CN103987654A - 用于高吞吐量生物分子测试的磁性生物医学传感器和感测系统 - Google Patents
用于高吞吐量生物分子测试的磁性生物医学传感器和感测系统 Download PDFInfo
- Publication number
- CN103987654A CN103987654A CN201280060682.4A CN201280060682A CN103987654A CN 103987654 A CN103987654 A CN 103987654A CN 201280060682 A CN201280060682 A CN 201280060682A CN 103987654 A CN103987654 A CN 103987654A
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- Prior art keywords
- magnetic
- layer
- biosensor
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- free
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/12—Measuring magnetic properties of articles or specimens of solids or fluids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y25/00—Nanomagnetism, e.g. magnetoimpedance, anisotropic magnetoresistance, giant magnetoresistance or tunneling magnetoresistance
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/72—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/0098—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor involving analyte bound to insoluble magnetic carrier, e.g. using magnetic separation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R3/00—Apparatus or processes specially adapted for the manufacture or maintenance of measuring instruments, e.g. of probe tips
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/02—Measuring direction or magnitude of magnetic fields or magnetic flux
- G01R33/06—Measuring direction or magnitude of magnetic fields or magnetic flux using galvano-magnetic devices
- G01R33/09—Magnetoresistive devices
- G01R33/093—Magnetoresistive devices using multilayer structures, e.g. giant magnetoresistance sensors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/12—Measuring magnetic properties of articles or specimens of solids or fluids
- G01R33/1269—Measuring magnetic properties of articles or specimens of solids or fluids of molecules labeled with magnetic beads
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T29/00—Metal working
- Y10T29/49—Method of mechanical manufacture
- Y10T29/49002—Electrical device making
- Y10T29/4902—Electromagnet, transformer or inductor
Landscapes
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Health & Medical Sciences (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- Nanotechnology (AREA)
- Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Electrochemistry (AREA)
- Investigating Or Analyzing Materials By The Use Of Magnetic Means (AREA)
- Measuring Magnetic Variables (AREA)
- Hall/Mr Elements (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161549035P | 2011-10-19 | 2011-10-19 | |
| US61/549,035 | 2011-10-19 | ||
| PCT/US2012/061156 WO2013059692A1 (en) | 2011-10-19 | 2012-10-19 | Magnetic biomedical sensors and sensing system for high-throughput biomolecule testing |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103987654A true CN103987654A (zh) | 2014-08-13 |
Family
ID=47144143
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201280060682.4A Pending CN103987654A (zh) | 2011-10-19 | 2012-10-19 | 用于高吞吐量生物分子测试的磁性生物医学传感器和感测系统 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9823316B2 (https=) |
| EP (1) | EP2768769A1 (https=) |
| JP (1) | JP2015503085A (https=) |
| CN (1) | CN103987654A (https=) |
| IN (1) | IN2014CN03583A (https=) |
| WO (1) | WO2013059692A1 (https=) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110462416A (zh) * | 2017-03-30 | 2019-11-15 | 高通股份有限公司 | 采用具有不同磁场灵敏度的隧道磁阻(tmr)器件以提高检测灵敏度的tmr传感器 |
| WO2020199786A1 (zh) * | 2019-04-02 | 2020-10-08 | 京东方科技集团股份有限公司 | 微流控芯片、液态样本检测装置和方法 |
| CN112689759A (zh) * | 2018-08-09 | 2021-04-20 | Bbb有限公司 | 使用磁性纳米粒子的生物传感器,以及使用生物传感器的检测装置和检测方法 |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5886967B2 (ja) | 2011-09-14 | 2016-03-16 | リージェンツ オブ ザ ユニバーシティ オブ ミネソタ | 外部磁界を必要としない磁気生体センサ |
| PT2800970T (pt) | 2012-01-04 | 2016-12-27 | Magnomics S A | Dispositivo monolítico combinando cmos com sensores magnetorresistivos |
| WO2013119719A1 (en) * | 2012-02-06 | 2013-08-15 | Ludwig, Lester, F. | Microprocessor-controlled microfluidic platform for pathogen, toxin, biomarker, and chemical detection with removable updatable sensor array for food and water safety, medical, and laboratory apllications |
| FI127032B (fi) * | 2014-03-21 | 2017-10-13 | Magnasense Tech Oy | Mittausjärjestely, laite varustettuna mittausjärjestelyllä ja menetelmä näytteen mittaamiseksi |
| JP6457243B2 (ja) * | 2014-11-06 | 2019-01-23 | 株式会社東芝 | 電流センサ、及びスマートメータ |
| JP6439413B6 (ja) * | 2014-12-01 | 2019-01-30 | Tdk株式会社 | 磁気センサ、磁気ヘッド及び生体磁気センサ |
| EP3035347B1 (en) * | 2014-12-16 | 2017-11-15 | IMEC vzw | Spin torque majority gate device |
| US9702748B2 (en) | 2015-10-14 | 2017-07-11 | International Business Machines Corporation | Graphene-based magnetic hall sensor for fluid flow analysis at nanoscale level |
| US9841469B2 (en) | 2016-01-26 | 2017-12-12 | Nxp Usa, Inc. | Magnetic field sensor with multiple sense layer magnetization orientations |
| US9897667B2 (en) * | 2016-01-26 | 2018-02-20 | Nxp Usa, Inc. | Magnetic field sensor with permanent magnet biasing |
| US10545196B2 (en) | 2016-03-24 | 2020-01-28 | Nxp Usa, Inc. | Multiple axis magnetic sensor |
| US10145907B2 (en) * | 2016-04-07 | 2018-12-04 | Nxp Usa, Inc. | Magnetic field sensor with permanent magnet biasing |
| US9933496B2 (en) | 2016-04-21 | 2018-04-03 | Nxp Usa, Inc. | Magnetic field sensor with multiple axis sense capability |
| EP3385741B1 (en) * | 2017-04-07 | 2019-12-18 | Crocus Technology S.A. | Magnetic sensor cell for measuring one- and two-dimensional magnetic fields and method for measuring said magnetic fields using the magnetic sensor cell |
| WO2018185608A1 (en) | 2017-04-07 | 2018-10-11 | Crocus Technology Sa | Magnetic sensor cell for measuring one- and two-dimensional magnetic fields and method for measuring said magnetic fields using the magnetic sensor cell |
| WO2019109363A1 (en) * | 2017-12-09 | 2019-06-13 | Dongguan Bang Bang Tang Electronic Technologies Co., Ltd. | Current sensor for biomedical measurements |
| US10371723B2 (en) * | 2017-12-21 | 2019-08-06 | Shenzhen Dansha Technology Co., Ltd. | Current sensor for biomedical measurements |
| AU2019310601A1 (en) | 2018-07-27 | 2021-02-04 | Zepto Life Technology, Inc. | System and method for sensing analytes in GMR-based detection of biomarkers |
| US20190078146A1 (en) * | 2018-11-15 | 2019-03-14 | Xianlan Technology Co., Limited | System and method for gene detection |
| CN109283228B (zh) * | 2018-11-19 | 2024-07-23 | 江苏多维科技有限公司 | 一种基于磁阻元件的氢气传感器及其检测氢气的方法 |
| US10852369B2 (en) | 2019-01-09 | 2020-12-01 | Infineon Technologies Ag | Stray field robust xMR sensor using perpendicular anisotropy |
| US11327073B2 (en) | 2019-04-12 | 2022-05-10 | Western Digital Technologies, Inc. | Thermal sensor array for molecule detection and related detection schemes |
| US11579217B2 (en) | 2019-04-12 | 2023-02-14 | Western Digital Technologies, Inc. | Devices and methods for frequency- and phase-based detection of magnetically-labeled molecules using spin torque oscillator (STO) sensors |
| US11738336B2 (en) | 2019-04-12 | 2023-08-29 | Western Digital Technologies, Inc. | Spin torque oscillator (STO) sensors used in nucleic acid sequencing arrays and detection schemes for nucleic acid sequencing |
| US11112468B2 (en) * | 2019-04-12 | 2021-09-07 | Western Digital Technologies, Inc. | Magnetoresistive sensor array for molecule detection and related detection schemes |
| EP3941625A1 (en) | 2019-04-12 | 2022-01-26 | Western Digital Technologies Inc. | Nucleic acid sequencing by synthesis using magnetic sensor arrays |
| US11609208B2 (en) | 2019-04-12 | 2023-03-21 | Western Digital Technologies, Inc. | Devices and methods for molecule detection based on thermal stabilities of magnetic nanoparticles |
| US11208682B2 (en) | 2019-09-13 | 2021-12-28 | Western Digital Technologies, Inc. | Enhanced optical detection for nucleic acid sequencing using thermally-dependent fluorophore tags |
| US11747329B2 (en) | 2019-11-22 | 2023-09-05 | Western Digital Technologies, Inc. | Magnetic gradient concentrator/reluctance detector for molecule detection |
| EP4087625A4 (en) | 2020-01-08 | 2024-03-13 | Zepto Life Technology, LLC | POLYMER COMPOSITIONS AND BIOSURFACES INCLUDING THEM ON SENSORS |
| WO2021183403A2 (en) * | 2020-03-10 | 2021-09-16 | Western Digital Technologies, Inc. | Magnetic sensor arrays for nucleic acid sequencing and methods of making and using them |
| WO2022011067A1 (en) * | 2020-07-08 | 2022-01-13 | Roche Sequencing Solutions, Inc. | Single-molecule. real-time. label-free dynamic biosensing with nanoscale magnetic field sensors |
| US12269484B2 (en) | 2021-02-26 | 2025-04-08 | NearField Atomics Inc. | Systems and methods to keep drivers, pilots, or others alert or focused by electromagnetic delivery of signals |
| ES3034407T3 (en) | 2021-03-22 | 2025-08-18 | Nearfield Atomics Inc | Systems and methods for measuring magnetic fields from solvated target molecules using a magnetoresistive sensor |
| WO2024148266A1 (en) * | 2023-01-06 | 2024-07-11 | Regents Of The University Of Minnesota | Magnetic particle spectroscopy method and device |
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| WO2003054523A2 (en) * | 2001-12-21 | 2003-07-03 | Koninklijke Philips Electronics N.V. | Sensor and method for measuring the areal density of magnetic nanoparticles on a micro-array |
| US20030175155A1 (en) * | 2002-03-18 | 2003-09-18 | Bayer Healthcare, Llc | Storage cartridge for biosensors |
| US20050244873A1 (en) * | 2004-04-28 | 2005-11-03 | Canon Kabushiki Kaisha | Detecting method, detection device and detection kit |
| WO2006080558A1 (en) * | 2005-01-31 | 2006-08-03 | Canon Kabushiki Kaisha | Magnetic material sensor and detection method employing this sensor, and target material detection sensor and target material detection kit |
| US20070045126A1 (en) * | 2004-02-06 | 2007-03-01 | Beer Greg P | Oxidizable species as an internal reference for biosensors and method of use |
| JP2007212233A (ja) * | 2006-02-08 | 2007-08-23 | Asahi Kasei Corp | バイオセンサ |
| CN101046464A (zh) * | 2006-03-31 | 2007-10-03 | 佳能株式会社 | 传感器元件、磁性粒子的检测方法及目标物质的检测方法 |
| CN101313218A (zh) * | 2005-11-25 | 2008-11-26 | 皇家飞利浦电子股份有限公司 | 用于酶活性确定的磁性生物传感器 |
| CN101315429A (zh) * | 2007-05-31 | 2008-12-03 | 佳能株式会社 | 目标物质检测套件和目标物质检测方法 |
| CN101379384A (zh) * | 2006-02-03 | 2009-03-04 | 皇家飞利浦电子股份有限公司 | 带有基准单元的磁传感器装置 |
| CN101438162A (zh) * | 2006-05-09 | 2009-05-20 | 皇家飞利浦电子股份有限公司 | 精准的磁性生物传感器 |
| CN101443674A (zh) * | 2006-05-10 | 2009-05-27 | 皇家飞利浦电子股份有限公司 | 用于激励磁阻传感器的系统和方法 |
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| US20100117641A1 (en) * | 2006-09-28 | 2010-05-13 | Headway Technologies, Inc. | Detection of magnetic beads using a magnetoresistive device together with ferromagnetic resonance |
| US20100160184A1 (en) * | 2008-12-22 | 2010-06-24 | Electronics And Telecommunication Research Institute | Cross type magnetic array sensors for biomolecules magnetic bead detection |
| US20100213934A1 (en) * | 2009-02-26 | 2010-08-26 | Regents Of The University Of Minnesota | High magnetic moment particle detection |
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2012
- 2012-10-19 JP JP2014537321A patent/JP2015503085A/ja active Pending
- 2012-10-19 IN IN3583CHN2014 patent/IN2014CN03583A/en unknown
- 2012-10-19 CN CN201280060682.4A patent/CN103987654A/zh active Pending
- 2012-10-19 WO PCT/US2012/061156 patent/WO2013059692A1/en not_active Ceased
- 2012-10-19 US US14/352,638 patent/US9823316B2/en active Active
- 2012-10-19 EP EP12783469.5A patent/EP2768769A1/en not_active Withdrawn
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110462416A (zh) * | 2017-03-30 | 2019-11-15 | 高通股份有限公司 | 采用具有不同磁场灵敏度的隧道磁阻(tmr)器件以提高检测灵敏度的tmr传感器 |
| CN110462416B (zh) * | 2017-03-30 | 2022-05-24 | 高通股份有限公司 | 采用具有不同磁场灵敏度的隧道磁阻(tmr)器件以提高检测灵敏度的tmr传感器 |
| CN112689759A (zh) * | 2018-08-09 | 2021-04-20 | Bbb有限公司 | 使用磁性纳米粒子的生物传感器,以及使用生物传感器的检测装置和检测方法 |
| WO2020199786A1 (zh) * | 2019-04-02 | 2020-10-08 | 京东方科技集团股份有限公司 | 微流控芯片、液态样本检测装置和方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2015503085A (ja) | 2015-01-29 |
| IN2014CN03583A (https=) | 2015-09-25 |
| EP2768769A1 (en) | 2014-08-27 |
| US9823316B2 (en) | 2017-11-21 |
| WO2013059692A9 (en) | 2014-03-27 |
| WO2013059692A1 (en) | 2013-04-25 |
| US20140292318A1 (en) | 2014-10-02 |
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