CN104000916B - A kind of compositions for the treatment of sheep infective pustule - Google Patents
A kind of compositions for the treatment of sheep infective pustule Download PDFInfo
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- CN104000916B CN104000916B CN201410191803.XA CN201410191803A CN104000916B CN 104000916 B CN104000916 B CN 104000916B CN 201410191803 A CN201410191803 A CN 201410191803A CN 104000916 B CN104000916 B CN 104000916B
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Abstract
The invention discloses a kind of compositions for the treatment of sheep infective pustule, it is characterized in that: it is made up of following raw material: Indigo Naturalis 5-20 part, Cortex Phellodendri 2-8 part, Radix Et Rhizoma Rhei 2-8 part, Galla Chinensis 1-8 part, Borneolum Syntheticum 1-4 part, Oleum Brassicae campestris 10-25 part.The present invention has heat-clearing and toxic substances removing, anti-inflammation, and arresting sweating stops blooding, understand things pain-stopping, the feature of efficacy consolidation, and to treatment sheep infective pustule Be very effective, cure rate is high, and safe and convenient to use, has no side effect.This compositions make unguentum can effectively the medication of avoiding over be single, the pimple particularly forming not yet ulceration to some also can be held concurrently solid simultaneously, and can ensure dose the long period and maintain drug effect, to raising curative effect reduce death cause close important.
Description
Technical field
The present invention relates to agricultural medical art, be specifically related to a kind of compositions for the treatment of sheep infective pustule.
Background technology
Sheep infective pustule is also known as sore mouth virus or furuncle skin ulcer.Be a kind of contagious disease being caused sheep by virus, form pimple, vesicle, pustule with positions such as lip, tongue, nose, breast and form excipuliform incrustation for feature.Sick just lip enlargement is turned up, and then under lip, abdomen, the red point that pockmarks are large and pimple appear in the inferior many places of extremity, pudendum, tail, forms vesicle and pustule through 1-2 days.Most sick sheep is in lip, pudendum, the inferior quilt of tail oligotrichosis portion's visible Fructus Mori shape projection, and the equal enlargement of the upper and lower lip of some trouble sheep be mushroom, and the whole face had chaps, festers.Minority suffers from serious ophthalmia, and single cases oral cavity sends rotten odor, tongue body xanthochromia, flows yellow saliva, and tongue body enlargement is festered, difficulty of searching for food.The course of disease about 1 week.Lamb is how dead because hunger collapse exhaustion or secondary infection pneumonia etc. are sick.This disease has generation every year in China, although mortality rate is low, and morbidity face width, normal popular in sporadic season, be one of infectious disease having a strong impact on lamb healthy growth and sheep husbandry development.Sheep infective pustule method is treated a lot of as: (1) 0.5% potassium permanganate solution cleaning wound surface or embrocate affected part with 3%-5% iodine tincture, to the sick sheep penicillin cooperation dexamethasone intramuscular injection occurring General Symptoms in prior art.(2) fresh Folium Allii tuberosi 100g mashes, and vegetable oil dresses affected part in right amount; (3) Galla Chinensis 60g, Herba Portulacae 30g grind to the powder spreading wound surface altogether; (4) Indigo Naturalis 30g, Radix Et Rhizoma Rhei 25g, Borneolum Syntheticum 5g grind to the powder spreading wound surface etc. altogether.The sheep that upper genus method is light to some state of an illness has certain curative effect, but often curative effect is not ideal enough to the heavier sheep of the part state of an illness, and effect is slowly affected the state of an illness adversely and even increased the weight of the state of an illness and cause death.
Summary of the invention
The present invention aims to provide a kind of compositions for the treatment of sheep infective pustule, and to solve in numerous treatment technology, to treat sheep infective pustule curative effect not ideal enough, and effect is slowly affected the state of an illness adversely and even increased the weight of the state of an illness and cause dead problem.Especially better to the sheep therapeutic effect that the state of an illness is heavier.
The present invention is achieved by the following technical programs:
Treat a compositions for sheep infective pustule, it is made up of following raw material: Indigo Naturalis 5-20 part, Cortex Phellodendri 2-8 part, Radix Et Rhizoma Rhei 2-8 part, Galla Chinensis 1-8 part, Borneolum Syntheticum 1-4 part, Oleum Brassicae campestris 10-25 part.
Further, described compositions is made up of following raw material: Indigo Naturalis 5-15 part, Cortex Phellodendri 5-7 part, Radix Et Rhizoma Rhei 5-7 part, Galla Chinensis 3-5 part, Borneolum Syntheticum 1-2 part, Oleum Brassicae campestris 18-20 part.
Further, described compositions is made up of following raw material: Indigo Naturalis 10 parts, Cortex Phellodendri 6 parts, Radix Et Rhizoma Rhei 6 parts, Galla Chinensis 4 parts, Borneolum Syntheticum 1.5 parts, Oleum Brassicae campestris 19 parts.
The preparation technology of the compositions of described treatment sheep infective pustule is:
After each raw material of Chinese medicine is pulverized respectively, put into clean container mixing by formula ratio and mix thoroughly, then pour formula ratio salad oil into stirring and make it into paste, add or do not add adjuvant, making the preparation formulation of needs by conventional method.
The mastic that the present invention obtains can adopt conventional known corresponding preparations method, adds customary adjuvant, as substrate Adeps caprae seu ovis, Cera Flava, paraffin, hydro carbons and glue class, makes ointment, plaster etc., preferred ointment.
Tell the compositions for the treatment of sheep infective pustule ointment preparation technology be:
Pulverized respectively by each raw material of Chinese medicine, put into clean container mixing after porphyrize and mix thoroughly, then pour Oleum Brassicae campestris into stirring and make it into paste, add adjuvant vaseline, grinding evenly makes ointment.
Prescription of the present invention, and to be obtained according to medication experience optimization by studying for a long period of time and screening by inventor.Each ingredient properties and effect as follows:
Indigo Naturalis: the dry pigment in dicotyledon medicine acanthaceous vegetable acanthaceous indigo, dicotyledon medicine leguminous plant Folium et Caulis Indigoferae Tinctoriae, dicotyledon medicine cruciferae isatis, careless Folium Isatidis or polygonaceae plant polygonum tinctorium ait. leaf.Nature and flavor are salty-cold.Heat-clearing and toxic substances removing, blood cooling and ecchymoses removing, purging liver-fire, arresting convulsion.Cure mainly: epidemic febrile disease intenseness of heat, macule, spit blood, spit blood, pharyngalgia aphtha, pediatric epilepsy scared, skin ulcer swells, erysipelas, snake bite and insect sting.Indigo Naturalis (Folium et Caulis Indigoferae Tinctoriae) alcohol immersion (0.5 grams per milliliter) all has inhibitory action to anthrax bacillus, pneumobacillus, dysentery bacterium, vibrio cholera, golden yellow and Staphylococcus albus in vitro.
Cortex Phellodendri: Rutaceae deciduous tree plant Cortex Phellodendri (Cortex Phellodendri). remove the bark of cork with wampee (Cortex Phellodendri).This product is containing the multiple alkaloid such as berberine, phellodendrine.Heat clearing and damp drying, eliminating fire and detoxication, brings down a fever except steaming.Cure mainly damp-heat vaginal discharge, pyretic stranguria beriberi, dysentery jaundice, skin infection swells and ache, eczema eczema, fever due to yin deficiency, and night sweat is passed out semen.Cortex Phellodendri antimicrobial spectrum is similar to Rhizoma Coptidis with antibacterial efficacy, all has inhibitory action to multiple malignant bacterias such as dysentery bacterium, Bacillus typhi, tubercule bacillus, staphylococcus aureus, Hemolytic streptococcuss; To some dermatophytes, also there is inhibitory action to leptospira, hepatitis B surface antigen; Protective effect is had to platelet; External can impel the absorption of subcutaneous oozing of blood; In addition, function of gallbladder promoting, diuresis, blood pressure lowering, the effect such as antipyretic is also had.
Radix Et Rhizoma Rhei: being collectively referred to as of the perennial plant of multiple Polygonaceae Rheum, there is purging heat to relax the bowels, removing damp-heat effect, Radix Et Rhizoma Rhei has anti-infectious function, all inhibitory action is had to multiple Gram-positive and negative bacteria, wherein the most responsive is staphylococcus and streptococcus, is secondly diphtheria corynebacterium, Typhoid and paratyphoid bacillus, Diplococcus pneumoniae, dysentery bacterium etc.; Infected by influenza also has inhibitory action; Caused by tannin, therefore there is again constipation phenomenon after rushing down; There are function of gallbladder promoting and digestion promoting function; In addition, stop blooding in addition, protect the liver, blood pressure lowering, the effect such as reduction serum cholesterol.Radix Et Rhizoma Rhei pushes away Chen Zhixin, has ventilation quality, appetite stimulator, QI and blood regulating, the effects such as fluent mechanism of qi, can accelerate the timely excretion of internal metabolism refuse and toxin, reduce self poisoning chance, in turn ensure that blood circulation simultaneously, digest and assimilate, the normal physiological function of the system such as water liquid metabolism.
Galla Chinensis: have another name called hundred worm storehouses, Mass Galla chinesis et camelliae Fermentata, gall, for the horned gall aphid of Homoptera aphid section or the female worm of melaphis peitan Tsai et Tang parasitize Anacardiaceae plant " Fructus rhois chinensis " and belong to tender leaf or the petiole of other plant together, stab and generate a kind of cryptomere consor thing insect gall, gained after drying times drying, has pathogenic fire reducing of astringing the lung, relieving diarrhea with astringents, arresting sweating stops blooding, and effect of removing dampness sore, also has antibacterial and detoxicating effect, effectively removing toxic substances can be played for antibacterial, antibacterial.
Borneolum Syntheticum: the native crystal compound of separating out in the resin of Dipterocarpaceae plant borneo camphor tree, the BORNEOLUM SYNTHETICUM of synthetic, and the processed goods of Herba Blumeae Balsamiferae distillation crystallization.The main crystallization obtained from the resin and volatile oil of Borneolum Syntheticum containing Borneolum Syntheticum 59.78% ~ 58.93%, isoborneol 38.98% ~ 37.52%, Camphora 2.70% ~ 2.09%., almost pure dextro Borneolum Syntheticum. contain multiple ter penoids in the resin of Borneolum Syntheticum and volatile oil. except Borneolum Syntheticum, still containing triterpenes components such as sesquiterpene constituents and oleanolic acid, alphitolic acid, asiatic acid, dipterocarpol, dryobalanone, erythrodiol such as Humuleno, beta-elemene, caryophyllene. logical all keys, loose stagnated fire, removing nebula improving eyesight, reducing swelling and alleviating pain.Control apoplexy locked mouth, calentura coma, infantile convulsion expectorant fan, deafness with qi stagnation, sore throat, aphtha, otitis media, carbuncle, hemorrhoid, order is nebula film also, enterobiasis.
Oleum Brassicae campestris: be commonly called as vegetable oil, being again Herba Coriandri oil, is the liquid of the transparent or semitransparent shape pressing gained with the seed of crucifer Semen Brassicae Campestris (i.e. Brassica campestris L).Oleum Brassicae campestris golden yellow color or pale brown, has certain penetrating odor, is among the peoplely called " blue or green abnormal smells from the patient ".Oleum Brassicae campestris sweet in the mouth, pungent, warm in nature, can moisturize parasite killing, loose erysipelas, detumescence poison, clinical in ascaris and food intestinal obstruction, effect is better.
Above-mentioned each composition, Indigo Naturalis heat-clearing and toxic substances removing, blood cooling and ecchymoses removing, Cortex Phellodendri heat clearing and damp drying, eliminating fire and detoxication, Radix Et Rhizoma Rhei ventilation quality, removing damp-heat, the hemostasis of Galla Chinensis arresting sweating, removing dampness sore, Borneolum Syntheticum open hole powder fire, reducing swelling and alleviating pain, then Oleum Brassicae campestris parasite killing of arranging in pairs or groups, detumescence poison, effect of anti-inflammation, removing toxic substances and promoting subsidence of swelling, hemostasis and pain-relieving played altogether by each medicine while playing single effect.
Beneficial effect of the present invention is: this compositions has anti-inflammation, and arresting sweating stops blooding, understand things pain-stopping, the feature of efficacy consolidation, and to treatment sheep infective pustule Be very effective, cure rate is high, and safe and convenient to use, has no side effect.This compositions make unguentum can effectively the medication of avoiding over be single, particularly also can hold concurrently solid to the pimple that some are forming not yet ulceration simultaneously, and can dose be ensured the long period and maintain drug effect, the sheep therapeutic effect heavier to the state of an illness is good, greatly reduces mortality rate.
Accompanying drawing explanation
Fig. 1 is simpler production process chart of the present invention
Fig. 2 is ointment fabrication processing figure of the present invention
Fig. 3 is plaster fabrication processing figure of the present invention
Detailed description of the invention
Below in conjunction with drawings and Examples, technical scheme of the present invention is further described, but described in claimed scope is not limited to.
Embodiment 1:
Prescription: Indigo Naturalis 25g, Cortex Phellodendri 25g, Radix Et Rhizoma Rhei 25g, Galla Chinensis 15g, Borneolum Syntheticum 5g, Oleum Brassicae campestris 90g.
Preparation technology: put into clean container mixing after being pulverized respectively by each raw material of Chinese medicine as shown in Figure 1 and mix thoroughly, then pour salad oil into stirring and make it into paste.
Usage and dosage: first use 0.1%-0.2% potassium permanganate solution cleaning affected part, then with compositions ointment coating affected part, to the sick sheep that indivedual ointment comes off, repaste chrisma after will again cleaning wound surface.
Embodiment 2:
Prescription: Indigo Naturalis 50g, Cortex Phellodendri 30g, Radix Et Rhizoma Rhei 30g, Galla Chinensis 20g, Borneolum Syntheticum 6g, Oleum Brassicae campestris 95g.
Preparation technology: put into clean container mixing after being pulverized respectively by each raw material of Chinese medicine as shown in Figure 1 and mix thoroughly, then pour salad oil into stirring and make it into paste.
Usage and dosage: first use 0.1%-0.2% potassium permanganate solution cleaning affected part, then with compositions ointment coating affected part, to the sick sheep that indivedual ointment comes off, repaste chrisma after will again cleaning wound surface.
Embodiment 3:
Prescription: Indigo Naturalis 75g, Cortex Phellodendri 35g, Radix Et Rhizoma Rhei 35g, Galla Chinensis 25g, Borneolum Syntheticum 10g, Oleum Brassicae campestris 100g.
Preparation technology: put into clean container mixing after being pulverized respectively by each raw material of Chinese medicine as shown in Figure 1 and mix thoroughly, then pour salad oil into stirring and make it into paste.
Usage and dosage: first use 0.1%-0.2% potassium permanganate solution cleaning affected part, then with compositions ointment coating affected part, to the sick sheep that indivedual ointment comes off, repaste chrisma after will again cleaning wound surface.
Embodiment 4:
Prescription: Indigo Naturalis 25g, Cortex Phellodendri 25g, Radix Et Rhizoma Rhei 25g, Galla Chinensis 15g, Borneolum Syntheticum 5g, Oleum Brassicae campestris 90g.
Preparation technology: pulverized respectively by each raw material of Chinese medicine as shown in Figure 2, put into clean container mixing after porphyrize and mix thoroughly, then pour salad oil into stirring and make it into paste, add adjuvant vaseline 15g, ointment 200g is evenly made in grinding.
Usage and dosage: first use 0.1%-0.2% potassium permanganate solution cleaning affected part, then with compositions ointment coating affected part, to the sick sheep that indivedual ointment comes off, repaste chrisma after will again cleaning wound surface.
Embodiment 5:
Prescription: Indigo Naturalis 50g, Cortex Phellodendri 30g, Radix Et Rhizoma Rhei 30g, Galla Chinensis 20g, Borneolum Syntheticum 6g, Oleum Brassicae campestris 95g.
Preparation technology: pulverized respectively by each raw material of Chinese medicine as shown in Figure 2, put into clean container mixing after porphyrize and mix thoroughly, then pour salad oil into stirring and make it into paste, add adjuvant vaseline 20g, ointment 251g is evenly made in grinding.
Usage and dosage: first use 0.1%-0.2% potassium permanganate solution cleaning affected part, then with compositions ointment coating affected part, to the sick sheep that indivedual ointment comes off, repaste chrisma after will again cleaning wound surface.
Embodiment 6:
Prescription: Indigo Naturalis 75g, Cortex Phellodendri 35g, Radix Et Rhizoma Rhei 35g, Galla Chinensis 25g, Borneolum Syntheticum 10g, Oleum Brassicae campestris 100g.
Preparation technology: pulverized respectively by each raw material of Chinese medicine as shown in Figure 2, put into clean container mixing after porphyrize and mix thoroughly, then pour salad oil into stirring and make it into paste, add adjuvant vaseline 25g, ointment 305g is evenly made in grinding.
Usage and dosage: first use 0.1%-0.2% potassium permanganate solution cleaning affected part, then with compositions ointment coating affected part, to the sick sheep that indivedual ointment comes off, repaste chrisma after will again cleaning wound surface.
Embodiment 7:
Prescription: Indigo Naturalis 25g, Cortex Phellodendri 25g, Radix Et Rhizoma Rhei 25g, Galla Chinensis 15g, Borneolum Syntheticum 5g, Oleum Brassicae campestris 100g.
Preparation technology: put into clean container mixing after being pulverized respectively by each raw material of Chinese medicine as shown in Figure 3 and mix thoroughly, then Oleum Brassicae campestris is poured into heating (temperature controls at 200-220 DEG C), pull medicinal residues out, obtain medicine oil, add Plumbum preparatium 30g and stir the plaster obtaining non-releasing fire-toxin, put into cold water to soak and within 72 hours, obtain the plaster of releasing fire-toxin, the plaster of releasing fire-toxin is spread onto in the framed back material such as paper or cloth and obtains plaster 125g.
Usage and dosage: first use 0.1%-0.2% potassium permanganate solution cleaning affected part, be then directly attached to affected part with compositions plaster, to the sick sheep that indivedual ointment comes off, paste use again after will again cleaning wound surface.
Embodiment 8:
Prescription: Indigo Naturalis 50g, Cortex Phellodendri 30g, Radix Et Rhizoma Rhei 30g, Galla Chinensis 20g, Borneolum Syntheticum 6g, Oleum Brassicae campestris 110g.
Preparation technology: put into clean container mixing after being pulverized respectively by each raw material of Chinese medicine as shown in Figure 3 and mix thoroughly, then Oleum Brassicae campestris is poured into heating (temperature controls at 200-220 DEG C), pull medicinal residues out, obtain medicine oil, add Plumbum preparatium 33g and stir the plaster obtaining non-releasing fire-toxin, put into cold water to soak and within 72 hours, obtain the plaster of releasing fire-toxin, the plaster of releasing fire-toxin is spread onto in the framed back material such as paper or cloth and obtains plaster 138g.
Usage and dosage: first use 0.1%-0.2% potassium permanganate solution cleaning affected part, be then directly attached to affected part with compositions plaster, to the sick sheep that indivedual ointment comes off, paste use again after will again cleaning wound surface.
Embodiment 9:
Prescription: Indigo Naturalis 75g, Cortex Phellodendri 35g, Radix Et Rhizoma Rhei 35g, Galla Chinensis 25g, Borneolum Syntheticum 10g, Oleum Brassicae campestris 120g.
Preparation technology: put into clean container mixing after being pulverized respectively by each raw material of Chinese medicine as shown in Figure 3 and mix thoroughly, then Oleum Brassicae campestris is poured into heating (temperature controls at 200-220 DEG C), pull medicinal residues out, obtain medicine oil, add Plumbum preparatium 36g and stir the plaster obtaining non-releasing fire-toxin, put into cold water to soak and within 72 hours, obtain the plaster of releasing fire-toxin, the plaster of releasing fire-toxin is spread onto in the framed back material such as paper or cloth and obtains plaster 151g.
Usage and dosage: first use 0.1%-0.2% potassium permanganate solution cleaning affected part, be then directly attached to affected part with compositions plaster, to the sick sheep that indivedual ointment comes off, paste use again after will again cleaning wound surface.
Experimental example
Since nineteen ninety-five, adopt the prescription of embodiment of the present invention 1-9 and using method, and existing method, respectively the sheep of different syndromes degree treated, scheme and the results are shown in following table:
Table 1
Table 2
Anti-inflammatory analgetic experimental program and the results are shown in following table:
Table 3
(standards of grading are: antiinflammatory in 1-2 days, pain relieving, antipruritic be 5 points, antiinflammatory in 2-3 days, pain relieving, antipruritic be 4 points, antiinflammatory in 3-4 days, pain relieving, antipruritic be 3 points, by that analogy, full marks 5 points.)
Above-mentioned experimental result shows, adopt the unguentum that the present composition is made, ideal at the slight sheep infective pustule for the treatment of, the cure rate of 100% can be reached, in treatment serious symptom sheep infective pustule, cure rate also reaches more than 90%, and compositions of the present invention is described, to treatment sheep infective pustule, especially serious symptom pustule is evident in efficacy, greatly reduces the mortality rate of severe disease sheep.Clean with only alone potassium permanganate or adopt compared with Indigo Naturalis, Radix Et Rhizoma Rhei, Borneolum Syntheticum apply, seriously disease treatment having notable difference, illustrates that present composition curative effect is more excellent.In addition, also to show that the present invention treats the effect of sheep infective pustule more faster and better than the effect of prior art for anti-inflammatory analgetic result of the test.Therefore, the present composition has the features such as determined curative effect, cure rate are high, Be very effective, is the another excellent selection for the treatment of sheep infective pustule.
Claims (4)
1. treat a compositions for sheep infective pustule, it is characterized in that: it is made up of following raw material: Indigo Naturalis 10 parts, Cortex Phellodendri 6 parts, Radix Et Rhizoma Rhei 6 parts, Galla Chinensis 4 parts, Borneolum Syntheticum 1.5 parts, Oleum Brassicae campestris 19 parts.
2. treat a preparation for sheep infective pustule, it is characterized in that: be prepared by preparation compositions according to claim 1; Preparation technology is: after being pulverized respectively by each raw material of Chinese medicine, puts into clean container mixing and mixes thoroughly, then pour formula ratio Oleum Brassicae campestris into stirring and make it into paste, add or do not add adjuvant, making the preparation formulation of needs by conventional method by formula ratio.
3. the preparation for the treatment of sheep infective pustule according to claim 2, is characterized in that: described preparation is ointment or plaster.
4. the preparation for the treatment of sheep infective pustule according to claim 3, it is characterized in that: the preparation technology of ointment is: each raw material of Chinese medicine is pulverized respectively, puts into clean container mixing after porphyrize and mix thoroughly, then pour Oleum Brassicae campestris into stirring and make it into paste, add adjuvant vaseline, grinding evenly makes ointment.
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| CN105168269A (en) * | 2015-08-27 | 2015-12-23 | 吴传飞 | Medicine for treating sore mouth disease and preparation method, detection method and application thereof |
| CN105998942A (en) * | 2016-07-03 | 2016-10-12 | 张俊清 | Traditional Chinese medicine composition for curing contagious ecthyma |
| CN112755118A (en) * | 2021-01-18 | 2021-05-07 | 广西壮族自治区兽医研究所 | Compound preparation for treating contagious pustule of sheep and preparation method thereof |
| CN113101351A (en) * | 2021-04-23 | 2021-07-13 | 刘齐贵 | Pharmaceutical formulations containing alum and methods for treating inflammatory and erosive skin and mucous membranes |
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| CN102716225A (en) * | 2011-06-20 | 2012-10-10 | 王长锋 | Externally dressed drug for treating burns and scalds |
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| CN102716225A (en) * | 2011-06-20 | 2012-10-10 | 王长锋 | Externally dressed drug for treating burns and scalds |
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