CN104004225A - Application of tetrabromo bisphenol A as antibacterial agent and antibacterial material - Google Patents
Application of tetrabromo bisphenol A as antibacterial agent and antibacterial material Download PDFInfo
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- CN104004225A CN104004225A CN201410178889.2A CN201410178889A CN104004225A CN 104004225 A CN104004225 A CN 104004225A CN 201410178889 A CN201410178889 A CN 201410178889A CN 104004225 A CN104004225 A CN 104004225A
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- bisphenol
- tetrabromo
- antibacterial
- tetrabromo bisphenol
- gram
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Abstract
The invention discloses an application of tetrabromo bisphenol A as an antibacterial agent and an antibacterial material, and belongs to the field of antibacterial agent. The application of the tetrabromo bisphenol A as the antibacterial agent is provided, and the tetrabromo bisphenol A is applicable as the antibacterial agent for gram-positive bacteria and has the structural formula as shown in the specification. The antibacterial material comprises the tetrabromo bisphenol A. The tetrabromo bisphenol A can remarkably inhibit the growth of the gram-positive bacteria, and the minimum inhibitory concentration on staphylococcus aureus, bacillus, streptomyces and the like is 2-8 [mu]g/ml, so that the tetrabromo bisphenol A has good antibacterial effect and is a good antibacterial agent; and the antibacterial material comprises the tetrabromo bisphenol A, by adding the tetrabromo bisphenol A, the antibacterial rate can reach more than 90%, and the antibacterial material can play an excellent inhibitory effect on the growth of the gram-positive bacteria.
Description
Technical field
The present invention relates to antiseptic-germicide field, particularly a kind of tetrabromo-bisphenol is as application and the anti-biotic material of antiseptic-germicide.
Background technology
Anti-biotic material is the new function material that a class has sterilization, bacteriostasis property, is widely used.Its nucleus is antiseptic-germicide, and antiseptic-germicide is mainly divided into two large classes: inorganic antiseptic and organic antibacterial agent, by a small amount of antiseptic-germicide is added in common material, make it to have anti-microbial property.
Anti-biotic material is mainly divided into inorganic antibacterial material and organic anti-bacterial material.Although inorganic antibacterial material activity is high, easy to change, cost is higher; And organic antibacterial agent is due to poor heat resistance, be unsuitable for being added into plastics, resin, these defects have all limited the use range of anti-biotic material.
Tetrabromo-bisphenol (Tetrabromobisphenol A, TBBPA) be a kind of bromide fire retardant, tetrabromo-bisphenol is the bromide fire retardant of current output in the world and consumption maximum, be widely used in acrylonitrile-butadiene-polystyrene (Acrylonitrile butadiene Styrene copolymers, ABS), in impact resistant polystyrene (High Impact polystyrene HIPS) and polycarbonate (Polycarbonate, PC) class plastics superpolymer.
Summary of the invention
In order to solve the problem of prior art, the embodiment of the present invention provides application and the anti-biotic material of a kind of tetrabromo-bisphenol as antiseptic-germicide.Described technical scheme is as follows:
On the one hand, the embodiment of the present invention provides the application of a kind of tetrabromo-bisphenol as antiseptic-germicide, and described tetrabromo-bisphenol is applicable to the antiseptic-germicide of gram-positive microorganism, and the structural formula of described tetrabromo-bisphenol is:
On the other hand, the embodiment of the present invention provides a kind of anti-biotic material, and described anti-biotic material comprises a kind of and tetrabromo-bisphenol in plastics and resin, and the massfraction of described tetrabromo-bisphenol is 5%-20%.
Preferably, the massfraction of described tetrabromo-bisphenol is 10%-20%.
Particularly, described plastics are polypropylene, polyethylene or polystyrene.
Particularly, described resin is epoxy resin or resol.
The beneficial effect that the technical scheme that the embodiment of the present invention provides is brought is: tetrabromo-bisphenol provided by the invention can significantly suppress the growth of gram-positive microorganism, minimum inhibition concentration to streptococcus aureus, bacillus and streptomycete etc. is 2-8 μ g/ml, by adding tetrabromo-bisphenol, can make antibiotic rate reach more than 90%, the antibacterial effect of visible this tetrabromo-bisphenol is good, it is good antiseptic-germicide, anti-biotic material provided by the invention comprises tetrabromo-bisphenol, and this anti-biotic material can play good restraining effect to the growth of gram-positive microorganism.
Embodiment
For making the object, technical solutions and advantages of the present invention clearer, below embodiment of the present invention is described further in detail.
Embodiment mono-
Tetrabromo-bisphenol is carried out to minimum inhibition concentration (Minimum Inhibition Concentration, MIC) test experiments, and specific experiment step is as follows:
From flat board, inoculate a little bacterium in the Erlenmeyer flask of LB substratum (Luria-Bertani substratum) is housed, 37 ℃ of shaking table incubated overnight 12h-14h; Wherein, bacterium comprises: gram-positive microorganism and Gram-negative bacteria; The formula of LB substratum is as follows: Tryptones (Tryptone) 10g/L, yeast extract (Yeast extract) 5g/L, sodium-chlor (NaCl) 10g/L.
From Erlenmeyer flask, drawing bacterium liquid the 2nd day morning transfers in the Erlenmeyer flask of LB substratum that 5ml is housed with 1% volume ratio, continue in 37 ℃ of shaking tables and cultivate 4h-5h, to OD600 (OD600 represents that this bacterium liquid is at the light absorption value at 600nm wavelength place) be 0.6～0.8, and record the concrete OD value (optical density, optical density(OD)) of bacterium liquid.
With LB substratum, by 1000 times of the bacterium liquid dilutions after cultivating, making bacterial concentration is 10
5cFU/ml, draws the bacterium liquid after dilution, and adds in 96 orifice plates every hole 150 μ l.
Compound concentration is the tetrabromo-bisphenol solution of 128 μ g/ml, draws this tetrabromo-bisphenol solution of 150 μ l and adds in the 1st hole in 96 orifice plates, mixes in rear sucking-off 150 μ l to the 2 holes, by that analogy.
After dropwising, 96 orifice plates are put into shaking table and through 37 ℃, cultivate 12h-14h.
Visual inspection, the concentration that does not become the muddy corresponding minimum in hole is the minimum inhibition concentration of this bacterium, specifically referring to table 1.
Table 1 is that tetrabromo-bisphenol is to the minimum inhibition concentration of several bacteriums (MIC)
From table 1, tetrabromo-bisphenol has good inhibition to gram-positive microorganism.
The tetrabromo-bisphenol that the embodiment of the present invention provides can significantly suppress the growth of gram-positive microorganism, minimum inhibition concentration to streptococcus aureus, bacillus and streptomycete etc. is 2-8 μ g/ml, the antibacterial effect of visible this tetrabromo-bisphenol is good, is good antiseptic-germicide.
Embodiment bis-
According to the method for using in State Standard of the People's Republic of China's " antibacterial, the degerming of family expenses and similar applications electrical equipment, particular requirement of purification function anti-biotic material ", tetrabromo-bisphenol is made an addition to respectively in acrylic plastering and epoxy resin and is prepared into anti-biotic material, and this anti-biotic material is carried out to antibacterial test, wherein, the massfraction of tetrabromo-bisphenol can be 5%, 10% and 20%.
Test-results demonstration, the tetrabromo-bisphenol that the interpolation massfraction in acrylic plastering and epoxy resin is 5% all reaches more than 90% the antibiotic rate of streptococcus aureus.
Preferably, the tetrabromo-bisphenol that the interpolation massfraction in acrylic plastering and epoxy resin is 10-20% all reaches more than 99% the antibiotic rate of streptococcus aureus.
Anti-biotic material provided by the invention comprises tetrabromo-bisphenol, by adding tetrabromo-bisphenol, can make antibiotic rate reach more than 90%, makes this anti-biotic material can play good restraining effect to the growth of gram-positive microorganism.
The foregoing is only preferred embodiment of the present invention, in order to limit the present invention, within the spirit and principles in the present invention not all, any modification of doing, be equal to replacement, improvement etc., within all should being included in protection scope of the present invention.
Claims (5)
1. tetrabromo-bisphenol is as an application for antiseptic-germicide, and described tetrabromo-bisphenol is applicable to the antiseptic-germicide of gram-positive microorganism, and the structural formula of described tetrabromo-bisphenol is:
2. an anti-biotic material, is characterized in that, described anti-biotic material comprises a kind of and tetrabromo-bisphenol in plastics and resin, and the massfraction of described tetrabromo-bisphenol is 5%-20%.
3. anti-biotic material according to claim 2, is characterized in that, the massfraction of described tetrabromo-bisphenol is 10%-20%.
4. anti-biotic material according to claim 2, is characterized in that, described plastics are polypropylene, polyethylene or polystyrene.
5. anti-biotic material according to claim 2, is characterized in that, described resin is epoxy resin or resol.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410178889.2A CN104004225A (en) | 2014-04-29 | 2014-04-29 | Application of tetrabromo bisphenol A as antibacterial agent and antibacterial material |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410178889.2A CN104004225A (en) | 2014-04-29 | 2014-04-29 | Application of tetrabromo bisphenol A as antibacterial agent and antibacterial material |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104004225A true CN104004225A (en) | 2014-08-27 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410178889.2A Pending CN104004225A (en) | 2014-04-29 | 2014-04-29 | Application of tetrabromo bisphenol A as antibacterial agent and antibacterial material |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107897181A (en) * | 2017-12-08 | 2018-04-13 | 江汉大学 | A kind of application of bisphenol-A and anti-biotic material |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1380370A (en) * | 2002-03-25 | 2002-11-20 | 葛明槽 | Fire-resistant powder coating material and its production process |
-
2014
- 2014-04-29 CN CN201410178889.2A patent/CN104004225A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1380370A (en) * | 2002-03-25 | 2002-11-20 | 葛明槽 | Fire-resistant powder coating material and its production process |
Non-Patent Citations (1)
| Title |
|---|
| OKAZAKI，KANZO 等: ""Chemotherapeutics for dermatomycoses. V. Fungistatic activity of bis- and triphenols"", 《YAKUGAKU ZASSHI》, vol. 72, no. 11, 31 December 1952 (1952-12-31), pages 1403 - 1404 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107897181A (en) * | 2017-12-08 | 2018-04-13 | 江汉大学 | A kind of application of bisphenol-A and anti-biotic material |
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Application publication date: 20140827 |
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| RJ01 | Rejection of invention patent application after publication |