CN103998420B - (s)2‑n(3‑o‑(丙‑2‑醇)‑1‑丙基‑4‑羟基苯)‑3‑苯基丙酰胺的分离的立体异构形式 - Google Patents
(s)2‑n(3‑o‑(丙‑2‑醇)‑1‑丙基‑4‑羟基苯)‑3‑苯基丙酰胺的分离的立体异构形式 Download PDFInfo
- Publication number
- CN103998420B CN103998420B CN201280060570.9A CN201280060570A CN103998420B CN 103998420 B CN103998420 B CN 103998420B CN 201280060570 A CN201280060570 A CN 201280060570A CN 103998420 B CN103998420 B CN 103998420B
- Authority
- CN
- China
- Prior art keywords
- pain
- neuropathic pain
- hours
- treatment
- phenylpropanamide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 0 C*(C(Cc1cc*(*)cc1)COCC(N)O)C(CCc1ccccc1)=O Chemical compound C*(C(Cc1cc*(*)cc1)COCC(N)O)C(CCc1ccccc1)=O 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/22—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161568219P | 2011-12-08 | 2011-12-08 | |
| US61/568,219 | 2011-12-08 | ||
| PCT/IL2012/050512 WO2013084238A1 (en) | 2011-12-08 | 2012-12-06 | Isolated stereoisomeric forms of (s) 2-n (3-o-(propan 2-ol) -1-propyl-4-hydroxybenzene) -3-phenylpropylamide |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103998420A CN103998420A (zh) | 2014-08-20 |
| CN103998420B true CN103998420B (zh) | 2018-04-17 |
Family
ID=48573665
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201280060570.9A Active CN103998420B (zh) | 2011-12-08 | 2012-12-06 | (s)2‑n(3‑o‑(丙‑2‑醇)‑1‑丙基‑4‑羟基苯)‑3‑苯基丙酰胺的分离的立体异构形式 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US9381173B2 (https=) |
| EP (1) | EP2788317B1 (https=) |
| JP (2) | JP6411893B2 (https=) |
| CN (1) | CN103998420B (https=) |
| AU (1) | AU2012348529B2 (https=) |
| CA (1) | CA2856665C (https=) |
| DK (1) | DK2788317T3 (https=) |
| ES (1) | ES2763946T3 (https=) |
| HU (1) | HUE048570T2 (https=) |
| IN (1) | IN2014MN00919A (https=) |
| WO (1) | WO2013084238A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015173813A1 (en) * | 2014-05-14 | 2015-11-19 | Novaremed Ltd. | Pharmaceutical composition comprising stereoisomers of n-(1-(4-hydroxyphenyl)-3-(2-hydroxypropoxy)propan-2-yl)-3-phenylpropanamide for the prevention and treatment of type ii diabetes |
| KR102062268B1 (ko) | 2018-05-18 | 2020-01-03 | 한국교통대학교 산학협력단 | 발광 특성 또는 전하 전달 특성이 우수한 아지드계 가교제 |
| CN113329746B (zh) * | 2019-01-23 | 2025-05-02 | 诺瓦麦有限公司 | 用于治疗或预防疼痛、炎症和/或自身免疫的化合物 |
| EP3939578A1 (en) | 2020-07-13 | 2022-01-19 | Novaremed Ltd. | Compounds for treatment or prevention of an infection resulting from a coronavirus and/or a coronavirus-induced disease |
| WO2026037478A1 (en) | 2023-08-11 | 2026-02-19 | Novaremed AG | (s,s)-(3-o-(propan-2-ol)-2-amino-prop-1-yl-4-hydroxybenzene and its analogues for the treatment of chronic pain |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060148874A1 (en) * | 2004-03-26 | 2006-07-06 | Eliahu Kaplan | Compounds for use in the treatment of aids and other viral diseases and HIV-related infections and compositions containing such compounds, methods of treating such diseases and infections and methods of making such compounds and compositions |
| WO2009109850A2 (en) * | 2008-03-06 | 2009-09-11 | Novaremed Ltd. | A method of treating or preventing pain |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1546088B1 (en) | 2002-10-03 | 2014-12-17 | Novaremed Ltd. | Compounds for use in the treatment of autoimmune diseases, immuno-allergical diseases and organ or tissue transplantation rejection |
| US20090197781A1 (en) | 2008-01-31 | 2009-08-06 | Hari Babu Sunkara | Wellbore Fluids Comprising Poly(trimethylene ether) glycol Polymers |
| US8802734B2 (en) * | 2009-09-09 | 2014-08-12 | Novaremed Limited | Method of treating or preventing pain |
| EP2475361B1 (en) | 2009-09-09 | 2019-11-06 | Novaremed Ltd. | N-substituted benzenepropanamides for use in the treatment of pain and inflammation |
| GB0916073D0 (en) | 2009-09-14 | 2009-10-28 | Cintec Int Ltd | Improvements in and relating to building anchor systems |
-
2012
- 2012-12-06 DK DK12855522.4T patent/DK2788317T3/da active
- 2012-12-06 ES ES12855522T patent/ES2763946T3/es active Active
- 2012-12-06 EP EP12855522.4A patent/EP2788317B1/en active Active
- 2012-12-06 CN CN201280060570.9A patent/CN103998420B/zh active Active
- 2012-12-06 CA CA2856665A patent/CA2856665C/en active Active
- 2012-12-06 AU AU2012348529A patent/AU2012348529B2/en active Active
- 2012-12-06 WO PCT/IL2012/050512 patent/WO2013084238A1/en not_active Ceased
- 2012-12-06 HU HUE12855522A patent/HUE048570T2/hu unknown
- 2012-12-06 JP JP2014545450A patent/JP6411893B2/ja active Active
-
2014
- 2014-05-16 IN IN919MUN2014 patent/IN2014MN00919A/en unknown
- 2014-05-30 US US14/291,901 patent/US9381173B2/en active Active
-
2017
- 2017-07-21 JP JP2017142137A patent/JP2018021023A/ja active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060148874A1 (en) * | 2004-03-26 | 2006-07-06 | Eliahu Kaplan | Compounds for use in the treatment of aids and other viral diseases and HIV-related infections and compositions containing such compounds, methods of treating such diseases and infections and methods of making such compounds and compositions |
| WO2009109850A2 (en) * | 2008-03-06 | 2009-09-11 | Novaremed Ltd. | A method of treating or preventing pain |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2012348529B2 (en) | 2017-03-30 |
| HK1201059A1 (en) | 2015-08-21 |
| EP2788317B1 (en) | 2019-10-02 |
| WO2013084238A1 (en) | 2013-06-13 |
| DK2788317T3 (da) | 2020-01-20 |
| JP2015500831A (ja) | 2015-01-08 |
| EP2788317A4 (en) | 2015-07-08 |
| US9381173B2 (en) | 2016-07-05 |
| IN2014MN00919A (https=) | 2015-04-17 |
| CA2856665A1 (en) | 2013-06-13 |
| CN103998420A (zh) | 2014-08-20 |
| US20140275270A1 (en) | 2014-09-18 |
| JP2018021023A (ja) | 2018-02-08 |
| ES2763946T3 (es) | 2020-06-01 |
| AU2012348529A1 (en) | 2014-06-12 |
| JP6411893B2 (ja) | 2018-10-31 |
| HUE048570T2 (hu) | 2020-08-28 |
| CA2856665C (en) | 2019-11-12 |
| EP2788317A1 (en) | 2014-10-15 |
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