CN103977263A - External traditional Chinese medicine composition for treating bedsore stage III - Google Patents

Abstract

The invention relates to an external traditional Chinese medicine composition for treating bedsore stage III. The composition is prepared from the following raw materials in parts by weight: 30-60 parts of bletilla, 10-20 parts of Japanese beauty-berries, 10-20 parts of lithospermum, 10-20 parts of sargent gloryvine, 10-20 parts of polygonum cuspidatum, 10-20 parts of nakedflower beautyberry branchlets and leaves, 18-22 parts of rheum officinale, 10-20 parts of mirabilite, 10-20 parts of leaves of loropetalum Chinese, 35-65 parts of pearls, 0.8-1.5 parts of alumen and 0.8-1.5 parts of calamine. The preparation method comprises the following steps: weighing the raw materials in weight ratio to grind into powder; sieving by a 100-mesh sieve; after uniformly mixing and stirring, adding a proper amount of sesame oil; and stirring to a paste. The medicines are reasonably matched to have a synergistic effect, so that the composition has the functions of clearing away heat and toxic materials, healing sore and eliminating swelling, promoting blood circulation to remove blood stasis and removing slough and promoting growth of tissue regeneration. The composition has the advantages of convenience in material taking, low cost, safe use, good effect and the like.

Description

A kind of external medicine composition for the treatment of III phase decubital ulcer

Technical field

The invention belongs to Chinese materia medica technical field, be specifically related to a kind of external medicine composition for the treatment of III phase decubital ulcer.

Background technology

Decubital ulcer claims again pressure ulcer, is due to the long-term pressurized of local organization, and the skin that disturbance of blood circulation causes and subcutaneous tissue continuous ischemia, anoxia, malnutrition, low the formed ulcer of organizational vitality or tissue necrosis, be mainly in long-term bedridden patients.Decubital ulcer Chinese medicine is called " bed-sore ", and primary disease is many because prolonged illness asthenia of qi and blood declines, or paralyzed limbs is useless, and with unsuccessful, function weakens, and yang-energy is not transported, and QI and blood can not be declared logical, causes failure of skin and muscle to be nourished; Or patient's long-term bed, excessive rest on bed impairing QI, the deficiency of vital energy is hematogenous blockage, pressurized position stagnation of QI-blood, local skin, muscle arteries and veins lose in warm moisten foster, the poly-meat corruption of poison, skin and flesh necrosis forms, and has a strong impact on patient's life quality.The pathological change occurring according to decubital ulcer is divided into the I phase (ruddy phase of congestion): pressurized position skin is red, swollen, hot, and epidermis is not damaged; The II phase (inflammatory infiltration phase): skin is purplish red, subcutaneous have a scleroma, and epidermis has blister, and ulceration manifests moist ruddy wound surface, patient's feels pain; The III phase (ulcerative stage): skin ulceration, tissue infection, pus flow out, ulcer, and the pain increased, can deeply reach subcutaneous tissue, involves fascia and muscle.Clinical Processing is very thorny, though there is several different methods treatment III phase decubital ulcer at present, effect is undesirable.Inventor applies for many years external medicine composition in clinical, has obtained good curative effect.

Summary of the invention

The object of the invention is to overcome the defect that prior art exists, provide that a kind of selection is easy, easy to prepare, expense is cheap, have no side effect and the external medicine composition of evident in efficacy, lasting treatment III phase decubital ulcer.

Technical scheme of the present invention is: a kind of external medicine composition for the treatment of III phase decubital ulcer, it is characterized in that according to weight proportion, crude drug consists of: 30～60 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 10～20 parts of Folium Callicarpae Formosanaes, 10～20 parts of Radix Arnebiae (Radix Lithospermi)s, 10～20 parts of Caulis Sargentodoxaes, 10～20 parts of Rhizoma Polygoni Cuspidati, 10～20 parts of Folium et Ramulus Callicarpae nudiflorae, 18～22 parts of Radix Et Rhizoma Rhei, 10～20 parts, Natrii Sulfas, 10～20 parts of Folium Loropetalis, 35～65 parts of Margaritas, 0.8～1.5 part of Alumen, 0.8～1.5 part of Calamina; Get by weight ratio each crude drug pulverize, cross 100 mesh sieves, after mixing and stirring, add Oleum Sesami appropriate, stir into pasty state.

Preferable range of the present invention is: 45 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 15 parts of Folium Callicarpae Formosanaes, 15 parts of Radix Arnebiae (Radix Lithospermi)s, 15 parts of Caulis Sargentodoxaes, 15 parts of Rhizoma Polygoni Cuspidati, 15 parts of Folium et Ramulus Callicarpae nudiflorae, 20 parts of Radix Et Rhizoma Rhei, 15 parts, Natrii Sulfas, 15 parts of Folium Loropetalis, 45 parts of Margaritas, 1.2 parts of Alumens, 1.2 parts of Calaminas, get by weight ratio each crude drug pulverize, cross 100 mesh sieves, after mixing and stirring, add Oleum Sesami appropriate, stir into pasty state.

Using method: the used time, after the conventional debridement in decubital ulcer place, sterilization, be applied to wound surface with the Chinese medicine composition that aseptic cotton carrier handle prepares, the scope of smearing is greater than extent of disease 3～4cm, and thickness 1～2mm covers with sterile gauze, within 2～3 days, changing dressings 1 time, 10 days is a course for the treatment of.

The present invention, mainly by effect of heat-clearing and toxic substances removing, healing up sore and subduing swelling, blood circulation promoting and blood stasis dispelling, putrefaction-removing granulation-promoting, improves the blood circulation of patient bedridden in long term pressurized tissue, promotes epithelial cell to organize Fast Growth, reaches the object for the treatment of decubital ulcer.The described Pseudobulbus Bletillae (Rhizoma Bletillae): bitter, sweet, puckery, cold.Return lung, stomach, Liver Channel.Main Function is: astringing to arrest bleeding, detumescence and promoting granulation.Modern pharmacology research, this product has multiple polysaccharide, also contains volatile oil, starch, can shorten clotting time and suppress fibrinolysis activity, has good local hemostasis effect.Meanwhile, the Pseudobulbus Bletillae (Rhizoma Bletillae) also has protection mucosa and antifungal effect.Shennong's Herbal cloud: " main carbuncle, malignant boil, lose cellulitis, the dead flesh of impairment of YIN, pathogen in stomach." in we, be monarch drug.Folium Callicarpae Formosanae: bitter, puckery, cool.Return liver, lung, stomach warp.Act as astringing to arrest bleeding, heat-clearing and toxic substances removing, can strengthen the anastaltic effect of the Pseudobulbus Bletillae (Rhizoma Bletillae).Radix Arnebiae (Radix Lithospermi): Gan Han, GUIXIN Liver Channel.Can removing heat from blood and promoting blood circulation, removing toxic substances rash is mainly used in the effect of removing pathogenic heat from blood and toxic substance from the body in we, is used for treating decubital ulcer later stage ulcer and does not close up for a long time.Modern pharmacological research, Radix Arnebiae (Radix Lithospermi) also has certain antiinflammatory action.Caulis Sargentodoxae: bitter flat, return large intestine channel.Can heat-clearing and toxic substances removing, promoting blood circulation and stopping pain, this product is longer than heat-clearing and toxic substances removing, and eliminating carbuncle pain relieving has good effect to pathopyretic ulcer, to the feasible soak of wound surface that occurs to infect, can impel wound surface clean, healing acceleration.Rhizoma Polygoni Cuspidati: bitter cold, return liver and gall, lung meridian.Can heat-clearing and toxic substances removing, again can blood circulation promoting and blood stasis dispelling, burn and scald and carbuncle sore tumefacting virus are had to good effect.Folium et Ramulus Callicarpae nudiflorae: there is hemostasis, antiinflammatory, blood stasis dispelling, the effect of pain relieving, has good effect to suppurative skin ulcer." south of the Five Ridges gather medicinal herbs record ": " leaf: decoct washing traumatic injury wound, can eliminating blood stasis to promote regeneration of blood." modern pharmacological research thinks that this product has control traumatic infection, makes wound surface dry, reduces the incidence rate of septicemia, minimizing is oozed out, and protection granulation tissue also promotes the effect of ulcer healing.Radix Et Rhizoma Rhei, bitter cold.Can clearing away heat-fire, hemostasis removing toxic substances.Natrii Sulfas, salty, bitter cold.Under can rushing down, softening the hard mass, heat clearing away, external has the effect of clearing heat for detumescence.Above seven medicine compatibilities, can heat clearing away, removing toxic substances, hemostasis, detumescence, and the sore of invigorating blood circulation again, promotes the recovery of wound surface ulcer, is ministerial drug.Folium Loropetali: bitter, puckery, cool.Heat-clearing and toxic substances removing, convergence, hemostasis, for burn or scald, traumatic hemorrhage.Margarita powder: there is heat-clearing and toxic substances removing, the effect of convergence wound, the wound (knife injury, burn, scald etc.) to skin has good repair.Margarita powder can promote the growth of collagenocyte in human body, and collagenocyte is the main person who has rendered outstanding service who impels skin regeneration, and Margarita powder also has more significant antiinflammation simultaneously, can inflammation-inhibiting cell regeneration, prevent that wound from further worsening.Margarita powder is outer can fill interstice for wound, and adhesion vascular tissue brings into play its antiinflammatory, promotes effect that collagenocyte is grown, and impels body cell regeneration.In addition, when recover at the position of being wound, can allow skin recover original smooth state, neither can produce ugly pigementation, also reduce residual any cicatrix offending the eye.Alumen, acid, puckery, cold.There is astriction, can also detoxifying and relieving itching, be used for sore, can treat again the itch pain of decubitus ulcer face while recovering uncomfortable." medical center bun want ": raw with removing toxic substances, forge and anhydrate by granulation promoting.Calamina: sweet, flat, can removing toxic substances and promoting granulation sore, again can removing dampness antipruritic.Modern pharmacological research: can partially absorb wound extract, have convergence, protective effect; Still can suppress local staphylococcic growth.Above four medicines, as one group of adjuvant drug, mainly play the antipruritic effect of promoting tissue regeneration and ulcer healing.Oleum Sesami: this product nature and flavor are sweet, cool, has effect of loosening bowel to relieve constipation, removing toxic substances and promoting granulation.According to recording in Compendium of Material Medica: " have moisturize, the merit of removing toxic substances, pain relieving, detumescence." clinically also decoct plaster with Oleum Sesami, there is granulation promoting meat, an effect of the pain that relieves the pain, subduing inflammation, benefit rhagades of the skin.In we, as medium, make the stepless action of various medicine energy in decubital ulcer surface, play a role, for making medicine.

The invention has the beneficial effects as follows: all medicines are reasonably combined, mutually play synergism, can reach effect of heat-clearing and toxic substances removing, healing up sore and subduing swelling, blood circulation promoting and blood stasis dispelling, putrefaction-removing granulation-promoting.Have and draw materials conveniently, cheap, use the advantages such as safe, effective, alleviate patient's misery.

Detailed description of the invention

Embodiment 1: 30 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 10 parts of Folium Callicarpae Formosanaes, 10 parts of Radix Arnebiae (Radix Lithospermi)s, 10 parts of Caulis Sargentodoxaes, 10 parts of Rhizoma Polygoni Cuspidati, 10 parts of Folium et Ramulus Callicarpae nudiflorae, 18 parts of Radix Et Rhizoma Rhei, 10 parts, Natrii Sulfas, 10 parts of Folium Loropetalis, 35 parts of Margaritas, 0.8 part of Alumen, 0.8 part of Calamina, get by weight ratio each crude drug pulverize, cross 100 mesh sieves, after mixing and stirring, add Oleum Sesami appropriate, stir into pasty state.

Embodiment 2: 45 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 15 parts of Folium Callicarpae Formosanaes, 15 parts of Radix Arnebiae (Radix Lithospermi)s, 15 parts of Caulis Sargentodoxaes, 15 parts of Rhizoma Polygoni Cuspidati, 15 parts of Folium et Ramulus Callicarpae nudiflorae, 20 parts of Radix Et Rhizoma Rhei, 15 parts, Natrii Sulfas, 15 parts of Folium Loropetalis, 45 parts of Margaritas, 1.2 parts of Alumens, 1.2 parts of Calaminas, get by weight ratio each crude drug pulverize, cross 100 mesh sieves, after mixing and stirring, add Oleum Sesami appropriate, stir into pasty state.

Embodiment 3: 60 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 20 parts of Folium Callicarpae Formosanaes, 20 parts of Radix Arnebiae (Radix Lithospermi)s, 20 parts of Caulis Sargentodoxaes, 20 parts of Rhizoma Polygoni Cuspidati, 20 parts of Folium et Ramulus Callicarpae nudiflorae, 22 parts of Radix Et Rhizoma Rhei, 20 parts, Natrii Sulfas, 20 parts of Folium Loropetalis, 65 parts of Margaritas, 1.5 parts of Alumens, 1.5 parts of Calaminas, get by weight ratio each crude drug pulverize, cross 100 mesh sieves, after mixing and stirring, add Oleum Sesami appropriate, stir into pasty state.

Using method: the used time, after the conventional debridement in decubital ulcer place, sterilization, be applied to wound surface with the Chinese medicine composition that aseptic cotton carrier handle prepares, the scope of smearing is greater than extent of disease 3～4cm, and thickness 1～2mm covers with sterile gauze, within 2～3 days, changing dressings 1 time, 10 days is a course for the treatment of.

Therapeutic effect:

Efficacy determination: formulate recovery from illness: inflammation disappears, ulcer healing with reference to " guideline of clinical investigations of new Chinese medicine treatment decubital ulcer ".Effective: ulcerative stage secretions reduces relatively, slough incrustation.Ulcer surface area reduces more than 80%, and wound surface is clean, and granulation tissue is fresh.Effective: wound surface has rheuminess thing, and granulation tissue is stale, ulcer surface area reduces more than 30%.Invalid: local unchanged or increase the weight of after treatment, ulcer surface area is without obvious minimizing, and wound surface has purulent secretion, filth.

Effect: select to meet III phase decubital ulcer diagnostic criteria 40 routine patients, 50 ~ 65 years old age, male 26 examples, female's 14 examples.Through treatment, recovery from illness 17 examples, account for 42.5%; Effective 12 examples, account for 30%; Effective 8 examples, account for 20%; Invalid 3 examples, account for 7.5%, and total effective rate is 92.5%, have no toxic and side effects and occur.

Claims (1)

1. treat the external medicine composition of III phase decubital ulcer for one kind, it is characterized in that according to weight proportion, crude drug consists of: 30～60 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 10～20 parts of Folium Callicarpae Formosanaes, 10～20 parts of Radix Arnebiae (Radix Lithospermi)s, 10～20 parts of Caulis Sargentodoxaes, 10～20 parts of Rhizoma Polygoni Cuspidati, 10～20 parts of Folium et Ramulus Callicarpae nudiflorae, 18～22 parts of Radix Et Rhizoma Rhei, 10～20 parts, Natrii Sulfas, 10～20 parts of Folium Loropetalis, 35～65 parts of Margaritas, 0.8～1.5 part of Alumen, 0.8～1.5 part of Calamina; Get by weight ratio each crude drug pulverize, cross 100 mesh sieves, after mixing and stirring, add Oleum Sesami to stir into pasty state.