CN104000830A - Compound crotamiton preparation and application thereof - Google Patents
Compound crotamiton preparation and application thereof Download PDFInfo
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- CN104000830A CN104000830A CN201410211239.3A CN201410211239A CN104000830A CN 104000830 A CN104000830 A CN 104000830A CN 201410211239 A CN201410211239 A CN 201410211239A CN 104000830 A CN104000830 A CN 104000830A
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Abstract
The invention belongs to the technical field of medicine technology and provides a compound crotamiton preparation. Active components of the preparation comprise crotamiton and mometasone furoate. The compound crotamiton preparation is suitable for treating scabies, is high in curative effect, is good in safety, has a two-week effective rate reaching 68.33% and a four-week effective rate reaching 83.33% and is free of any obvious adverse reactions.
Description
Technical field
The invention belongs to medical technical field, be specifically related to a kind of compound recipe crotamiton preparation and the application in preparation treatment scabies medicine thereof.
Background technology
Scabies (scabies) is commonly called as " chancre ", is to colonize in by sarcoptic mite a kind of contagion dermatoses causing in human body skin top layer.Sarcoptic mite belongs to demodicid mite and belongs to, and claims again acaricide, is a kind of permanent parasitic mite.Colonize in people and mammiferous skin, invade human body, cause scabies.Acaricide multiparasitization is at the thinner position of skin, for fold place, umbilicus week, groin, penis, scrotum etc. under webs and both sides thereof, the fossa cubitalis, axillary fossa, female breast are located.Because acaricide is in mechanical stimulus and the toxinferous stimulation of acaricide of keratodermatitis tunneling, can cause inflammation and the violent pruritus of skin.Infringement is from the beginning of being pinhead-sized pimple, papulovesicle or phlysis.Chang Yin scratches and causes that scratch, blood crusts, pigmentation, eczema sample become or pustule, furuncle and phyma appear in secondary infection, and nephritis and exfoliative dermatitis can occur minority.Penis, scrotum place often can form scabies tuberosity, and as treatment not in time, the state of an illness can increase the weight of gradually, the delay several months, infects other people simultaneously.Can be popular in the poor rural area of sanitary condition, cities and towns and building site crowd in China.
The treatment of current scabies only has the preparations such as sulfur frost preparation, benzyl benzoate cream, crotamiton emulsifiable paste.The preparations such as sulfur frost, benzyl benzoate cream, because stink is large, have certain zest, and some patient can come in contact the untoward reaction such as dermatitis, can not be accepted by patient.
Crotamiton emulsifiable paste (commodity are called Eurax), is used for the treatment of scabies pruritus.The advantage of crotamiton emulsifiable paste is there is no abnormal smells from the patient, but in its product description, the untoward reaction of listing is " can cause contact dermatitis allergy ", points for attention comprise " agents area is answered drug withdrawal if any the situation such as burn feeling, redness; and by topical remedy clean, seek advice to doctor if desired.”
Urgent clinical needs one does not have abnormal smells from the patient at present, can not cause contact dermatitis allergy after medication, can treat effectively in time the external preparation of scabies.
Summary of the invention
The object of the present invention is to provide the compound recipe crotamiton preparation that can not cause that contact dermatitis is irritated after a kind of medication and can treat effectively in time scabies.
Another object of the present invention is to provide the application of this compound recipe crotamiton preparation in preparation treatment scabies medicine.
The inventor is in long-term department of dermatologry clinical practice, find to be used for the treatment of at present the momestasone furoate of eczema, neurodermatitis, atoipc dermatitis and skin pruritus, if with crotamiton composition compound preparation, can not only improve the untoward reaction of crotamiton ointment, there is rapid anti-inflammatory, alleviate pruritus texts, and the two coupling has synergism to the treatment of scabies.
A first aspect of the present invention, has been to provide a kind of compound recipe crotamiton preparation, and the active ingredient of said preparation is crotamiton and momestasone furoate, and in preparation, the percentage by weight of crotamiton and momestasone furoate is 10-30 ︰ 1, is preferably 20 ︰ 1.
Compound recipe crotamiton preparation of the present invention is external preparation, as ointment, ointment, gel, paste etc.
Compound recipe crotamiton preparation of the present invention, in the time preparing ointment, ointment, gel, paste etc., can adopt pharmaceutic adjuvant well known in the art.
Preferably, the present invention also provides a kind of compound recipe crotamiton ointment, and in this ointment, the content of crotamiton is 10%, and the content of momestasone furoate is 0.5%, by weight.
Further, in this ointment, the percentage by weight of each component is as follows:
Prepare ointment of the present invention, can adopt lapping-in method well known in the art, fusion process and emulsion process etc.
A second aspect of the present invention, has been to provide the application of above-mentioned compound recipe crotamiton preparation in preparation treatment scabies medicine.
In formula of the present invention, wherein crotamiton is anti-acaricide medicine, acts on the nervous system of sarcoptic mite, makes sarcoptic mite paralysis and death; In addition still there is slight local anesthetic action and can be antipruritic.
In formula of the present invention, wherein momestasone furoate have accelerate inflammation disappear, antipruritic, prevent the effects such as the contact dermatitis that crotamiton causes, momestasone furoate is " soft hormone " simultaneously, has on the one hand high partial result, on the other hand at the local catabolite that is non-activity by the cruel rapid metabolism of enzyme, thereby inhibition and local untoward reaction to hypothalmus-pituitary-adrenal axis are reduced, therefore be specially adapted to child's skin.
Compound recipe crotamiton provided by the invention, is applicable to scabies.This product curative effect is high, and safety is good, and its two weeks effective percentage reach 68.33%, and surrounding effective percentage reaches 83.33%.With respect to crotamiton emulsifiable paste, this product has inflammation and disappears soon, and antipruritic effect is good, has effectively prevented the contact dermatitis that crotamiton causes simultaneously.
Compound recipe crotamiton preparation of the present invention, has curative effect high, and antipruritic fast, without obvious adverse reaction, and cost is lower, is easily accepted by patient, as promotes the use of, and can produce obvious economic benefit and social benefit.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described in further detail, but enforcement of the present invention is not limited only to this.
Embodiment 1: the preparation of compound recipe crotamiton ointment
Every 1000g ointment composed as follows:
Get glyceryl monostearate, stearic acid heating and melting, temperature remains on 70～80 DEG C, separately gets crotamiton, momestasone furoate, glycerol and water appropriate, grinds to form suspension, slowly adds in oil phase, is stirred to cooling and get final product to same direction.
Embodiment 2: the test of pesticide effectiveness of compound recipe crotamiton ointment of the present invention
One, data and method
1, case: select scabies patient's 120 examples that Shanghai Long March Hospital Dermatology Outpatient Department clarifies a diagnosis for 2010 to 2014 as object of study, the course of disease 1 to 2 week.Inclusion criteria: have contagion history, the morbidity of common colony; There are the erythra such as pimple, papulovesicle, tuberosity, tunnel at the thin tender position of skin; Infringement place can be found sarcoptic mite.Rejecting standard: Pregnant and lactant women; To crotamiton or momestasone furoate allergy sufferers; Using at present additive method treatment scabies person.
2, be divided into two groups according to table of random number.Treatment group: 60 examples, male's 42 examples, women's 18 examples, 18～34 years old age, average 23.5 years old.Matched group: 60 examples, male's 41 examples, women's 19 examples, 17～32 years old age, average 22.9 years old.
3, Therapeutic Method: treatment group: use preparation of the present invention to be coated with and put Head And Face whole skin in addition on the skin, be coated with for the second time, then have a bath medicine is washed away after the 48h of interval after 24h, wear clean clothes, the quilt cover that more changes the sheet, repeated 1 time after 1 week.Matched group external crotamiton, the same treatment group of usage.Difference Estimating curative effect after 2 weeks, 4 weeks.(be coated with about 30g ointment at every turn, comprise about 3g crotamiton, 0.15g momestasone furoate in treatment group, matched group comprises about 3g crotamiton)
4, efficacy determination: by level Four standard.Recovery from illness: whole body is without pruritus, original deflorescence, without new breakout, males scrotum tuberosity diminishes or occurs without new tuberosity; Effective: pruritus that whole body is slight, has erythema to grab crust, without new pimple, papulovesicle, tuberosity; Invalid: whole body pruritus does not alleviate, there is new breakout.
5, result: two groups of sexes, age differences not statistically significant.Treatment group and treatment of control group the results are shown in Table 1, it is effective percentage that recovery from illness adds effective, total effective rate two groups two weeks time is respectively 68.33% and 38.33%, total effective rate when surrounding is respectively 83.33% and 60.00%, all there were significant differences (P ﹤ 0.01) to learn by statistics processing, illustrates that treatment group curative effect is apparently higher than matched group.
Table 1 treatment group and the comparison of matched group curative effect
Visible, two weeks effective percentage of compound recipe crotamiton provided by the invention reach 68.33%, and surrounding effective percentage reaches 83.33%, far above the crotamiton emulsifiable paste of folk prescription.And this product has inflammation and disappear soon, antipruritic effect is good, uses merely crotamiton, and local pruritus inflammation is obvious, adds with after hormone, and in 8 hours, pruritus goes down, and has effectively prevented the contact dermatitis that crotamiton causes simultaneously.
Below the preferred embodiment of the invention is illustrated, but the invention is not limited to described embodiment, those of ordinary skill in the art also can make all modification being equal to or replacement under the prerequisite without prejudice to the invention spirit, and the modification that these are equal to or replacement are all included in the application's claim limited range.
Claims (6)
1. a compound recipe crotamiton preparation, is characterized in that, the active ingredient of said preparation is crotamiton and momestasone furoate, and in preparation, the percentage by weight of crotamiton and momestasone furoate is 10-30 ︰ 1.
2. a kind of compound recipe crotamiton preparation according to claim 1, is characterized in that, in preparation, the percentage by weight of crotamiton and momestasone furoate is 20 ︰ 1.
3. a kind of compound recipe crotamiton preparation according to claim 1, is characterized in that, described compound recipe crotamiton preparation is ointment, ointment, gel, or paste.
4. a kind of compound recipe crotamiton preparation according to claim 1, is characterized in that, described compound recipe crotamiton preparation is ointment, and in ointment, the content of crotamiton is 10%, and the content of momestasone furoate is 0.5%, by weight.
5. a kind of compound recipe crotamiton preparation according to claim 4, is characterized in that, in this ointment, the percentage by weight of each component is as follows:
6. the compound recipe crotamiton preparation as described in as arbitrary in claim 1 to 5 application in preparation treatment scabies medicine.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410211239.3A CN104000830B (en) | 2014-05-19 | 2014-05-19 | Compound crotamiton preparation and application thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410211239.3A CN104000830B (en) | 2014-05-19 | 2014-05-19 | Compound crotamiton preparation and application thereof |
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| CN104000830A true CN104000830A (en) | 2014-08-27 |
| CN104000830B CN104000830B (en) | 2017-02-01 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104906173A (en) * | 2015-06-25 | 2015-09-16 | 浙江理工大学 | Antibacterial itching relieving preparation and preparation method thereof |
| CN107115329A (en) * | 2017-04-28 | 2017-09-01 | 中国人民解放军第二军医大学第二附属医院 | A kind of compound Butenafine preparation and its application |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1747703A (en) * | 2003-02-07 | 2006-03-15 | 帝国制药美国公司 | Methods of administering a dermatological agent to a subject |
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2014
- 2014-05-19 CN CN201410211239.3A patent/CN104000830B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1747703A (en) * | 2003-02-07 | 2006-03-15 | 帝国制药美国公司 | Methods of administering a dermatological agent to a subject |
Non-Patent Citations (4)
| Title |
|---|
| 吴华红: "艾洛松霜治疗疥疮结节40例临床疗效观察", 《岭南皮肤性病科杂志》 * |
| 张石革等: "疥疮与抗疥疮药", 《中国药房》 * |
| 李鸿国等: "38例幼儿疥疮临床分析", 《沈阳部队医药》 * |
| 陈海洲: "艾洛松乳膏与醋酸去炎松尿素乳膏治疗疥疮结节的临床比较", 《岭南皮肤性病科杂志》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104906173A (en) * | 2015-06-25 | 2015-09-16 | 浙江理工大学 | Antibacterial itching relieving preparation and preparation method thereof |
| CN107115329A (en) * | 2017-04-28 | 2017-09-01 | 中国人民解放军第二军医大学第二附属医院 | A kind of compound Butenafine preparation and its application |
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| Publication number | Publication date |
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| CN104000830B (en) | 2017-02-01 |
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