-02-22 | 江苏浦金药业有限公司 | A kind of sterilizing methods in Venenum Bufonis Injection preparation process |
| CN111450135A (en) * | 2020-05-18 | 2020-07-28 | 山西省芮城县红宝兽药有限责任公司 | High-purity radix isatidis and preparation method of injection thereof |
| CN114452339A (en) * | 2022-01-12 | 2022-05-10 | 河南百草元兽药有限公司 | Isatis root injection and preparation method thereof |
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| CN104013654B (en) | 2017-12-26 |
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