CN103998455B - 合成蛋白质的方法 - Google Patents

合成蛋白质的方法 Download PDF

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Publication number
CN103998455B
CN103998455B CN201280062427.3A CN201280062427A CN103998455B CN 103998455 B CN103998455 B CN 103998455B CN 201280062427 A CN201280062427 A CN 201280062427A CN 103998455 B CN103998455 B CN 103998455B
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China
Prior art keywords
peptide
seaoff
group
iii
amino acid
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Expired - Fee Related
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CN201280062427.3A
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English (en)
Chinese (zh)
Other versions
CN103998455A (zh
Inventor
O.梅尔尼克
L.雷鲍特
V.奥卡格尼
A.德尔马斯
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NATIONAL CENTER FOR SCIENTIFIC RESEARCH
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NATIONAL CENTER FOR SCIENTIFIC RESEARCH
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
    • C07K1/026—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution by fragment condensation in solution
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/042—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers characterised by the nature of the carrier
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/045—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers using devices to improve synthesis, e.g. reactors, special vessels
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/34—Introducing sulfur atoms or sulfur-containing groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CN201280062427.3A 2011-10-17 2012-10-16 合成蛋白质的方法 Expired - Fee Related CN103998455B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR1159348A FR2981352B1 (fr) 2011-10-17 2011-10-17 Procede de synthese de proteines
FR1159348 2011-10-17
PCT/EP2012/070454 WO2013057084A1 (fr) 2011-10-17 2012-10-16 Procede de synthese de proteines

Publications (2)

Publication Number Publication Date
CN103998455A CN103998455A (zh) 2014-08-20
CN103998455B true CN103998455B (zh) 2018-05-29

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CN201280062427.3A Expired - Fee Related CN103998455B (zh) 2011-10-17 2012-10-16 合成蛋白质的方法

Country Status (10)

Country Link
US (1) US9206224B2 (enExample)
EP (1) EP2768842B1 (enExample)
JP (1) JP6321542B2 (enExample)
CN (1) CN103998455B (enExample)
CA (1) CA2852833A1 (enExample)
ES (1) ES2702786T3 (enExample)
FR (1) FR2981352B1 (enExample)
IN (1) IN2014CN02870A (enExample)
SG (1) SG11201401540WA (enExample)
WO (1) WO2013057084A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2971509B1 (fr) * 2011-02-16 2013-02-22 Centre Nat Rech Scient Procede de preparation de peptides par assemblage de multiples fragments peptidiques
KR20160040556A (ko) 2013-07-11 2016-04-14 노파르티스 아게 미생물 트랜스글루타미나제를 사용한 리신-특이적 화학효소적 단백질 변형
NL2027769B1 (en) 2021-03-18 2022-09-29 Univ Delft Tech C-terminal peptide modification

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011051906A1 (fr) * 2009-10-29 2011-05-05 Centre National De La Recherche Scientifique (Cnrs) Procede de ligation native de polypeptides

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU711451B2 (en) 1995-05-04 1999-10-14 Scripps Research Institute, The Synthesis of proteins by native chemical ligation
CA2273071C (en) 1996-12-24 2008-07-29 The Scripps Research Institute Method for ligating oligopeptides
WO1998056807A1 (en) * 1997-06-13 1998-12-17 Gryphon Sciences Solid phase native chemical ligation of unprotected or n-terminal cysteine protected peptides in aqueous solution
WO2001068565A2 (en) 2000-03-16 2001-09-20 The Regents Of The University Of California Chemoselective ligation by use of a phosphine
US6972320B2 (en) 2000-05-12 2005-12-06 Wisconsin Alumni Research Foundation Ligation method and reagents to form an amide bond
EP1456225A2 (en) 2001-11-14 2004-09-15 Geneprot, Inc. Extended native chemical ligation of three or more peptide fragments
KR20070083815A (ko) * 2004-10-26 2007-08-24 론자 아게 고체상 합성에서 ｓ-알킬-술페닐 보호기
EP1846765B1 (en) * 2005-02-11 2009-05-27 MERCK PATENT GmbH Solid-phase oligosaccharide tagging: a technique for manipulation of immobilized carbohydrates
US7667076B2 (en) 2005-09-14 2010-02-23 Regents Of The University Of California Amide forming chemical ligation
JP5868864B2 (ja) 2009-11-16 2016-02-24 サントル ナスィオナル ド ラ ルシェルシュ スィアンティフィク（セ．エン．エル．エス．） 固相ペプチド合成により製造されるペプチドを精製するための化合物及び方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011051906A1 (fr) * 2009-10-29 2011-05-05 Centre National De La Recherche Scientifique (Cnrs) Procede de ligation native de polypeptides

Also Published As

Publication number Publication date
ES2702786T3 (es) 2019-03-05
FR2981352A1 (fr) 2013-04-19
WO2013057084A1 (fr) 2013-04-25
US20140256879A1 (en) 2014-09-11
CA2852833A1 (fr) 2013-04-25
FR2981352B1 (fr) 2015-07-03
IN2014CN02870A (enExample) 2015-07-03
JP2014532075A (ja) 2014-12-04
EP2768842B1 (fr) 2018-07-25
SG11201401540WA (en) 2014-06-27
US9206224B2 (en) 2015-12-08
JP6321542B2 (ja) 2018-05-09
CN103998455A (zh) 2014-08-20
EP2768842A1 (fr) 2014-08-27

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Granted publication date: 20180529

Termination date: 20191016