CN103998455B - 合成蛋白质的方法 - Google Patents

合成蛋白质的方法 Download PDF

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Publication number
CN103998455B
CN103998455B CN201280062427.3A CN201280062427A CN103998455B CN 103998455 B CN103998455 B CN 103998455B CN 201280062427 A CN201280062427 A CN 201280062427A CN 103998455 B CN103998455 B CN 103998455B
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CN
China
Prior art keywords
peptide
seaoff
group
iii
amino acid
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Expired - Fee Related
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CN201280062427.3A
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English (en)
Chinese (zh)
Other versions
CN103998455A (zh
Inventor
O.梅尔尼克
L.雷鲍特
V.奥卡格尼
A.德尔马斯
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NATIONAL CENTER FOR SCIENTIFIC RESEARCH
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NATIONAL CENTER FOR SCIENTIFIC RESEARCH
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
    • C07K1/026—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution by fragment condensation in solution
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/042—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers characterised by the nature of the carrier
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/045—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers using devices to improve synthesis, e.g. reactors, special vessels
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/34—Introducing sulfur atoms or sulfur-containing groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CN201280062427.3A 2011-10-17 2012-10-16 合成蛋白质的方法 Expired - Fee Related CN103998455B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR1159348 2011-10-17
FR1159348A FR2981352B1 (fr) 2011-10-17 2011-10-17 Procede de synthese de proteines
PCT/EP2012/070454 WO2013057084A1 (fr) 2011-10-17 2012-10-16 Procede de synthese de proteines

Publications (2)

Publication Number Publication Date
CN103998455A CN103998455A (zh) 2014-08-20
CN103998455B true CN103998455B (zh) 2018-05-29

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CN201280062427.3A Expired - Fee Related CN103998455B (zh) 2011-10-17 2012-10-16 合成蛋白质的方法

Country Status (10)

Country Link
US (1) US9206224B2 (https=)
EP (1) EP2768842B1 (https=)
JP (1) JP6321542B2 (https=)
CN (1) CN103998455B (https=)
CA (1) CA2852833A1 (https=)
ES (1) ES2702786T3 (https=)
FR (1) FR2981352B1 (https=)
IN (1) IN2014CN02870A (https=)
SG (1) SG11201401540WA (https=)
WO (1) WO2013057084A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2971509B1 (fr) * 2011-02-16 2013-02-22 Centre Nat Rech Scient Procede de preparation de peptides par assemblage de multiples fragments peptidiques
EP3019515B1 (en) * 2013-07-11 2019-08-21 Novartis AG Lysine-specific chemoenzymatic protein modifications using microbial transglutaminase
NL2027769B1 (en) 2021-03-18 2022-09-29 Univ Delft Tech C-terminal peptide modification

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011051906A1 (fr) * 2009-10-29 2011-05-05 Centre National De La Recherche Scientifique (Cnrs) Procede de ligation native de polypeptides

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI0832096T1 (en) 1995-05-04 2001-12-31 Scripps Research Inst Synthesis of proteins by native chemical ligation
WO1998028434A1 (en) 1996-12-24 1998-07-02 The Scripps Research Institute General chemical ligation
ATE285415T1 (de) * 1997-06-13 2005-01-15 Gryphon Therapeutics Inc Festphasige native chemische ligation von ungeschützten oder n-cystein-geschützten peptiden in wässrigen lösungen
US6570040B2 (en) 2000-03-16 2003-05-27 The Regents Of The University Of California Chemoselective ligation
DE60110127T2 (de) 2000-05-12 2006-02-02 Wisconsin Alumni Research Foundation, Madison Ligationsverfahren und reagenzien zur bildung einer amid-bindung
JP4399627B2 (ja) 2001-11-14 2010-01-20 ジェネプロット インコーポレーティッド ３つまたはそれ以上の成分による化学ペプチド連結
WO2006045603A1 (en) * 2004-10-26 2006-05-04 Lonza Ag S-alkyl-sulphenyl protection groups in solid-phase synthesis
EP1846765B1 (en) * 2005-02-11 2009-05-27 MERCK PATENT GmbH Solid-phase oligosaccharide tagging: a technique for manipulation of immobilized carbohydrates
US7667076B2 (en) 2005-09-14 2010-02-23 Regents Of The University Of California Amide forming chemical ligation
WO2011058188A1 (en) 2009-11-16 2011-05-19 Centre National De La Recherche Scientifique - Cnrs - Compounds and methods for purifying peptides produced by solid phase peptide synthesis

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011051906A1 (fr) * 2009-10-29 2011-05-05 Centre National De La Recherche Scientifique (Cnrs) Procede de ligation native de polypeptides

Also Published As

Publication number Publication date
EP2768842B1 (fr) 2018-07-25
ES2702786T3 (es) 2019-03-05
FR2981352A1 (fr) 2013-04-19
EP2768842A1 (fr) 2014-08-27
SG11201401540WA (en) 2014-06-27
CN103998455A (zh) 2014-08-20
IN2014CN02870A (https=) 2015-07-03
JP6321542B2 (ja) 2018-05-09
US20140256879A1 (en) 2014-09-11
US9206224B2 (en) 2015-12-08
FR2981352B1 (fr) 2015-07-03
CA2852833A1 (fr) 2013-04-25
JP2014532075A (ja) 2014-12-04
WO2013057084A1 (fr) 2013-04-25

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Granted publication date: 20180529

Termination date: 20191016